Research Topics
Genomes and Genes | Torbjørn OmlandSummaryAffiliation: University of Oslo Country: Norway Publications
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Detail Information
Publications
Impact of systemic hypertension on the diagnostic performance of B-type natriuretic peptide in patients with acute dyspneaAndreas S Pahle
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Am J Cardiol 104:966-71. 2009..Accordingly, BNP performs well as an indicator of HF in patients presenting in emergency departments regardless of a history of hypertension or elevated blood pressure on admission...
Prognostic value of cardiac troponin I measured with a highly sensitive assay in patients with stable coronary artery diseaseTorbjørn Omland
Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
J Am Coll Cardiol 61:1240-9. 2013....
High-sensitivity cardiac troponin T levels are increased in stable COPDAnke M C Neukamm
Department of Cardiology, Division of Medicine, Akershus University Hospital, Sykehusveien 27, Lørenskog 1478, Norway
Heart 99:382-7. 2013..To assess the distribution of high-sensitivity cardiac troponin T (hs-cTnT) concentrations in stable chronic obstructive pulmonary disease (COPD), and whether hs-cTnT is associated with pulmonary function...
Type 2 diabetes and pre-diabetes are associated with obstructive sleep apnea in extremely obese subjects: a cross-sectional studyJan Magnus Fredheim
Morbid Obesity Centre, Department of Medicine, Vestfold Hospital Trust, 3103 Tønsberg, Norway
Cardiovasc Diabetol 10:84. 2011..The aim of our study is to test whether prediabetes and type 2 diabetes are associated with obstructive sleep apnea (OSA) in extremely obese (BMI ≥ 40 kg/m²) subjects...
Plasma osteoprotegerin levels in the general population: relation to indices of left ventricular structure and functionTorbjørn Omland
Akershus University Hospital, Lorenskog, Norway
Hypertension 49:1392-8. 2007..These findings are compatible with the theory that osteoprotegerin may play a pathophysiological role in the development of left ventricular hypertrophy and systolic dysfunction...
Prognostic value of B-Type natriuretic peptides in patients with stable coronary artery disease: the PEACE TrialTorbjørn Omland
Department of Medicine, Akershus University Hospital, Lorenskog, Norway
J Am Coll Cardiol 50:205-14. 2007....
Advances in congestive heart failure management in the intensive care unit: B-type natriuretic peptides in evaluation of acute heart failureTorbjørn Omland
Department of Medicine, Akershus University Hospital, Lørenskog, Norway
Crit Care Med 36:S17-27. 2008..Following the introduction of rapid, automated assays for determination of BNP and NT-proBNP, these peptides are increasingly used for diagnostic and prognostic purposes...
Amino-terminal pro-B-type natriuretic peptides in stable and unstable ischemic heart diseaseTorbjørn Omland
Division of Medicine, Akerhus University Hospital, University of Oslo, Oslo, Norway
Am J Cardiol 101:61-6. 2008..In patients with stable coronary artery disease, measurement may be performed for prognostication purposes at 6- to 18-month intervals. In the case of clinical suspicion of disease progression, a new sample may be warranted...
New features of troponin testing in different clinical settingsT Omland
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
J Intern Med 268:207-17. 2010..However, increased sensitivity comes with a cost of decreased specificity, and serial testing, as well as clinical context and judgment, is likely to become increasingly important in the interpretation of troponin assay results...
New sensitive cardiac troponin assays for the early diagnosis of myocardial infarctionT Omland
Institute of Clinical Medicine, University of Oslo, Norway
Drugs Today (Barc) 47:303-12. 2011..Thus, with the use of more sensitive assays, clinical context and serial testing to document a rise and/or fall in concentrations will be increasingly important for correct interpretation of troponin results...
B-type natriuretic peptides: prognostic markers in stable coronary artery diseaseTorbjørn Omland
Professor of Medicine, Department of Medicine, Akershus University Hospital, University of Oslo, NO 1478 Lørenskog, Norway
Expert Rev Mol Diagn 8:217-25. 2008..Data documenting that BNP or NT-proBNP measurements can be used to guide treatment decisions in patients with stable coronary artery disease are still lacking...
