Affiliation: University of Oslo
- Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressionsSiri Leknes
Department of Psychology, University of Oslo, Postboks 1094, Blindern 0317, Oslo, Norway
Soc Cogn Affect Neurosci 8:741-9. 2013..Since pupil dilation can be associated with increased attractiveness and approach behaviour, this effect could also represent a mechanism by which oxytocin increases human affiliation. ..
- The importance of context: when relative relief renders pain pleasantSiri Leknes
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences Nuffield Division of Anaesthetics, University of Oxford, Oxford, UK
Pain 154:402-10. 2013..The findings of this study point to a role for brainstem and reward circuitry in a context-induced "hedonic flip" of pain...
- Pain relief as an opponent process: a psychophysical investigationSiri Leknes
Oxford Centre for Functional MRI of the Brain, Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Oxford, UK
Eur J Neurosci 28:794-801. 2008..Importantly, the high relief pleasantness ratings confirmed the hypothesized link between relief and reward...
- Relief as a reward: hedonic and neural responses to safety from painSiri Leknes
Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, Oxford, Oxfordshire, United Kingdom
PLoS ONE 6:e17870. 2011..In conclusion, relief differs from appetitive rewards due to its reliance on negative expectations, the violation of which is reflected in relief-related accumbens activation...
- Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantnessChantal Berna
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
Biol Psychiatry 67:1083-90. 2010..We hypothesized that dysregulation of the neural circuitry underlying emotion regulation is the mechanism whereby pain processing is affected during depressed mood...
- Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjectsVishvarani Wanigasekera
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 109:17705-10. 2012..These results support the notion of future imaging-based subject-stratification paradigms that can guide therapeutic decisions...
- A common neurobiology for pain and pleasureSiri Leknes
Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Nat Rev Neurosci 9:314-20. 2008..Understanding the mutually inhibitory effects that pain and reward processing have on each other, and the neural mechanisms that underpin such modulation, is important for alleviating unnecessary suffering and improving well-being...