Research Topics
Genomes and Genes | Gunhild M MaelandsmoSummaryAffiliation: University of Oslo Country: Norway Publications
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Publications
Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanomaGunhild M Maelandsmo
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
Clin Cancer Res 9:3383-8. 2003....- Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell linesTrine Lillehammer
Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
J Gene Med 9:440-51. 2007..Full-length TRAIL, delivered from an adenoviral vector (Ad-hTRAIL), was studied in combination with DTIC or the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in human melanoma cell lines... 
Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaBIda Grotterød
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
BMC Cancer 10:241. 2010..The upstream signal transduction mechanisms leading to increased NF-kappaB activity are, however, incompletely characterized...- Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleusBirgit Ø Engesaeter
Department of Tumor Biology, Rikshospitalet Radiumhospitalet Health Enterprise, Montebello, N 0310 Oslo, Norway
J Gene Med 8:707-18. 2006..We have previously shown that PCI enhances transgene expression from AdhCMV-lacZ, and the aim of the present study was to further increase the understanding of photochemically mediated adenoviral transduction... - Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell linesBirgit Ø Engesaeter
Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
Cancer Biol Ther 5:1511-20. 2006..The presented results indicate that photochemically mediated delivery of AdhCMV-TRAIL allows a selective enhancement in cell killing, and suggest that PCI may be relevant and advantageous for therapeutic gene delivery in vivo... - Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptorAnette Bonsted
Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet HF, Montebello, N 0310 Oslo, Norway
J Gene Med 8:286-97. 2006..Biological and physical targeting techniques may be combined to redirect gene therapy vectors to specific cells and enhance gene transfer... - Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanomaKristin Andersen
Department of Tumor Biology, Institute of Cancer Research, University of Oslo, Montebello, Norway
Mod Pathol 17:990-7. 2004..We have also evaluated the relationship between the expression of these two antigens and cell cycle and signal transduction factors... 
Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanomaGeir Frode Oy
Department of Tumor Biology, Institute for Cancer Research, Oslo, Norway
Int J Cancer 126:350-61. 2010..Development of resistance to the antiproliferative effects of IGFBP-3 may be an important step in progression of malignant melanomas...- Expression of activated extracellular signal-regulated kinases 1/2 in malignant melanomas: relationship with clinical outcomeKjersti Jørgensen
Department of Pathology, Institute for Cancer Research, The Norwegian Radium Hospital, HF, Montebello, Oslo, Norway
Clin Cancer Res 9:5325-31. 2003.... - Interferon-gamma-induced suppression of S100A4 transcription is mediated by the class II transactivatorKjetil Boye
Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
Tumour Biol 28:27-35. 2007..Our data suggest a model where CIITA represses S100A4 transcription through sequestering of CBP/p300, thereby reducing the level of CBP/p300 at the S100A4 promoter, which in turn leads to inhibition of S100A4 transcription... - Photochemical internalization: a new tool for drug deliveryKristian Berg
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
Curr Pharm Biotechnol 8:362-72. 2007.... - Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genesKjetil Boye
Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
Int J Cancer 123:1301-10. 2008.... - Specific isolation of disseminated cancer cells: a new method permitting sensitive detection of target molecules of diagnostic and therapeutic valueSiri Tveito
Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310, Oslo, Norway
Clin Exp Metastasis 24:317-27. 2007..By use of the CellPick system it is possible to specifically isolate bead-rosetted or otherwise labelled target cells from a heterogeneous cell population for further molecular characterization... - Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft modelsAnna Bergamaschi
Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
Mol Oncol 3:469-82. 2009..These two new breast cancer xenografts represent useful preclinical tools for developing and testing of new therapies and improving our knowledge on breast cancer biology... - Cystatin E/M suppresses legumain activity and invasion of human melanomaJon J Briggs
Department of Tumor Biology, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo, Norway
BMC Cancer 10:17. 2010..Although cystatin E/M is normally expressed in the skin, its role in cysteine protease regulation and progression of malignant melanoma has not been studied... - S100A4 and metastasis: a small actor playing many rolesKjetil Boye
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
Am J Pathol 176:528-35. 2010..In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression... - A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growthMerete Thune Wiiger
Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
Cancer Immunol Immunother 59:1665-74. 2010.... - Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo -- use of the human tyrosinase promoter with human enhancersTrine Lillehammer
Department of Tumor Biology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
Cancer Gene Ther 12:864-72. 2005.... - Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude miceKjersti Flatmark
