E K Rofstad

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cancer Res 65:2387-96. 2005
  2. ncbi Microenvironment-induced cancer metastasis
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Radiat Biol 76:589-605. 2000
  3. ncbi Xenograft model systems for human melanoma
    E K Rofstad
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Mol Med Today 2:394-403. 1996
  4. ncbi Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts
    E K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    J Invest Dermatol 117:1042-9. 2001
  5. ncbi Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Radiat Biol 75:1377-93. 1999
  6. ncbi Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 62:661-4. 2002
  7. ncbi Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 66:6699-707. 2006
  8. pmc Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8
    E K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Br J Cancer 86:301-8. 2002
  9. ncbi Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 62:1847-53. 2002
  10. ncbi Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 63:4055-61. 2003

Collaborators

  • H Lyng
  • D R Olsen
  • A Skretting
  • K Berg
  • T Stokke
  • C Trope
  • J Moan
  • T Danielsen
  • I Bjørnaes
  • B A Graff
  • I Tufto
  • K Sundfør
  • K G Brurberg
  • K Måseide
  • M Hvidsten
  • O Kaalhus
  • R Skøyum
  • Y Kvinnsland
  • I Jakobsen
  • G A Dahle
  • B Smith-Sørensen
  • H A Grønlund
  • A L Børresen-Dale
  • K Solberg
  • K Eide
  • E O Pettersen
  • J M Dornish
  • J M Nesland
  • R Oftebro
  • M E Juul
  • R O Larsen
  • T E Aastveit
  • C L Davies
  • T Lindmo
  • Z Malik
  • T Ranheim

Detail Information

Publications51

  1. ncbi The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cancer Res 65:2387-96. 2005
    ....
  2. ncbi Microenvironment-induced cancer metastasis
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Radiat Biol 76:589-605. 2000
    ....
  3. ncbi Xenograft model systems for human melanoma
    E K Rofstad
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Mol Med Today 2:394-403. 1996
    ....
  4. ncbi Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts
    E K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    J Invest Dermatol 117:1042-9. 2001
    ..This study suggests that some melanoma patients may benefit from combined local treatment and long-term anti-angiogenic therapy involving thrombospondin-1...
  5. ncbi Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Radiat Biol 75:1377-93. 1999
    ..The purpose of the work reported here was (1) to determine the fraction of radiobiologically hypoxic cells in individual tumours and (2) to differentiate quantitatively between chronic and acute hypoxia...
  6. ncbi Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 62:661-4. 2002
    ..Hypoxic cells could not be detected in these tumors. Our study suggests that interstitial hypertension may facilitate tumor cell intravasation and, hence, promote metastasis by mechanisms independent of tumor hypoxia...
  7. ncbi Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 66:6699-707. 2006
    ..Moreover, the possibility that the pH(e) of the primary tumor may be an important prognostic parameter for melanoma patients merits clinical investigation...
  8. pmc Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8
    E K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Br J Cancer 86:301-8. 2002
    ....
  9. ncbi Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 62:1847-53. 2002
    ..The study reported here suggests that metastatic spread may be promoted by hypoxia in the primary tumor and identifies the plasminogen activation system as an important target for the treatment of malignant melanoma...
  10. ncbi Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Res 63:4055-61. 2003
    ..In conclusion, the present preclinical study showed that TSP-1 has antiangiogenic, antimetastatic, and radiopotentiating properties that merit additional investigation in clinical studies...
  11. ncbi Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor
    Einar K Rofstad
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cancer Res 64:13-8. 2004
    ..The metastatic frequency was higher in tumors regrowing after irradiation than in unirradiated tumors because the irradiation induced tumor hypoxia, and tumor hypoxia induced up-regulation of uPAR...
  12. ncbi Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts
    Einar K Rofstad
    Department of Biophysics, Radiation Biology and Tumor Physiology Group, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Int J Radiat Oncol Biol Phys 58:493-9. 2004
    ....
