Gunhild M Maelandsmo

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma
    Gunhild M Maelandsmo
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Clin Cancer Res 9:3383-8. 2003
  2. pmc Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaB
    Ida Grotterød
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    BMC Cancer 10:241. 2010
  3. ncbi Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines
    Trine Lillehammer
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Gene Med 9:440-51. 2007
  4. ncbi Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus
    Birgit Ø Engesaeter
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Health Enterprise, Montebello, N 0310 Oslo, Norway
    J Gene Med 8:707-18. 2006
  5. pmc Nuclear legumain activity in colorectal cancer
    Mads H Haugen
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 8:e52980. 2013
  6. ncbi Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines
    Birgit Ø Engesaeter
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Cancer Biol Ther 5:1511-20. 2006
  7. ncbi Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
    Anette Bonsted
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet HF, Montebello, N 0310 Oslo, Norway
    J Gene Med 8:286-97. 2006
  8. doi Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma
    Geir Frode Oy
    Department of Tumor Biology, Institute for Cancer Research, Oslo, Norway
    Int J Cancer 126:350-61. 2010
  9. ncbi Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma
    Kristin Andersen
    Department of Tumor Biology, Institute of Cancer Research, University of Oslo, Montebello, Norway
    Mod Pathol 17:990-7. 2004
  10. ncbi Photochemical internalization: a new tool for drug delivery
    Kristian Berg
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Curr Pharm Biotechnol 8:362-72. 2007

