J Moan

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters
    Johan Moan
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Cancer 103:132-5. 2003
  2. pmc Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps
    Helena Gonzalez
    Department of Dermatology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    BMC Dermatol 7:1. 2007
  3. ncbi request reprint Colon cancer: prognosis for different latitudes, age groups and seasons in Norway
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 89:148-55. 2007
  4. ncbi request reprint The temperature dependence of protoporphyrin IX production in cells and tissues
    J Moan
    Department of Biophysics, Institute for Cancer Research, Oslo, Norway
    Photochem Photobiol 70:669-73. 1999
  5. doi request reprint At what time should one go out in the sun?
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Adv Exp Med Biol 624:86-8. 2008
  6. ncbi request reprint Solar radiation, vitamin D and survival rate of colon cancer in Norway
    Johan Moan
    Avdeling for strålingsbiologi, Institutt for kreftforskning, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 78:189-93. 2005
  7. doi request reprint Ultraviolet radiation and malignant melanoma
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Ullernchausseen 70, Montebello 0310, Norway
    Adv Exp Med Biol 624:104-16. 2008
  8. ncbi request reprint On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters
    J Moan
    Institute for Cancer Research, Oslo, Norway
    Int J Cancer 92:139-43. 2001
  9. ncbi request reprint Transfer of protoporphyrin IX between cells
    Johan Moan
    Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol 76:526-9. 2002
  10. ncbi request reprint [The photobiology of vitamin D--a topic of renewed focus]
    Johan Moan
    Avdeling for strålingsbiologi, Rikshospitalet Radiumhospitalet, 0310 Oslo
    Tidsskr Nor Laegeforen 126:1048-52. 2006

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters
    Johan Moan
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Cancer 103:132-5. 2003
    ..The esters seem to penetrate less into the circulation than ALA, and PpIX formed by them in the skin is faster cleared than PpIX formed from ALA. This is also true after oral and i.p. administration of the drugs...
  2. pmc Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps
    Helena Gonzalez
    Department of Dermatology, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    BMC Dermatol 7:1. 2007
    ..Our aim was to investigate the photostability of seven commercial sunscreen products after natural UV exposure (UVnat) and artificial UV exposure (UVart)...
  3. ncbi request reprint Colon cancer: prognosis for different latitudes, age groups and seasons in Norway
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 89:148-55. 2007
    ..The seasonal effect was slightly, but not significantly, better for the younger than for the older age group. The effect was similar for all three geographical regions, irrespective of SCC incidence...
  4. ncbi request reprint The temperature dependence of protoporphyrin IX production in cells and tissues
    J Moan
    Department of Biophysics, Institute for Cancer Research, Oslo, Norway
    Photochem Photobiol 70:669-73. 1999
    ..The latter activation energy was within the error limits similar to that for the activity of the enzyme porphobilinogen deaminase, suggesting that this enzyme might represent a rate-limiting step for PpIX production in living tissue...
  5. doi request reprint At what time should one go out in the sun?
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Adv Exp Med Biol 624:86-8. 2008
    ..In view of this, short, nonerythemogenic exposures around noon should be recommended rather than longer nonerythemogenic exposures in the afternoon. This would give a maximal yield of vitamin D at a minimal CMM risk...
  6. ncbi request reprint Solar radiation, vitamin D and survival rate of colon cancer in Norway
    Johan Moan
    Avdeling for strålingsbiologi, Institutt for kreftforskning, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 78:189-93. 2005
    ..One possible interpretation of the present data is that, the level of calcidiol, or its derivative calcitriol (1alpha,25-dihydroxyvitamin D3, 1alpha,25-(OH)2D3), may act positively in concert with conventional therapies of colon cancer...
  7. doi request reprint Ultraviolet radiation and malignant melanoma
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Ullernchausseen 70, Montebello 0310, Norway
    Adv Exp Med Biol 624:104-16. 2008
    ..Comparisons of skin cancer data from Norway and Australia/New Zealand indicate that squamous cell carcinoma and basal cell carcinoma are mainly related to annual solar UVB fluences, while UVA fluences play a larger role for CMM...
  8. ncbi request reprint On the pharmacokinetics of topically applied 5-aminolevulinic acid and two of its esters
    J Moan
    Institute for Cancer Research, Oslo, Norway
    Int J Cancer 92:139-43. 2001
    ....
  9. ncbi request reprint Transfer of protoporphyrin IX between cells
    Johan Moan
    Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol 76:526-9. 2002
    ..Light exposure slightly increased the rate of loss of PpIX from WiDr cells...
