F Micci

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. doi request reprint MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Lett 347:75-8. 2014
  2. doi request reprint Genomic aberration patterns and expression profiles of squamous cell carcinomas of the vulva
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Genes Chromosomes Cancer 52:551-63. 2013
  3. ncbi request reprint Trisomy 7 in postoperative spindle cell nodules
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, Ullernchaussen 70, 0310 Oslo, Norway
    Cancer Genet Cytogenet 174:147-50. 2007
  4. ncbi request reprint Pairwise comparison of genomic imbalances between primary and recurrent well differentiated liposarcomas
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, Ullernchausseen 70, Montebello, Oslo, Norway
    Cancer Genet Cytogenet 178:163-7. 2007
  5. ncbi request reprint Pathogenetic mechanisms in endometrial stromal sarcoma
    F Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet, Oslo, Norway
    Cytogenet Genome Res 118:190-5. 2007
  6. doi request reprint Consistent numerical chromosome aberrations in thecofibromas of the ovary
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, 0310 Oslo, Norway
    Virchows Arch 452:269-76. 2008
  7. doi request reprint Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 48:184-93. 2009
  8. doi request reprint t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Cancer Lett 277:205-11. 2009
  9. pmc Genomic aberrations in borderline ovarian tumors
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Transl Med 8:21. 2010
  10. doi request reprint Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 49:1046-53. 2010

