Johan Moan

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. pmc Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study
    Jøran Hjelmesaeth
    Morbid Obesity Center, Vestfold Hospital Trust, Health Region South, Tønsberg, Norway
    Cardiovasc Diabetol 8:7. 2009
  2. pmc Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 105:668-73. 2008
  3. ncbi request reprint Colon cancer: prognosis for different latitudes, age groups and seasons in Norway
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 89:148-55. 2007
  4. doi request reprint Immediate pigment darkening: its evolutionary roles may include protection against folate photosensitization
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello 0310 Oslo, Norway
    FASEB J 26:971-5. 2012
  5. ncbi request reprint Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemes
    Xiao Pudroma
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Environ Pathol Toxicol Oncol 30:235-40. 2011
  6. ncbi request reprint The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate
    Liwei Ma
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol Sci 5:755-9. 2006
  7. ncbi request reprint Prostate cancer survival is dependent on season of diagnosis
    Zoya Lagunova
    Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Prostate 67:1362-70. 2007
  8. ncbi request reprint Photodegradation of 5-methyltetrahydrofolate in the presence of Uroporphyrin
    Tran Thi Thu Tam
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 94:201-4. 2009
  9. ncbi request reprint Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions
    Miron Kaliszewski
    Department of Radiation Biology, Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 87:67-72. 2007
  10. ncbi request reprint A new method for photodynamic therapy of melanotic melanoma -- effects of depigmentation with violet light photodynamic therapy
    Li Wei Ma
    Department of Radiation Biophysics, Institute for Cancer Research, Rikshospital Radiumhospital HF and Plasma Room Physics, University of Oslo, Oslo, Norway
    J Environ Pathol Toxicol Oncol 26:165-72. 2007

Collaborators

Detail Information

Publications78

  1. pmc Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study
    Jøran Hjelmesaeth
    Morbid Obesity Center, Vestfold Hospital Trust, Health Region South, Tønsberg, Norway
    Cardiovasc Diabetol 8:7. 2009
    ..We aimed to explore whether MS is associated with abnormal serum levels of PTH, 25(OH)D and magnesium in a population of morbidly obese patients...
  2. pmc Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 105:668-73. 2008
    ....
  3. ncbi request reprint Colon cancer: prognosis for different latitudes, age groups and seasons in Norway
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 89:148-55. 2007
    ..The seasonal effect was slightly, but not significantly, better for the younger than for the older age group. The effect was similar for all three geographical regions, irrespective of SCC incidence...
  4. doi request reprint Immediate pigment darkening: its evolutionary roles may include protection against folate photosensitization
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello 0310 Oslo, Norway
    FASEB J 26:971-5. 2012
    ..We here propose that the biological role of IPD is protection of folates against photodegradation, which would be of large evolutionary importance for early hominids...
  5. ncbi request reprint Fluorescence photobleaching of ALA and ALA-heptyl ester induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: a comparison of two light sources and different illumination schemes
    Xiao Pudroma
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Environ Pathol Toxicol Oncol 30:235-40. 2011
    ..These have been suggested to allow reoxygenation of the irradiated tissue, with a consequent enhancement of singlet oxygen production in the second and subsequent fractions...
  6. ncbi request reprint The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate
    Liwei Ma
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol Sci 5:755-9. 2006
    ..The present data seem to favour the latter mechanism. Folic acid may have a role as an adjuvant in photodynamic therapy with systemically administered ALA and its derivatives...
  7. ncbi request reprint Prostate cancer survival is dependent on season of diagnosis
    Zoya Lagunova
    Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Prostate 67:1362-70. 2007
    ..More recently, both prostate cancer incidence and mortality have been shown to increase with increasing latitude, which probably relates to photosynthesis of vitamin D...