  10. ncbi request reprint [The photobiology of vitamin D--a topic of renewed focus]
    Johan Moan
    Avdeling for strålingsbiologi, Rikshospitalet Radiumhospitalet, 0310 Oslo
    Tidsskr Nor Laegeforen 126:1048-52. 2006
    ....
  11. ncbi request reprint Antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy can be enhanced by the use of a low dose of photofrin in human tumor xenografts
    Q Peng
    Department of Pathology, The Norwegian Radium Hospital, Institute for Cancer Research, University of Oslo, Montebello, 0310 Oslo, Norway
    Cancer Res 61:5824-32. 2001
    ..These data indicate that targeting both neoplastic cells and stroma with ALA and Pf (a low dose) can potentiate antitumor PDT effect with no risk of prolonged skin photosensitivity...
  12. ncbi request reprint Kinetics of photobleaching of protoporphyrin IX in the skin of nude mice exposed to different fluence rates of red light
    R Sørensen
    Department of Biophysics, Institute for Cancer Research, Oslo, Norway
    Photochem Photobiol 68:835-40. 1998
    ..The decay rate was slightly faster after systemic application than after topical application of ALA, but did not depend on the time (1-8 h) between application and analysis...
  13. ncbi request reprint Production of protoporphyrin IX induced by 5-aminolevulinic acid in transplanted human colon adenocarcinoma of nude mice can be increased by ultrasound
    L Ma
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Cancer 78:464-9. 1998
    ..Our results provide a theoretical basis for possible clinical use of ultrasound-combined ALA or ALA based photodynamic therapy...
  14. ncbi request reprint Fluorescence spectroscopy of normal mouse skin exposed to 5-aminolaevulinic acid and red light
    P Juzenas
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 61:78-86. 2001
    ..ALA-induced porphyrins are transported away from the treated area and partly deposited in remote skin sites...
  15. ncbi request reprint Phototransformations of 5-aminolevulinic acid-induced protoporphyrin IX in vitro: a spectroscopic study
    S Bagdonas
    Department of Biophysics, Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol 72:186-92. 2000
    ..Traces of a photoproduct(s) with fluorescence emission slightly blue-shifted compared with that of PpIX, supposedly water-soluble porphyrins, were also detected after light exposure...
  16. ncbi request reprint The bystander effect in photodynamic inactivation of cells
    J Dahle
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Biochim Biophys Acta 1475:273-80. 2000
    ..The degree of bystander effect was higher for cells dying by necrosis than for cell dying by apoptosis...
  17. pmc Cooperative effects of photodynamic treatment of cells in microcolonies
    J Dahle
    Department of Biophysics, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo
    Proc Natl Acad Sci U S A 94:1773-8. 1997
    ..Our findings clearly indicate some kind of cooperativity between cells treated with Photofrin and light...
  18. ncbi request reprint Production of protoporphyrin IX from 5-aminolevulinic acid and two of its esters in cells in vitro and tissues in vivo
    A Juzeniene
    Department of Biophysics, The Norwegian Radium Hospital, N 0310 Montebello, Oslo, Norway
    Cell Mol Biol (Noisy-le-grand) 48:911-6. 2002
    ..The stratum corneum may bind the esters temporarily, and slow down their penetration into the living cells where PpIX is formed...
  19. ncbi request reprint Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin
    A Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway
    Br J Dermatol 155:791-9. 2006
    ..Despite extensive investigations, the differences in biodistribution and pharmacokinetics of protoporphyrin IX (PpIX) induced by ALA and its derivatives are still not well understood, notably for humans...
  20. ncbi request reprint Photodynamic inhibition of enzymatic detachment of human cancer cells from a substratum
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1670:1-11. 2004
    ..Photodynamic inhibition of enzymatic cell detachment may be related to PDT-induced inhibition of tumour metastasis...
  21. doi request reprint Topical aminolaevulinic acid- and aminolaevulinic acid methyl ester-based photodynamic therapy with red and violet light: influence of wavelength on pain and erythema
    P Mikolajewska
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello 0310 Oslo, Norway
    Br J Dermatol 161:1173-9. 2009
    ..Choosing the optimal wavelength is important. Red light penetrates deeper into tissue, while violet light is more efficient in activating PpIX but does not penetrate so deeply...
  22. doi request reprint Calcitriol treatment improves methyl aminolaevulinate-based photodynamic therapy in human squamous cell carcinoma A431 cells
    E Cicarma
    Department of Radiation Biology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo 0310, Norway
    Br J Dermatol 161:413-8. 2009
    ..However, MAL-based PDT is not very efficient for poorly differentiated skin carcinoma. Thus, novel strategies to enhance the PDT effect are needed...