A sensitive cardiac troponin T assay in stable coronary artery diseaseTorbjørn Omland
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
N Engl J Med 361:2538-47. 2009..The distribution and determinants of very low circulating troponin T levels, as well as their association with cardiovascular events, in such patients are unknown...
Natriuretic peptides: physiologic and analytic considerationsTorbjørn Omland
Akershus University Hospital, Lørenskog, Norway
Heart Fail Clin 5:471-87. 2009..Fully automated analyses of both BNP and NT-proBNP can be rapidly performed on large hospital-based platforms as well as on small point-of-care devices...
N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromesTorbjørn Omland
Department of Cardiology, National Hospital, Oslo, Norway
Circulation 106:2913-8. 2002..We assessed the relation between subacute plasma N-BNP levels and long-term, all-cause mortality in a large, contemporary cohort of patients with ACS...
Obstructive sleep apnea is associated with increased high-sensitivity cardiac troponin T levelsAnna Randby
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Chest 142:639-46. 2012..We hypothesized that the severity of OSA, as assessed by the apnea-hypopnea index (AHI), is associated with circulating levels of hs-cTnT in the general population...
Diagnostic utility of a single-epitope sandwich B-type natriuretic peptide assay in stable coronary artery disease: data from the Akershus Cardiac Examination (ACE) 1 StudyHelge Røsjø
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Clin Biochem 45:1269-75. 2012..To assess the merit of a novel single-epitope sandwich (SES) assay specific to the stable part of BNP in patients with reversible myocardial ischemia as post-translational modifications of BNP may influence assay performance...
Prognostic value of chromogranin A in severe sepsis: data from the FINNSEPSIS studyHelge Røsjø
Division of Medicine, Akershus University Hospital, Sykehusveien 27, 1478, Lørenskog, Norway
Intensive Care Med 38:820-9. 2012..To assess the prognostic information of chromogranin A (CgA), a marker associated with adrenergic tone and myocardial function, in patients with severe sepsis...
Prevalence of cardiovascular risk factors and concentration of C-reactive protein in Type D personality persons without cardiovascular diseaseGunnar Einvik
Division of Medicine, Akershus University Hospital and University of Oslo, Norway
Eur J Cardiovasc Prev Rehabil 18:504-9. 2011..We hypothesized that Type D personality is associated with higher prevalence of traditional cardiovascular risk factors and higher concentration of C-reactive protein...
Plasma levels of soluble tumor necrosis factor receptor type I during the acute phase following complicated myocardial infarction predicts survival in high-risk patientsThor Ueland
Section of Endocrinology, National University Hospital, Oslo, Norway
J Am Coll Cardiol 46:2018-21. 2005..We sought to determine the relationship between circulating cytokine levels and clinical outcomes in patients with heart failure (HF) following acute myocardial infarction (AMI)...
NT-proBNP independently predicts long term mortality after acute exacerbation of COPD - a prospective cohort studyArne Didrik Høiseth
Division of Medicine, Akershus University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Respir Res 13:97. 2012..The prognostic value of NT-proBNP in patients hospitalized with AECOPD is sparsely studied. Our objective was to test the hypothesis that NT-proBNP independently predicts long term mortality following AECOPD...
Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohortGunnar Einvik
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Gen Hosp Psychiatry 34:262-7. 2012....
Prognostic value of N-terminal pro-atrial and pro-brain natriuretic peptide in patients with acute coronary syndromesTorbjørn Omland
Department of Cardiology, The National Hospital, Oslo, Norway
Am J Cardiol 89:463-5. 2002
Acute exacerbation of COPD is associated with fourfold elevation of cardiac troponin TVidar Søyseth
Department of Medicine, Akershus University Hospital, University of Oslo, Sykehusvn 25, Lørenskog 1478, Norway
Heart 99:122-6. 2013....
Sleep apnoea, anxiety, depression and somatoform pain: a community-based high-risk sampleHarald Hrubos-Strøm
Dept of Otopharyngeology, Surgical Division, Akershus University Hospital, 1478 Lørenskog, Norway
Eur Respir J 40:400-7. 2012..In conclusion, more than one-third of participants in a community-based, Berlin Questionnaire high-risk sample were diagnosed with a psychiatric disorder. A negative association between OSA and psychiatric morbidity was found...
