Affiliation: University of Bergen
- Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastorisJeffrey McKinney
Department of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway
Protein Expr Purif 33:185-94. 2004..This supports previous observations that the enzyme in vivo may be stabilized by additional interactions...
- Different properties of the central and peripheral forms of human tryptophan hydroxylaseJeffrey McKinney
Department of Biomedicine, Section of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway
J Neurochem 92:311-20. 2005....
- Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2Ana C Calvo
Department of Biomedicine, University of Bergen, Bergen, Norway
J Neurochem 114:853-63. 2010....
- Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorderSven Cichon
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Hum Mol Genet 17:87-97. 2008..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD...