Dag Rune Olsen

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. pmc Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy
    Therese Seierstad
    Department of Medical Physics, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    Mol Cancer 7:33. 2008
  2. ncbi Proton therapy - a systematic review of clinical effectiveness
    Dag Rune Olsen
    Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Radiother Oncol 83:123-32. 2007
  3. doi Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming
    Nina Jeppesen Edin
    Department of Physics, University of Oslo, Biophysics Group, PB 1048 Blindern, N 0316 Oslo, Norway
    Int J Radiat Biol 85:1157-65. 2009
  4. doi Strategies for biologic image-guided dose escalation: a review
    Aste Søvik
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet University Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 73:650-8. 2009
  5. doi Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation
    Nina Jeppesen Edin
    Department of Physics, University of Oslo, Norway
    Int J Radiat Biol 88:311-9. 2012
  6. doi Late regional density changes of the lung after radiotherapy for breast cancer
    Randi Vågane
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet University Hospital, Oslo, Norway
    Radiother Oncol 90:148-52. 2009
  7. doi A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and volumetric modulated arc treatment techniqu
    Safora Johansen
    Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Acta Oncol 48:495-503. 2009
  8. ncbi Radiotherapy adapted to spatial and temporal variability in tumor hypoxia
    Aste Søvik
    Department of Medical Physics, The Norwegian Radium Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 68:1496-504. 2007
  9. doi Automatic segmentation and recognition of lungs and lesion from CT scans of thorax
    Manish Kakar
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Comput Med Imaging Graph 33:72-82. 2009
  10. doi Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer
    Safora Johansen
    Department of Medical Physics, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Acta Oncol 47:391-6. 2008