  8. ncbi request reprint Photodegradation of 5-methyltetrahydrofolate in the presence of Uroporphyrin
    Tran Thi Thu Tam
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 94:201-4. 2009
    ..Our results show that singlet oxygen is likely to be the main intermediate in the photodegradation of 5MTHF mediated by Uro. Our findings may be useful for further studies the evolution of human skin colours...
  9. ncbi request reprint Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions
    Miron Kaliszewski
    Department of Radiation Biology, Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 87:67-72. 2007
    ..Our work shows that solutions should be prepared immediately before use and stored at low temperatures. The pH of stock solutions should not exceed 5...
  10. ncbi request reprint A new method for photodynamic therapy of melanotic melanoma -- effects of depigmentation with violet light photodynamic therapy
    Li Wei Ma
    Department of Radiation Biophysics, Institute for Cancer Research, Rikshospital Radiumhospital HF and Plasma Room Physics, University of Oslo, Oslo, Norway
    J Environ Pathol Toxicol Oncol 26:165-72. 2007
    ..This finding indicates a new PDT modality that can be further developed for treatment of superficial melanotic melanomas and possibly other diseases where pigmentation is a problem...
  11. doi request reprint Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude
    Alina Carmen Porojnicu
    Deparment of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Adv Exp Med Biol 624:43-54. 2008
    ..Based on our results we suggest that calcidiol concentration at the time of cancer diagnosis is related to survival and discuss briefly ways to improve the vitamin D levels in the general population...
  12. ncbi request reprint Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role?
    Alina Carmen Porojnicu
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Lung Cancer 55:263-70. 2007
    ..Seasonal and gender variations in Vitamin D level have been estimated from the analyses...
  13. ncbi request reprint Influence of narrowband UVB phototherapy on vitamin D and folate status
    Emanuela Cicarma
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Exp Dermatol 19:e67-72. 2010
    ..Such therapy leads to enhanced cutaneous vitamin D synthesis, which may be one of the mechanisms of action. Furthermore, another nutrient, folate, can probably also be influenced by UV radiation...
  14. doi request reprint Vitamin D status in healthy Romanian caregivers and risk of respiratory infections
    Alina C Porojnicu
    Department of Radiation Biology, Oslo University Hospital, Monetebllo, Oslo, Norway
    Public Health Nutr 15:2157-62. 2012
    ..To investigate the vitamin D status during winter of a healthy population of hospital employees and to assess the correlation between vitamin D status and risk of infections in the upper respiratory tract...
  15. doi request reprint Sunbeds as vitamin D sources
    Johan Moan
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Photochem Photobiol 85:1474-9. 2009
    ....
  16. ncbi request reprint Solar radiation, vitamin D and survival rate of colon cancer in Norway
    Johan Moan
    Avdeling for strålingsbiologi, Institutt for kreftforskning, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 78:189-93. 2005
    ..One possible interpretation of the present data is that, the level of calcidiol, or its derivative calcitriol (1alpha,25-dihydroxyvitamin D3, 1alpha,25-(OH)2D3), may act positively in concert with conventional therapies of colon cancer...
  17. doi request reprint The seasonality of pandemic and non-pandemic influenzas: the roles of solar radiation and vitamin D
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Int J Infect Dis 14:e1099-105. 2010
    ..Seasonal variations in ultraviolet B (UVB) radiation cause seasonal variations in vitamin D status. This may influence immune responses and play a role in the seasonality of influenza...
  18. doi request reprint Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema
    Patrycja Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Pharm Res 27:2213-20. 2010
    ..To determine the impact of skin pretreatment with microneedles (MNs) on ALA- and MAL-induced protoporphyrin IX (PpIX) production, as well as MN impact on pain sensations during light exposure and erythema after PDT...
  19. ncbi request reprint The influence of light and darkness on cutaneous fluorescence in mice
    Petras Juzenas
    Department of Radiation Biology, The Norwegian Radium Hospital, N 310 Oslo, Norway
    Luminescence 21:159-63. 2006
    ..The presence of cutaneous PpIX together with ambient light may comprise a photosensitizing mechanism by which PpIX may be a photomessenger between ambient light and internal rhythms...
