Håvard Jenssen

Summary

Affiliation: University Hospital of North Norway
Country: Norway

Publications

  1. ncbi request reprint Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, 9038, Tromsø, Norway
    Antiviral Res 61:101-9. 2004
  2. ncbi request reprint Modelling of anti-HSV activity of lactoferricin analogues using amino acid descriptors
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
    J Pept Sci 11:97-103. 2005
  3. ncbi request reprint Prediction of activity, synthesis and biological testing of anti-HSV active peptides
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, Tromsø, N 9038, Norway
    Chem Biol Drug Des 68:58-66. 2006
  4. ncbi request reprint A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
    Antiviral Res 64:119-26. 2004
  5. ncbi request reprint Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface
    Jeanette H Andersen
    Department of Medical Microbiology, University Hospital of North Norway, Tromsø, Norway
    J Med Virol 74:262-71. 2004
  6. doi request reprint Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
    Antiviral Res 79:192-8. 2008
  7. ncbi request reprint Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir
    Jeanette Hammer Andersen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038, Tromsø, Norway
    Antiviral Res 58:209-15. 2003
  8. ncbi request reprint Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus
    Orjan Samuelsen
    Department of Medical Microbiology, University Hospital of North Norway, P O Box 56, N 9038 Tromsø, Norway
    FEBS Lett 579:3421-6. 2005

Detail Information

Publications8

  1. ncbi request reprint Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, 9038, Tromsø, Norway
    Antiviral Res 61:101-9. 2004
    ..Structural parameters such as hydrophobicity, molecular size, spatial distribution of charged and lipophilic amino acids, and the cyclic structure of Lfcin also seem to be important factors to govern antiviral activity against HSV...
  2. ncbi request reprint Modelling of anti-HSV activity of lactoferricin analogues using amino acid descriptors
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
    J Pept Sci 11:97-103. 2005
    ..In this study it is shown that theoretically derived amino acid descriptors can be used to model the anti-viral activity of peptides, as well as other peptide properties, even more accurately...
  3. ncbi request reprint Prediction of activity, synthesis and biological testing of anti-HSV active peptides
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, Tromsø, N 9038, Norway
    Chem Biol Drug Des 68:58-66. 2006
    ..This may reflect differences in mode of action of peptides depending on the amino acid content...
  4. ncbi request reprint A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
    Antiviral Res 64:119-26. 2004
    ..The two most potent antiviral peptides exhibited synergy with acyclovir against HSV...
  5. ncbi request reprint Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface
    Jeanette H Andersen
    Department of Medical Microbiology, University Hospital of North Norway, Tromsø, Norway
    J Med Virol 74:262-71. 2004
    ..Both LF and Lfcin were dependent on the presence of heparan sulphate at the cell surface to exert their antiviral activity...
  6. doi request reprint Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin
    Håvard Jenssen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038 Tromsø, Norway
    Antiviral Res 79:192-8. 2008
    ..In contrast, the cellular localization of iron-saturated (holo)-Lf appeared to differ from that of apo-Lf, indicating that holo- and apo-Lf may exhibit different antiviral mechanisms...
  7. ncbi request reprint Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir
    Jeanette Hammer Andersen
    Department of Medical Microbiology, University Hospital of North Norway, N 9038, Tromsø, Norway
    Antiviral Res 58:209-15. 2003
    ..The 50% effective concentration (EC(50)) for ACV and LF or Lfcin, when combined with ACV, could be reduced by two- to sevenfold compared to the EC(50) when the drugs were used alone...
  8. ncbi request reprint Induced resistance to the antimicrobial peptide lactoferricin B in Staphylococcus aureus
    Orjan Samuelsen
    Department of Medical Microbiology, University Hospital of North Norway, P O Box 56, N 9038 Tromsø, Norway
    FEBS Lett 579:3421-6. 2005
    ..In conclusion, this study shows that S. aureus has intrinsic resistance mechanisms against antimicrobial peptides that can be induced upon exposure, and that this may confer low-level cross-resistance to other antimicrobial peptides...