Research Topics
| B RolstadSummaryAffiliation: University of Oslo Country: Norway Publications
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Detail Information
Publications
The athymic nude rat: an animal experimental model to reveal novel aspects of innate immune responses?B Rolstad
Dept of Anatomy, University of Oslo, Blindern, Norway
Immunol Rev 184:136-44. 2001..Their contribution to allograft rejection in T-cell-reconstituted rats is therefore questionable, and their role in innate immune response in these rats still enigmatic...
Rat natural killer cell receptor systems and recognition of MHC class I moleculesB Rolstad
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Blindern, Norway
Immunol Rev 181:149-57. 2001..These findings show that allospecific NK cells sometimes show features reminiscent of the adaptive immune response...
Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subsetC Naper
Department of Anatomy, University of Oslo, Norway
Eur J Immunol 29:2046-53. 1999..These data provide evidence for the MHC-dependent regulation of the allospecific repertoire within a subset of potentially autoreactive Ly-49+ rat NK cells...
A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomainsK M Torgersen
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Cell Signal 13:213-20. 2001..We suggest that the dominant negative effect is caused by the ability of the mutant to sequester signalling molecules in cytosol and thereby inhibit redistribution of signalling molecules to lipid rafts upon T-cell activation...
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicityK M Torgersen
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
J Biol Chem 272:5495-500. 1997....
The effect of in vivo depletion of NKR-P1+ or CD8+ lymphocytes on the acute rejection of allogeneic lymphocytes (ALC) in the ratG Løvik
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
Scand J Immunol 54:341-7. 2001..The results demonstrate that NK cell responses can be greatly diminished after in vivo treatment with these MoAbs. Furthermore, they demonstrate that ALC is not necessarily linked to expression of the CD8 molecule...
C1qRp elicits a Ca++ response in rat NK cells but does not influence NK-mediated cytotoxicityG Løvik
Department of Anatomy and Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1105, Blindern, N 0317 Oslo, Norway
Scand J Immunol 53:410-5. 2001..The response induced by the antibodies was only minimally reduced in the presence of EGTA, indicating that most of the response is owing to the Ca++ mobilization from intracellular calcium stores...
Functional coupling of NKR-P1 receptors to various heterotrimeric G proteins in rat interleukin-2-activated natural killer cellsA Al-Aoukaty
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
J Biol Chem 272:31604-8. 1997..These results are the first to demonstrate the physical and functional coupling of NKR-P1 to the heterotrimeric G proteins in NK cells...
Characterization and molecular cloning of rat C1qRp, a receptor on NK cellsG Løvik
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Eur J Immunol 30:3355-62. 2000..The mAb did not affect the cytotoxic function of NK cells, and C1qRp on NK cells may have functions not related to NK killing...
Genes in two MHC class I regions control recognition of a single rat NK cell allodeterminantC Naper
Department of Anatomy, University of Oslo, Norway
Int Immunol 8:1779-85. 1996..Cav1, RT1.Ca and RT1.Cc, and also prevents the deletion of NK cells of this specificity during their development...
The role of natural killer cells in resistance to the intracellular bacterium Listeria monocytogenes in ratsH Shegarfi
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
Scand J Immunol 70:238-44. 2009....
Phenotype and natural killer cell sensitivity of a radiation-induced acute T-cell leukaemia (Roser leukaemia) in PVG ratsJ Nestvold
Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, NO-0317 Oslo, Norway
Scand J Immunol 60:153-8. 2004..RL-T, furthermore, expresses major histocompatibility complex (MHC) I antigens, both classical (RT1.A) and nonclassical (RT1.C), which makes it susceptible to killing by alloreactive natural killer cells in vitro...
Long-term donor chimerism after MHC (RT1) mismatched bone marrow transplantation in the rat: the role of host alloreactive NK cellsE Engh
Laboratory Animal Department, Department of Physiology, Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
Scand J Immunol 54:198-203. 2001..R8 and PVG.R23 rats, in accordance with the patterns of NK alloreactivity in these strain combinations. NK cells may therefore be a primary obstacle to successful allogeneic BM engraftment in this model...
Mesenchymal stromal cells fail to alleviate experimental graft-versus-host disease in rats transplanted with major histocompatibility complex-mismatched bone marrowS Zinöcker
Department of Immunology, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway
Scand J Immunol 76:464-70. 2012..In conclusion, repeated administrations of MSC failed to alleviate GVHD after fully or partially MHC-mismatched allo-SCT in the rat...
Investigation of lipopolysaccharide receptor expression on human monocytes after major orthopaedic surgeryD Bastian
Department of Orthopaedics, Faculty of Dentistry, Rikshospitalet Radiumhospitalet Medical Care, University of Oslo, Oslo, Norway
Eur Surg Res 40:239-45. 2008..The receptors CD14 and CD11b are involved in the LPS receptor complex, whereas human lymphocyte antigen (HLA)-DR binds endotoxin peptides. It is still uncertain whether the expression of all these receptors changes after major surgery...
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid raftsK M Torgersen
Department of Medical Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Box 1112, Blindern, N-0317 Oslo, Norway
J Biol Chem 276:29313-8. 2001..We suggest that a transient release from Csk-mediated inhibition by displacement of Csk from lipid rafts is important for normal T cell activation...
RT1-U: identification of a novel, active, class Ib alloantigen of the rat MHCL Y Leong
Department of Immunology, The Babraham Institute, Cambridge, United Kingdom
J Immunol 162:743-52. 1999..The sequences of these class Ib genes group together in phylogenetic analysis, suggesting a unique locus or family. The combined serological, CTL, and sequence data all indicate that these products are genetically polymorphic...
