Ola D Saugstad

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Response to resuscitation of the newborn: early prognostic variables
    Ola D Saugstad
    Department of Paediatric Research, Rikshospitalet University Hospital, Sognsvannsvn 20, NO 0027 Oslo, Norway
    Acta Paediatr 94:890-5. 2005
  2. ncbi request reprint Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet, University of Oslo, Norway
    Biol Neonate 87:27-34. 2005
  3. ncbi request reprint Optimal oxygenation at birth and in the neonatal period
    Ola Didrik Saugstad
    Department of Pediatrics, Rikshospitalet Medical Center, Faculty of Medicine, University of Oslo, Oslo, Norway
    Neonatology 91:319-22. 2007
  4. ncbi request reprint Non-selective fetal reduction is malpractice
    Ola Didrik Saugstad
    Department of Pediatric Research, Faculty Division, Rikshospitalet, University of Oslo, Norway
    J Perinat Med 34:355-8. 2006
  5. ncbi request reprint Take a breath--but do not add oxygen (if not needed)
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Medical Center, Faculty of Medicine, University of Oslo, Oslo, Norway
    Acta Paediatr 96:798-800. 2007
  6. ncbi request reprint Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease
    Ola D Saugstad
    Department of Pediatric Research, Rikshospitalet Radiumhospitalet Health Trust, University of Oslo, Oslo, Norway
    Acta Paediatr 96:185-90. 2007
  7. ncbi request reprint Oxygen and retinopathy of prematurity
    O D Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Perinatol 26:S46-50; discussion S63-4. 2006
  8. ncbi request reprint New guidelines for newborn resuscitation
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Faculty Division, University of Oslo, Oslo, Norway
    Acta Paediatr 96:333-7. 2007
  9. ncbi request reprint When newborn infants are bound to die
    Ola Didrik Saugstad
    Department of Pediatric Research, University of Oslo, Oslo, Norway
    Acta Paediatr 94:1535-7. 2005
  10. ncbi request reprint Oxidative stress in the newborn--a 30-year perspective
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Faculty Division, University of Oslo, Oslo, Norway
    Biol Neonate 88:228-36. 2005

Detail Information

Publications91

  1. ncbi request reprint Response to resuscitation of the newborn: early prognostic variables
    Ola D Saugstad
    Department of Paediatric Research, Rikshospitalet University Hospital, Sognsvannsvn 20, NO 0027 Oslo, Norway
    Acta Paediatr 94:890-5. 2005
    ..To characterize the development of clinically relevant variables the first minutes after birth and identify early prognostic markers in newborn infants requiring resuscitation...
  2. ncbi request reprint Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet, University of Oslo, Norway
    Biol Neonate 87:27-34. 2005
    ..It is discussed whether depressed newborn infants should be resuscitated with room air or 100% O2...
  3. ncbi request reprint Optimal oxygenation at birth and in the neonatal period
    Ola Didrik Saugstad
    Department of Pediatrics, Rikshospitalet Medical Center, Faculty of Medicine, University of Oslo, Oslo, Norway
    Neonatology 91:319-22. 2007
    ..In recent years it has become clear that even a brief exposure to high oxygen concentration at birth and an oxygen saturation (SaO(2)) >93-95% in extremely low birth weight (ELBW) infants is more toxic than previously believed...
  4. ncbi request reprint Non-selective fetal reduction is malpractice
    Ola Didrik Saugstad
    Department of Pediatric Research, Faculty Division, Rikshospitalet, University of Oslo, Norway
    J Perinat Med 34:355-8. 2006
    ..Further, ovarian stimulating programs should strictly adhere to protocols aiming at mono-ovulation...
  5. ncbi request reprint Take a breath--but do not add oxygen (if not needed)
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Medical Center, Faculty of Medicine, University of Oslo, Oslo, Norway
    Acta Paediatr 96:798-800. 2007
  6. ncbi request reprint Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease
    Ola D Saugstad
    Department of Pediatric Research, Rikshospitalet Radiumhospitalet Health Trust, University of Oslo, Oslo, Norway
    Acta Paediatr 96:185-90. 2007
    ..To investigate whether intractable respiratory distress syndrome in three Norwegian term infants was due to mutations in the ABCA3 gene...
  7. ncbi request reprint Oxygen and retinopathy of prematurity
    O D Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Perinatol 26:S46-50; discussion S63-4. 2006
    ..However, by strictly avoiding hyperoxia, that is, SaO2>92-93% and avoiding fluctuations in SaO2, it is possible to control and prevent severe retinopathy of prematurity in most cases...