  13. ncbi Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Cancer Res 60:4932-8. 2000
    ..Our observations suggest that efficient antiangiogenic treatment of melanoma may require identification and blocking of common functional features of several angiogenic factors...
  14. pmc Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 77:897-902. 1998
    ..Transient hypoxia might promote the malignant progression of tumours by temporarily increasing the angiogenic potential of tumour cells showing low VEGF expression under normoxic conditions...
  15. pmc Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 80:1697-707. 1999
    ....
  16. ncbi Microvascular permeability of human melanoma xenografts to macromolecules: relationships to tumor volumetric growth rate, tumor angiogenesis, and VEGF expression
    B A Graff
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway
    Microvasc Res 61:187-98. 2001
    ..Our study suggests that the effective microvascular permeability of macromolecules can be high even in slowly growing tumors, poorly angiogenic tumors, and tumors showing low VEGF expression...
  17. ncbi Intratumor heterogeneity in perfusion in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
    I Bjørnaes
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Magn Reson Imaging 18:997-1002. 2000
    ..These observations imply that measurements of mean tumor perfusion may have limited value as a predictive assay for outcome of treatment...
  18. ncbi VEGF, bFGF and EGF in the angiogenesis of human melanoma xenografts
    T Danielsen
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Cancer 76:836-41. 1998
    ..VEGF is probably important in the angiogenesis of melanomas. However, heterogeneity in rate of angiogenesis among melanomas cannot be attributed to heterogeneity in rate of secretion of VEGF, bFGF and/or EGF only...
  19. pmc The constitutive level of vascular endothelial growth factor (VEGF) is more important than hypoxia-induced VEGF up-regulation in the angiogenesis of human melanoma xenografts
    T Danielsen
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 82:1528-34. 2000
    ..Thus, the constitutive, genetically determined level of VEGF was probably more important than hypoxia-induced upregulation in the angiogenesis of the melanoma xenografts...
  20. pmc Fraction of radiobiologically hypoxic cells in human melanoma xenografts measured by using single-cell survival, tumour growth delay and local tumour control as end points
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 78:893-8. 1998
    ..The wide range of the hypoxic fractions and the significant differences among the lines suggest that A-07, D-12. R-18 and U-25 tumours should be useful models in future studies attempting to develop non-invasive assays of tumour hypoxia...
  21. ncbi Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging
    H Lyng
    Department of Biophysics, Norwegian Radium Hospital, Oslo, Norway
    J Magn Reson Imaging 14:750-6. 2001
    ..Dynamic contrast-enhanced MR imaging may therefore possibly be useful in prediction of treatment outcome...
  22. ncbi Effects of hyperthermia on bioenergetic status and phosphorus T1S in human melanoma xenografts monitored by 31P-MRS
    D R Olsen
    Department of Medical Physics, The Norwegian Radium Hospital, Oslo
    Magn Reson Imaging 17:1049-56. 1999
    ..Consequently, 31P-MRS measurements of tumor bioenergetic status and the T1 of the Pi resonance may perhaps be utilized to distinguish between vascular effects of mild and conventional hyperthermia...
  23. pmc Tumour necrotisation in nude mice xenografts by the reversible protein synthesis inhibitor zilascorb(2H)
    E O Pettersen
    Department of Tissue Culture, Norwegian Radium Hospital, Oslo
    Br J Cancer 67:650-6. 1993
    ..We therefore conclude that zilascorb(2H)-induced cancer cell lethality in tumour xenografts probably comes as a secondary consequence of prolonged protein synthesis inhibition...
  24. ncbi Intra- and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy
    H Lyng
    Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
    Int J Cancer 96:182-90. 2001
    ..Moreover, the perfusion and perfusion heterogeneity may increase during the early phase of radiotherapy and influence tumor response...
  25. pmc Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern
    E K Rofstad
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 70:804-12. 1994
    ..The four orthotopic human melanoma xenograft model systems show great promise for future studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern...