  23. ncbi request reprint Photoproducts formed from photofrin II in cells
    J Moan
    Institute for Cancer Research, Montebello, Oslo, Norway
    J Photochem Photobiol B 1:429-36. 1988
    ..During light exposure a fluorescent product is formed in the cells with fluorescence excitation and emission characteristics similar to those of the "age pigment" lipofuscin (lambda exc = 350 nm, lambda em = 440 nm)...
  24. ncbi request reprint Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: differences in protoporphyrin IX fluorescence kinetics and the role of the stratum corneum
    J T Van Den Akker
    Department of Biophysics, Norwegin Radium Hospital, Oslo, Norway
    Photochem Photobiol 72:681-9. 2000
    ..This, together with the results from the different application times and concentrations indicates that ALAHE diffuses more slowly across the stratum corneum than ALA...
  25. ncbi request reprint Porphyrin derivatives having physical and chemical characteristics similar to those of the active components of hematoporphyrin derivative and with very strong photosensitizing effects
    S Sommer
    Institute for Cancer Research, Department of Biophysics, Oslo, Norway
    J Photochem Photobiol B 1:241-6. 1987
    ..Furthermore, they are much better photosensitizers in a cellular system than are crude Hpd or Photofrin II, and, like the components of Hpd, they are taken up and retained by cells according to their degree of non-polarity...
  26. ncbi request reprint The mode of cell death induced by photodynamic treatment depends on cell density
    J Dahle
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Photochem Photobiol 70:363-7. 1999
    ..The difference in mode of cell death for the different cell densities was not related to any observable difference in subcellular localization pattern of TPPS4 at equitoxic doses of photodynamic treatment...
  27. pmc Anti-tumour activity of photodynamic therapy in combination with mitomycin C in nude mice with human colon adenocarcinoma
    L W Ma
    Department of Biophysics, Institute of Cancer Research, Montebello, Oslo, Norway
    Br J Cancer 71:950-6. 1995
    ..The results suggest that the increased susceptibility to photoinactivation of Photofrin-sensitised tumours may be due to MMC-induced accumulation of the tumour cells in S-phase...
  28. ncbi request reprint Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy
    Asta Juzeniene
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Montebello, Oslo, Norway
    Lasers Med Sci 19:139-49. 2004
    ..All these differences are related to difference in the spectra of the lamps. Thus, PDT light sources with emissions that are visually similar have significantly different photobiological properties...
  29. pmc Addressing the health benefits and risks, involving vitamin D or skin cancer, of increased sun exposure
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 105:668-73. 2008
    ....
  30. ncbi request reprint Noninvasive fluorescence excitation spectroscopy during application of 5-aminolevulinic acid in vivo
    Petras Juzenas
    Department of Biophysics, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol Sci 1:745-8. 2002
    ..The fluorescence excitation spectra calculated for the depth 1.1 mm obtained the best fit with the experimentally measured spectra after topical application of ALA...
  31. doi request reprint Malignant melanomas on head/neck and foot: differences in time and latitudinal trends in Norway
    A Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310 Oslo Institute of Physics, University of Oslo, Blindern 0316 Oslo, Norway
    J Eur Acad Dermatol Venereol 26:821-7. 2012
    ....
  32. ncbi request reprint pH-dependent spectral properties of HpIX, TPPS2a, mTHPP and mTHPC
    B Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, Oslo, Norway
    Photochem Photobiol 74:246-52. 2001
    ..The tumor localizing properties of mTHPP and mTHPC reported in the literature appear to be due to factors other than pH-dependent changes in the lipophilicity of the drugs...
  33. ncbi request reprint Bystander effects in cell death induced by photodynamic treatment UVA radiation and inhibitors of ATP synthesis
    J Dahle
    Department of Biophysics, Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol 73:378-87. 2001
    ....
  34. ncbi request reprint Hematoporphyrin ethers--III. Cellular uptake and photosensitizing properties
    J Moan
    Institute for Cancer Research, Norwegian Radium Hospital, Oslo
    Int J Biochem 20:1401-4. 1988
    ..6. With respect to cell uptake and retention of the dyes, the data did not show any uniform relationship to the polarity of the drugs, in contrast to what has been found earlier for Hp diethers of linear hydrocarbons...
  35. ncbi request reprint The photosensitizing effect of the photoproduct of protoporphyrin IX
    L Ma
    Department of Biophysics, Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 60:108-13. 2001
    ..The fluorescence of Ppp was bleached during 670 nm light exposure. Exposure of Ppp at 670 nm gives no PpIX back. Thus, the phototransformation of PpIX to Ppp is probably not a reversible process...