  8. ncbi request reprint New guidelines for newborn resuscitation
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Faculty Division, University of Oslo, Oslo, Norway
    Acta Paediatr 96:333-7. 2007
    ..A number of gaps in newborn resuscitation have been identified and discussed...
  9. ncbi request reprint When newborn infants are bound to die
    Ola Didrik Saugstad
    Department of Pediatric Research, University of Oslo, Oslo, Norway
    Acta Paediatr 94:1535-7. 2005
    ..Does a liberal view on withholding or withdrawing treatment lead to poorer overall outcome results even for babies above the threshold of viability specified by the institution?..
  10. ncbi request reprint Oxidative stress in the newborn--a 30-year perspective
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet Faculty Division, University of Oslo, Oslo, Norway
    Biol Neonate 88:228-36. 2005
    ..Inflammation and oxidative stress seem to be two sides of the same coin in newborn babies both contributing to injury partly through similar mechanisms...
  11. ncbi request reprint Toxic effects of different meconium fractions on lung function: new therapeutic strategies for meconium aspiration syndrome?
    O D Saugstad
    Department of Pediatric Research and Pediatrics, Rikshospitalet Medical Center, University of Oslo, Oslo, Norway
    J Perinatol 28:S113-5. 2008
    ..These results indicate that at least part of the symptoms seen in the meconium aspiration syndrome could be prevented by blocking the active substances of meconium such as bile acids and free fatty acids...
  12. doi request reprint Why are we still using oxygen to resuscitate term infants?
    O D Saugstad
    Department of Pediatric Research, Oslo University Hospital, University of Oslo, Oslo, Norway
    J Perinatol 30:S46-50. 2010
    ..For extremely low birth weight infants, initial FiO(2) could be between 0.21 and 0.30 and adjusted according to the response in SaO(2) and heart rate...
  13. ncbi request reprint Oxygen for newborn resuscitation: how much is enough?
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Pediatrics 118:789-92. 2006
  14. ncbi request reprint Room air resuscitation-two decades of neonatal research
    Ola Didrik Saugstad
    Department of Pediatric, Research Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Early Hum Dev 81:111-6. 2005
    ..Although the optimal oxygen concentration probably is not known for newborn infants in need of resuscitation, pure oxygen should be avoided. These data should be reflected in new guidelines that are under way...
  15. doi request reprint Delayed onset of cardiac compressions in cardiopulmonary resuscitation of newborn pigs with asphyctic cardiac arrest
    Ingrid Dannevig
    Department of Pediatrics, Akershus University Hospital, Lørenskog, Norway
    Neonatology 99:153-62. 2011
    ..However, it may take longer than 30 s to establish effective pulmonary gas exchange. Whether a longer period of initial ventilation to reverse asphyxia would result in less need for cardiac compressions is unknown...
  16. doi request reprint Resuscitation of severely asphyctic newborn pigs with cardiac arrest by using 21% or 100% oxygen
    Anne L Solevåg
    Department of Paediatric Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway a l solevag medisin uio no
    Neonatology 98:64-72. 2010
    ..In spite of evidence suggesting that resuscitation with 100% O(2) is detrimental, international guidelines still recommend its use. Clinical studies comparing 21% and 100% O(2) included many infants with only mild and moderate asphyxia...
  17. doi request reprint Return of spontaneous circulation with a compression:ventilation ratio of 15:2 versus 3:1 in newborn pigs with cardiac arrest due to asphyxia
    Anne L Solevåg
    Department of Paediatrics, Akershus University Hospital, 1478 Lørenskog and Department of Paediatric Research, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
    Arch Dis Child Fetal Neonatal Ed 96:F417-21. 2011
    ..The authors aimed to compare these two C:V ratios in a neonatal swine model of cardiac arrest following asphyxia...
  18. ncbi request reprint Meconium induced IL-8 production and intratracheal albumin alleviated lung injury in newborn pigs
    Paal H H Lindenskov
    Department of Pediatric Research, Institute for Surgical Research, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Pediatr Res 57:371-7. 2005
    ..Rescue treatment with albumin in meconium aspiration improved lung compliance in piglets and may represent a new therapeutic approach to MAS...
  19. doi request reprint Transcriptome profiling of the newborn mouse brain after hypoxia-reoxygenation: hyperoxic reoxygenation induces inflammatory and energy failure responsive genes
    Embjørg J Wollen
    Department of Pediatric Research, Clinic of Women and Child Health, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Pediatr Res 75:517-26. 2014
    ..Supplemental oxygen used during resuscitation can be detrimental to the newborn brain. The aim was to determine how different oxygen therapies affect gene transcription in a hypoxia-reoxygenation model...