  20. ncbi request reprint Electrostatic properties of cells estimated by absorption and fluorescence spectroscopy
    Beata Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, N 0310 Oslo, Norway
    Cell Biochem Biophys 41:1-10. 2004
    ..Numerous microvilli present on the surface of WiDr cells indicated marked uncertainties in cell surface area estimations. This gives large uncertainties in the real surface charge densities of cells...
  21. ncbi request reprint Sun and sun beds: inducers of vitamin D and skin cancer
    Emanuela Cicarma
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
    Anticancer Res 29:3495-500. 2009
    ..Populations living at high latitudes would probably benefit from moderately increasing their exposure to UVB to provide a good vitamin D status...
  22. doi request reprint 5-Methyltetrahydrofolate can be photodegraded by endogenous photosensitizers
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Free Radic Biol Med 47:1199-204. 2009
    ..This study suggests that 5MTHF in blood can be photodegraded in the presence of the flavins and porphyrins, but protected by bilirubins. This may have health and evolutionary implications...
  23. doi request reprint Ultraviolet radiation and malignant melanoma
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Ullernchausseen 70, Montebello 0310, Norway
    Adv Exp Med Biol 624:104-16. 2008
    ..Comparisons of skin cancer data from Norway and Australia/New Zealand indicate that squamous cell carcinoma and basal cell carcinoma are mainly related to annual solar UVB fluences, while UVA fluences play a larger role for CMM...
  24. doi request reprint Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy
    Patrycja Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Transl Res 152:128-33. 2008
    ..Pretreatment with (R)L-sulforaphane before topical ALA-PDT may improve penetration of ALA through the stratum corneum, and, subsequently, increase PpIX synthesis...
  25. doi request reprint Bioimpedance for pain monitoring during cutaneous photodynamic therapy: Preliminary study
    Patrycja Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 8:307-13. 2011
    ..Different methods for dealing with the pain have been developed over the past years, ranging from cooling with air or water to nerve blocking. However, the mechanisms responsible for the pain induction have not yet been fully understood...
  26. doi request reprint At what time should one go out in the sun?
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Adv Exp Med Biol 624:86-8. 2008
    ..In view of this, short, nonerythemogenic exposures around noon should be recommended rather than longer nonerythemogenic exposures in the afternoon. This would give a maximal yield of vitamin D at a minimal CMM risk...
  27. ncbi request reprint Topical applications of iron chelators in photosensitization
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol Sci 6:1268-74. 2007
    ..Further studies are needed to evaluate the role of PpIX induced by iron chelators used, against photoaging and cancer prevention...
  28. ncbi request reprint Seasonal variation of 1,25-dihydroxyvitamin D and its association with body mass index and age
    Johan Moan
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    J Steroid Biochem Mol Biol 113:217-21. 2009
    ..Furthermore, there seems to be a correlation between the levels of the two vitamin D metabolites, indicating that the regulation of 1,25(OH)2 vitamin D is not always tight, notably in persons with high BMI...
  29. doi request reprint The action spectrum for folic acid photodegradation in aqueous solutions
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 126:11-6. 2013
    ..The action spectrum demonstrated that UVB and UVA degrade folic acid. Protecting skin against UVB and UVA radiation by sunscreens may help to protect folic acid in human blood under intense solar radiation. ..
  30. doi request reprint Vitamin D, sun, sunbeds and health
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Ullernchausseen 70, Montebello N 0310 Oslo, Norway
    Public Health Nutr 15:711-5. 2012
    ..To review the health effects of solar radiation, sunbeds and vitamin D...
  31. doi request reprint UVA, UVB and incidence of cutaneous malignant melanoma in Norway and Sweden
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 11:191-8. 2012
    ..Also, UVB induction of vitamin D may be involved. CMM incidence rates among young people have decreased or been constant since about 1990 in Norway and Sweden. All reasons for UVA contributing to CMM will be discussed...