Collaborators

Detail Information

Publications34

  1. pmc Principal component analysis for the comparison of metabolic profiles from human rectal cancer biopsies and colorectal xenografts using high-resolution magic angle spinning 1H magnetic resonance spectroscopy
    Therese Seierstad
    Department of Medical Physics, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    Mol Cancer 7:33. 2008
    ..A further aim was to investigate metabolic changes following irradiation of HT29 xenografts...
  2. ncbi Proton therapy - a systematic review of clinical effectiveness
    Dag Rune Olsen
    Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Radiother Oncol 83:123-32. 2007
    ..Several proton facilities are currently operating or under planning world-wide - in the United States, Asia and Europe. Until now no systematic review assessing the clinical effectiveness of this treatment modality has been published...
  3. doi Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming
    Nina Jeppesen Edin
    Department of Physics, University of Oslo, Biophysics Group, PB 1048 Blindern, N 0316 Oslo, Norway
    Int J Radiat Biol 85:1157-65. 2009
    ..To investigate the mechanisms of elimination of low-dose hyper-radiosensitivity (HRS) in T-47D cells induced by 0.3 Gy low dose-rate (LDR) priming...
  4. doi Strategies for biologic image-guided dose escalation: a review
    Aste Søvik
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet University Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 73:650-8. 2009
    ..We conclude with a summary of the current status of biologic image-based dose escalation and of areas where further work is needed for this strategy to become incorporated into clinical practice...
  5. doi Low dose hyper-radiosensitivity is eliminated during exposure to cycling hypoxia but returns after reoxygenation
    Nina Jeppesen Edin
    Department of Physics, University of Oslo, Norway
    Int J Radiat Biol 88:311-9. 2012
    ..The presence of HRS in response to subsequent challenge irradiation was measured by clonogenic survival...
  6. doi Late regional density changes of the lung after radiotherapy for breast cancer
    Randi Vågane
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet University Hospital, Oslo, Norway
    Radiother Oncol 90:148-52. 2009
    ..To investigate density changes in lung tissue, 3-4 years after postoperative adjuvant radiotherapy for breast cancer, based on dose dependence and regional differences...
  7. doi A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and volumetric modulated arc treatment techniqu
    Safora Johansen
    Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Acta Oncol 48:495-503. 2009
    ..Furthermore, to predict the risk for induced malignancies in CB using linear and non linear models...
  8. ncbi Radiotherapy adapted to spatial and temporal variability in tumor hypoxia
    Aste Søvik
    Department of Medical Physics, The Norwegian Radium Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 68:1496-504. 2007
    ..To explore the feasibility and clinical potential of adapting radiotherapy to temporal and spatial variations in tumor oxygenation...
  9. doi Automatic segmentation and recognition of lungs and lesion from CT scans of thorax
    Manish Kakar
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Comput Med Imaging Graph 33:72-82. 2009
    ..Results reveal an accuracy of delineation to be 94.06%, 94.32% and 89.04% for left lung, right lung and lesion, respectively. Average sensitivity of the SVM classifier was seen to be 89.48%...
  10. doi Estimated risk for secondary cancer in the contra-lateral breast following radiation therapy of breast cancer
    Safora Johansen
    Department of Medical Physics, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Acta Oncol 47:391-6. 2008
    ..To facilitate a discussion about the impact of dose heterogeneity on the risk for secondary contralateral breast (CB) cancer predicted with linear and non linear models associated with primary breast irradiation...
  11. doi DCEMRI of spontaneous canine tumors during fractionated radiotherapy: a pharmacokinetic analysis
    Ste Søvik
    Department of Radiation Biology, Oslo University Hospital, Oslo, Norway
    Radiother Oncol 93:618-24. 2009
    ....
  12. doi Adapting biological feedback in radiotherapy
    Aste Søvik
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Semin Radiat Oncol 20:138-46. 2010
    ..Finally, we discuss to what degree biologically adapted radiotherapy may be expected to improve treatment outcome and which issues need to be resolved for this strategy to reach its full potential...
  13. ncbi Improved image quality of low-dose thoracic CT examinations with a new postprocessing software
    Anne Catrine Tregde Martinsen
    The Interventional Centre, Oslo University Hospital, Oslo, Norway
    J Appl Clin Med Phys 11:3242. 2010
    ..2, 0.1 and 0.3 for the full-dose, low-dose and low-dose enhanced series, respectively. There is a potential for improving diagnostic performance of low-dose CT chest examinations using this new postprocessing filter...
  14. pmc The clinical impact of mean vessel size and solidity in breast carcinoma patients
    Lars Tore Gyland Mikalsen
    Department of Physics, University of Oslo, Oslo, Norway
    PLoS ONE 8:e75954. 2013
    ..e. the size and shape of vessels in the studied hot spots...
  15. doi Late effects after radiotherapy for locally advanced cervical cancer: comparison of two brachytherapy schedules and effect of dose delivered weekly
    Taran Paulsen Hellebust
    Department of Medical Physics, Division of Cancer Medicine and Radiotherapy, Institute for Cancer Research, Radiumhospitalet, Rikshospitalet University Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 76:713-8. 2010
    ....
  16. pmc Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions
    Kathrine Røe
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Neoplasia 12:818-25. 2010
    ....
  17. doi Dose evaluation and risk estimation for secondary cancer in contralateral breast and a study of correlation between thorax shape and dose to organs at risk following tangentially breast irradiation during deep inspiration breath-hold and free breathing
    Safora Johansen
    Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    Acta Oncol 50:563-8. 2011
