Tom-H Karlsen

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. doi request reprint Gallbladder polyps in primary sclerosing cholangitis: not so benign
    Tom H Karlsen
    Medical Department, Rikshospitalet University Hospital, Oslo, Norway
    Curr Opin Gastroenterol 24:395-9. 2008
  2. doi request reprint The utility of genome-wide association studies in hepatology
    Tom H Karlsen
    Medical Department, Oslo University Hospital, Norwegian Primary Sclerosing Cholangitis Research Center, Rikshospitalet, Oslo, Norway
    Hepatology 51:1833-42. 2010
  3. doi request reprint Primary sclerosing cholangitis
    Tom H Karlsen
    Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
    Best Pract Res Clin Gastroenterol 24:655-66. 2010
  4. pmc SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
    Kristian Holm
    Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Norway
    BMC Bioinformatics 11:600. 2010
  5. doi request reprint Genome-wide association analysis in primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet University Hospital and University of Oslo, 0027 Oslo, Norway
    Gastroenterology 138:1102-11. 2010
  6. ncbi request reprint Genetic epidemiology of primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
    World J Gastroenterol 13:5421-31. 2007
  7. ncbi request reprint Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    J Hepatol 46:899-906. 2007
  8. ncbi request reprint Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis
    T H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Genes Immun 8:275-8. 2007
  9. ncbi request reprint Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Gastroenterology 131:781-7. 2006
  10. doi request reprint Genetics of cholestatic liver disease in 2010
    Tom H Karlsen
    Norwegian PSC Research Center, Medical Department, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Curr Opin Gastroenterol 26:251-8. 2010