  32. doi request reprint Vitamin D status in Norwegian children and adolescents with excess body weight
    Zoya Lagunova
    Department of Radiation Biology, Oslo University Hospital, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Pediatr Diabetes 12:120-6. 2011
    ..A high body mass index (BMI) is associated with a low vitamin D status. The purpose of this study was to determine the prevalence of vitamin D deficiency and insufficiency in Norwegian children and adolescents with excess body weight...
  33. doi request reprint Changes in human skin after topical PDT with hexyl aminolevulinate
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 5:176-81. 2008
    ..Photodynamic therapy (PDT) induces physiological changes in human skin, but details and kinetics are not known...
  34. ncbi request reprint Changes in risk of death from breast cancer with season and latitude: sun exposure and breast cancer survival in Norway
    Alina Carmen Porojnicu
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Breast Cancer Res Treat 102:323-8. 2007
    ..The overall data support our earlier hypothesis that season of diagnosis and therapy start improves the survival for breast cancer...
  35. ncbi request reprint Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Methods Mol Biol 635:97-106. 2010
    ..The content and distribution of ALA intracellularly and in tissues is difficult to measure, but PpIX content, on a relative scale, can be easily measured by fluorimetric assays...
  36. doi request reprint Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007
    Emanuela Cicarma
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 101:174-8. 2010
    ..The leveling off of melanoma trend is probably associated with melanoma prevention campaigns and with increasing awareness, although vitamin D could play a role...
  37. doi request reprint Sun beds and cod liver oil as vitamin D sources
    Alina Carmen Porojnicu
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 91:125-31. 2008
    ..Within eight weeks after the last exposure the 25(OH)D(3) level decreased to the initial value in all volunteers irrespective of vitamin D supplementation or not...
  38. doi request reprint 5-Methyltetrahydrofolate is photosensitive in the presence of riboflavin
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 7:814-8. 2008
    ..Thus, a dark skin colour may be favourable for prevention of folate degradation under high solar fluence rates, such as in equatorial areas...
  39. ncbi request reprint Deferoxamine photosensitizes cancer cells in vitro
    Petras Juzenas
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
    Biochem Biophys Res Commun 332:388-91. 2005
    ..In conclusion, the present study describes a novel approach of using iron chelating agents without 5-aminolevulinic acid (ALA) to photosensitize cancer cells...
  40. doi request reprint Where the sun does not shine: is sunshine protective against melanoma of the vulva?
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 101:179-83. 2010
    ....
  41. ncbi request reprint The dependency of vitamin D status on body mass index, gender, age and season
    Zoya Lagunova
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    Anticancer Res 29:3713-20. 2009
    ..Recently, overweight and obesity have been shown to be related to low vitamin D status...
  42. ncbi request reprint Solar radiation, vitamin D and cancer incidence and mortality in Norway
    Johan Moan
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
    Anticancer Res 29:3501-9. 2009
    ....
  43. ncbi request reprint Season of diagnosis is a predictor of cancer survival. Sun-induced vitamin D may be involved: a possible role of sun-induced Vitamin D
    Alina Porojnicu
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Steroid Biochem Mol Biol 103:675-8. 2007
    ..In view of these calcitriol and calcidiol data, the seasonal variation of cancer survival may be related to the calcidiol gradient, indicating that this Vitamin D metabolite may be more important than believed so far...
  44. ncbi request reprint The influence of temperature on photodynamic cell killing in vitro with 5-aminolevulinic acid
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 84:161-6. 2006
    ..Thus, the photodynamic effect with 5-aminolevulinic acid may be enhanced by heating the tumour area before, and by cooling it immediately after the treatment...
  45. doi request reprint Reflectance spectroscopy and fluorescein angiography applied to assess photodynamic response in healthy mouse skin treated with topical hexylaminolevulinate
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 7:239-45. 2010
    ..The aim of this study was to measure photosensitization responses in healthy mouse skin using non-invasive reflectance spectroscopy and fluorescein angiography...
