B S Skalhegg

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA
    B S Skalhegg
    Institute for Nutrition Reserarch, University of Oslo, Norway
    Front Biosci 5:D678-93. 2000
  2. ncbi request reprint Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
    B S Skalhegg
    Institute of Medical Biochemistry, University of Oslo, Norway
    J Cell Physiol 177:85-93. 1998
  3. ncbi request reprint Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis
    N Reinton
    Institute of Medical Biochemistry, University of Oslo, Oslo, N 0317, Norway
    Dev Biol 223:194-204. 2000
  4. ncbi request reprint CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis
    C R Carlson
    Institute of Medical Biochemistry, University of Oslo, PO Box 1112 Blindern, N 0317 Oslo, Norway
    J Cell Sci 114:3243-54. 2001
  5. ncbi request reprint Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95
    S Orstavik
    Institute of Medical Biochemistry, Faculty of Medicine, University of Oslo, Norway
    Biol Cell 92:27-37. 2000
  6. ncbi request reprint A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece
    N Reinton
    Institute of Medical Biochemistry, University of Oslo, N 0317 Oslo, Norway
    Biol Reprod 63:607-11. 2000
  7. ncbi request reprint Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes
    K Tasken
    Institute of Medical Biochemistry, University of Oslo, Norway
    J Biol Chem 268:21276-83. 1993
  8. ncbi request reprint Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh)
    K Tasken
    Institute of Medical Biochemistry, University of Oslo, Norway
    J Biol Chem 268:23483-9. 1993
  9. ncbi request reprint The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon
    N Reinton
    Institute of Medical Biochemistry, University of Oslo, Norway
    Genomics 49:290-7. 1998
  10. pmc Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
    O Witczak
    Institute of Medical Biochemistry, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern N 0317 Oslo, Norway
    EMBO J 18:1858-68. 1999

Detail Information

Publications16

  1. ncbi request reprint Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA
    B S Skalhegg
    Institute for Nutrition Reserarch, University of Oslo, Norway
    Front Biosci 5:D678-93. 2000
    ..Here we will describe features of this signaling pathway that may contribute to explain how differential effects of cAMP may be contributed to features of the PKA signaling pathway...
  2. ncbi request reprint Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
    B S Skalhegg
    Institute of Medical Biochemistry, University of Oslo, Norway
    J Cell Physiol 177:85-93. 1998
    ..05). Taken together, our results demonstrate great differences in PKA isozyme composition, which should be taken into consideration when using lymphoid cell lines as model system for cAMP/PKA effects in normal lymphocytes...
  3. ncbi request reprint Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis
    N Reinton
    Institute of Medical Biochemistry, University of Oslo, Oslo, N 0317, Norway
    Dev Biol 223:194-204. 2000
    ....
  4. ncbi request reprint CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis
    C R Carlson
    Institute of Medical Biochemistry, University of Oslo, PO Box 1112 Blindern, N 0317 Oslo, Norway
    J Cell Sci 114:3243-54. 2001
    ..Our results suggest that T54 phosphorylation of RIIalpha by CDK1 might serve to regulate the centrosomal association of PKA during the cell cycle...
  5. ncbi request reprint Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95
    S Orstavik
    Institute of Medical Biochemistry, Faculty of Medicine, University of Oslo, Norway
    Biol Cell 92:27-37. 2000
    ..The similarity in sequence and localization of HA95 and AKAP95 suggests that the two molecules constitute a novel family of nuclear proteins that may exhibit related functions...
  6. ncbi request reprint A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece
    N Reinton
    Institute of Medical Biochemistry, University of Oslo, N 0317 Oslo, Norway
    Biol Reprod 63:607-11. 2000
    ..This novel C alpha-s splice variant appeared to have an independent anchor in the human sperm midpiece as it could not be completely solubilized even in the presence of both detergent and cAMP...
  7. ncbi request reprint Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes
    K Tasken
    Institute of Medical Biochemistry, University of Oslo, Norway
    J Biol Chem 268:21276-83. 1993
    ..RI alpha-RI beta heterodimers complexed with the catalytic subunit represent a novel isozyme of cAKI (RI alpha RI beta C2), which enhances the possibilities for diversification of cAMP-mediated effects...
  8. ncbi request reprint Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh)
    K Tasken
    Institute of Medical Biochemistry, University of Oslo, Norway
    J Biol Chem 268:23483-9. 1993
    ..The finding that the protein synthesis inhibitor cycloheximide gave changes in RI alpha and C alpha mRNA similar to cAMP and that co-treatment with cycloheximide and cAMP resulted in additive effects tend to support this notion...
  9. ncbi request reprint The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon
    N Reinton
    Institute of Medical Biochemistry, University of Oslo, Norway
    Genomics 49:290-7. 1998
    ..Our results indicate that the C gamma gene is a retroposon specifically transcribed in primate testicular germ cells...
  10. pmc Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
    O Witczak
    Institute of Medical Biochemistry, Faculty of Medicine, University of Oslo, PO Box 1112, Blindern N 0317 Oslo, Norway
    EMBO J 18:1858-68. 1999
    ..Furthermore, AKAP450 was shown to co-purify in centrosomal preparations. The observation of two mRNAs and several splice products suggests additional functions for the AKAP450 gene...
  11. ncbi request reprint Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase
    S Ørstavik
    Institute of Medical Biochemistry, Faculty of Medicine, University of Oslo, Blindern, N 0316 Oslo, Norway
    Eur J Biochem 268:5066-73. 2001
    ..We suggest that the various Cbeta splice variants when complexed with regulatory subunits may give rise to novel holoenzymes of protein kinase A that may be important for mediating specific effects of cAMP...
  12. ncbi request reprint Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
    E M Aandahl
    Institute of Medical Biochemistry, University of Oslo, Norway
    FASEB J 12:855-62. 1998
    ..These observations imply that increased activation of PKA type I may contribute to the progressive T cell dysfunction in HIV infection and that PKA type I may be a potential target for immunomodulating therapy...
  13. pmc Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
    T Vang
    Department of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
    J Exp Med 193:497-507. 2001
    ..We propose a mechanism whereby PKA through activation of Csk intersects signaling by Src kinases and inhibits T cell activation...
  14. ncbi request reprint Differential expression and regulation of the PKA signalling pathway in fast and slow skeletal muscle
    F Hoover
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Blindern, Norway
    Anat Embryol (Berl) 203:193-201. 2001
    ..These observations demonstrate that PKA levels in skeletal muscle are subject to control at several levels and suggest that some of the differences may be in the pattern of electrical activity that motoneurons impose on the SOL and EDL...
  15. ncbi request reprint Kinetic properties of the C-terminal Src kinase, p50csk
    T Vang
    Institute of Medical Biochemistry, University of Oslo, Norway
    Biochim Biophys Acta 1384:285-93. 1998
    ..Phosphorylation of a physiological substrate (Lck) and autophosphorylation of Csk was not inhibited by phosphate, indicating that the phosphate-dependent inhibition of Csk activity was substrate specific...
  16. ncbi request reprint Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95
    T Eide
    Institute of Medical Biochemistry, University of Oslo, Blindern, Oslo, N 0317, Norway
    Exp Cell Res 238:305-16. 1998
    ..The results show a distinct redistribution of AKAP95 during mitosis, suggesting that the interaction between AKAP95 and RIIalpha may be cell cycle-dependent...