  20. pmc Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen
    Helene C D Østerholt
    Department of Pediatrics, Akershus University Hospital, Lørenskog, Norway
    PLoS ONE 7:e38839. 2012
    ..We examined the effects of 100% oxygen resuscitation and treatment with the antioxidant, N-acetylcysteine (NAC), on lung 3-nitrotyrosine (3-NT), LMW HA, inflammation, TNFα and IL1ß in a newborn pig model of resuscitation...
  21. ncbi request reprint Reoxygenation with 100 or 21% oxygen after cerebral hypoxemia-ischemia-hypercapnia in newborn piglets
    Anne Beate Solas
    Department of Pediatric Research, The National Hospital, University of Oslo, Oslo, Norway
    Biol Neonate 85:105-11. 2004
    ..This indicates that the brain tolerated reoxygenation with 21% as well as with 100% O(2) in the present model of experimental asphyxia in spite of the differences in MABP and cerebral microcirculation...
  22. ncbi request reprint Resuscitation with 100% O2 increases cerebral injury in hypoxemic piglets
    Berit H Munkeby
    Department of Pediatric Research, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Pediatr Res 56:783-90. 2004
    ..Our findings suggest that resuscitation of asphyxiated piglets with 100% O2 is detrimental to the piglet brain compared with resuscitation with 21% O2...
  23. doi request reprint Accumulation of 8-oxoguanine in liver DNA during hyperoxic resuscitation of newborn mice
    Yngve Sejersted
    Department of Pediatric Research, University of Oslo, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Pediatr Res 66:533-8. 2009
    ..The duration of supplementary oxygen use during resuscitation should be kept as short as justifiable to minimize the risk of genetic instability...
  24. doi request reprint Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age
    Ingrid B Helland
    Department of Nutrition, Institute of Basic Medical Sciences, Oslo, Norway
    Pediatrics 122:e472-9. 2008
    ..We also examined the relation between plasma fatty acid pattern and BMI in children, because an association between arachidonic acid and adipose tissue size has been suggested...
  25. ncbi request reprint Comparison of pulmonary and inflammatory effects of lipid- and water-soluble components in meconium in newborn piglets
    Per Arne Tølløfsrud
    Department of Pediatric Research, National Hospital, Oslo, Oslo, Norway
    Biol Neonate 84:330-7. 2003
    ....
  26. ncbi request reprint Intratracheal albumin reduces interleukin-8 in tracheobronchial aspirates in piglets after meconium aspiration
    Per Arne Tølløfsrud
    Department of Pediatric Research, The National Hospital, Oslo, Norway
    J Perinat Med 32:78-83. 2004
    ..In conclusion, albumin significantly decreased interleukin-8 concentrations in tracheobronchial aspirates after meconium aspiration...
  27. ncbi request reprint Transcriptome profiling of the newborn mouse lung after hypoxia and reoxygenation: hyperoxic reoxygenation affects mTOR signaling pathway, DNA repair, and JNK-pathway regulation
    Embjørg J Wollen
    Department of Pediatric Research, Women and Children s Division, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Pediatr Res 74:536-44. 2013
    ..The use of oxygen in acute treatment of asphyxiated term newborns is associated with increased mortality. It is unclear how hyperoxic reoxygenation after hypoxia affects transcriptional changes in the newborn lung...
  28. doi request reprint The impact of hyaluronan on monocyte Toll-like receptor expression in term infant cord blood
    Helene C D Osterholt
    Department of Pediatrics, Akershus University Hospital, Lørenskog, Norway
    Acta Paediatr 101:706-13. 2012
    ....
  29. ncbi request reprint Complement C5a is a key mediator of meconium-induced neutrophil activation
    Albert Castellheim
    Department of Pediatric Research, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Pediatr Res 57:242-7. 2005
    ..The data suggest that complement activation is largely responsible for the neutrophil inflammatory responses induced by meconium in vitro and that C5a is a key mediator of this response...
  30. doi request reprint Meconium-induced release of cytokines is mediated by the TRL4/MD-2 complex in a CD14-dependent manner
    Bodil Salvesen
    Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, Oslo, Norway
    Mol Immunol 47:1226-34. 2010
    ..The cyanobacterial product CyP is a potent LPS antagonist binding to the TLR4/MD-2 complex. The aim of the present study was to investigate the role of the CD14/TLR4/MD-2 complex in meconium-induced inflammation...
  31. ncbi request reprint Resuscitation of newborn infants with 21% or 100% oxygen: follow-up at 18 to 24 months
    Ola D Saugstad
    Department of Pediatric Research, Rikshospitalet, University of Oslo, Oslo, Norway
    Pediatrics 112:296-300. 2003
    ..To follow-up children who had been resuscitated at birth with either 21% or 100% oxygen (O2)...
