Aurora Martinez


Affiliation: University of Bergen
Country: Norway


  1. Aubi O, Knappskog P, Martinez A. Early Stage Discovery and Validation of Pharmacological Chaperones for the Correction of Protein Misfolding Diseases. Methods Mol Biol. 2019;1873:279-292 pubmed publisher
  2. Brasil S, Briso Montiano Á, Gamez A, Underhaug J, Flydal M, Desviat L, et al. New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type. Biochim Biophys Acta. 2018;1864:640-648 pubmed publisher
  3. request reprint
    Hole M, Jorge Finnigan A, Underhaug J, Teigen K, Martinez A. Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms. Curr Drug Targets. 2016;17:1515-26 pubmed
    ..It is expected that synergistic combinations of different pharmacological chaperones could provide patient-tailored therapeutic options. ..
  4. Scherer T, Allegri G, Sarkissian C, Ying M, Grisch Chan H, Rassi A, et al. Tetrahydrobiopterin treatment reduces brain L-Phe but only partially improves serotonin in hyperphenylalaninemic ENU1/2 mice. J Inherit Metab Dis. 2018;41:709-718 pubmed publisher
  5. Urbaneja M, Skjærven L, Aubi O, Underhaug J, López D, Arregi I, et al. Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia. Sci Rep. 2017;7:13959 pubmed publisher
    ..The identified hits appear promising as pharmacological chaperones aimed at therapies for AML based on conformational stabilization of NPM. ..