Hrvoje Miletic

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi request reprint Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteins
    Hrvoje Miletic
    Abteilung für Neuropathologie, Universitat zu Koln, D 50931 Cologne, Germany
    Hum Gene Ther 15:1091-100. 2004
  2. ncbi request reprint Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene
    Hrvoje Miletic
    Abteilung für Neuropathologie, Universitat zu Koln, Koln, Germany
    Mol Ther 15:1373-81. 2007
  3. ncbi request reprint A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells
    Yvonne Heidemarie Fischer
    University of Lund, Stem Cell Center, BMC B10, 22184 Lund, Sweden
    J Gene Med 9:335-44. 2007
  4. ncbi request reprint Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma
    Hrvoje Miletic
    Department of Biomedicine, University of Bergen, Jonas Liesvei 91, Bergen, Norway
    Clin Cancer Res 13:6761-8. 2007
  5. ncbi request reprint Multimodal imaging of neural progenitor cell fate in rodents
    Yannic Waerzeggers
    Laboratory for Gene Therapy and Molecular Imagin, Max Planck Institute for Neurological Research, Cologne, Germany
    Mol Imaging 7:77-91. 2008
  6. pmc Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer
    Stian Knappskog
    Section of Oncology, Institute of Medicine, University of Bergen, Jonas Lies vei 65, Bergen, 5020, Norway
    Breast Cancer Res 14:R47. 2012
  7. ncbi request reprint Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms
    Hrvoje Miletic
    Department of Biomedicine, University of Bergen, NorLux Neuro Oncology, Bergen, Norway
    Expert Opin Ther Targets 13:455-68. 2009
  8. pmc Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy
    Peter C Huszthy
    Department of Biomedicine, University of Bergen, Bergen, Norway
    PLoS ONE 4:e6314. 2009
  9. pmc EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis
    Krishna M Talasila
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Acta Neuropathol 125:683-98. 2013
  10. doi request reprint In vivo animal models for studying brain metastasis: value and limitations
    Inderjit Daphu
    Norlux Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5019, Bergen, Norway
    Clin Exp Metastasis 30:695-710. 2013

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteins
    Hrvoje Miletic
    Abteilung für Neuropathologie, Universitat zu Koln, D 50931 Cologne, Germany
    Hum Gene Ther 15:1091-100. 2004
    ..In conclusion, lentiviral vectors pseudotyped with LCMV glycoproteins represent an attractive option for gene therapy of malignant glioma...
  2. ncbi request reprint Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene
    Hrvoje Miletic
    Abteilung für Neuropathologie, Universitat zu Koln, Koln, Germany
    Mol Ther 15:1373-81. 2007
    ..In conclusion, BM-TICs expressing a suicide gene were highly effective in the treatment of malignant glioma in a rat model and therefore hold great potential for the therapy of malignant brain tumors in humans...
  3. ncbi request reprint A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cells
    Yvonne Heidemarie Fischer
    University of Lund, Stem Cell Center, BMC B10, 22184 Lund, Sweden
    J Gene Med 9:335-44. 2007
    ....
  4. ncbi request reprint Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant glioma
    Hrvoje Miletic
    Department of Biomedicine, University of Bergen, Jonas Liesvei 91, Bergen, Norway
    Clin Cancer Res 13:6761-8. 2007
    ..Here, we evaluated the therapeutic efficacy of LCMV-GP and vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped vectors...
  5. ncbi request reprint Multimodal imaging of neural progenitor cell fate in rodents
    Yannic Waerzeggers
    Laboratory for Gene Therapy and Molecular Imagin, Max Planck Institute for Neurological Research, Cologne, Germany
    Mol Imaging 7:77-91. 2008
    ..In conclusion, multimodal imaging can be used for longitudinal noninvasive monitoring of grafted NPCs in rodents...
  6. pmc Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer
    Stian Knappskog
    Section of Oncology, Institute of Medicine, University of Bergen, Jonas Lies vei 65, Bergen, 5020, Norway
    Breast Cancer Res 14:R47. 2012
    ..ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and Chk2 in response to genotoxic stress. Here, we sought to evaluate ATM's potential role in resistance to chemotherapy...
  7. ncbi request reprint Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanisms
    Hrvoje Miletic
    Department of Biomedicine, University of Bergen, NorLux Neuro Oncology, Bergen, Norway
    Expert Opin Ther Targets 13:455-68. 2009
    ..GBM appears to be an optimal target for anti-angiogenic therapy as the tumour shows a high degree of endothelial cell proliferation and pro-angiogenic growth factor expression...
