A A Maghazachi

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi Role of the heterotrimeric G proteins in stromal-derived factor-1alpha-induced natural killer cell chemotaxis and calcium mobilization
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Blindern, Norway
    Biochem Biophys Res Commun 236:270-4. 1997
  2. ncbi D-galactosyl-beta1-1'-sphingosine and D-glucosyl-beta1-1'-sphingosine induce human natural killer cell apoptosis
    Azzam A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P O B 1105 Blindern, N 0317 Oslo, Norway
    Biochem Biophys Res Commun 320:810-5. 2004
  3. ncbi Compartmentalization of human natural killer cells
    Azzam A Maghazachi
    Department of Anatomy, University of Oslo, POB 1105, Blindern N 0317, Oslo, Norway
    Mol Immunol 42:523-9. 2005
  4. ncbi Intracellular signaling events at the leading edge of migrating cells
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N 0317 Oslo, Norway
    Int J Biochem Cell Biol 32:931-43. 2000
  5. ncbi Chemokines, G proteins and natural killer cells
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Arch Immunol Ther Exp (Warsz) 48:65-72. 2000
  6. ncbi Intracellular signalling pathways induced by chemokines in natural killer cells
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Blindern, Norway
    Cell Signal 11:385-90. 1999
  7. ncbi Chemokines activate natural killer cells through heterotrimeric G-proteins: implications for the treatment of AIDS and cancer
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    FASEB J 12:913-24. 1998
  8. ncbi Insights into seven and single transmembrane-spanning domain receptors and their signaling pathways in human natural killer cells
    Azzam A Maghazachi
    Department of Anatomy, University of Oslo, Norway
    Pharmacol Rev 57:339-57. 2005
  9. ncbi Expression and regulation of chemokine receptors in human natural killer cells
    M Inngjerdingen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Blood 97:367-75. 2001
  10. ncbi Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309
    M Inngjerdingen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Immunol 164:4048-54. 2000

Collaborators

  • B Rolstad
  • M Inngjerdingen
  • E Knudsen
  • Lise Kveberg
  • Marco Idzko
  • L Adorini
  • Yixin Jin
  • Bassam B Damaj
  • Ling Wang
  • Johannes Rolin
  • Sandra Gessani
  • Kristin L Sand
  • K L Sand
  • Yassin Al-Falahi
  • Devrim Oz-Arslan
  • Maria Cristina Gauzzi
  • Y Al-Falahi
  • J Rolin
  • Cecilia Barrena Becerra
  • Henry J Esber
  • Ying Wen
  • Wolfgang Rüscher
  • Johannes Norgauer
  • Stephan Sorichter
  • Daniel Myrtek
  • Mirjana Ziemer
  • Cristina Purificato
  • Filippo Belardelli
  • Karim Donato
  • Kenn C Daniel
  • A Al-Aoukaty
  • Bassam Damaj
  • Yenan Bryceson