  36. pmc The influence of iron chelators on the accumulation of protoporphyrin IX in 5-aminolaevulinic acid-treated cells
    K Berg
    Institute for Cancer Research, Department of Biophysics, Montebello, Norway
    Br J Cancer 74:688-97. 1996
    ..The ferrochelatase inhibitor dihydropyridine 3,5-diethoxycarbonyl-1,4-dihydrocollidine reduced the accumulation of PpIX in both cell lines...
  37. pmc The relationship between skin cancers, solar radiation and ozone depletion
    J Moan
    Institute for Cancer Research, Montebello, Oslo, Norway
    Br J Cancer 65:916-21. 1992
    ..For the population as a whole sun exposure during vacations to sunny countries has so far been of minor importance in skin cancer induction...
  38. ncbi request reprint Uptake of topically applied 5-aminolevulinic acid and production of protoporphyrin IX in normal mouse skin: dependence on skin temperature
    P Juzenas
    Department of Biophysics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol 69:478-81. 1999
    ..Practically no PpIX was formed in the skin as long as skin temperature was kept low (12 degrees C)...
  39. ncbi request reprint Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin model
    Asta Juzeniene
    Biophysics Department, The Norwegian Radium Hospital, Oslo
    Photochem Photobiol 76:329-34. 2002
    ..But for long application times and high concentrations, systemic effect of ALA applied topically on relatively large areas should be considered...
  40. doi request reprint Sun exposure and cancer survival in Norway: changes in the risk of death with season of diagnosis and latitude
    Alina Carmen Porojnicu
    Deparment of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Adv Exp Med Biol 624:43-54. 2008
    ..Based on our results we suggest that calcidiol concentration at the time of cancer diagnosis is related to survival and discuss briefly ways to improve the vitamin D levels in the general population...
  41. ncbi request reprint The lengths of DNA fragments light-induced in the presence of a photosensitizer localized at the nuclear membrane of human cells
    E Kvam
    Department of Biophysics, Institute for Cancer Research, Montebello, Oslo, Norway
    Biochim Biophys Acta 1049:33-7. 1990
    ..The average length of these DNA fragments was found to be 155 kilobases (kb)...
  42. pmc Correlation of distribution of sulphonated aluminium phthalocyanines with their photodynamic effect in tumour and skin of mice bearing CaD2 mammary carcinoma
    Q Peng
    Department of Pathology, Norwegian Radium Hospital, Montebello, Oslo
    Br J Cancer 72:565-74. 1995
    ..The kinetic patterns of uptake, retention and localisation of A1PcS2 and A1PcS4 are roughly correlated with their photodynamic effect on the tumour and normal skin...
  43. ncbi request reprint Photosensitization with protoporphyrin IX inhibits attachment of cancer cells to a substratum
    A B Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochem Biophys Res Commun 322:452-7. 2004
    ..Complex processes, including changes in cellular shape and reorganization of the cytoskeleton, are suggested to participate in the observed ALA-PDT effect on the cell adhesion...
  44. ncbi request reprint Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
    K Berg
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    Cancer Res 59:1180-3. 1999
    ..g., in gene therapy, vaccination, and cancer treatment...
  45. ncbi request reprint Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role?
    Alina Carmen Porojnicu
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Lung Cancer 55:263-70. 2007
    ..Seasonal and gender variations in Vitamin D level have been estimated from the analyses...
  46. ncbi request reprint A new method for photodynamic therapy of melanotic melanoma -- effects of depigmentation with violet light photodynamic therapy
    Li Wei Ma
    Department of Radiation Biophysics, Institute for Cancer Research, Rikshospital Radiumhospital HF and Plasma Room Physics, University of Oslo, Oslo, Norway
    J Environ Pathol Toxicol Oncol 26:165-72. 2007
    ..This finding indicates a new PDT modality that can be further developed for treatment of superficial melanotic melanomas and possibly other diseases where pigmentation is a problem...
  47. ncbi request reprint pH effects on the cellular uptake of four photosensitizing drugs evaluated for use in photodynamic therapy of cancer
    Eva G Friberg
    Department of Biophysics, Institute for Cancer Research, Montebello, N 0310 Oslo, Norway
    Cancer Lett 195:73-80. 2003
    ..The present work indicates that tumor selectivity of dyes, which get more lipophilic with decreasing pH value, may be related to the low extracellular pH value...