  8. pmc Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy
    Peter C Huszthy
    Department of Biomedicine, University of Bergen, Bergen, Norway
    PLoS ONE 4:e6314. 2009
    ..Lentiviral gene therapy is an attractive therapeutic option for human glioblastoma, which we validated in a clinically relevant animal model...
  9. pmc EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis
    Krishna M Talasila
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Acta Neuropathol 125:683-98. 2013
    ..In conclusion, our results indicate that activation of wild-type EGFR promotes invasion and glioblastoma development independent of angiogenesis, whereas loss of its activity results in angiogenic tumor growth...
  10. doi request reprint In vivo animal models for studying brain metastasis: value and limitations
    Inderjit Daphu
    Norlux Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5019, Bergen, Norway
    Clin Exp Metastasis 30:695-710. 2013
    ..By combining the knowledge obtained from animal models, new important information on the molecular mechanisms behind metastasis will be obtained, leading to the future development of new therapeutic strategies...
  11. pmc A reproducible brain tumour model established from human glioblastoma biopsies
    Jian Wang
    Department of Biomedicine, University of Bergen, N 5009 Bergen, Norway
    BMC Cancer 9:465. 2009
    ..However, implementing tumour models based on primary tissue requires that these models can be sufficiently standardised with consistently high take rates...
  12. pmc In vivo models of primary brain tumors: pitfalls and perspectives
    Peter C Huszthy
    NorLux, Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway
    Neuro Oncol 14:979-93. 2012
    ....
  13. doi request reprint NUMB does not impair growth and differentiation status of experimental gliomas
    Philipp Euskirchen
    Department of Biomedicine, University of Bergen, Norway
    Exp Cell Res 317:2864-73. 2011
    ..We thus show that in experimental gliomas, NUMB overexpression most likely does not exert a tumor suppressor function such as seen in epithelial cancers...
  14. pmc Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma
    Jian Wang
    Translational Cancer Research Group, Department of Biomedicine, University of Bergen, Bergen, Norway
    PLoS ONE 6:e23062. 2011
    ..Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy...
  15. doi request reprint Cancer stem cells and angiogenesis
    Rolf Bjerkvig
    NorLux Neuro Oncology, Department of Biomedicine, University of Bergen, N 5009, Bergen, Norway
    Semin Cancer Biol 19:279-84. 2009
    ....
  16. pmc Tumor versus Stromal Cells in Culture-Survival of the Fittest?
    Krishna M Talasila
    Department of Biomedicine, University of Bergen, Bergen, Norway
    PLoS ONE 8:e81183. 2013
    ..This result has an important impact on the establishment of new tumor cell cultures from brain tumors and raises the question of the proper conditions for the growth of the tumor cell populations of interest. ..
  17. doi request reprint Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastoma
    Peter C Huszthy
    Department of Biomedicine, The Gade Institute, University of Bergen, Bergen, Norway
    Clin Cancer Res 14:1571-80. 2008
    ....
  18. pmc Visualization of CD44 and CD133 in normal pancreas and pancreatic ductal adenocarcinomas: non-overlapping membrane expression in cell populations positive for both markers
    Heike Immervoll
    Section for Pathology, Gade Institute, University of Bergen, Bergen, Norway
    J Histochem Cytochem 59:441-55. 2011
    ..The preferentially centroacinar localization of the doubly positive cells in the normal parenchyma suggests that this population could be of particular interest in attempts to identify tumor-initiating cells in PDAC...
  19. doi request reprint Glioma proliferation as assessed by 3'-fluoro-3'-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade glioma
    Roland Ullrich
    Max Planck Institute for Neurological Research with Klaus Joachim Zülch Laboratories, Cologne, Germany
    Clin Cancer Res 14:2049-55. 2008
    ....
  20. ncbi request reprint A 30-year-old patient with tuberous sclerosis
    Werner Stenzel
    Department of Neuropathology, University of Cologne, Cologne, Germany
    Brain Pathol 17:333-4. 2007
  21. ncbi request reprint Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology
    Lutz W Kracht
    Max Planck Institute for Neurological Research, Cologne, Germany
    Clin Cancer Res 10:7163-70. 2004
    ..It remains unclear whether the increased [11C]MET uptake is limited to solid tumor tissue or even detects infiltrating tumor parts...