  46. ncbi request reprint Is the seasonal variation in cancer prognosis caused by sun-induced folate degradation?
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, Health Enterprise, Rikshospitalet Radiumhospitalet, Montebello, N 0310 Oslo, Norway
    Med Hypotheses 69:182-5. 2007
    ..It is known that folic acid, a synthetic form of folate, is degraded by UV radiation. We have also found that the most common folate derivative in the human body, 5-methyltetrahydrofolate, is UV sensitive...
  47. doi request reprint Cutaneous malignant melanoma incidence rates in Norway
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, Norway
    Scand J Public Health 41:336-9. 2013
    ..However, a decrease in incidence rates is observed in some countries. If the reason for this could be found, it might be useful to transfer the knowledge to other fields of medicine...
  48. ncbi request reprint The effect of sub-lethal ALA-PDT on the cytoskeleton and adhesion of cultured human cancer cells
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1722:43-50. 2005
    ..Some signal transduction processes are suggested to be involved in ALA-PDT-induced changes in cytoskeleton, cell shape, and adhesion...
  49. doi request reprint Depth profile of protoporphyrin IX fluorescence in an amelanotic mouse melanoma model
    Petras Juzenas
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Photochem Photobiol 85:760-4. 2009
    ..16 +/- 0.03 mm(2) h(-1)), MAL (0.045 +/- 0.005 mm(2) h(-1)) and HAL (0.037 +/- 0.003 mm(2) h(-1)), the behavior of the drugs after different application times could be estimated in this tumor model...
  50. ncbi request reprint Influence of light exposure on the kinetics of protoporphyrin IX formation in normal skin of hairless mice after application of 5-aminolevulinic acid methyl ester
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Oslo, Norway
    J Invest Dermatol 125:1039-44. 2005
    ..The rate of elimination of PpIX from the volume of detection was faster after 420 nm light irradiation than that after 632 nm. These findings are discussed in view of penetration depths of light and ALA-Me, and diffusion of PpIX...
  51. doi request reprint Serum 25-hydroxyvitamin D is a predictor of serum 1,25-dihydroxyvitamin D in overweight and obese patients
    Zoya Lagunova
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    J Nutr 141:112-7. 2011
    ..Therefore, it may also be valuable to measure both serum 25(OH)D and 1,25(OH)(2)D for the evaluation of vitamin D status in overweight and obese persons...
  52. ncbi request reprint Biophysical aspects of photodynamic therapy
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Environ Pathol Toxicol Oncol 25:7-28. 2006
    ..These are all important parameters for optimally effective PDT. The present review will give a brief, physically based, overview of PDT and then discuss some of the main biophysical aspects of this therapeutic modality...
  53. ncbi request reprint Influence of human serum albumin on photodegradation of folic acid in solution
    Pavel Vorobey
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol 82:817-22. 2006
    ..The oxygen dependence of FA photodegradation and the inhibition of this process by sodium azide indicate that singlet oxygen may participate in the photosensitizing activity of FA photoproducts...
  54. doi request reprint Development of different human skin colors: a review highlighting photobiological and photobiophysical aspects
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Photochem Photobiol B 96:93-100. 2009
    ..The genetical processes behind some of the changes of skin color will be also briefly reviewed...
  55. doi request reprint Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy
    Mateusz Kwitniewski
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, 0310, Norway
    Photochem Photobiol Sci 10:25-8. 2011
    ..For the first time we present data showing that metabolic targeted therapy with dichloroacetate (DCA) may improve the outcome of photodynamic therapy. This treatment modality can be easily introduced into clinical practice guidelines...
  56. ncbi request reprint Photodegradation of 5-methyltetrahydrofolate: biophysical aspects
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Photochem Photobiol 82:1651-5. 2006
    ..5MTHF mainly absorbs, and is degraded by, UVB and UVC, radiation that does not penetrate the earth's atmosphere and the human skin well...