  48. ncbi request reprint Photobleaching of hypericin bound to human serum albumin, cultured adenocarcinoma cells and nude mice skin
    Anatoly B Uzdensky
    Department of Biophysics, Institute for Cancer Research, Montebello, Oslo, Norway
    Photochem Photobiol 76:320-8. 2002
    ..The excitation spectrum of these products resembled that of hypericin. Hypericin appears to be more photostable than most sensitizers used in PDT, including mTHPC and Photofrin...
  49. pmc Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D
    A C Porojnicu
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Br J Cancer 93:571-4. 2005
    ..364, 95% CI, -0.15 to 0.87; P = 0.025) for patients younger than 30 years. This finding may be related to higher endogenous levels of vitamin D in autumn, with a favourable influence on the conventional therapy...
  50. ncbi request reprint Prostate cancer survival is dependent on season of diagnosis
    Zoya Lagunova
    Department of Radiation Biology, Institute for Cancer Research, Montebello, Oslo, Norway
    Prostate 67:1362-70. 2007
    ..More recently, both prostate cancer incidence and mortality have been shown to increase with increasing latitude, which probably relates to photosynthesis of vitamin D...
  51. ncbi request reprint pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential
    Beata Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, N 0310 Oslo, Norway
    Cancer Lett 222:39-47. 2005
    ..Application of tetraethylammonium chloride did not affect the cellular uptake of any of the photosensitizers. We conclude that the pH dependent uptake of photosensitizers is not mainly related to altered transmembrane potential...
  52. ncbi request reprint Topical applications of iron chelators in photosensitization
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol Sci 6:1268-74. 2007
    ..Further studies are needed to evaluate the role of PpIX induced by iron chelators used, against photoaging and cancer prevention...
  53. ncbi request reprint Electrostatic properties of cells estimated by absorption and fluorescence spectroscopy
    Beata Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, N 0310 Oslo, Norway
    Cell Biochem Biophys 41:1-10. 2004
    ..Numerous microvilli present on the surface of WiDr cells indicated marked uncertainties in cell surface area estimations. This gives large uncertainties in the real surface charge densities of cells...
  54. ncbi request reprint Systemic component of protoporphyrin IX production in nude mouse skin upon topical application of aminolevulinic acid depends on the application conditions
    Johanna T H M van den Akker
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Photochem Photobiol 75:172-7. 2002
    ....
  55. ncbi request reprint Temperature effect on accumulation of protoporphyrin IX after topical application of 5-aminolevulinic acid and its methylester and hexylester derivatives in normal mouse skin
    Asta Juzeniene
    Department of Biophysics, The Norwegian Radium Hospital, Oslo
    Photochem Photobiol 76:452-6. 2002
    ....
  56. doi request reprint Comparison of the time and latitude trends of melanoma incidence in anorectal region and perianal skin with those of cutaneous malignant melanoma in Norway
    E Micu
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Eur Acad Dermatol Venereol 25:1444-9. 2011
    ..However, melanomas may arise also on non-sun-exposed areas (uveal and mucosal melanomas) and little is known about a possible relationship between sun exposure and melanoma on such locations...
  57. pmc The distribution of porphyrins with different tumour localising ability among human plasma proteins
    M Kongshaug
    Institute for Cancer Research, Norwegian Radium Hospital, Oslo
    Br J Cancer 59:184-8. 1989
    ..On the other hand, the LDL binding capacity for a drug is suggested to be a good index for cellular uptake. Such an index does not necessarily imply that the actual uptake occurs by the LDL pathway...
  58. ncbi request reprint Influence of light exposure on the kinetics of protoporphyrin IX formation in normal skin of hairless mice after application of 5-aminolevulinic acid methyl ester
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, Oslo, Norway
    J Invest Dermatol 125:1039-44. 2005
    ..The rate of elimination of PpIX from the volume of detection was faster after 420 nm light irradiation than that after 632 nm. These findings are discussed in view of penetration depths of light and ALA-Me, and diffusion of PpIX...
  59. ncbi request reprint The influence of temperature on photodynamic cell killing in vitro with 5-aminolevulinic acid
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 84:161-6. 2006
    ..Thus, the photodynamic effect with 5-aminolevulinic acid may be enhanced by heating the tumour area before, and by cooling it immediately after the treatment...
  60. ncbi request reprint The effect of folic acid on porphyrin synthesis in tumors and normal skin of mice treated with 5-aminolevulinic acid or methyl 5-aminolevulinate
    Liwei Ma
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol Sci 5:755-9. 2006
    ..The present data seem to favour the latter mechanism. Folic acid may have a role as an adjuvant in photodynamic therapy with systemically administered ALA and its derivatives...