Cardiac arrhythmias in obstructive sleep apnea (from the Akershus Sleep Apnea Project)Silje K Namtvedt
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Am J Cardiol 108:1141-6. 2011..8, p = 0.035). In conclusion, the prevalence of ventricular premature complexes is increased in middle-aged patients with mainly mild or moderate OSA, suggesting an association between OSA and ventricular arrhythmias even in mild OSA...
Impaired endothelial function in persons with obstructive sleep apnoea: impact of obesitySilje K Namtvedt
Department of Internal Medicine, Division of Medicine, Akershus University Hospital, Lorenskog, Norway
Heart 99:30-4. 2013..As obesity is highly prevalent in OSA, we wanted to test the hypothesis that OSA is associated with endothelial dysfunction independently of obesity...
Troponin I Measured by a High-Sensitivity Assay in Patients with Suspected Reversible Myocardial Ischemia: Data from the Akershus Cardiac Examination (ACE) 1 StudyHelge Røsjø
Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Clin Chem 58:1565-73. 2012..Whether cardiac troponin concentrations are increased by reversible myocardial ischemia is controversial. Differences in the structure of cardiac troponin I (cTnI) and cTnT may have implications for diagnostic utility...
Determinants of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort studyArne Didrik Høiseth
Dept, of Medicine, Akershus University Hospital and Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, Oslo, Norway
BMC Pulm Med 12:22. 2012..e. 14 ng/L) is common during Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and associated with increased mortality. The objective of the study was to identify factors associated with hs-cTnT levels during AECOPD...
Inflammatory response and re-stenosis after percutaneous coronary intervention in heart transplant recipients and patients with native atherosclerosisAina Hognestad
Department of Cardiology, Rikshospitalet, University of Oslo, Norway
J Heart Lung Transplant 24:1026-32. 2005....
Osteoprotegerin and cardiovascular mortality in patients with non-ST elevation acute coronary syndromesRagnhild Røysland
Division of Medicine, Akershus University Hospital, Sykehusveien 27, Lørenskog, Norway
Heart 98:786-91. 2012..To assess the relationship between osteoprotegerin (OPG) and cardiovascular death, and the pathobiological mechanisms contributing to the association, in acute coronary syndromes (ACS)...
Determinants of cardiac troponin T elevation in COPD exacerbation - a cross-sectional studyPål H Brekke
Department of Medicine, Akershus University Hospital, Lørenskog, Norway
BMC Pulm Med 9:35. 2009..The factors associated with cTnT elevation in COPD are not known...
Novel cardiovascular risk markers in depression: no association between depressive symptoms and osteoprotegerin or adiponectin in persons at high risk for sleep apneaGunnar Einvik
Division of Medicine, Akershus University Hospital and Institute of Clinical Medicine, University of Oslo, Norway
J Affect Disord 145:400-4. 2013....
Major depressive disorder, anxiety disorders, and cardiac biomarkers in subjects at high risk of obstructive sleep apneaGunnar Einvik
Division of Medicine, Akershus University Hospital, Pb 95, 1478 Lørenskog, Norway
Psychosom Med 73:378-84. 2011....
Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardiumHelge Røsjø
Medical Division and EpiGen, Institute of Clinical Epidemiology and Molecular Biology, Akershus University Hospital, Lørenskog, Norway
Circ Heart Fail 3:503-11. 2010..Chromogranin B (CgB) is a member of the granin protein family. Because CgB is often colocalized with chromogranin A (CgA), a recently discovered cardiac biomarker, we hypothesized that CgB is regulated during heart failure (HF) development...
Obstructive sleep apnea, verbal memory, and executive function in a community-based high-risk population identified by the Berlin Questionnaire Akershus Sleep Apnea ProjectHarald Hrubos-Strøm
Department of Clinical Science, Research Centre, Akershus University Hospital, Lørenskog, Norway
Sleep Breath 16:223-31. 2012....
Underdiagnosis of myocardial infarction in COPD - Cardiac Infarction Injury Score (CIIS) in patients hospitalised for COPD exacerbationPål H Brekke
Department of Medicine and Faculty Division, Akershus University Hospital, N 1478 Lørenskog, Norway
Respir Med 102:1243-7. 2008..We used Cardiac Infarction Injury Score (CIIS) to assess the prevalence of prior myocardical infarction (MI) in COPD patients and compared this to clinicians' previous diagnosis of MI...