    ....
  18. ncbi Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections
    Lars Tore Gyland Mikalsen
    Department of Physics, University of Oslo, Postboks 1048 Blindern, N 0316, Oslo, Norway
    Anticancer Res 31:4053-60. 2011
    ..We present a method of automatic vessel identification applied to CD34 immunohistochemical sections which facilitates increased reproducibility...
  19. doi The elimination of low-dose hyper-radiosensitivity by transfer of irradiated-cell conditioned medium depends on dose rate
    Nina Jeppesen Edin
    Department of Physics, The Biophysics Group, University of Oslo, Blindern, Oslo, Norway
    Radiat Res 171:22-32. 2009
    ..However, an increase in clonogenic survival was observed in cells receiving only medium transfer without subsequent irradiation that was independent of dose rate...
  20. ncbi On the parameter describing the generalised equivalent uniform dose (gEUD) for tumours
    Aste Søvik
    Department of Medical Physics, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Phys Med 23:100-6. 2007
    ..Although the current work shows limitations of the gEUD model for tumours, gEUD may still be preferable for biological treatment plan optimization, evaluation and reporting...
  21. pmc Hypoxic tumor kinase signaling mediated by STAT5A in development of castration-resistant prostate cancer
    Kathrine Røe
    Department of Oncology, Akershus University Hospital, Lørenskog, Norway
    PLoS ONE 8:e63723. 2013
    ..Hence, the study detected STAT5A as a candidate to be further investigated for its potential as marker of advanced prostate cancer and as possible therapeutic target protein...
  22. doi Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice
    Eirik Hagtvet
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    J Drug Target 19:701-8. 2011
    ..The liposomal DXR formulation alone showed no inhibitory effect on tumor growth. However, upon exposure to low frequency US in situ inhibition of tumor growth was demonstrated...
  23. doi Artificial neural networks for prediction of response to chemoradiation in HT29 xenografts
    Manish Kakar
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    Int J Radiat Oncol Biol Phys 75:506-11. 2009
    ..To evaluate the feasibility of using neural networks for predicting treatment response by using longitudinal measurements of apparent diffusion coefficient (ADC) obtained from diffusion-weighted magnetic resonance imaging (DWMRI)...
  24. doi Iterative reconstruction reduces abdominal CT dose
    Anne Catrine Trægde Martinsen
    The Intervention Centre, Oslo University Hospital, Rikshospitalet, Postboks 4950 Nydalen, N 0424 Oslo, Norway
    Eur J Radiol 81:1483-7. 2012
    ....
  25. ncbi Reconstruction of a ring applicator using CT imaging: impact of the reconstruction method and applicator orientation
    Taran Paulsen Hellebust
    Department of Medical Physics, Rikshospital Radiumhospital Medical Center, Oslo, Norway
    Phys Med Biol 52:4893-904. 2007
    ..However, with restrictive guidelines for applicator reconstruction the uncertainties for all methods are low compared to other factors influencing the accuracy of brachytherapy...
  26. ncbi Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study
    Aste Søvik
    Department of Medical Physics and Technology, The Norwegian Radium Hospital, and Department of Physics, University of Oslo, 0316 Oslo, Norway
    Phys Med Biol 52:499-513. 2007
    ..This could potentially improve treatment outcome in a subpopulation of patients who respond poorly to conventional radiotherapy...
  27. ncbi Teleradiology with satellite units - six years experience at the norwegian radium hospital
    Albrecht Reith
    The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Stud Health Technol Inform 134:209-16. 2008
    ..Standardization and quality assurance of radiotherapy at the quality level of a comprehensive cancer center can be offered to a much larger population and may play a role in improved cancer survival outcome...
  28. ncbi Radiobiological responses for two cell lines following continuous low dose-rate (CLDR) and pulsed dose rate (PDR) brachytherapy
    Per Henrik Hanisch
    Department of Medical Physics, The University of Oslo, Oslo, Norway
    Acta Oncol 46:602-11. 2007
    ..The underlying cause of this difference is unclear, but cell-cycle parameters, like G2-accumulation is tested and found to be the same for the two cell lines...
  29. ncbi Contralateral breast doses following radiotherapy of the breast and regional lymph nodes: Measurements and treatment planning calculations
    Safora Johansen
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Radiother Oncol 82:332-6. 2007
    ....
  30. ncbi Adapting radiotherapy to hypoxic tumours
    Eirik Malinen
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Phys Med Biol 51:4903-21. 2006
    ..In conclusion, improved tumour control of hypoxic tumours by dose redistribution may be expected following hypoxia imaging, tumour control predictions, inverse treatment planning and IMRT...
  31. ncbi Electron paramagnetic resonance (EPR) dosimetry using lithium formate in radiotherapy: comparison with thermoluminescence (TL) dosimetry using lithium fluoride rods
    Tor Arne Vestad
    Department of Physics, University of Oslo, P O Box 1048, Blindern, N 0316 Oslo, Norway
    Phys Med Biol 49:4701-15. 2004
    ....
  32. ncbi Dose painting: art or science?
    Kari Tanderup
    Radiother Oncol 79:245-8. 2006
  33. ncbi Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
    Jostein Dahle
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HE, Montebello, 0310 Oslo, Norway
    Nucl Med Biol 33:271-9. 2006
    ..4 days. Incubation of lymphoma cells with (227)Th-DOTA-p-benzyl-rituximab resulted in a significant antigen-dependent inhibition of cell growth. The data presented here warrant further studies of (227)Th-DOTA-p-benzyl-rituximab...
  34. ncbi Dose optimisation in single plane interstitial brachytherapy
    Kari Tanderup
    Department of Oncology, Aarhus University Hospital, Aarhus, Denmark
    Radiother Oncol 81:105-11. 2006
    ..Brachytherapy dose distributions can be optimised by modulation of source dwell times. In this study dose optimisation in single planar interstitial implants was evaluated in order to quantify the potential benefit in patients...