  26. pmc 31P-nuclear magnetic resonance spectroscopy in vivo of six human melanoma xenograft lines: tumour bioenergetic status and blood supply
    H Lyng
    Department of Biophysics and Medical Physics, Norwegian Radium Hospital, Motebello, Oslo
    Br J Cancer 68:1061-70. 1993
    ....
  27. ncbi Microvascular permeability to macromolecules in human melanoma xenografts assessed by contrast-enhanced MRI--intertumor and intratumor heterogeneity
    I Bjørnaes
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Magn Reson Imaging 19:723-30. 2001
    ..e. values that are up to 10-fold higher than those of normal tissues...
  28. pmc Proton relaxation times and interstitial fluid pressure in human melanoma xenografts
    H Lyng
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Br J Cancer 75:180-3. 1997
    ....
  29. ncbi Disease control of uterine cervical cancer: relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy
    H Lyng
    Department of Biophysics, The Norwegian Radium Hospital, Oslo
    Clin Cancer Res 6:1104-12. 2000
    ....
  30. ncbi Changes in oxygen tension during radiotherapy of head and neck tumours
    H Lyng
    Department of Biophysics, The Norwegian Radium Hospital, Oslo
    Acta Oncol 38:1037-42. 1999
    ....
  31. pmc Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
    E K Rofstad
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Br J Cancer 83:354-9. 2000
    ....
  32. ncbi Interstitial fluid pressure, fraction of necrotic tumor tissue, and tumor cell density in human melanoma xenografts
    I Tufto
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Acta Oncol 37:291-7. 1998
    ..These two observations suggest that the IFP of tumors depends on the cell density, but the cell density is probably not a major determinant of the IFP...
  33. ncbi Interstitial fluid pressure in human melanoma xenografts. Relationship to fractional tumor water content, tumor size, and tumor volume-doubling time
    I Tufto
    Department of Biophysics, Norwegian Radium Hospital, Oslo
    Acta Oncol 34:361-5. 1995
    ..These observations suggest that simple general relationships between the IFP and the other pathophysiological parameters measured here, might not exist in tumors...
  34. pmc Step-down heating of human melanoma xenografts: effects of the tumour microenvironment
    E K Rofstad
    Institute for Cancer Research, Norwegian Radium Hospital, Oslo
    Br J Cancer 70:453-8. 1994
    ..This suggests that SDH may be exploited clinically to achieve increased cell inactivation in tumours relative to the surrounding normal tissues...
  35. pmc Detection of necrosis in human tumour xenografts by proton magnetic resonance imaging
    I Jakobsen
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 71:456-61. 1995
    ..Consequently, the possibility exists that MRI might be used for detection of necrotic regions in tumours and hence for prediction of tumour treatment response...
  36. ncbi Spin-lattice relaxation time of inorganic phosphate in human tumor xenografts measured in vivo by 31P-magnetic resonance spectroscopy. Influence of oxygen tension
    D R Olsen
    Department of Medical Physics, Norwegian Radium Hospital, Oslo
    Acta Oncol 34:339-43. 1995
    ..Consequently, the T1 of the Pi resonance can probably not be utilized to estimate the oxygenation status of tumors, at least not in tumors with necrotic regions...
  37. pmc Temporal heterogeneity in oxygen tension in human melanoma xenografts
    K G Brurberg
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics and Centre for Research and Training in Radiation Therapy, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Br J Cancer 89:350-6. 2003
    ....
  38. ncbi Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis
    H Lyng
    Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 46:935-46. 2000
    ..The aims were to investigate (a) whether possible changes in pO(2) differed among and within tumors and (b) whether the changes could be attributed to changes in vascular density, cell density, and frequency of mitosis and apoptosis...