Collaborators

Detail Information

Publications36

  1. ncbi Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma
    Gunhild M Maelandsmo
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Clin Cancer Res 9:3383-8. 2003
    ....
  2. pmc Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaB
    Ida Grotterød
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway
    BMC Cancer 10:241. 2010
    ..The upstream signal transduction mechanisms leading to increased NF-kappaB activity are, however, incompletely characterized...
  3. ncbi Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines
    Trine Lillehammer
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    J Gene Med 9:440-51. 2007
    ..Full-length TRAIL, delivered from an adenoviral vector (Ad-hTRAIL), was studied in combination with DTIC or the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) in human melanoma cell lines...
  4. ncbi Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus
    Birgit Ø Engesaeter
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Health Enterprise, Montebello, N 0310 Oslo, Norway
    J Gene Med 8:707-18. 2006
    ..We have previously shown that PCI enhances transgene expression from AdhCMV-lacZ, and the aim of the present study was to further increase the understanding of photochemically mediated adenoviral transduction...
  5. pmc Nuclear legumain activity in colorectal cancer
    Mads H Haugen
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 8:e52980. 2013
    ..1. The discovery of nuclear localized legumain launches an entirely novel arena of legumain biology and functions in cancer...
  6. ncbi Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines
    Birgit Ø Engesaeter
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Cancer Biol Ther 5:1511-20. 2006
    ..The presented results indicate that photochemically mediated delivery of AdhCMV-TRAIL allows a selective enhancement in cell killing, and suggest that PCI may be relevant and advantageous for therapeutic gene delivery in vivo...
  7. ncbi Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
    Anette Bonsted
    Department of Radiation Biology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet HF, Montebello, N 0310 Oslo, Norway
    J Gene Med 8:286-97. 2006
    ..Biological and physical targeting techniques may be combined to redirect gene therapy vectors to specific cells and enhance gene transfer...
  8. doi Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma
    Geir Frode Oy
    Department of Tumor Biology, Institute for Cancer Research, Oslo, Norway
    Int J Cancer 126:350-61. 2010
    ..Development of resistance to the antiproliferative effects of IGFBP-3 may be an important step in progression of malignant melanomas...
  9. ncbi Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma
    Kristin Andersen
    Department of Tumor Biology, Institute of Cancer Research, University of Oslo, Montebello, Norway
    Mod Pathol 17:990-7. 2004
    ..We have also evaluated the relationship between the expression of these two antigens and cell cycle and signal transduction factors...
  10. ncbi Photochemical internalization: a new tool for drug delivery
    Kristian Berg
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Curr Pharm Biotechnol 8:362-72. 2007
    ....
  11. ncbi Expression of activated extracellular signal-regulated kinases 1/2 in malignant melanomas: relationship with clinical outcome
    Kjersti Jørgensen
    Department of Pathology, Institute for Cancer Research, The Norwegian Radium Hospital, HF, Montebello, Oslo, Norway
    Clin Cancer Res 9:5325-31. 2003
    ....
  12. ncbi Interferon-gamma-induced suppression of S100A4 transcription is mediated by the class II transactivator
    Kjetil Boye
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Tumour Biol 28:27-35. 2007
    ..Our data suggest a model where CIITA represses S100A4 transcription through sequestering of CBP/p300, thereby reducing the level of CBP/p300 at the S100A4 promoter, which in turn leads to inhibition of S100A4 transcription...
  13. ncbi Specific isolation of disseminated cancer cells: a new method permitting sensitive detection of target molecules of diagnostic and therapeutic value
    Siri Tveito
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310, Oslo, Norway
    Clin Exp Metastasis 24:317-27. 2007
    ..By use of the CellPick system it is possible to specifically isolate bead-rosetted or otherwise labelled target cells from a heterogeneous cell population for further molecular characterization...
  14. doi Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes
    Kjetil Boye
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
    Int J Cancer 123:1301-10. 2008
    ....
  15. doi Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties
    Ingrid J Bettum
    Department of Tumor Biology, Institute for Cancer Research, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway
    Cancer Lett 344:28-39. 2014
    ..Our data establishes S100A4 as an inducer of a cytokine network enabling tumor cells to engage angiogenic and inflammatory stromal cells, which might contribute to pro-metastatic activity of S100A4...
  16. doi Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models
    Anna Bergamaschi
    Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Mol Oncol 3:469-82. 2009
    ..These two new breast cancer xenografts represent useful preclinical tools for developing and testing of new therapies and improving our knowledge on breast cancer biology...
  17. pmc Cystatin E/M suppresses legumain activity and invasion of human melanoma
    Jon J Briggs
    Department of Tumor Biology, Institute for Cancer Research, Radiumhospitalet, Oslo University Hospital, Oslo, Norway
    BMC Cancer 10:17. 2010
    ..Although cystatin E/M is normally expressed in the skin, its role in cysteine protease regulation and progression of malignant melanoma has not been studied...
  18. ncbi Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo -- use of the human tyrosinase promoter with human enhancers
    Trine Lillehammer
    Department of Tumor Biology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Cancer Gene Ther 12:864-72. 2005
    ....
  19. pmc A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth
    Merete Thune Wiiger
    Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    Cancer Immunol Immunother 59:1665-74. 2010
