Klaus Meyer

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi request reprint Use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for multiplex genotyping
    Klaus Meyer
    Bevital AS, c o Section for Pharmacology, University of Bergen, Bergen, Norway
    Adv Clin Chem 53:1-29. 2011
  2. ncbi request reprint High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry
    Klaus Meyer
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Clin Chem 50:391-402. 2004
  3. doi request reprint MALDI-TOF MS genotyping of polymorphisms related to 1-carbon metabolism using common and mass-modified terminators
    Klaus Meyer
    Bevital A S, Armauer Hansens Hus, University of Bergen, Bergen, Norway
    Clin Chem 55:139-49. 2009
  4. ncbi request reprint Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
    Ase Fredriksen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Hum Mutat 28:856-65. 2007
  5. pmc Plasma folate, related genetic variants, and colorectal cancer risk in EPIC
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, Section for Pharmacology, Department of Internal Medicine, University of Bergen, and Haukeland University Hospital, 5021 Laboratory Building, 9th Floor, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:1328-40. 2010
  6. pmc Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, and Haukeland University Hospital, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:2549-61. 2010
  7. doi request reprint Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer--a large nested case-control study within the JANUS cohort in Norway
    Stefan de Vogel
    Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
    Int J Cancer 134:197-206. 2014
  8. doi request reprint Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Department of Pharmacology, Institute of Medicine, University of Bergen, and Haukeland University Hospital, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:28-38. 2010
  9. doi request reprint Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort
    Stefan de Vogel
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Int J Epidemiol 42:201-10. 2013
  10. doi request reprint Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women
    Bettina M Riedel
    Section of Clinical Pharmacology, Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
    J Nutr 141:1784-90. 2011