  39. pmc Transient perfusion in human melanoma xenografts
    I Tufto
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 71:789-93. 1995
    ..Consequently, acute hypoxia caused by transient perfusion is probably a less pronounced phenomenon in malignant tissue than previous studies of rodent tumours have suggested...
  40. pmc Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    K Sundfør
    Department of Gynaecology, The Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 78:822-7. 1998
    ..The present study suggests that a high incidence of metastases in squamous cell carcinoma of the uterine cervix is associated with poor oxygenation of the primary tumour and not with a high vascular density...
  41. ncbi Transvascular and interstitial transport of a 19 kDa linear molecule in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
    I Bjørnaes
    Group of Radiation Biology and Tumor Physiology, Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    J Magn Reson Imaging 14:608-16. 2001
    ....
  42. pmc Hypoxia induces p53 accumulation in the S-phase and accumulation of hypophosphorylated retinoblastoma protein in all cell cycle phases of human melanoma cells
    T Danielsen
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Br J Cancer 78:1547-58. 1998
    ..Moreover, the cell cycle-dependent induction of p53 by hypoxia suggests that the primary function of p53 accumulation during hypoxia is other than to arrest the cells...
  43. ncbi Intratumour heterogeneity in microvessel oxyhaemoglobin saturations
    K Måseide
    Department of Biophysics, Institute for Cancer Research and The Norwegian Cancer Society, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Cancer Lett 162:245-51. 2001
    ..In central tumour regions, low saturations were prevailing although subregions of intermediate and high saturations could also be found...
  44. pmc Heat sensitivity and thermotolerance in vitro of human breast carcinoma, malignant melanoma and squamous cell carcinoma of the head and neck
    E K Rofstad
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello
    Br J Cancer 61:22-8. 1990
    ....
  45. pmc Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts
    B A Graff
    Department of Biophysics, Institute for Cancer Research, The Norweigian Radium Hospital, Montebello, Oslo, Norway
    Br J Cancer 88:291-7. 2003
    ....
  46. pmc Oxygen tension and vascular density in human cervix carcinoma
    H Lyng
    Department of Biophysics, Institute for Cancer Research, Oslo, Norway
    Br J Cancer 74:1559-63. 1996
    ..Model calculations indicated that these differences in pO2 could be explained by differences in the oxygen delivery alone and by differences in the oxygen consumption rate alone...
  47. pmc Energy metabolism in human melanoma cells under hypoxic and acidic conditions in vitro
    R Skøyum
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Br J Cancer 76:421-8. 1997
    ..The data presented here suggest that the heterogeneity is rather caused by differences in the capacity of the tumour cells to reduce the rate of energy consumption when exposed to hypoxia...
  48. ncbi No association between radiosensitivity and TP53 status, G1 arrest or protein levels of p53, myc, ras or raf in human melanoma lines
    T Danielsen
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    Int J Radiat Biol 75:1149-60. 1999
    ....
  49. pmc Relationship between changes in antigen expression and protein synthesis in human melanoma cells after hyperthermia and photodynamic treatment
    C L Davies
    Department of Biophysics, Institute for Cancer Research, Oslo, Norway
    Br J Cancer 58:306-13. 1988
    ....
  50. ncbi Oxygen tension and vascular density in adenocarcinoma and squamous cell carcinoma of the uterine cervix
    K Sundfør
    Department of Gynecology, The Norwegian Radium Hospital, Montebello, Oslo
    Acta Oncol 37:665-70. 1998
    ..The difference in prognosis between patients with adenocarcinoma and patients with squamous cell carcinoma is probably not attributable to differences in tumor oxygenation or vascularization...
  51. pmc PLD-repair in human melanoma xenografts following single dose and fractionated irradiation
    E K Rofstad
    Institute for Cancer Research, Norwegian Radium Hospital, Oslo
    Br J Cancer 61:856-60. 1990
    ..Consequently, PLD-repair is probably not a major cause of failure in the radiation therapy of malignant melanoma when treated with 2.0 Gy fractions...