Collaborators

Detail Information

Publications30

  1. doi request reprint MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway Electronic address
    Cancer Lett 347:75-8. 2014
    ..The transcript of both cases was an in-frame fusion between exon 5 of MEAF6 and exon 2 of PHF1. Both genes are involved in epigenetic modification, and this may well be their main pathogenetic theme also in ESS tumorigenesis. ..
  2. doi request reprint Genomic aberration patterns and expression profiles of squamous cell carcinomas of the vulva
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Genes Chromosomes Cancer 52:551-63. 2013
    ..Notable among the downregulated genes were MAL (in 2q11), KRT4 (in 12q13), and OLFM4 (in 13q14), whereas upregulated genes included SPRR2G (in 1q21.3) and S100A7A (in 1q21.3)...
  3. ncbi request reprint Trisomy 7 in postoperative spindle cell nodules
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, Ullernchaussen 70, 0310 Oslo, Norway
    Cancer Genet Cytogenet 174:147-50. 2007
    ..The other case, from the urinary bladder, showed presence of trisomy 7 by interphase-FISH performed on nuclei extracted from paraffin-embedded tissue...
  4. ncbi request reprint Pairwise comparison of genomic imbalances between primary and recurrent well differentiated liposarcomas
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, Ullernchausseen 70, Montebello, Oslo, Norway
    Cancer Genet Cytogenet 178:163-7. 2007
    ..The findings illustrate that the phenotypic changes some WDL undergo with time may have a genomic correlate, and that a pathogenetic continuum exists between WDL and dedifferentiated, more malignant liposarcomas...
  5. ncbi request reprint Pathogenetic mechanisms in endometrial stromal sarcoma
    F Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet, Oslo, Norway
    Cytogenet Genome Res 118:190-5. 2007
  6. doi request reprint Consistent numerical chromosome aberrations in thecofibromas of the ovary
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, 0310 Oslo, Norway
    Virchows Arch 452:269-76. 2008
    ..The nonrandom occurrence of these aneuploidies in these benign tumors strongly indicates that they play a major pathogenetic role, but how trisomies and other aneuploidies contribute to tumorigenesis remains unknown...
  7. doi request reprint Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 48:184-93. 2009
    ..A detailed map of the rearrangements should provide clues to the positions of oncogenes and potential fusion genes important in ovarian carcinogenesis...
  8. doi request reprint t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Cancer Lett 277:205-11. 2009
    ..The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result...
  9. pmc Genomic aberrations in borderline ovarian tumors
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    J Transl Med 8:21. 2010
    ..According to the scientific literature, less than 30 borderline ovarian tumors have been karyotyped and less than 100 analyzed for genomic imbalances by CGH...
  10. doi request reprint Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
    Francesca Micci
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 49:1046-53. 2010
    ....
  11. ncbi request reprint Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B cell malignancies
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre Montebello, 0310, Oslo, Norway
    Virchows Arch 450:559-65. 2007
    ..Other pathogenetic possibilities could be deregulation of the neighboring NOTCH3 and/or ABHD9 genes, located distal to BRD4 in 19p13...
  12. ncbi request reprint Deregulation of HMGA2 in an aggressive angiomyxoma with t(11;12)(q23;q15)
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Virchows Arch 448:838-42. 2006
    ..FISH analyses demonstrated no structural alteration of HMGA2 at the cytogenetic level; however, expression of the full-length gene was detected molecularly...
  13. ncbi request reprint Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo
    Cancer Res 66:107-12. 2006
    ..The PHF1 gene encodes a protein with two zinc finger motifs whose involvement in tumorigenesis and/or tumor progression has not been reported before, but its rearrangement clearly defines a new pathogenetic subgroup of ESS...
  14. ncbi request reprint Complete cytogenetic characterization of the human breast cancer cell line MA11 combining G-banding, comparative genomic hybridization, multicolor fluorescence in situ hybridization, RxFISH, and chromosome-specific painting
    F Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, N-0310, Oslo, Norway
    Cancer Genet Cytogenet 131:25-30. 2001
    ..The full cytogenetic characterization we present may guide future searches for the mechanism of organ-selective metastasis in this model system and, possibly, also in vivo...
  15. ncbi request reprint Characterization of supernumerary rings and giant marker chromosomes in well-differentiated lipomatous tumors by a combination of G-banding, CGH, M-FISH, and chromosome- and locus-specific FISH
    F Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Cytogenet Genome Res 97:13-9. 2002
    ..In addition, the rings and giant markers often contained interspersed sequences from several other chromosomes that did not give an equally clear impression of being nonrandomly involved...
  16. doi request reprint High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Cell Mol Med 12:553-63. 2008
    ..Nonetheless, incidence of these aberrations seems to be negligible in the majority of long-term ASC cultures, at least under the culture conditions used here...
  17. doi request reprint Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 47:558-64. 2008
    ..Based on the structure of the novel fusion gene detected, its transforming mechanism is thought to be the same as for other fusion genes involving EWSR1 or PBX1...
  18. ncbi request reprint Genomic aberrations in carcinomas of the uterine corpus
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Genes Chromosomes Cancer 40:229-46. 2004
    ....
  19. ncbi request reprint G-banding and molecular cytogenetic analyses of marginal zone lymphoma
    Hege Vangstein Aamot
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Br J Haematol 130:890-901. 2005
    ..Both these lymphomas had involvement of the IGH gene at 14q32, and one of them also of the RHOH/TTF gene at 4p13, which encodes a new member of the RHO protein subfamily...
  20. ncbi request reprint M-FISH cytogenetic analysis of non-Hodgkin lymphomas with t(14;18)(q32;q21) and add(1)(p36) as a secondary abnormality shows that the extra material often comes from chromosome arm 17q
    H Aamot
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo
    Leuk Lymphoma 43:1051-6. 2002
    ..It appears, therefore, that der(1)t(1;17)(p36;q11-21) is a common secondary aberration in NHLs with t(14;18) as the primary abnormality, accounting for about one-third of all add(1)(p36) chromosomes seen in this cytogenetic subset...
  21. ncbi request reprint Cytogenetic characterization of tumors of the vulva and vagina
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Genes Chromosomes Cancer 38:137-48. 2003
    ..Breakpoint clusters were seen in 11q13-23, 2q22-35, and 19q13, as well as in the centromeres and pericentromeric bands of chromosomes 3, 8, 9, 13, 14, and 22...
  22. pmc DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets
    Qinghua Wu
    Department of Pathology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Mol Cancer 6:45. 2007
    ..Direct bisulphite sequencing analysis was used to confirm the methylation status of individual genes. The MSP results were compared with clinico- pathological features...
  23. ncbi request reprint Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17)
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Cancer Genet Cytogenet 144:119-24. 2003
    ..Evidently, karyotypic, and hence pathogenetic, heterogeneity exists for tumors classified as endometrial stromal sarcomas based on their phenotypic features...
  24. doi request reprint Molecular cytogenetic analysis of a gliosarcoma with osseous metaplasia
    H S S Dahlback
    Section for Cancer Cytogenetics, Institute for Medical Informatics, Oslo, Norway
    Cytogenet Genome Res 134:88-95. 2011
    ..In addition to chromosomal changes often found in gliomas (+7, -10, -13, and -22), the tumour cells also harboured a hitherto unknown t(3;21)(q13∼21;q21∼22)...
  25. ncbi request reprint Molecular cytogenetic characterization of desmoid tumors
    Petter Brandal
    Institute for Cancer Research, The Norwegian Radium Hospital Montebello, Oslo, Norway
    Cancer Genet Cytogenet 146:1-7. 2003
    ....
  26. pmc A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
    Rolf I Skotheim
    Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Mol Cancer 8:5. 2009
    ..However, the available methodologies to detect such fusions all have their distinct short-comings...
  27. pmc Are keratoacanthomas variants of squamous cell carcinomas? A comparison of chromosomal aberrations by comparative genomic hybridization
    Ole Petter F Clausen
    Institute and Department of Pathology, Rikshospitalet, University of Oslo, Oslo, Norway
    J Invest Dermatol 126:2308-15. 2006
    ..0434). The patterns of recurrent aberrations were also different in the two types of neoplasms, pointing to different genetic mechanisms involved in their developments...
  28. ncbi request reprint The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers
    Qinghua Wu
    Department of Pathology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Epigenetics 2:237-43. 2007
    ..We conclude that promoter hypermethylation of EPHB2, EPHB3 and EPHB4 is not a common event in colon and ovarian cancers and therefore plays no major role in these tumors...
  29. doi request reprint Molecular characterization of the MLL-SEPT6 fusion gene in acute myeloid leukemia: identification of novel fusion transcripts and cloning of genomic breakpoint junctions
    Nuno Cerveira
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Haematologica 93:1076-80. 2008
    ..These data suggest that a non-homologous end-joining repair mechanism may be involved in the generation of MLL-SEPT6 rearrangements in acute myeloid leukemia...
  30. ncbi request reprint Fusion genes in angiomatoid fibrous histiocytoma
    Karolin H Hallor
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Cancer Lett 251:158-63. 2007
    ..Nonetheless, RT-PCR for these fusion transcripts remains a valuable diagnostic adjunct in the distinction between AFH and other soft tissue tumors or metastases that may simulate it...