Detail Information

Publications20

  1. ncbi request reprint Use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for multiplex genotyping
    Klaus Meyer
    Bevital AS, c o Section for Pharmacology, University of Bergen, Bergen, Norway
    Adv Clin Chem 53:1-29. 2011
    ..This review gives an introduction to multiplex genotyping by MALDI-MS and will focus on the latest developments of this technology...
  2. ncbi request reprint High-level multiplex genotyping of polymorphisms involved in folate or homocysteine metabolism by matrix-assisted laser desorption/ionization mass spectrometry
    Klaus Meyer
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Clin Chem 50:391-402. 2004
    ..Future large epidemiologic studies of the genetic basis of hyperhomocysteinemia will require high-throughput assays for polymorphisms of genes related to folate and Hcy metabolism...
  3. doi request reprint MALDI-TOF MS genotyping of polymorphisms related to 1-carbon metabolism using common and mass-modified terminators
    Klaus Meyer
    Bevital A S, Armauer Hansens Hus, University of Bergen, Bergen, Norway
    Clin Chem 55:139-49. 2009
    ..We developed a genotyping method based on MALDI-TOF MS and compared assay performance for formats based on standard and mass-modified terminators...
  4. ncbi request reprint Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
    Ase Fredriksen
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Bergen, Norway
    Hum Mutat 28:856-65. 2007
    ..2756A>G (tHcy), BHMT c.716G>A (DMG), CBS c.844_845ins68 (tHcy, betaine), CBS c.699C>T (tHcy, betaine, cystathionine) and TCN2 c.776C>G (MMA). No associations were observed for the other polymorphisms investigated...
  5. pmc Plasma folate, related genetic variants, and colorectal cancer risk in EPIC
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, Section for Pharmacology, Department of Internal Medicine, University of Bergen, and Haukeland University Hospital, 5021 Laboratory Building, 9th Floor, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:1328-40. 2010
    ..We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort...
  6. pmc Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, and Haukeland University Hospital, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:2549-61. 2010
    ..Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive...
  7. doi request reprint Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer--a large nested case-control study within the JANUS cohort in Norway
    Stefan de Vogel
    Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
    Int J Cancer 134:197-206. 2014
    ..Ratios of metabolites reflecting one-carbon balance may be associated with prostate cancer risk, as demonstrated for the glycine/serine ratio, and should be explored in future studies...
  8. doi request reprint Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition
    Simone J P M Eussen
    LOCUS for Homocysteine and Related Vitamins, Department of Pharmacology, Institute of Medicine, University of Bergen, and Haukeland University Hospital, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 19:28-38. 2010
    ..In summary, results from this large European cohort study showed an inverse association between vitamin B2 and GC risk, which is borderline significant, and a significant inverse association between vitamin B6 and GC risk...
  9. doi request reprint Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort
    Stefan de Vogel
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Int J Epidemiol 42:201-10. 2013
    ..Although individual studies have been inconsistent, meta-analyses of epidemiological data suggest that high folate and vitamin B12 levels may be associated with increased prostate cancer risk...
  10. doi request reprint Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women
    Bettina M Riedel
    Section of Clinical Pharmacology, Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
    J Nutr 141:1784-90. 2011
    ..It remains to be determined whether this polymorphic effect on serum holoTC alters its diagnostic utility as Cbl status indicator...
  11. doi request reprint North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
    Simone J P M Eussen
    Department of Public Health and Primary Health Care and Section for Pharmacology, Institute of Medicine, Faculty of Dentistry and Medicine, University of Bergen, 5021 Laboratory Building, 9th Floor, Bergen, Norway
    Br J Nutr 110:363-74. 2013
    ..In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle...
  12. ncbi request reprint Biomarkers related to one-carbon metabolism as potential risk factors for distal colorectal adenomas
    Stefan de Vogel
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 20:1726-35. 2011
    ..However, plasma folate and vitamins B2 and B12 have inconsistently been associated with colorectal cancer risk, and there have been no previous studies relating plasma concentrations of methionine, choline, and betaine to this outcome...
  13. ncbi request reprint The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition
    Stein Emil Vollset
    LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
    Cancer Epidemiol Biomarkers Prev 16:2416-24. 2007
    ..However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer...
  14. pmc Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients
    Hall Schartum-Hansen
    Section for Cardiology, Department of Clinical Science, University of Bergen, Bergen, Norway
    PLoS ONE 8:e69454. 2013
    ....
  15. doi request reprint Plasma choline, nicotine exposure, and risk of low bone mineral density and hip fracture: the Hordaland health study
    Jannike Øyen
    Department of Rheumatology, Haukeland University Hospital, Bergen, Norway Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
    J Bone Miner Res 29:242-50. 2014
    ..Low plasma choline was associated with low BMD in both sexes and increased the risk of hip fracture in elderly women. These results should motivate further studies on choline, nicotine exposure, and bone metabolism...
  16. pmc Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study
    Elin Strand
    Department of Clinical Science, University of Bergen, 5021 Bergen, Norway
    BMC Med 11:216. 2013
    ..We investigated the potential influence of impaired glucose metabolism on the relation between dietary intake of n-3 LCPUFAs and risk of acute myocardial infarction (AMI) in patients with coronary artery disease...
  17. ncbi request reprint Functional inference of the methylenetetrahydrofolate reductase 677C > T and 1298A > C polymorphisms from a large-scale epidemiological study
    Arve Ulvik
    LOCUS for Homocysteine and Related Vitamins, Department of Internal Medicine, Pharmacology Section, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway
    Hum Genet 121:57-64. 2007
    ..In conclusion, this report demonstrates functional inference of the MTHFR 677 C > T and 1,298 A > C polymorphisms from a large-scale epidemiological study...
  18. ncbi request reprint Targeted Quantification of C-Reactive Protein and Cystatin C and Its Variants by Immuno-MALDI-MS
    Klaus Meyer
    Bevital AS, Laboratory building, 9th Floor, Jonas Lies veg 87, 5021 Bergen, Norway
    Anal Chem 86:5807-14. 2014
    ....
  19. ncbi request reprint Screening for serum total homocysteine in newborn children
    Helga Refsum
    Department of Pharmacology, University of Oxford, UK
    Clin Chem 50:1769-84. 2004
    ..Newborn screening for total homocysteine (tHcy) in blood may identify babies with vitamin B12 (B12) deficiency or homocystinuria, but data on the causes of increased tHcy in screening samples are sparse...
  20. pmc Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts
    Abee L Boyles
    Epidemiology Branch, National Institute of Environmental Health Sciences NIH, Durham, North Carolina 27709, USA
    Am J Med Genet A 146:440-9. 2008
    ..No associations were found between any of the polymorphisms and CPO. Genetic variations in the nine metabolic genes examined here do not confer a substantial degree of risk for clefts...