Kurt Kristiansen

Summary

Affiliation: University of Troms
Country: Norway

Publications

  1. ncbi request reprint Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function
    Kurt Kristiansen
    Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Pharmacol Ther 103:21-80. 2004
  2. ncbi request reprint Putative drug binding conformations of monoamine transporters
    Aina Westrheim Ravna
    Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Bioorg Med Chem 14:666-75. 2006
  3. ncbi request reprint Bioinformatics: from genome to drug targets
    Svein G Dahl
    Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    Ann Med 34:306-12. 2002
  4. ncbi request reprint Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins
    Trond Lamark
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 278:34568-81. 2003
  5. pmc The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions
    Jack Ansgar Bruun
    Biochemistry Department, Institute of Medical Biology, University of Tromsø 9037 Tromsø, Norway
    Nucleic Acids Res 33:2661-75. 2005
  6. pmc tGRAP, the G-protein coupled receptors mutant database
    Oyvind Edvardsen
    Department of Pharmacology, Institute of Pharmacy, Breivika, University of Tromsø, N 9037 Tromsø, Norway
    Nucleic Acids Res 30:361-3. 2002
  7. ncbi request reprint Molecular biology of serotonin receptors structure and function at the molecular level
    Wesley K Kroeze
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Top Med Chem 2:507-28. 2002
  8. ncbi request reprint Gene conversion as a source of nucleotide diversity in Plasmodium falciparum
    Kaare M Nielsen
    Department of Organismic and Evolutionary Biology, Harvard University, USA
    Mol Biol Evol 20:726-34. 2003
  9. ncbi request reprint Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6
    David A Shapiro
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:11441-9. 2002
  10. ncbi request reprint Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors
    Joachim D Paasche
    MSD Cardiovascular Research Center and Institute for Surgical Research, Rikshospitalet University Hospital, University of Oslo, Norway
    Mol Pharmacol 67:1581-90. 2005

Collaborators

  • Espen Michaelsen
  • Aina Westrheim Ravna
  • S G Dahl
  • Bryan Roth
  • M P Oksvold
  • M W Beukers
  • Wesley K Kroeze
  • Jack Ansgar Bruun
  • Joachim D Paasche
  • Geir Bjørkøy
  • Terje Johansen
  • Trond Lamark
  • Kaare M Nielsen
  • David A Shapiro
  • Oyvind Edvardsen
  • Henrik S Huitfeldt
  • Garth Tylden
  • Havard Attramadal
  • Ernst Ivan Simon Thomassen
  • Heidi K Johansen
  • Toril Attramadal
  • Ingvild Mikkola
  • Turid Holm
  • Dyann F Wirth
  • Daniel L Hartl
  • Jacob Kasper
  • Maria Perander
  • Mehee Choi
  • Elena R Lozovsky
  • Sarah K Volkman
  • Trevor Bedford
  • Aud Øvervatn
  • Heidi Outzen
  • David M Weiner
  • Anne Lise Reiersen

Detail Information

Publications10

  1. ncbi request reprint Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function
    Kurt Kristiansen
    Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Pharmacol Ther 103:21-80. 2004
    ..Constitutively activating mutations or agonist binding disrupts such constraining interactions leading to receptor conformations that associates with and activate G-proteins...
  2. ncbi request reprint Putative drug binding conformations of monoamine transporters
    Aina Westrheim Ravna
    Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Bioorg Med Chem 14:666-75. 2006
    ..An unconserved amino acid, Asp499 in TMH10 in NET, may contribute to the low affinity of S-citalopram to NET...
  3. ncbi request reprint Bioinformatics: from genome to drug targets
    Svein G Dahl
    Department of Pharmacology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    Ann Med 34:306-12. 2002
    ..Such studies have provided new insight into the detailed molecular mechanisms of two important classes of membrane proteins, which may be of value in the discovery and development of new pharmaceuticals...
  4. ncbi request reprint Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins
    Trond Lamark
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 278:34568-81. 2003
    ..An interaction between the cell polarity scaffold protein Par6 and MEK5 was found. Furthermore, p62 interacts both with MEK5 and NBR1 in addition to the aPKCs. Evidence for involvement of p62 in MEK5-ERK5 signaling is presented...
  5. pmc The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions
    Jack Ansgar Bruun
    Biochemistry Department, Institute of Medical Biology, University of Tromsø 9037 Tromsø, Norway
    Nucleic Acids Res 33:2661-75. 2005
    ..These findings suggest a critical role for the recognition helix and N-terminal arm of the paired class homeodomain in protein-protein interactions...
  6. pmc tGRAP, the G-protein coupled receptors mutant database
    Oyvind Edvardsen
    Department of Pharmacology, Institute of Pharmacy, Breivika, University of Tromsø, N 9037 Tromsø, Norway
    Nucleic Acids Res 30:361-3. 2002
    ..Moreover, this tool allows the construction of tailor-made sequence alignment views from any combination of receptors belonging to the same class. The database is available at http://tGRAP.uit.no/...
  7. ncbi request reprint Molecular biology of serotonin receptors structure and function at the molecular level
    Wesley K Kroeze
    Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Top Med Chem 2:507-28. 2002
    ..Finally, examples will be given to demonstrate that a detailed knowledge of the predicted structure of one receptor can be useful for structure-based drug design...
  8. ncbi request reprint Gene conversion as a source of nucleotide diversity in Plasmodium falciparum
    Kaare M Nielsen
    Department of Organismic and Evolutionary Biology, Harvard University, USA
    Mol Biol Evol 20:726-34. 2003
    ..The 5' and 3' flanking regions differ in 47.7% and 39.8% of the nucleotide sites, respectively. Hence synonymous sites and flanking regions are not conserved in sequence in spite of their high AT content and T skew...
  9. ncbi request reprint Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6
    David A Shapiro
    Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:11441-9. 2002
    ..L. Roth and D. A. Shapiro (2001) Expert Opin. Ther. Targets 5, 685-695) and others, that this may represent a general mechanism of activation for many, but not all, G-protein-coupled receptors...
  10. ncbi request reprint Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors
    Joachim D Paasche
    MSD Cardiovascular Research Center and Institute for Surgical Research, Rikshospitalet University Hospital, University of Oslo, Norway
    Mol Pharmacol 67:1581-90. 2005
    ..In conclusion, recycling of ET(A) receptor is mediated by a motif with the structural characteristics of an internal PDZ ligand. This structural motif may represent a more general principle of endocytic sorting of GPCRs...