H Refsum

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
  2. ncbi Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome
    H Refsum
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway
    Br J Nutr 85:S109-13. 2001
  3. ncbi Recent data are not in conflict with homocysteine as a cardiovascular risk factor
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Curr Opin Lipidol 9:533-9. 1998
  4. ncbi Homocysteine and cardiovascular disease
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Annu Rev Med 49:31-62. 1998
  5. ncbi Biological and environmental determinants of plasma homocysteine
    J Schneede
    Department of Pharmacology, University of Bergen, Norway
    Semin Thromb Hemost 26:263-79. 2000
  6. ncbi Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study
    O Nygard
    Department of Public Health and Primary Health Care, University of Bergen, Norway
    Am J Clin Nutr 67:263-70. 1998
  7. ncbi Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study
    L El-Khairy
    Department of Public Health and Primary Health Care and the Department of Pharmacology, University of Bergen, Norway
    Am J Clin Nutr 70:1016-24. 1999
  8. ncbi Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study
    O Nygard
    Department of Clinical Biology, University of Bergen, Norway
    Am J Clin Nutr 65:136-43. 1997
  9. ncbi Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line
    T Fiskerstrand
    Department of Pharmacology, University of Bergen, 5021 Bergen, Norway
    J Biol Chem 273:20180-4. 1998
  10. ncbi The Hordaland Homocysteine Studies
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Lipids 36:S33-9. 2001