Cardiac troponin T levels and exercise stress testing in patients with suspected coronary artery disease: the Akershus Cardiac Examination (ACE) 1 studyRagnhild Røysland
Division of Medicine, Akershus University Hospital, 1478 Lørenskog, Norway
Clin Sci (Lond) 122:599-606. 2012..Mechanisms other than reversible myocardial ischaemia may play a role for acute exercise-induced increases in circulating cTnT levels...
Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective propertiesHelge Røsjø
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
PLoS ONE 7:e37401. 2012..As cardiac production of chromogranin A and B, two related proteins, is increased in heart failure (HF), we hypothesized that SgII could play a role in cardiovascular pathophysiology...
Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trialRagnhild Røysland
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Am Heart J 160:286-93. 2010..The association between OPG and outcome in patients with chronic heart failure (CHF) is unknown...
Prognostic usefulness of circulating high-sensitivity troponin T in aortic stenosis and relation to echocardiographic indexes of cardiac function and anatomyHelge Røsjø
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Am J Cardiol 108:88-91. 2011....
Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcomeHelge Røsjø
Division of Medicine, Akershus University Hospital, Sykehusveien 27, 1478 Lørenskog, Norway
Intensive Care Med 37:77-85. 2011..To assess the clinical utility of a recently developed highly sensitive cardiac troponin T (hs-cTnT) assay for providing prognostic information on patients with sepsis...
A farewell to body-mass index?Charlotte Kragelund
Department of Medicine, Akershus University Hospital, NO 1478 Lørenskog, Norway
Lancet 366:1589-91. 2005
Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromesTorbjørn Omland
Department of Medicine, Akershus University Hospital, Lørenskog, Norway Faculty of Medicine, University of Oslo, Oslo, Norway
J Am Coll Cardiol 51:627-33. 2008..This study was designed to assess the association between osteoprotegerin (OPG) levels on admission and long-term prognosis in patients with acute coronary syndromes (ACS)...
Prognostic value of osteoprotegerin in heart failure after acute myocardial infarctionThor Ueland
Research Institute for Internal Medicine, Section of Endocrinology, National University Hospital, Oslo, Norway
J Am Coll Cardiol 44:1970-6. 2004..We sought to determine the relationship between osteoprotegerin (OPG) and clinical outcomes in patients with heart failure (HF) after acute myocardial infarction (AMI)...
A Norwegian population-based study on the risk and prevalence of obstructive sleep apnea. The Akershus Sleep Apnea Project (ASAP)Harald Hrubos-Strøm
Department of Clinical Science, Research Centre, Akershus University Hospital, Lørenskog, Norway
J Sleep Res 20:162-70. 2011..The estimated prevalence of OSA was comparable to previous estimates from general populations in the USA, Australia and Europe...
B-type natriuretic peptide and long-term survival in patients with stable coronary artery diseaseTorbjørn Omland
Cardiology Division, Department of Medicine, Akershus University Hospital, University of Oslo, Oslo, Norway
Am J Cardiol 95:24-8. 2005..005) provided prognostic information above and beyond conventional risk markers. In patients with clinically stable, angiographically documented coronary artery disease, plasma BNP levels are independently related to long-term survival...
New statistical methods for the evaluation of cardiovascular risk markers: what the clinician should knowHelge Røsjø
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Clin Sci (Lond) 117:13-5. 2009....
Clinical and laboratory diagnostics of cardiovascular disease: focus on natriuretic peptides and cardiac ischemiaTorbjørn Omland
University of Oslo Faculty Division Akershus University Hospital, Department of Medicine, Akershus University Hospital, Nordbyhagen, Norway
Scand J Clin Lab Invest Suppl 240:18-24. 2005..Recently, a relationship between circulating levels of BNP and NT-proBNP and long-term all cause mortality in patients with stable coronary artery disease has been documented...
Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: Prediction of significant coronary lesions and long-term prognosisJørgen Gravning
Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway Center for Heart Failure Research, University of Oslo, Oslo, Norway
Am Heart J 165:716-24. 2013..However, the role of sensitive cardiac troponin (cTn) assays in prediction of significant coronary lesions and long-term prognosis in non-ST-elevation acute coronary syndrome (NSTE-ACS) remains unresolved...