  32. ncbi request reprint Newborn piglets exposed to hypoxia after nicotine or saline pretreatment: long-term effects on brain and heart
    Jannicke H Andresen
    Medical Faculty, Department of Pediatric Research, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Matern Fetal Neonatal Med 22:161-8. 2009
    ..Hypothesising that nicotine might give a better outcome because of its anti-apoptotic and anti-inflammatory effects...
  33. doi request reprint Mechanisms of complement activation and effects of C1-inhibitor on the meconium-induced inflammatory reaction in human cord blood
    Bodil Salvesen
    Institute of Immunology, Medical Faculty, University of Oslo and Rikshospitalet University Hospital, Sognsvannsveien 20, 0027 Oslo, Norway
    Mol Immunol 46:688-94. 2009
    ..C1-inhibitor (C1-INH) regulates complement and contact-system activation mainly by protease inhibition, but may reduce inflammation by other mechanisms as well...
  34. ncbi request reprint Inflammation increases vulnerability to hypoxia in newborn piglets: effect of reoxygenation with 21% and 100% O2
    Kristin Lyng
    Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway
    Am J Obstet Gynecol 192:1172-8. 2005
    ..The purpose of this study was to assess whether inflammation increases vulnerability to hypoxia, and influences the effect of 100% O(2) and 21% O 2 reoxygenation on brain...
  35. doi request reprint Effects of nicotine infusion on striatal glutamate and cortical non-protein-bound iron in hypoxic newborn piglets
    Jannicke Hanne Andresen
    Department of Pediatric Research, Medical Faculty, Institute for Surgical Research, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    Neonatology 94:284-92. 2008
    ..Nicotine's effects have further been shown to be dose-dependent, with lower doses showing neuroprotective, and higher doses showing neurotoxic effects...
  36. ncbi request reprint Complement activation reflects severity of meconium aspiration syndrome in newborn pigs
    Paal H H Lindenskov
    Department of Pediatric Research PFI, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Pediatr Res 56:810-7. 2004
    ..0005). TCC increased substantially in MAS and was closely correlated to lung dysfunction. Complement activation preceded cytokine release, which may suggest a primary role for complement in the pathophysiology of MAS...
  37. doi request reprint Longitudinal myocardial contribution to peak systolic flow and stroke volume in the neonatal heart
    Hans H Odland
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, University of Oslo, N 0027 Oslo, Norway
    Pediatr Res 70:345-51. 2011
    ..In conclusion, this study provides validity of accounting systolic D in the long axis as the longitudinal contribution to SV and peak systolic tissue velocity as the longitudinal contribution to PSF...
  38. doi request reprint Nicotine affects the expression of brain-derived neurotrophic factor mRNA and protein in the hippocampus of hypoxic newborn piglets
    Jannicke Hanne Andresen
    Department of Pediatric Research, Institute of Surgical Research, Medical Faculty, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    J Perinat Med 37:553-60. 2009
    ..This might imply neuroprotective effects of nicotine in asphyxiated neonates...
  39. ncbi request reprint Prolonged apneas and hypoxia mediated by nicotine and endotoxin in piglets
    J Frederik Frøen
    Department of Pediatric Research, The National Hospital, University of Oslo, Norway
    Biol Neonate 81:119-25. 2002
    ..We investigated the acute effects of nicotine and endotoxin on repeated apnea by laryngeal reflex stimulation and the following autoresuscitation...
  40. ncbi request reprint Comparison of short- and long-duration oxygen treatment after cerebral asphyxia in newborn piglets
    Anne Beate Solas
    Department of Pediatric Research, The National Hospital, Oslo, Norway
    Pediatr Res 56:125-31. 2004
    ..In conclusion, after experimental asphyxia, newborn piglets can be reoxygenated as efficiently with 100% O(2) for only 5 min as 100% O(2) for 20 min compared with room air...
  41. ncbi request reprint Detrimental effects of nicotine and endotoxin in the newborn piglet brain during severe hypoxemia
    J Frederik Frøen
    Department of Pediatric Research, The National Hospital, University of Oslo, Norway
    Biol Neonate 82:188-96. 2002
    ..02). These findings contribute in explaining how nicotine and inflammatory response to bacterial toxins could act as cofactors for hypoxic-ischemic neurologic injury in the immature brain...
  42. doi request reprint Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat
    Marit L Dalen
    Department of Pediatric Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Pediatr Res 71:247-52. 2012
    ..It is not known whether supplemental oxygen during resuscitation affects the protection offered by subsequent HT...