  57. doi request reprint Pilot study of folate status in healthy volunteers and in patients with psoriasis before and after UV exposure
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 101:111-6. 2010
    ..Further studies, using proper, adequate 5-methyltetrahydrofolate methodology, are needed to clarify the influence of broadband phototherapy on folate degradation and the consequences of these on the health of psoriasis patients...
  58. ncbi request reprint Milestones in the development of photodynamic therapy and fluorescence diagnosis
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 6:1234-45. 2007
    ....
  59. ncbi request reprint Erythrocytes-the 'house elves' of photodynamic therapy
    Lars Kaestner
    Institute for Cancer Research, Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol Sci 3:981-9. 2004
    ..Future aspects of applications of photosensitisation of red blood cells are discussed...
  60. ncbi request reprint Ultraviolet photodegradation of folic acid
    Morten Kristian Off
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    J Photochem Photobiol B 80:47-55. 2005
    ..However, experiments performed in heavy water indicate that generation of singlet oxygen is probably not the explanation for the photosensitizing of folic acid...
  61. ncbi request reprint Singlet oxygen in photosensitization
    Johan Moan
    Institute of Physics, Oslo University Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Environ Pathol Toxicol Oncol 25:29-50. 2006
    ..Since the discovery of oxygen by Joseph Priestley in 1775 it has been recognized that oxygen can be both beneficial and harmful to life...
  62. ncbi request reprint pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential
    Beata Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, N 0310 Oslo, Norway
    Cancer Lett 222:39-47. 2005
    ..Application of tetraethylammonium chloride did not affect the cellular uptake of any of the photosensitizers. We conclude that the pH dependent uptake of photosensitizers is not mainly related to altered transmembrane potential...
  63. ncbi request reprint Vitamin D3 from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway)
    Trude Eid Robsahm
    The Cancer Registry of Norway, Institute of Population Based Cancer Research, Montebello, 0310 Oslo, Norway
    Cancer Causes Control 15:149-58. 2004
    ..To investigate whether prognosis of breast-, colon- and prostate cancer may be related to vitamin D(3), induced from solar ultra-violet (UV) radiation, through studies on geographical and seasonal variations in UV radiation...
  64. ncbi request reprint Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy
    Asta Juzeniene
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway
    Lasers Med Sci 19:139-49. 2004
    ..All these differences are related to difference in the spectra of the lamps. Thus, PDT light sources with emissions that are visually similar have significantly different photobiological properties...
  65. ncbi request reprint Synergistic and tumour selective effects of chemotherapy and ultrasound treatment
    Gunnar Myhr
    The Norwegian Radium Hospital, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Cancer Lett 232:206-13. 2006
    ....
  66. ncbi request reprint Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice
    Petras Juzenas
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, NO 0310 Montebello, Oslo, Norway
    Biochem Biophys Res Commun 297:468-72. 2002
    ..Topical application of ALA-Me followed by exposure with laser light (633nm) delayed the growth of the tumors slightly. Light alone also had a significant effect on the tumor growth...
  67. ncbi request reprint An outline of the hundred-year history of PDT
    Johan Moan
    Department of Biophysics, Institute for Cancer Research, Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Anticancer Res 23:3591-600. 2003
    ..Therefore, in the present historical review, the early work is weighted more heavily than recent work that is more easily accessible to the readers...
  68. ncbi request reprint Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice
    Soraya Sharfaei
    Division of Dermatology, Montreal University Hospital Center, Notre Dame Hospital, 1560 Sherbrooke East, Montreal, Quebec, Canada H2L 4M1
    Arch Dermatol Res 294:237-42. 2002
    ..In conclusion, topical MAL followed by light under suberythematous conditions delayed the appearance of UV-induced skin tumours without increasing mortality or morbidity, and thus acted in a prophylactic manner...