  61. ncbi request reprint Changes in risk of death from breast cancer with season and latitude: sun exposure and breast cancer survival in Norway
    Alina Carmen Porojnicu
    Department of Radiation Biology, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Breast Cancer Res Treat 102:323-8. 2007
    ..The overall data support our earlier hypothesis that season of diagnosis and therapy start improves the survival for breast cancer...
  62. ncbi request reprint Is the seasonal variation in cancer prognosis caused by sun-induced folate degradation?
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, Health Enterprise, Rikshospitalet Radiumhospitalet, Montebello, N 0310 Oslo, Norway
    Med Hypotheses 69:182-5. 2007
    ..It is known that folic acid, a synthetic form of folate, is degraded by UV radiation. We have also found that the most common folate derivative in the human body, 5-methyltetrahydrofolate, is UV sensitive...
  63. doi request reprint Application of 5-aminolevulinic acid and its derivatives for photodynamic therapy in vitro and in vivo
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Methods Mol Biol 635:97-106. 2010
    ..The content and distribution of ALA intracellularly and in tissues is difficult to measure, but PpIX content, on a relative scale, can be easily measured by fluorimetric assays...
  64. ncbi request reprint Season of diagnosis is a predictor of cancer survival. Sun-induced vitamin D may be involved: a possible role of sun-induced Vitamin D
    Alina Porojnicu
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Steroid Biochem Mol Biol 103:675-8. 2007
    ..In view of these calcitriol and calcidiol data, the seasonal variation of cancer survival may be related to the calcidiol gradient, indicating that this Vitamin D metabolite may be more important than believed so far...
  65. ncbi request reprint Deferoxamine photosensitizes cancer cells in vitro
    Petras Juzenas
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
    Biochem Biophys Res Commun 332:388-91. 2005
    ..In conclusion, the present study describes a novel approach of using iron chelating agents without 5-aminolevulinic acid (ALA) to photosensitize cancer cells...
  66. ncbi request reprint Biological activity of 5-aminolevulinic acid and its methyl ester after storage under different conditions
    Miron Kaliszewski
    Department of Radiation Biology, Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    J Photochem Photobiol B 87:67-72. 2007
    ..Our work shows that solutions should be prepared immediately before use and stored at low temperatures. The pH of stock solutions should not exceed 5...
  67. doi request reprint Changes in human skin after topical PDT with hexyl aminolevulinate
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway
    Photodiagnosis Photodyn Ther 5:176-81. 2008
    ..Photodynamic therapy (PDT) induces physiological changes in human skin, but details and kinetics are not known...
  68. doi request reprint Photodegradation of 5-methyltetrahydrofolate in the presence of Uroporphyrin
    Tran Thi Thu Tam
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 94:201-4. 2009
    ..Our results show that singlet oxygen is likely to be the main intermediate in the photodegradation of 5MTHF mediated by Uro. Our findings may be useful for further studies the evolution of human skin colours...
  69. ncbi request reprint Singlet oxygen in photosensitization
    Johan Moan
    Institute of Physics, Oslo University Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Environ Pathol Toxicol Oncol 25:29-50. 2006
    ..Since the discovery of oxygen by Joseph Priestley in 1775 it has been recognized that oxygen can be both beneficial and harmful to life...
  70. ncbi request reprint The influence of light and darkness on cutaneous fluorescence in mice
    Petras Juzenas
    Department of Radiation Biology, The Norwegian Radium Hospital, N 310 Oslo, Norway
    Luminescence 21:159-63. 2006
    ..The presence of cutaneous PpIX together with ambient light may comprise a photosensitizing mechanism by which PpIX may be a photomessenger between ambient light and internal rhythms...
  71. ncbi request reprint Spectroscopic evidence of monomeric aluminium phthalocyanine tetrasulphonate in aqueous solutions
    Petras Juzenas
    Institute for Cancer Research, Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
    J Photochem Photobiol B 75:107-10. 2004
    ..In conclusion, the present spectroscopic results show that AlPcS(4) does not form aggregates and is a very stable compound in aqueous solutions...
  72. ncbi request reprint The stability of 5-aminolevulinic acid in solution
    Øystein Bech Gadmar
    Department of Pathology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 67:187-93. 2002
    ..Temperature studies of the formation kinetics of the UV absorbing product also indicate that a complex formation process is involved...
  73. ncbi request reprint The effect of sub-lethal ALA-PDT on the cytoskeleton and adhesion of cultured human cancer cells
    Anatoly Uzdensky
    Institute for Cancer Research, 0310 Montebello, Oslo, Norway
    Biochim Biophys Acta 1722:43-50. 2005
    ..Some signal transduction processes are suggested to be involved in ALA-PDT-induced changes in cytoskeleton, cell shape, and adhesion...