Department of Tumor Biology and Institute for Cancer Research, The Norwegian Radium Hospital, Oslo 0310, Norway
Eur J Cancer 40:1593-8. 2004..The study provides useful background information on the 12 colorectal cancer cell lines in a clinically relevant orthotopic tumour model... - Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serumKjersti Flatmark
Department of Tumor Biology and Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway
Tumour Biol 25:31-40. 2004..The antibodies and the IFMA may still be useful for research purposes... - Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastasesAnne Hansen Ree
Department of Tumor Biology, The Norwegian Radium Hospital, Oslo
Anticancer Res 22:1949-57. 2002..The observations in this study strengthen the assumption that com1 may be involved in the tumor cell response to regulatory signals upon metastasis formation... - PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particlesBirgit Ø Engesaeter
Department of Tumor Biology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
Cancer Gene Ther 12:439-48. 2005..In summary, the data presented imply that adenoviral receptor binding is important and clathrin-mediated endocytosis is the predominant uptake mechanism for adenoviral particles in photochemically treated cells... - Human osteosarcoma xenografts and their sensitivity to chemotherapySkjalg Bruheim
Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, 0310, Norway
Pathol Oncol Res 10:133-41. 2004..01), whereas the expression of MRP1 and cisplatin growth inhibition was positively correlated (r=0.82; p<0.005). This panel of xenografts should constitute a good tool for pharmacological and molecular studies in osteosarcoma... - Nuclear localization of the metastasis-related protein S100A4 correlates with tumour stage in colorectal cancerKjersti Flatmark
Department of Tumor Biology and Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
J Pathol 200:589-95. 2003..The nuclear localization of S100A4 in colorectal cancer and its relationship to tumour stage suggest that this protein may be involved in gene regulatory pathways of relevance to the metastatic phenotype of cancer cells... - Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21Leonardo A Meza-Zepeda
Department of Tumour Biology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
Oncogene 21:2261-9. 2002..Quite likely, the different genes may give selective advantages to different subsets of tumours... - Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradationJørn Henriksen
Department of Tumour Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
Oncogene 22:5358-61. 2003..The results suggest that inactivation of otherwise intact TP53 by aberrations in the proteasome pathway may contribute to the characteristic aneuploidy observed in OS... - Use of a murine secreted alkaline phosphatase as a non-immunogenic reporter gene in miceGunhild M Maelandsmo
Department of Tumor Biology, Norwegian Radium Hospital, 0310 Oslo, Norway
J Gene Med 7:307-15. 2005..No antibodies were detected to mSEAP. CONCLUSIONS: Taken together, these data illustrate that mSEAP is a sensitive, non-immunogenic reporter gene for preclinical mouse studies... - Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancerTeresa Cabezon
Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
Int J Cancer 121:1433-44. 2007..Using a specific ELISA test, we detected a significant higher concentration of S100A4 in the tumor interstitial fluid (TIF) as compared to their corresponding normal counterparts (NIF)... - Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent mannerThrina Loennechen
Department of Pharmacology, Institute of Pharmacy, University of Troms, 9037 Troms, Norway
Biochem Pharmacol 66:2341-53. 2003..It can be concluded that colchicine modulates the expression of MT1-MMP and TIMP-2 and hence the activation of proMMP-2 independently of the S100A4 level in osteosarcoma cells... - S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cellsBerit Mathisen
Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
Clin Exp Metastasis 20:701-11. 2003..Thus, one of the mechanisms by which S100A4 may exert its effect on metastasis of some tumors is by regulating the MMP-2 activity... - Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivoDaniel A Muruve
Faculty of Medicine, University of Calgary, 3330 Hospital Dr N W, Calgary, AB, T2N 4N1 Canada
J Virol 78:5966-72. 2004..These results demonstrate that HD-Ad vectors induce intact innate but attenuated adaptive immune responses in vivo... - Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcomeVivi Ann Flørenes
Department of Pathology, Norwegian Radium Hospital, HF, Montebello, Oslo
Am J Clin Pathol 122:412-20. 2004..006) and between nuclear p-TrkA and cytoplasmic E-cadherin (P = .022) was seen. We present the first evidence of a role for TrkA activation in a subset of melanomas as a predictor of an aggressive phenotype and poor outcome... - S100B in bone marrow aspirates in healthy individuals and malignant melanoma patientsRagnar S Faye
Department of aTumor Biology, Rikshospitalet Medical Centre fMedical Faculty, University of Oslo, Oslo, Norway
Melanoma Res 18:134-40. 2008..Unlike S100B in PB, S100B in BM demonstrated no prognostic value. The explanation for the unexpected high S100B in BM remains elusive... - Matrix metalloproteinases participate in osteosarcoma invasionKristin Bjørnland
Institute for Surgical Research, Rikshospitalet, 0027 Oslo, Norway
J Surg Res 127:151-6. 2005..Thus, the aim of the present study was to evaluate the involvement of MMPs in a panel of human OS cell lines, xenografts and biopsies...