  43. doi request reprint Role of complement and CD14 in meconium-induced cytokine formation
    Bodil Salvesen
    Institute of Immunology and Department of Pediatric Research, University of Oslo and Rikshospitalet University Hospital, Oslo, Norway
    Pediatrics 121:e496-505. 2008
    ..The aim of this study was to investigate the relative role of complement and CD14 in meconium-induced cytokine production...
  44. pmc Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs
    Rønnaug Solberg
    Department of Pediatric Research, Oslo University Hospital, Rikshospitalet, University of Oslo, Norway
    PLoS ONE 5:e9606. 2010
    ..We hypothesized that the quantification of metabolites after hypoxia and resuscitation would enable the detection of markers of hypoxia as well as markers enabling the monitoring and evaluation of resuscitation strategies...
  45. ncbi request reprint Reduced left ventricular function in hypoxemic newborn pigs: a strain Doppler echocardiographic study
    Wenche Bakken Børke
    Department of Pediatric Research, Institute for Surgical Research, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Pediatr Res 59:630-5. 2006
    ..To explore the full picture of a global hypoxemic injury, both long- and short-axis functions have to be considered...
  46. doi request reprint Extended series of cardiac compressions during CPR in a swine model of perinatal asphyxia
    Anne L Solevåg
    Department of Paediatric Research, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
    Resuscitation 81:1571-6. 2010
    ..An extended series of cardiac compressions offers the theoretical advantage of improving coronary perfusion pressures and hence, we aimed to explore the impact of compression cycles of two different durations...
  47. doi request reprint Nicotine in a small-to-moderate dose does not cause a significant increase in plasma catecholamine levels in newborn piglets
    Jannicke Hanne Andresen
    Department of Pediatric Research, Medical Faculty, Institute for Surgical Research, Rikshospitalet Medical Center, University of Oslo, Oslo, Norway
    Neonatology 94:279-83. 2008
    ..Recently, nicotine has been investigated in a piglet model of perinatal asphyxia, where the question has been raised whether nicotine's effect on the sympathetic nervous system can explain some of the positive effects...
  48. ncbi request reprint Resuscitation with 21 or 100% oxygen in hypoxic nicotine-pretreated newborn piglets: possible neuroprotective effects of nicotine
    Jannicke H Andresen
    Department of Pediatric Research, Medical Faculty, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Neonatology 93:36-44. 2008
    ..Perinatal asphyxia is a major concern in perinatal medicine. Resuscitation and ways to prevent and minimize adverse outcomes after perinatal asphyxia are subject to extensive research...
  49. ncbi request reprint Resuscitation of hypoxic newborn piglets with oxygen induces a dose-dependent increase in markers of oxidation
    Rønnaug Solberg
    Department of Pediatric Research, Medical Faculty, University of Oslo Rikshospitalet Medical Centre, Oslo, N 0027, Norway
    Pediatr Res 62:559-63. 2007
    ..The increase in the hydroxyl attack may lead to a pro-oxidative status and risk for genetic instability...
  50. ncbi request reprint Neuronal formation of free radicals plays a minor role in hypoxic cell death in human NT2-N neurons
    Runar Almaas
    Department of Pediatric Research, National Hospital, Oslo, Norway
    Pediatr Res 51:136-43. 2002
    ..Thus in this model, mechanisms downstream of the N-methyl-D-aspartate-glutamate receptor other than free radicals and nitric oxide have to be invoked...
  51. doi request reprint Albumin lavage does not improve the outcome of meconium aspiration syndrome
    Bodil Salvesen
    Department of Pediatric Research, Medical Faculty, University of Oslo and Rikshospitalet University Hospital, Oslo, Norway
    J Matern Fetal Neonatal Med 21:719-25. 2008
    ..Lung compliance increased when albumin was instilled after meconium as a rescue. The aim of this study was to combine the effect of albumin and lavage...
  52. doi request reprint Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation
    Marit Lunde Dalen
    Department of Paediatric Research, Rikshospitalet University Hospital and University of Oslo, N 0027, Norway
    Brain Res 1259:80-9. 2009
    ..We conclude that hypothermia protects isolated neurons after in vitro hypoxia, and that this protection is not affected by hyperoxic, normoxic or hypoxic reoxygenation...
  53. doi request reprint Atrioventricular valve annulus velocity and acceleration during global hypoxia in newborn pigs - assessment of myocardial function
    Hans Henrik Odland
    Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway
    Neonatology 97:100-7. 2010
    ..Global hypoxia may affect regions of the neonatal heart during systole and diastole differently...