Detail Information

Publications25

  1. doi request reprint Gallbladder polyps in primary sclerosing cholangitis: not so benign
    Tom H Karlsen
    Medical Department, Rikshospitalet University Hospital, Oslo, Norway
    Curr Opin Gastroenterol 24:395-9. 2008
    ..The present review aims to summarize existing knowledge on this topic...
  2. doi request reprint The utility of genome-wide association studies in hepatology
    Tom H Karlsen
    Medical Department, Oslo University Hospital, Norwegian Primary Sclerosing Cholangitis Research Center, Rikshospitalet, Oslo, Norway
    Hepatology 51:1833-42. 2010
    ..By reviewing the GWAS performed in hepatology so far on this broader background, extensions and guidelines for the rational application of the study design in hepatology are proposed...
  3. doi request reprint Primary sclerosing cholangitis
    Tom H Karlsen
    Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway
    Best Pract Res Clin Gastroenterol 24:655-66. 2010
    ..In the present review, we aim to summarise the present knowledge of PSC with a particular emphasis on the possible basis of disease variability...
  4. pmc SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
    Kristian Holm
    Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Norway
    BMC Bioinformatics 11:600. 2010
    ....
  5. doi request reprint Genome-wide association analysis in primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet University Hospital and University of Oslo, 0027 Oslo, Norway
    Gastroenterology 138:1102-11. 2010
    ..We aimed to characterize the genetic susceptibility to primary sclerosing cholangitis (PSC) by means of a genome-wide association analysis of single nucleotide polymorphism (SNP) markers...
  6. ncbi request reprint Genetic epidemiology of primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
    World J Gastroenterol 13:5421-31. 2007
    ..This review summarises present knowledge on the genetic susceptibility to PSC, as well as genetic associations with disease progression and clinical subsets of particular interest (inflammatory bowel disease and cholangiocarcinoma)...
  7. ncbi request reprint Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    J Hepatol 46:899-906. 2007
    ..We aimed to clarify to what extent such combinations influence susceptibility to primary sclerosing cholangitis (PSC)...
  8. ncbi request reprint Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis
    T H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Genes Immun 8:275-8. 2007
    ..This suggests different HLA associated genetic susceptibility to PSC and UC, and supports notions that UC in PSC may represent a distinct UC phenotype...
  9. ncbi request reprint Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Gastroenterology 131:781-7. 2006
    ..Ursodeoxycholic acid and rifampicin are known ligands. We investigated whether functional polymorphisms of the SXR gene influence disease susceptibility or disease progression in patients with primary sclerosing cholangitis (PSC)...
  10. doi request reprint Genetics of cholestatic liver disease in 2010
    Tom H Karlsen
    Norwegian PSC Research Center, Medical Department, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Curr Opin Gastroenterol 26:251-8. 2010
    ..Many of the cholestatic diseases show similar clinical features, despite underlying differences in the genetic etiology. The present review aims to present recent insight into this etiological heterogeneity...
  11. ncbi request reprint Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis
    Tom H Karlsen
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Am J Gastroenterol 102:115-21. 2007
    ..The pathogenetic link between PSC and IBD is unknown. We aimed to assess whether genetic risk factors in PSC can be identified on the basis of known IBD susceptibility genes and the shared PSC-IBD phenotype...
  12. doi request reprint Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C
    Johannes R Hov
    Department of Medicine and Research Institute for Internal Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    J Hepatol 52:712-7. 2010
    ..We aimed to exploit genetic differences between Northern Europe and Italy in an attempt to define a causative locus in this genetic region...
  13. ncbi request reprint Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
    Espen Melum
    Medical Department, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Hepatology 47:90-6. 2008
    ..Patients who are homozygous for the nonrisk alleles are unlikely to develop CCA; this finding could be helpful in identifying PSC patients with a low CCA risk...
  14. pmc Genome-wide association studies--a summary for the clinical gastroenterologist
    Espen Melum
    Medical Department, Rikshospitalet, Oslo University Hospital, N 0027 Oslo, Norway
    World J Gastroenterol 15:5377-96. 2009
    ..For each of the relevant conditions, findings from the various GWAS are summarized with a focus on the affected biological systems...
  15. doi request reprint Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Faculty Division Ulleval, Oslo University Hospital, University of Oslo, Oslo, Norway
    Ann Neurol 65:658-66. 2009
    ..We investigated the HLA class I alleles defined by their KIR binding motifs and the KIR genes to evaluate whether these genes could influence MS susceptibility or severity, alone or in combination...
  16. pmc Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
    Monika Forsbring
    Institute of Medical Microbiology, Rikshospitalet University Hospital HF and Centre for Molecular Biology and Neuroscience, University of Oslo, Oslo, Norway
    Carcinogenesis 30:1147-54. 2009
    ..Our findings demonstrate the importance of complete resequencing of selected candidate genes in order to identify rare genetic variants and their possible contribution to individual susceptibility to cancer development...
  17. doi request reprint Association to the Glypican-5 gene in multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Oslo University Hospital, Ulleval, University of Oslo, Oslo, Norway
    J Neuroimmunol 226:194-7. 2010
    ..006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene...
  18. doi request reprint Update on primary sclerosing cholangitis
    Tom H Karlsen
    Norwegian PSC Research Center, Medical Department, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Dig Liver Dis 42:390-400. 2010
    ....
  19. doi request reprint [Liver transplantation in Norway through 25 years]
    Tim Scholz
    Seksjon for transplantasjonskirurgi, Kirurgisk klinikk, Oslo universitetssykehus, Rikshospitalet, 0027 Oslo, Norway
    Tidsskr Nor Laegeforen 129:2587-92. 2009
    ..In Norway, liver transplantation has been the treatment of choice for irreversible acute and chronic liver failure for 25 years. The aim of this article is to present a summary of the results obtained...
  20. pmc Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
    Johannes R Hov
    Norwegian PSC Research Center, Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
    PLoS ONE 5:e12403. 2010
    ..We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants...
  21. ncbi request reprint Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis
    Christopher L Bowlus
    Division of Gastroenterology, University of California Davis Medical Center, 4150 V Street, PSSB3500, Sacramento, CA 95817, USA
    J Hepatol 45:704-10. 2006
    ..The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia...
  22. doi request reprint An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis
    Espen Melum
    Am J Gastroenterol 103:1045; author reply 1045-6. 2008
  23. doi request reprint Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
    Espen Melum
    Int J Cancer 123:241-2. 2008
  24. doi request reprint Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
    Andre Franke
    Institute for Clinical Molecular Biology, Christian Albrechts University, D 24105 Kiel, Germany
    Nat Genet 40:713-5. 2008
    ..Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection...
  25. pmc Use of and attitudes to a hospital information system by medical secretaries, nurses and physicians deprived of the paper-based medical record: a case report
    Hallvard Laerum
    INM, Faculty of Medicine, NTNU, Trondheim, Norway
    BMC Med Inform Decis Mak 4:18. 2004
    ..To evaluate the HIS comprehensively, the perspectives of medical secretaries and nurses are described as well as that of physicians...