B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failureAlf Inge Larsen
Department of Cardiology, Stavanger University Hospital, Norway
Int J Cardiol 136:358-62. 2009..This finding suggests that the degree of intrafibrillar edema is related to the secretion of NT-proBNP...
Prognostic value of chromogranin A in chronic heart failure: data from the GISSI-Heart Failure trialHelge Røsjø
Division of Medicine, Akershus University Hospital, Lørenskog, Norway
Eur J Heart Fail 12:549-56. 2010..To assess the association between circulating levels of chromogranin A (CgA) and outcome in a large population of patients with chronic heart failure (HF)...
Blood haemoglobin is an independent predictor of B-type natriuretic peptide (BNP)Cathrine Wold Knudsen
Department of Cardiology, , Oslo, Norway
Clin Sci (Lond) 109:69-74. 2005..Anaemia may contribute to elevated BNP levels in the absence of heart failure, and may represent an important confounder of the relationship between BNP, cardiac function and prognosis...
Body fat and fat-free mass measured by bioelectric impedance spectroscopy and dual-energy X-ray absorptiometry in obese and non-obese adultsPaula Berstad
Research Centre, Akershus University Hospital, Box 26, 1478 Lørenskog, Norway
Br J Nutr 107:1192-200. 2012..However, the large inter-individual variation suggests that this BIS device with the proprietary software is insufficient for estimation of single individual body FM and FFM...
[Depression and cardiovascular disease--is there an association?]Gunnar Einvik
Medisinsk divisjon, Akershus universitetssykehus, 1478 Lørenskog, og Institutt for sykehusmedisin, Universitetet i Oslo, Norway
Tidsskr Nor Laegeforen 130:729-32. 2010..Depression is associated with an increased risk of cardiovascular events. This review presents data from recent cohort- and interventional studies, and possible pathogenetic mechanisms...
Association between plasma chromogranin A concentration and long-term mortality after myocardial infarctionTorbjørn Omland
Department of Cardiology, The National Hospital, Oslo, Norway
Am J Med 114:25-30. 2003..We sought to assess the long-term prognostic value of circulating levels of chromogranin A after myocardial infarction...
Multiple cytokine biomarkers in heart failureMaria Vistnes
Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway
Expert Rev Mol Diagn 10:147-57. 2010..Nevertheless, multiplex protein analyses are likely to constitute an important part of experimental and clinical research on heart failure and cytokines, paving the way for more accurate heart failure treatment...
Prognostic value of plasma chromogranin A levels in patients with complicated myocardial infarctionMette Elise Estensen
Department of Medicine, Akershus University Hospital, , Norway
Am Heart J 152:927.e1-6. 2006..0001), history of diabetes (P = .004), and male sex (P = .021) were independently predictive of outcome. CONCLUSION: Chromogranin A is a strong and independent prognostic indicator in patients with complicated myocardial infarction...
Natriuretic peptides as markers of patent ductus arteriosus in preterm infantsHenrik Holmstrom
Department of Paediatrics, The National Hospital, Oslo, Norway
Clin Sci (Lond) 103:79-80. 2002
Impact of atrial fibrillation on the diagnostic performance of B-type natriuretic peptide concentration in dyspneic patients: an analysis from the breathing not properly multinational studyCathrine Wold Knudsen
, Oslo, Norway
J Am Coll Cardiol 46:838-44. 2005..CONCLUSIONS: In patients without, but not in those with HF, the presence of AF is associated with higher circulating BNP levels, suggesting that a higher diagnostic threshold should be used in patients with AF...
Diagnostic value of a rapid test for B-type natriuretic peptide in patients presenting with acute dyspnoe: effect of age and genderCathrine Wold Knudsen
Department of Cardiology, , Oslo, Norway
Eur J Heart Fail 6:55-62. 2004..CONCLUSION: Point-of-care BNP measurement in the emergency department discriminates well between patients with dyspnoe of cardiac and non-cardiac origin regardless of age and gender...
Diagnostic value of B-Type natriuretic peptide and chest radiographic findings in patients with acute dyspneaCathrine W Knudsen
, Oslo, Norway
Am J Med 116:363-8. 2004..CONCLUSION: In patients presenting to the emergency department with acute dyspnea, BNP levels and chest radiographs provide complementary diagnostic information that may be useful in the early evaluation of heart failure...