    ....
  20. pmc S100A4 and metastasis: a small actor playing many roles
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Am J Pathol 176:528-35. 2010
    ..In this review, we summarize the evidence connecting S100A4 and cancer metastasis and discuss the mechanisms by which S100A4 promotes tumor progression...
  21. ncbi Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice
    Kjersti Flatmark
    Department of Tumor Biology and Institute for Cancer Research, The Norwegian Radium Hospital, Oslo 0310, Norway
    Eur J Cancer 40:1593-8. 2004
    ..The study provides useful background information on the 12 colorectal cancer cell lines in a clinically relevant orthotopic tumour model...
  22. ncbi Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases
    Anne Hansen Ree
    Department of Tumor Biology, The Norwegian Radium Hospital, Oslo
    Anticancer Res 22:1949-57. 2002
    ..The observations in this study strengthen the assumption that com1 may be involved in the tumor cell response to regulatory signals upon metastasis formation...
  23. ncbi Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum
    Kjersti Flatmark
    Department of Tumor Biology and Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway
    Tumour Biol 25:31-40. 2004
    ..The antibodies and the IFMA may still be useful for research purposes...
  24. ncbi Nuclear localization of the metastasis-related protein S100A4 correlates with tumour stage in colorectal cancer
    Kjersti Flatmark
    Department of Tumor Biology and Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    J Pathol 200:589-95. 2003
    ..The nuclear localization of S100A4 in colorectal cancer and its relationship to tumour stage suggest that this protein may be involved in gene regulatory pathways of relevance to the metastatic phenotype of cancer cells...
  25. ncbi Human osteosarcoma xenografts and their sensitivity to chemotherapy
    Skjalg Bruheim
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, 0310, Norway
    Pathol Oncol Res 10:133-41. 2004
    ..01), whereas the expression of MRP1 and cisplatin growth inhibition was positively correlated (r=0.82; p<0.005). This panel of xenografts should constitute a good tool for pharmacological and molecular studies in osteosarcoma...
  26. ncbi PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles
    Birgit Ø Engesaeter
    Department of Tumor Biology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Cancer Gene Ther 12:439-48. 2005
    ..In summary, the data presented imply that adenoviral receptor binding is important and clathrin-mediated endocytosis is the predominant uptake mechanism for adenoviral particles in photochemically treated cells...
  27. ncbi Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
    Leonardo A Meza-Zepeda
    Department of Tumour Biology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
    Oncogene 21:2261-9. 2002
    ..Quite likely, the different genes may give selective advantages to different subsets of tumours...
  28. ncbi Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation
    Jørn Henriksen
    Department of Tumour Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Oncogene 22:5358-61. 2003
    ..The results suggest that inactivation of otherwise intact TP53 by aberrations in the proteasome pathway may contribute to the characteristic aneuploidy observed in OS...
  29. ncbi Use of a murine secreted alkaline phosphatase as a non-immunogenic reporter gene in mice
    Gunhild M Maelandsmo
    Department of Tumor Biology, Norwegian Radium Hospital, 0310 Oslo, Norway
    J Gene Med 7:307-15. 2005
    ..However, evaluation of vector efficacy can be compromised by immune responses directed against immunogenic reporter proteins...
  30. doi S100B in bone marrow aspirates in healthy individuals and malignant melanoma patients
    Ragnar S Faye
    Department of aTumor Biology, Rikshospitalet Medical Centre fMedical Faculty, University of Oslo, Oslo, Norway
    Melanoma Res 18:134-40. 2008
    ..Unlike S100B in PB, S100B in BM demonstrated no prognostic value. The explanation for the unexpected high S100B in BM remains elusive...
  31. ncbi Matrix metalloproteinases participate in osteosarcoma invasion
    Kristin Bjørnland
    Institute for Surgical Research, Rikshospitalet, 0027 Oslo, Norway
    J Surg Res 127:151-6. 2005
    ..Thus, the aim of the present study was to evaluate the involvement of MMPs in a panel of human OS cell lines, xenografts and biopsies...
  32. ncbi Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcome
    Vivi Ann Flørenes
    Department of Pathology, Norwegian Radium Hospital, HF, Montebello, Oslo
    Am J Clin Pathol 122:412-20. 2004
    ..006) and between nuclear p-TrkA and cytoplasmic E-cadherin (P = .022) was seen. We present the first evidence of a role for TrkA activation in a subset of melanomas as a predictor of an aggressive phenotype and poor outcome...
  33. pmc Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo
    Daniel A Muruve
    Faculty of Medicine, University of Calgary, 3330 Hospital Dr N W, Calgary, AB, T2N 4N1 Canada
    J Virol 78:5966-72. 2004
    ..These results demonstrate that HD-Ad vectors induce intact innate but attenuated adaptive immune responses in vivo...
  34. ncbi Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer
    Teresa Cabezon
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 121:1433-44. 2007
    ..Using a specific ELISA test, we detected a significant higher concentration of S100A4 in the tumor interstitial fluid (TIF) as compared to their corresponding normal counterparts (NIF)...
  35. ncbi Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner
    Thrina Loennechen
    Department of Pharmacology, Institute of Pharmacy, University of Tromsø, 9037 Tromsø, Norway
    Biochem Pharmacol 66:2341-53. 2003
    ..It can be concluded that colchicine modulates the expression of MT1-MMP and TIMP-2 and hence the activation of proMMP-2 independently of the S100A4 level in osteosarcoma cells...
  36. ncbi S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells
    Berit Mathisen
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Clin Exp Metastasis 20:701-11. 2003
    ..Thus, one of the mechanisms by which S100A4 may exert its effect on metastasis of some tumors is by regulating the MMP-2 activity...