Jeffrey McKinney

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris
    Jeffrey McKinney
    Department of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway
    Protein Expr Purif 33:185-94. 2004
  2. ncbi Different properties of the central and peripheral forms of human tryptophan hydroxylase
    Jeffrey McKinney
    Department of Biomedicine, Section of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway
    J Neurochem 92:311-20. 2005
  3. ncbi Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2
    Ana C Calvo
    Department of Biomedicine, University of Bergen, Bergen, Norway
    J Neurochem 114:853-63. 2010
  4. ncbi Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Mol Genet 17:87-97. 2008

Detail Information

Publications4

  1. ncbi Expression and purification of human tryptophan hydroxylase from Escherichia coli and Pichia pastoris
    Jeffrey McKinney
    Department of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway
    Protein Expr Purif 33:185-94. 2004
    ..This supports previous observations that the enzyme in vivo may be stabilized by additional interactions...
  2. ncbi Different properties of the central and peripheral forms of human tryptophan hydroxylase
    Jeffrey McKinney
    Department of Biomedicine, Section of Biochemistry and Molecular Biology, University of Bergen, Bergen, Norway
    J Neurochem 92:311-20. 2005
    ....
  3. ncbi Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2
    Ana C Calvo
    Department of Biomedicine, University of Bergen, Bergen, Norway
    J Neurochem 114:853-63. 2010
    ....
  4. ncbi Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder
    Sven Cichon
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Mol Genet 17:87-97. 2008
    ..Examination of the functional effects of TPH2 Pro206Ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-HT production in the brain as a pathophysiological mechanism in BPAD...