  54. ncbi request reprint Reoxygenation of hypoxic mice with 100% oxygen induces brain nuclear factor-kappa B
    Gaute Døhlen
    Department of Pediatric Research, Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Pediatr Res 58:941-5. 2005
    ..However, when reoxygenation occurs with 21% O2 (room air), no elevation in NF-kappaB activity is observed. Thus, reoxygenation with room air may induce less brain inflammation than reoxygenation with pure oxygen...
  55. doi request reprint Resuscitation of hypoxic newborn piglets with supplementary oxygen induces dose-dependent increase in matrix metalloproteinase-activity and down-regulates vital genes
    Rønnaug Solberg
    Department of Paediatric Research, University of Oslo, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Pediatr Res 67:250-6. 2010
    ..MMP-, VEGF-, and TGFbeta-superfamily are vital for the development, growth, and functional integrity of most tissues and our data rise concern about both short- and long-term consequences of even a brief hyperoxic exposure...
  56. ncbi request reprint Albumin mixed with meconium attenuates pulmonary dysfunction in a newborn piglet model with meconium aspiration
    Per Arne Tølløfsrud
    Department of Pediatric Research, National Hospital, NO 0027, Oslo, Norway
    Pediatr Res 52:545-53. 2002
    ..In conclusion, albumin given concurrently with meconium significantly reduced detrimental effects of meconium aspiration in the lungs of newborn piglets...
  57. ncbi request reprint Do negative life experiences predict the health-care-seeking of adolescents? A study of 10th-year students in Oslo, Norway
    Ole Rikard Haavet
    Department of General Practice and Community Medicine, University of Oslo, Oslo, Norway
    J Adolesc Health 37:128-34. 2005
    ..To analyze associations among the negative life experiences and health-care-seeking of adolescents during the 12 months before the study...
  58. ncbi request reprint Positive factors associated with promoting health in low-risk and high-risk populations of 15- and 16-year-old pupils in Oslo, Norway
    Ole Rikard Haavet
    Department of General Practice and Community Medicine, Section for General Practice, University of Oslo, Oslo, Norway
    Acta Paediatr 94:345-51. 2005
    ..To explore possible risk-reducing factors associated with the incidence of common illnesses and use of healthcare services among adolescents...
  59. ncbi request reprint The role of oxygen in neonatal resuscitation
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, University of Oslo, Oslo 0027, Norway
    Clin Perinatol 31:431-43. 2004
    ..Brain injury as assessed by glycerol augmentation, matrix injury, and neonatal mortality is less in infants given 21% versus 100% O2...
  60. ncbi request reprint Antioxidant activity in the newborn brain: a luciferase mouse model
    Gaute Dohlen
    Department of Pediatric Research, Rikshospitalet Medical Center, Oslo, Norway
    Neonatology 93:125-31. 2008
    ..The aim of this study is to present a model that can monitor genetic activity in vivo during pregnancy and the first 10 days of life...
  61. pmc Ejection time-corrected systolic velocity improves accuracy in the evaluation of myocardial dysfunction: a study in piglets
    Hans Henrik Odland
    Department of Pediatric Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Pediatr Cardiol 31:1070-8. 2010
    ..It is robust toward hemodynamic changes. This novel method has the potential of becoming a useful tool in clinical practice...
  62. ncbi request reprint Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8
    Berit Holthe Munkeby
    Department of Pediatric Research, Rikhospitalet University Hospital, Oslo, Norway
    Pediatr Res 58:542-8. 2005
    ..Altogether, these data strongly suggest that caution must be taken when applying pure O2 to the newborn infant...
  63. doi request reprint Association between umbilical cord artery pCO₂ and the Apgar score; elevated levels of pCO₂ may be beneficial for neonatal vitality after moderate acidemia
    Grete A B Kro
    Women and Children s Division, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Acta Obstet Gynecol Scand 92:662-70. 2013
    ..To determine the association between 5-min Apgar score and umbilical cord artery carbon dioxide tension (pCO₂)...
  64. pmc Lung Injury in Asphyxiated Newborn Pigs Resuscitated from Cardiac Arrest - The Impact of Supplementary Oxygen, Longer Ventilation Intervals and Chest Compressions at Different Compression-to-Ventilation Ratios
    Ingrid Dannevig
    Dept of Paediatrics, Akershus University Hospital, N 1478 Lørenskog, Norway Institute of Clinical Medicine, University of Oslo, N 1478 Lørenskog, Norway Dept of Paediatric Research, Oslo University Hospital, Rikshospitalet, P O Box 4950 Nydalen, N 0424 Oslo, Norway Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, P O Box 4950 Nydalen, 0424 Oslo, Norway
    Open Respir Med J 6:89-96. 2012
    ..We investigated the levels of lung inflammatory markers by comparing different ventilation, chest compression and inhaled oxygen fraction strategies in resuscitation of newly born pigs at cardiac arrest...
  65. pmc Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
    Yngve Sejersted
    Department of Microbiology and Pediatric Research, Centre for Molecular Biology and Neurosciences, University of Oslo and Oslo University Hospital, Rikshospitalet, Nydalen, N 0424 Oslo, Norway
    Proc Natl Acad Sci U S A 108:18802-7. 2011
    ..We propose that Neil3 exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells...
  66. ncbi request reprint Interleukin-10 reverses acute detrimental effects of endotoxin-induced inflammation on perinatal cerebral hypoxia-ischemia
    J Frederik Frøen
    Department of Pediatric Research, The National Hospital, University of Oslo, N 0027 Oslo, Norway
    Brain Res 942:87-94. 2002
    ..Thus IL-10 counteracts acute effects of endotoxin on cerebral metabolism, microcirculation and oxygen tension during hypoxia-ischemia in the perinatal brain...
  67. ncbi request reprint Oxygen for newborns: how much is too much?
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet University Hospital, University of Oslo, Norway
    J Perinatol 25:S45-9; discussion S50. 2005
    ..The neonatologist would be well served to think of oxygen as a medication, and use it sparingly...
  68. ncbi request reprint Reliability of pulse oximetry in hypoxic newborn pigs
    Anne Lee Solevåg
    Department of Pediatric Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway
    J Matern Fetal Neonatal Med 27:833-8. 2014
    ..The reliability of pulse oximetry in the lower SaO2-ranges has not been fully investigated. We wanted to investigate pulse oximeter performance in a pig model of perinatal asphyxia...
  69. ncbi request reprint Nitric oxide synthesis inhibition during cerebral hypoxemia and reoxygenation with 100% oxygen in newborn pigs
    Stefan Kutzsche
    Department of Pediatric Research, National Hospital, Ulleval University Hospital, Oslo, Norway
    Biol Neonate 82:197-206. 2002
    ..This deleterious effect during hypoxemia limits the use of L-NAME as a preventive drug but suggests beneficial effects during reoxygenation with 100% oxygen...
  70. ncbi request reprint Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants
    Ingrid B Helland
    Department of Paediatric Research, University of Oslo, Norway
    J Matern Fetal Neonatal Med 19:397-406. 2006
    ..We studied the effect of supplementing pregnant and lactating women with marine n-3 polyunsaturated fatty acids (PUFAs) as compared to n-6 PUFAs related to maternal and infant lipid levels...
  71. ncbi request reprint Meconium is a potent activator of complement in human serum and in piglets
    Albert Castellheim
    Department of Pediatric Research, Rikshospitalet University Hospital, Oslo 0027, Norway
    Pediatr Res 55:310-8. 2004
    ..In conclusion, meconium is a potent activator of the complement system both in vitro and in vivo. Complement may be important in the pathogenesis of MAS, and specific complement inhibition might be a possible treatment approach in MAS...
  72. doi request reprint Resuscitation of newborn infants with 21% or 100% oxygen: an updated systematic review and meta-analysis
    Ola Didrik Saugstad
    Department of Paediatric Research, Rikshospitalet Medical Centre, University of Oslo, Oslo, Norway
    Neonatology 94:176-82. 2008
    ..The issue of whether 21% O(2) is more effective than 100% O(2) for resuscitation of newborn infants remains controversial...
  73. ncbi request reprint Effect of interleukin-10 on newborn piglet brain following hypoxia-ischemia and endotoxin-induced inflammation
    Kristin Lyng
    Department of Pediatric Research, University of Oslo, Oslo, Norway
    Biol Neonate 87:207-16. 2005
    ..We wanted to assess (1) whether IL-10 had a beneficial effect on brain metabolism and microcirculation in newborn piglets after an inflammatory, hypoxic and ischemic challenge, and (2) whether IL-10 had any harmful effects per se...
  74. ncbi request reprint Bronchopulmonary dysplasia-oxidative stress and antioxidants
    Ola Didrik Saugstad
    Department of Pediatric Research, Rikshospitalet, University of Oslo, Norway
    Semin Neonatol 8:39-49. 2003
    ..So far, there has been no significant breakthrough regarding antioxidant therapies. Care should, however, be exercised in supplementing the preterm infant with antioxidants since this may affect growth and development...