  74. ncbi request reprint Porphyrin formation in actinic keratosis and basal cell carcinoma after topical application of methyl 5-aminolevulinate
    Even Angell-Petersen
    Department of Surgical Oncology, The Norwegian Radium Hospital, Oslo, Norway
    J Invest Dermatol 126:265-71. 2006
    ..In conclusion, application of the 160 mg/g cream for 3 hours gave advantageous porphyrin distributions for all types of lesions...
  75. ncbi request reprint Vitamin D3 from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway)
    Trude Eid Robsahm
    The Cancer Registry of Norway, Institute of Population Based Cancer Research, Montebello, 0310 Oslo, Norway
    Cancer Causes Control 15:149-58. 2004
    ..To investigate whether prognosis of breast-, colon- and prostate cancer may be related to vitamin D(3), induced from solar ultra-violet (UV) radiation, through studies on geographical and seasonal variations in UV radiation...
  76. ncbi request reprint pH, serum proteins and ionic strength influence the uptake of merocyanine 540 by WiDr cells and its interaction with membrane structures
    Beata Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, N 0310 Oslo, Norway
    Bioelectrochemistry 59:1-10. 2003
    ..The results might provide an explanation of the pH dependency of the cellular uptake of MC 540 observed in this study...
  77. ncbi request reprint Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice
    Petras Juzenas
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, NO 0310 Montebello, Oslo, Norway
    Biochem Biophys Res Commun 297:468-72. 2002
    ..Topical application of ALA-Me followed by exposure with laser light (633nm) delayed the growth of the tumors slightly. Light alone also had a significant effect on the tumor growth...
  78. ncbi request reprint pH-dependent modification of lipophilicity of porphyrin-type photosensitizers
    Beata Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, Oslo, Norway
    Photochem Photobiol 79:242-7. 2004
    ..99 +/- 0.04 after the application of a model taking aggregation of the drug into account. The contributions of various aqueous ionic species of mTHPP as functions of pH were calculated and compared with partition coefficients...
  79. ncbi request reprint Ultraviolet photodegradation of folic acid
    Morten Kristian Off
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    J Photochem Photobiol B 80:47-55. 2005
    ..However, experiments performed in heavy water indicate that generation of singlet oxygen is probably not the explanation for the photosensitizing of folic acid...
  80. pmc Relationship between changes in antigen expression and protein synthesis in human melanoma cells after hyperthermia and photodynamic treatment
    C L Davies
    Department of Biophysics, Institute for Cancer Research, Oslo, Norway
    Br J Cancer 58:306-13. 1988
    ....
  81. doi request reprint Sun beds and cod liver oil as vitamin D sources
    Alina Carmen Porojnicu
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 91:125-31. 2008
    ..Within eight weeks after the last exposure the 25(OH)D(3) level decreased to the initial value in all volunteers irrespective of vitamin D supplementation or not...
  82. doi request reprint 5-Methyltetrahydrofolate is photosensitive in the presence of riboflavin
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310, Oslo, Norway
    Photochem Photobiol Sci 7:814-8. 2008
    ..Thus, a dark skin colour may be favourable for prevention of folate degradation under high solar fluence rates, such as in equatorial areas...
  83. ncbi request reprint Seasonal variation of 1,25-dihydroxyvitamin D and its association with body mass index and age
    Johan Moan
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    J Steroid Biochem Mol Biol 113:217-21. 2009
    ..Furthermore, there seems to be a correlation between the levels of the two vitamin D metabolites, indicating that the regulation of 1,25(OH)2 vitamin D is not always tight, notably in persons with high BMI...
  84. doi request reprint 5-Methyltetrahydrofolate can be photodegraded by endogenous photosensitizers
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    Free Radic Biol Med 47:1199-204. 2009
    ..This study suggests that 5MTHF in blood can be photodegraded in the presence of the flavins and porphyrins, but protected by bilirubins. This may have health and evolutionary implications...
  85. ncbi request reprint Influence of human serum albumin on photodegradation of folic acid in solution
    Pavel Vorobey
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Photochem Photobiol 82:817-22. 2006
    ..The oxygen dependence of FA photodegradation and the inhibition of this process by sodium azide indicate that singlet oxygen may participate in the photosensitizing activity of FA photoproducts...
  86. ncbi request reprint Biophysical aspects of photodynamic therapy
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    J Environ Pathol Toxicol Oncol 25:7-28. 2006
    ..These are all important parameters for optimally effective PDT. The present review will give a brief, physically based, overview of PDT and then discuss some of the main biophysical aspects of this therapeutic modality...