  69. ncbi request reprint [Health effects of sun and solariums]
    Johan Moan
    Tidsskr Nor Laegeforen 126:1945-6; author reply 1946. 2006
  70. ncbi request reprint [The photobiology of vitamin D--a topic of renewed focus]
    Johan Moan
    Avdeling for strålingsbiologi, Rikshospitalet Radiumhospitalet, 0310 Oslo
    Tidsskr Nor Laegeforen 126:1048-52. 2006
    ....
  71. ncbi request reprint Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation
    Ryan F Donnelly
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, UK
    Photochem Photobiol 82:670-5. 2006
    ..The mechanisms of action of the patch, as compared with that of the cream, were studied by means of Cuprophan barriers that mimic compromised tumor stratum corneum and in a mouse model with transplanted tumors...
  72. ncbi request reprint Protoporphyrin IX fluorescence kinetics in UV-induced tumours and normal skin of hairless mice after topical application of 5-aminolevulinic acid methyl ester
    Petras Juzenas
    Division of Dermatology, Notre Dame Hospital, Montreal University Hospital Center, 1560 Sherbrooke Street East, Rm K 5201, Quebec, H2L 4M1, Montreal, Canada
    J Photochem Photobiol B 67:11-7. 2002
    ..In conclusion, the highest tumour to normal skin PpIX ratio was observed 3 h after application of 8% ALA-Me, suggesting that light exposure should be performed at this time in order to achieve an optimal PDT effect in this tumour model...
  73. ncbi request reprint On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation
    Sabine Collaud
    School of Pharmacy Geneva Lausanne, University of Geneva, 1211 Geneva, Switzerland
    Curr Med Chem Anticancer Agents 4:301-16. 2004
    ..Thereby, morphological, environmental, enzymatic, as well as cell-specific factors will be discussed...
  74. ncbi request reprint Porphyrin formation in actinic keratosis and basal cell carcinoma after topical application of methyl 5-aminolevulinate
    Even Angell-Petersen
    Department of Surgical Oncology, The Norwegian Radium Hospital, Oslo, Norway
    J Invest Dermatol 126:265-71. 2006
    ..In conclusion, application of the 160 mg/g cream for 3 hours gave advantageous porphyrin distributions for all types of lesions...
  75. ncbi request reprint Choice of optimal wavelength for PDT: the significance of oxygen depletion
    Kristian P Nielsen
    Department of Physics and Technology, University of Bergen, N 5007 Bergen, Norway
    Photochem Photobiol 81:1190-4. 2005
    ..At 390 nm, the light penetration into a tumor does not depend on the oxygenation of the blood...
  76. ncbi request reprint Comment on "the effects on human health from stratospheric ozone depletion and its interactions with climate change" by M. Norval, A. P. Cullen, F. R. de Gruijl, J. Longstreth, Y. Takizawa, R. M. Lucas, F. P. Noonan and J. C. van der Leun, Photochem. Phot
    William B Grant
    Sunlight, Nutrition, and Health Research Center SUNARC, 2115 Van Ness Avenue, San Francisco, CA 94109 2510, USA
    Photochem Photobiol Sci 6:912-5; discussion 916-8. 2007
    ..If this result is correct, melanoma risk is not related to ozone depletion. We consider the net effect of solar UVB on human health to be beneficial at or near current levels...
  77. pmc Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps
    Helena Gonzalez
    Department of Dermatology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    BMC Dermatol 7:1. 2007
    ..Our aim was to investigate the photostability of seven commercial sunscreen products after natural UV exposure (UVnat) and artificial UV exposure (UVart)...
  78. ncbi request reprint Reflectance spectra of pigmented and nonpigmented skin in the UV spectral region
    Kristian P Nielsen
    Department of Physics and Technology, University of Bergen, Bergen, Norway
    Photochem Photobiol 80:450-5. 2004
    ..Scattering from microstructures with high relative refractive indices plays a major role in tissue optics. Our results show that scattering from melanosomes and fragmented melanosomes is of particular significance...