Detail Information

Publications29

  1. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
    ..In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency...
  2. ncbi Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome
    H Refsum
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway
    Br J Nutr 85:S109-13. 2001
    ..This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome...
  3. ncbi Recent data are not in conflict with homocysteine as a cardiovascular risk factor
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Curr Opin Lipidol 9:533-9. 1998
    ..This observation is in accordance with the view that high total homocysteine itself may not be particularly deleterious, but provokes vascular occlusion under conditions predisposing to cardiovascular disease...
  4. ncbi Homocysteine and cardiovascular disease
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Annu Rev Med 49:31-62. 1998
    ..Supplementation with B-vitamins, in particular with folic acid, is an efficient, safe, and inexpensive means to reduce an elevated tHcy level. Studies are now in progress to establish whether such therapy will reduce cardiovascular risk...
  5. ncbi Biological and environmental determinants of plasma homocysteine
    J Schneede
    Department of Pharmacology, University of Bergen, Norway
    Semin Thromb Hemost 26:263-79. 2000
    ..The data represent the total number of combined homocysteine and methylmalonic acid determinations, requested by general practitioners in Norway during February 1998...
  6. ncbi Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study
    O Nygard
    Department of Public Health and Primary Health Care, University of Bergen, Norway
    Am J Clin Nutr 67:263-70. 1998
    ..These findings are relevant for establishing adequate reference ranges for tHcy and emphasize folate intake, smoking status, and coffee consumption as major acquired determinants of tHcy concentration in this general population...
  7. ncbi Lifestyle and cardiovascular disease risk factors as determinants of total cysteine in plasma: the Hordaland Homocysteine Study
    L El-Khairy
    Department of Public Health and Primary Health Care and the Department of Pharmacology, University of Bergen, Norway
    Am J Clin Nutr 70:1016-24. 1999
    ..Cysteine is structurally and metabolically related to homocysteine, but data on its association with cardiovascular disease and cardiovascular disease risk factors are sparse...
  8. ncbi Coffee consumption and plasma total homocysteine: The Hordaland Homocysteine Study
    O Nygard
    Department of Clinical Biology, University of Bergen, Norway
    Am J Clin Nutr 65:136-43. 1997
    ..The results of the present report should promote future studies on tHcy as a possible mediator of adverse clinical effects related to heavy coffee consumption...
  9. ncbi Disruption of a regulatory system involving cobalamin distribution and function in a methionine-dependent human glioma cell line
    T Fiskerstrand
    Department of Pharmacology, University of Bergen, 5021 Bergen, Norway
    J Biol Chem 273:20180-4. 1998
    ..This regulatory network is most prominent in the methionine-dependent P60 cells harboring a disruption of the network in the proximity of cobalamin(III) reductase...
  10. ncbi The Hordaland Homocysteine Studies
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Lipids 36:S33-9. 2001
    ..The Hordaland Homocysteine cohort will be used for future investigations of the stability of tHcy and vitamin status over time, and to investigate associations with mortality and morbidity including cancer incidence...
  11. ncbi Factor V Leiden, pregnancy complications and adverse outcomes: the Hordaland Homocysteine Study
    E Nurk
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    QJM 99:289-98. 2006
    ..The factor V Leiden (FVL) mutation is the most common cause of inherited thrombophilia in Caucasian populations, and women with this variant allele are at increased risk for pregnancy complications...
  12. ncbi The controversy over homocysteine and cardiovascular risk
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hansens Hus, University of Bergen, Norway
    Am J Clin Nutr 72:324-32. 2000
    ..Thus, only placebo-controlled intervention studies with tHcy-lowering B vitamins and clinical endpoints can provide additional valid arguments for the debate over whether tHcy is a causal CVD risk factor...
  13. ncbi Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study
    S E Vollset
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Am J Clin Nutr 74:130-6. 2001
    ..Few population-based studies have assessed relations between plasma or serum total homocysteine (tHcy) and all-cause mortality...
  14. ncbi Determinants of cobalamin status in newborns
    A L Bjørke Monsen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Pediatrics 108:624-30. 2001
    ..We investigated the relation between cobalamin status in newborns and in their healthy mothers who consumed an omnivorous diet...
  15. ncbi Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered?
    G T Bondevik
    Centre for International Health, University of Bergen, Bergen, Norway
    Eur J Clin Nutr 55:856-64. 2001
    ..The aim of this study was to investigate homocysteine and methylmalonic acid levels as markers of functional cobalamin and folate status in pregnant Nepali women...
  16. ncbi Response of the methionine synthase system to short-term culture with homocysteine and nitrous oxide and its relation to methionine dependence
    T Fiskerstrand
    Department of Pharmacology, University of Bergen, Norway
    Int J Cancer 72:301-6. 1997
    ..The inability of P60 to furnish CH3Cbl to the enzyme may explain both the Met-dependent phenotype and the increased sensitivity of Hcy remethylation to N2O exposure in these cells...
  17. ncbi Analysis of single-strand conformation polymorphism by capillary electrophoresis with laser-induced fluorescence detection using short-chain polyacrylamide as sieving medium
    J Ren
    Department of Clinical Biology, University of Bergen, Norway
    Anal Biochem 245:79-84. 1997
    ..The technique is simple and rapid and is well suited to analysis of large numbers of clinical samples...
  18. ncbi Plasma total cysteine as a risk factor for vascular disease: The European Concerted Action Project
    L El-Khairy
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Circulation 103:2544-9. 2001
    ..We studied the relation between plasma total cysteine (tCys) levels and the risk of vascular disease in the coronary, cerebral, and peripheral vessels...
  19. ncbi Biological and clinical implications of the MTHFR C677T polymorphism
    P M Ueland
    LOCUS for Homocysteine and Related Vitamins, Armauer Hanssens hus, University of Bergen, 5021, Bergen, Norway
    Trends Pharmacol Sci 22:195-201. 2001
    ....
  20. ncbi Methylmalonic acid and homocysteine in plasma as indicators of functional cobalamin deficiency in infants on macrobiotic diets
    J Schneede
    Department of Pharmacology and Toxicology, University of Bergen, Haukeland Hospital, Norway
    Pediatr Res 36:194-201. 1994
    ..Furthermore, the finding of high methylmalonic acid and total homocysteine in plasma of most macrobiotic infants demonstrates a functional cobalamin deficiency in these subjects...
  21. ncbi Chemical mismatch cleavage combined with capillary electrophoresis: detection of mutations exon 8 of the cystathionine beta-synthase gene
    J Ren
    Department of Pharmacology, University of Bergen, Norway
    Clin Chem 44:2108-14. 1998
    ..Thus, CMC combined with CE-LIF is suitable for screening of known mutations, giving expected CMC products, but will also detect unknown mutations, the locations of which are indicated by the fragment sizes...
  22. ncbi Plasma total homocysteine is influenced by prandial status in humans: the Hordaland Hhomocysteine Sstudy
    E Nurk
    Department of Public Health and Primary Health Care, University of Bergen, N 5021 Bergen, Norway
    J Nutr 131:1214-6. 2001
    ....
  23. ncbi Total homocysteine and cardiovascular disease
    O Nygard
    Division for Medical Statistics, Department of Public Health, University of Bergen, Norway, Sweden
    J Intern Med 246:425-54. 1999
    ..This paper reviews the biochemical, clinical, epidemiological and experimental data underlying this conclusion and is critically questioning whether elevated tHcy is a causal factor...
  24. ncbi Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure
    A B Guttormsen
    Department of Pharmacology, University of Bergen, Norway
    Kidney Int 52:495-502. 1997
    ..High-dose folic acid reduces fasting tHcy by improving tissue Hcy remethylation without affecting the low renal clearance of tHcy...
  25. ncbi Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype
    A B Guttormsen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, Bergen, Norway
    Am J Med Genet 100:204-13. 2001
    ..Abnormal tHcy response after methionine loading was the most sensitive test. Our data suggest that the urinary tHcy excretion rate is a simple, non-invasive approach for studying mild disturbances in Hcy metabolism...
  26. ncbi Hyperhomocysteinemia in terms of steady-state kinetics
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Eur J Pediatr 157:S45-9. 1998
    ..In contrast, the hyperhomocysteinemia in renal failure is accounted for by a marked reduction in tHcy clearance, suggesting an important role of kidney in elimination of Hcy from plasma...
  27. ncbi Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase
    B Riedel
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Biochem J 341:133-8. 1999
    ....
  28. ncbi Applications of short-chain polydimethylacrylamide as sieving medium for the electrophoretic separation of DNA fragments and mutation analysis in uncoated capillaries
    J Ren
    Department of Pharmacology, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Anal Biochem 276:188-94. 1999
    ..Our results demonstrate that CE in uncoated capillaries using PDMA as sieving medium is a simple, versatile, and reliable strategy for separation and mutation analysis of clinical DNA samples...
  29. ncbi Distribution and determinants of serum creatinine in the general population: the Hordaland Health Study
    B E Vikse
    Renal Research Group, Institute of Medicine, University of Bergen, Norway
    Scand J Clin Lab Invest 64:709-22. 2004
    ..The purpose of the present study was to investigate determinants of serum creatinine in the general population...