Detail Information

Publications25

  1. ncbi Role of the heterotrimeric G proteins in stromal-derived factor-1alpha-induced natural killer cell chemotaxis and calcium mobilization
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Blindern, Norway
    Biochem Biophys Res Commun 236:270-4. 1997
    ..Our results are the first to show that SDF-1alpha is chemoattractant for NK cells, and that this effect is coupled to G proteins...
  2. ncbi D-galactosyl-beta1-1'-sphingosine and D-glucosyl-beta1-1'-sphingosine induce human natural killer cell apoptosis
    Azzam A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, P O B 1105 Blindern, N 0317 Oslo, Norway
    Biochem Biophys Res Commun 320:810-5. 2004
    ..These results may have important implications on diseases where glycosphingolipids accumulate...
  3. ncbi Compartmentalization of human natural killer cells
    Azzam A Maghazachi
    Department of Anatomy, University of Oslo, POB 1105, Blindern N 0317, Oslo, Norway
    Mol Immunol 42:523-9. 2005
    ....
  4. ncbi Intracellular signaling events at the leading edge of migrating cells
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N 0317 Oslo, Norway
    Int J Biochem Cell Biol 32:931-43. 2000
    ..This review will discuss the intracellular signaling pathways induced by chemokines, particularly those activated at the leading edge of migrating cells which lead to cell polarization, cytoskeleton reorganization and motility...
  5. ncbi Chemokines, G proteins and natural killer cells
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Arch Immunol Ther Exp (Warsz) 48:65-72. 2000
    ..In this review, I will update the knowledge of the effect of chemokines on NK cell motility and the signal transduction pathways induced by chemokines in these cells...
  6. ncbi Intracellular signalling pathways induced by chemokines in natural killer cells
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Blindern, Norway
    Cell Signal 11:385-90. 1999
    ..This review discusses the intracellular signalling pathways induced by chemokines in NK and other cell types, and the relationships to HIV-1 signalling in these cells...
  7. ncbi Chemokines activate natural killer cells through heterotrimeric G-proteins: implications for the treatment of AIDS and cancer
    A A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    FASEB J 12:913-24. 1998
    ..Based on evidence showing the high lytic activity of these effector cells against transformed or virally infected cells, it is suggested that NK cells can be used to maximize the immunotherapeutic protocols for AIDS and cancer patients...
  8. ncbi Insights into seven and single transmembrane-spanning domain receptors and their signaling pathways in human natural killer cells
    Azzam A Maghazachi
    Department of Anatomy, University of Oslo, Norway
    Pharmacol Rev 57:339-57. 2005
    ..These pathways are crucial for NK cell biology, development, and functions...
  9. ncbi Expression and regulation of chemokine receptors in human natural killer cells
    M Inngjerdingen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Blood 97:367-75. 2001
    ..Our results may have implications for the dissemination of NK cells at the sites of tumor growth or viral replication. (Blood. 2001;97:367-375)..
  10. ncbi Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309
    M Inngjerdingen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Immunol 164:4048-54. 2000
    ..These results suggest that TARC utilizes CCR4 and CCR8. Our results are the first to show that IL-2-activated NK cells express CCR4 and CCR8, suggesting that these receptors are not exclusive for Th2 cells...
  11. ncbi Functional coupling of NKR-P1 receptors to various heterotrimeric G proteins in rat interleukin-2-activated natural killer cells
    A Al-Aoukaty
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, N 0317 Oslo, Norway
    J Biol Chem 272:31604-8. 1997
    ..These results are the first to demonstrate the physical and functional coupling of NKR-P1 to the heterotrimeric G proteins in NK cells...
  12. ncbi Sphingosine 1 phosphate induces the chemotaxis of human natural killer cells. Role for heterotrimeric G proteins and phosphoinositide 3 kinases
    Lise Kveberg
    Department of Anatomy, University of Oslo, Oslo, Norway
    Eur J Immunol 32:1856-64. 2002
    ..In contrast, SPP and DHSPP recruit PI3Kbeta isozyme into NK cell membranes, suggesting that although this isoform is not involved in chemotaxis, it is activated by these phospholipids...
  13. ncbi G protein-coupled receptors in natural killer cells
    Azzam A Maghazachi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    J Leukoc Biol 74:16-24. 2003
    ....
  14. ncbi Lck is required for stromal cell-derived factor 1 alpha (CXCL12)-induced lymphoid cell chemotaxis
    Marit Inngjerdingen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Blood 99:4318-25. 2002
    ..Together, these results suggest a role for Lck in CXCL12-induced signaling pathways leading to lymphocyte chemotaxis...
  15. ncbi Modulation of natural killer cell cytotoxicity and cytokine release by the drug glatiramer acetate
    K L Sand
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Cell Mol Life Sci 66:1446-56. 2009
    ..Further, GA inhibited the release of IFN-gamma 24 h but increased the release of TNF-alpha 48 h after incubation with NK cells...
  16. ncbi FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release
    Johannes Rolin
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway
    Cancer Immunol Immunother 59:575-86. 2010
    ..Further, the results suggest that FTY720 and SEW2871 may potentially be used as prophylactic and/or therapeutic drugs to treat cancer patients...
  17. ncbi Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor
    Yixin Jin
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Eur J Immunol 35:2699-708. 2005
    ..Our results provide one possible explanation for the tissue compartmentation of NK cells and their ability to secrete IFN-gamma. Furthermore, these results may provide novel information regarding NK cell regulation during inflammation...
  18. ncbi Lysophospholipids and chemokines activate distinct signal transduction pathways in T helper 1 and T helper 2 cells
    Ling Wang
    Department of Anatomy, University of Oslo, POB 1105 Blindern, N-0317 Oslo, Norway
    Cell Signal 16:991-1000. 2004
    ..PTX and SUR but not EGTA inhibit I-TAC- or eotaxin-induced [Ca(2+)](i) release in Th1 and Th2 cells. Our results indicate that lysophospholipids and chemokines stimulate different signal transduction pathways...
  19. ncbi Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization
    Yixin Jin
    Department of Anatomy, University of Oslo, Oslo, Norway
    Eur J Immunol 33:2083-9. 2003
    ..Moreover, LPA or PA but not sphingosine 1-phosphate, enhances IFN-gamma secretion by activated NK cells. Our results may shed some light on the findings that activated NK cells are found at the sites of tumor growth...
  20. ncbi Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation
    Yixin Jin
    Department of Anatomy and Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Blood 101:4909-15. 2003
    ..These results show differential effects of S1P on polyclonal T-cell proliferation and cytokine secretion...
  21. ncbi Role of chemokines in the biology of natural killer cells
    Azzam A Maghazachi
    Department of Physiology, Faculty of Medicine, Institute of Basic Medical Sciences, Blindern, 0317 Oslo, Norway
    Curr Top Microbiol Immunol 341:37-58. 2010
    ..Examples are their deleterious roles in autoimmune diseases such as rheumatoid arthritis and primary biliary cirrhosis...
  22. ncbi IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids
    Devrim Oz-Arslan
    Department of Anatomy, University of Oslo, Norway
    J Leukoc Biol 80:287-97. 2006
    ....
  23. ncbi Splenic natural killer cell activity in two models of experimental neurodegenerative diseases
    Yassin Al-Falahi
    Department of Physiology, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    J Cell Mol Med 13:2693-703. 2009
    ....
  24. ncbi Functional expression of H4 histamine receptor in human natural killer cells, monocytes, and dendritic cells
    Bassam B Damaj
    Bio Quant Inc, San Diego, CA 92121, USA
    J Immunol 179:7907-15. 2007
    ..They are also important for developing drugs that target H4R for the treatment of various disorders, such as autoimmune and immunodeficient diseases...
  25. ncbi Suppressive effect of 1alpha,25-dihydroxyvitamin D3 on type I IFN-mediated monocyte differentiation into dendritic cells: impairment of functional activities and chemotaxis
    Maria Cristina Gauzzi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanit, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 174:270-6. 2005
    ....