Erlend A Nagelhus

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1
    E A Nagelhus
    Nordic Centre of Excellence for Research in Water Imbalance Related Disorders and Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N 0317 Oslo, Norway
    Neuroscience 129:905-13. 2004
  2. pmc Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes
    Erlend A Nagelhus
    Nordic Centre for Water Imbalance Related Disorders and Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, P O Box 1105, Blindern, N 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 102:8030-5. 2005
  3. doi request reprint Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse
    Rune Enger
    Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Norway
    Glia 60:2018-26. 2012
  4. pmc Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
    Vinita Rangroo Thrane
    1 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, New York, USA 2 Letten Centre, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway 3 Centre for Molecular Medicine Norway, University of Oslo, Oslo, Norway 4 Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway 5
    Nat Med 19:1643-8. 2013
  5. doi request reprint Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus
    Nadia Nabil Haj-Yasein
    Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, Oslo, Norway
    Glia 60:867-74. 2012
  6. doi request reprint Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier
    Martine Eilert-Olsen
    Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway
    Glia 60:432-40. 2012
  7. pmc Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice
    Mahmood Amiry-Moghaddam
    Centre for Molecular Biology and Neuroscience, University of Oslo, 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 100:13615-20. 2003
  8. doi request reprint Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort
    Emilia Kerty
    Department of Neurology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Acta Ophthalmol 91:88-91. 2013
  9. pmc Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
    Vinita Rangroo Thrane
    1 Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 2 Letten Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway 3 Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway 4
    Sci Rep 3:2582. 2013
  10. ncbi request reprint The glia doctrine: addressing the role of glial cells in healthy brain ageing
    Erlend A Nagelhus
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway Centre for Molecular Medicine Norway NCMM, The Nordic EMBL Partnership, University of Oslo, Norway Department of Neurology, Oslo University Hospital, Norway
    Mech Ageing Dev 134:449-59. 2013

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1
    E A Nagelhus
    Nordic Centre of Excellence for Research in Water Imbalance Related Disorders and Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N 0317 Oslo, Norway
    Neuroscience 129:905-13. 2004
    ..We conclude that AQP4-mediated water flux represents an integral element of brain volume and ion homeostasis...
  2. pmc Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes
    Erlend A Nagelhus
    Nordic Centre for Water Imbalance Related Disorders and Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, P O Box 1105, Blindern, N 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 102:8030-5. 2005
    ..We suggest that CA XIV is the target of CA inhibitors that enhance subretinal fluid absorption in macular edema. In addition, CA XIV may facilitate CO(2) removal from neural retina and modulate photoreceptor function...
  3. doi request reprint Molecular scaffolds underpinning macroglial polarization: an analysis of retinal Müller cells and brain astrocytes in mouse
    Rune Enger
    Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Norway
    Glia 60:2018-26. 2012
    ..These data indicate that the molecular scaffolding in perivascular endfeet is more complex than previously assumed and that macroglia are heterogeneous with respect to the mechanisms that dictate their polarization...
  4. pmc Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
    Vinita Rangroo Thrane
    1 Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, New York, USA 2 Letten Centre, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway 3 Centre for Molecular Medicine Norway, University of Oslo, Oslo, Norway 4 Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway 5
    Nat Med 19:1643-8. 2013
    ..Instead, our findings identify failure of potassium buffering in astrocytes as a crucial mechanism in ammonia neurotoxicity and demonstrate the therapeutic potential of blocking this pathway by inhibiting NKCC1. ..
  5. doi request reprint Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus
    Nadia Nabil Haj-Yasein
    Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, Oslo, Norway
    Glia 60:867-74. 2012
    ..For both genotypes the ECS shrinkage was most pronounced in the pyramidal cell layer. Our data attribute a physiological role to AQP4 and indicate that this water channel regulates extracellular volume dynamics in the mammalian brain...
  6. doi request reprint Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier
    Martine Eilert-Olsen
    Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway
    Glia 60:432-40. 2012
    ..Our data also indicate that AQP4 and α-syntrophin are mutually dependent upon each other for proper perivascular expression...
  7. pmc Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice
    Mahmood Amiry-Moghaddam
    Centre for Molecular Biology and Neuroscience, University of Oslo, 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 100:13615-20. 2003
    ..These studies lead us to propose that water flux through perivascular AQP4 is needed to sustain efficient removal of K+ after neuronal activation...
  8. doi request reprint Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort
    Emilia Kerty
    Department of Neurology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, Norway
    Acta Ophthalmol 91:88-91. 2013
    ..IIH could be associated with malfunctioning intracerebral water homeostasis and cerebrospinal fluid (CSF) reabsorption based on functional or regulatory alterations of AQP4...
  9. pmc Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain
    Vinita Rangroo Thrane
    1 Division of Glia Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642 2 Letten Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway 3 Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway 4
    Sci Rep 3:2582. 2013
    ..As the central nervous system is devoid of lymphatic vessels, the paravascular space may serve as a lymphatic equivalent that represents a separate highway for the transport of lipids and signaling molecules. ..
  10. ncbi request reprint The glia doctrine: addressing the role of glial cells in healthy brain ageing
    Erlend A Nagelhus
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway Centre for Molecular Medicine Norway NCMM, The Nordic EMBL Partnership, University of Oslo, Norway Department of Neurology, Oslo University Hospital, Norway
    Mech Ageing Dev 134:449-59. 2013
    ..Systematic studies of glia and their functions are expected to eventually lead to earlier detection of ageing-related brain dysfunction and to interventions that could delay, reduce or prevent brain dysfunction. ..
  11. ncbi request reprint Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice
    W Puwarawuttipanit
    Centre for Molecular Biology and Neuroscience, and Nordic Centre for Water Imbalance Related Disorders, University of Oslo, P O Box 1105 Blindern, N 0317 Oslo, Norway
    Neuroscience 137:165-75. 2006
    ..1 and the alpha-syntrophin independent pool of aquaporin-4...