Eili Tranheim Kase
Affiliation: University of Oslo
Tranheim Kase E, NikoliÄ‡ N, Pettersen Hessvik N, Fjeldheim A, Jensen J, Thoresen G, et al
. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. 2012;47:483-93 pubmed publisher
..In conclusion, 22SHC seems to be an interesting model substance in the search of treatments for disorders involving aberrations in lipid metabolism. ..
Kase E, Nikolić N, Bakke S, Bogen K, Aas V, Thoresen G, et al
. Remodeling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells. PLoS ONE. 2013;8:e59972 pubmed publisher
..Thus, galactose improved glucose metabolism and metabolic switching of myotubes, representing a cell model that may be valuable for metabolic studies related to insulin resistance and disorders involving mitochondrial impairments. ..
Kase E, Feng Y, Badin P, Bakke S, Laurens C, Coué M, et al
. Primary defects in lipolysis and insulin action in skeletal muscle cells from type 2 diabetic individuals. Biochim Biophys Acta. 2015;1851:1194-201 pubmed publisher
..Despite reductions in intramyocellular lipolysis and HSL expression, overexpression of HSL did not rescue defects in insulin action in skeletal myotubes from obese T2D subjects. ..
Ho G, Kase E, Wangensteen H, Barsett H. Effect of Phenolic Compounds from Elderflowers on Glucose- and Fatty Acid Uptake in Human Myotubes and HepG2-Cells. Molecules. 2017;22: pubmed publisher
..Elderflower might therefore be valuable as a functional food against diabetes. ..
Astrand O, Viktorsson E, Kristensen A, Ekeberg D, Røberg Larsen H, Wilson S, et al
. Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors. J Steroid Biochem Mol Biol. 2017;165:323-330 pubmed publisher
..However, the blood plasma analysis from the in vivo tests revealed a concentration lower than needed to give any response, indicating either rapid metabolism or low bioavailability. ..
Ho G, Nguyen T, Kase E, Tadesse M, Barsett H, Wangensteen H. Enhanced Glucose Uptake in Human Liver Cells and Inhibition of Carbohydrate Hydrolyzing Enzymes by Nordic Berry Extracts. Molecules. 2017;22: pubmed publisher
..These results increase the value of these berries as a component of a healthy Nordic diet and have a potential benefit against diabetes. ..