  75. ncbi request reprint Optimal oxygen therapy in the newborn period
    Ola Didrik Saugstad
    Department of Pediatric Research, National Hospital, University of Oslo, Oslo, Norway
    Pediatr Pulmonol Suppl 26:112-3. 2004
  76. ncbi request reprint Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation
    Runar Almaas
    Department of Pediatric Research, Rikshospitalet, N 0027 Oslo, Norway
    J Neurochem 84:1018-27. 2003
    ..The effect of acidosis on neuronal survival depends on the timing of acidosis, as acidosis was protective during OGD and detrimental during reoxygenation...
  77. ncbi request reprint Morphological and hemodynamic magnetic resonance assessment of early neonatal brain injury in a piglet model
    Berit H Munkeby
    Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway
    J Magn Reson Imaging 20:8-15. 2004
    ....
  78. ncbi request reprint Fetal brain injury in experimental intrauterine asphyxia and inflammation in Göttingen minipigs
    Kristin Lyng
    Department of Obstetrics and Gynecology, Rikshospitalet University Hospital, Oslo, Norway
    J Perinat Med 34:226-34. 2006
    ..To examine fetal brain injury in the Göttingen minipig following intrauterine asphyxia and infection/inflammation induced at 3/4 of gestational length...
  79. ncbi request reprint Maternal health in sudden intrauterine unexplained death: do urinary tract infections protect the fetus?
    J Frederik Frøen
    Department of Obstetrics and Gynecology, Rikshospitalet University Clinic, University of Oslo, Oslo, Norway
    Obstet Gynecol 100:909-15. 2002
    ..To study the impact of maternal health and obstetric complications on the risk for sudden intrauterine unexplained death...
  80. ncbi request reprint Resuscitation with pure oxygen at birth: it is time for a change
    Ola Didrik Saugstad
    J Matern Fetal Neonatal Med 15:73-4. 2004
  81. ncbi request reprint [Should some newborn infants not be treated?]
    Ola Didrik Saugstad
    Tidsskr Nor Laegeforen 125:1308. 2005
  82. ncbi request reprint Cerebral inflammatory response after fetal asphyxia and hyperoxic resuscitation in newborn sheep
    Tina Markus
    Department of Pediatrics, Lund University, 221 85 Lund, Sweden
    Pediatr Res 62:71-7. 2007
    ..These may be early events leading to increased tissue damage after exposure to hyperoxemia at birth...
  83. ncbi request reprint Earlier Apgar score increase in severely depressed term infants cared for in Swedish level III units with 40% oxygen versus 100% oxygen resuscitation strategies: a population-based register study
    Lena Hellstrom-Westas
    Department of Pediatrics, University Hospital, SE 221 85 Lund, Sweden
    Pediatrics 118:e1798-804. 2006
    ....
  84. ncbi request reprint Oxygen saturations immediately after birth
    Ola Didrik Saugstad
    J Pediatr 148:569-70. 2006
  85. ncbi request reprint Surfactant therapy is still on the move
    Ola Didrik Saugstad
    J Matern Fetal Neonatal Med 14:145-6. 2003
  86. ncbi request reprint Maternal smoking and oral clefts: the role of detoxification pathway genes
    Rolv T Lie
    Department of Public Health and Primary Health Care, University of Bergen, Norway
    Epidemiology 19:606-15. 2008
    ..There is evidence for an effect of cigarette smoking on risk of oral clefts. There are also hypothetical pathways for a biologic effect involving toxic chemicals in cigarette smoke...
  87. ncbi request reprint Kinematic quality of reaching movements in preterm infants
    Bjørg Fallang
    Oslo University College, Health Sciences, Physiotherapy Programme, Norway
    Pediatr Res 53:836-42. 2003
    ..At the age of 6 mo, the advantage of the low-risk group in reaching behavior had disappeared and a disadvantage in the form of nonoptimal reaching behavior of the high-risk group emerged...
  88. ncbi request reprint [From the informed to the administrative autocracy]
    Ola Didrik Saugstad
    Tidsskr Nor Laegeforen 123:1732. 2003
  89. ncbi request reprint Fetal reduction: a neonatologist's point of view
    Ola Didrik Saugstad
    J Matern Fetal Neonatal Med 13:289-91. 2003
  90. ncbi request reprint Protect the innocent!
    Ola Didrik Saugstad
    J Matern Fetal Neonatal Med 13:1. 2003
  91. ncbi request reprint [Clinical medical research--from wrong to worse?]
    Ola Didrik Saugstad
    Pediatrisk forskningsinstitutt Universitetet i Oslo Rikshospitalet 0027 Oslo
    Tidsskr Nor Laegeforen 123:142. 2003