  87. doi request reprint Where the sun does not shine: is sunshine protective against melanoma of the vulva?
    Johan Moan
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    J Photochem Photobiol B 101:179-83. 2010
    ....
  88. ncbi request reprint The dependency of vitamin D status on body mass index, gender, age and season
    Zoya Lagunova
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    Anticancer Res 29:3713-20. 2009
    ..Recently, overweight and obesity have been shown to be related to low vitamin D status...
  89. ncbi request reprint Solar radiation, vitamin D and cancer incidence and mortality in Norway
    Johan Moan
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
    Anticancer Res 29:3501-9. 2009
    ....
  90. ncbi request reprint Sun and sun beds: inducers of vitamin D and skin cancer
    Emanuela Cicarma
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
    Anticancer Res 29:3495-500. 2009
    ..Populations living at high latitudes would probably benefit from moderately increasing their exposure to UVB to provide a good vitamin D status...
  91. doi request reprint Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial
    Z Lagunova
    Department of Radiation Biology, Oslo University Hospital The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway
    Br J Dermatol 169:434-40. 2013
    ..Solar ultraviolet (UV) radiation during the summer and vitamin D supplementation are two major sources of vitamin D for humans at northern latitudes. However, little is known about the relative efficiency of these two vitamin D sources...
  92. ncbi request reprint Quantitative assessment of epidermal melanogenesis in C3H/Tif hr/hr mice treated with topical furocoumarins and UVA radiation
    J S Kinley
    Norwegian Radium Hospital, Department of Biophysics, Oslo
    J Invest Dermatol 103:97-103. 1994
    ..The potency of 6,4,4'-trimethylangelicin, which does not form DNA interstrand crosslinks, may be related to its high DNA binding constant. Our data may be useful in the selection of compounds to treat vitiligo...
  93. ncbi request reprint Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy
    Q Peng
    Department of Pathology and Biophysics, Norwegian Radium Hospital, Oslo, Norway
    Ultrastruct Pathol 20:109-129. 1996
    ..A general model for PDT-induced tumor destruction is suggested...
  94. ncbi request reprint Photodegradation of 5-methyltetrahydrofolate: biophysical aspects
    Arnfinn Hykkerud Steindal
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Photochem Photobiol 82:1651-5. 2006
    ..5MTHF mainly absorbs, and is degraded by, UVB and UVC, radiation that does not penetrate the earth's atmosphere and the human skin well...
  95. doi request reprint Sunbeds as vitamin D sources
    Johan Moan
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Photochem Photobiol 85:1474-9. 2009
    ....
  96. doi request reprint Pilot study of folate status in healthy volunteers and in patients with psoriasis before and after UV exposure
    Asta Juzeniene
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 101:111-6. 2010
    ..Further studies, using proper, adequate 5-methyltetrahydrofolate methodology, are needed to clarify the influence of broadband phototherapy on folate degradation and the consequences of these on the health of psoriasis patients...
  97. doi request reprint Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007
    Emanuela Cicarma
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 101:174-8. 2010
    ..The leveling off of melanoma trend is probably associated with melanoma prevention campaigns and with increasing awareness, although vitamin D could play a role...
  98. ncbi request reprint An outline of the hundred-year history of PDT
    Johan Moan
    Department of Biophysics, Institute for Cancer Research, Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Anticancer Res 23:3591-600. 2003
    ..Therefore, in the present historical review, the early work is weighted more heavily than recent work that is more easily accessible to the readers...
  99. doi request reprint Depth profile of protoporphyrin IX fluorescence in an amelanotic mouse melanoma model
    Petras Juzenas
    Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Photochem Photobiol 85:760-4. 2009
    ..16 +/- 0.03 mm(2) h(-1)), MAL (0.045 +/- 0.005 mm(2) h(-1)) and HAL (0.037 +/- 0.003 mm(2) h(-1)), the behavior of the drugs after different application times could be estimated in this tumor model...
  100. ncbi request reprint Erythrocytes-the 'house elves' of photodynamic therapy
    Lars Kaestner
    Institute for Cancer Research, Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol Sci 3:981-9. 2004
    ..Future aspects of applications of photosensitisation of red blood cells are discussed...
  101. ncbi request reprint Increased binding of chlorin e6 to lipoproteins at low pH values
    B Cunderlikova
    Department of Biophysics, Institute for Cancer Research, Montebello, 0310 Oslo, Norway
    Int J Biochem Cell Biol 32:759-68. 2000
    ..The results of this study indicate a possible role of the acidic microenvironment in tumors for the preferential uptake and retention of several photosensitiziers...