Are Martin Holm

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Occurrence and clinical presentation of systemic pneumococcal infections in an unselected population in Oslo, Norway, between 1993 and 1997
    A M Holm
    Department of Medicine, Aker University Hospital, 0514 Oslo, Norway
    Eur J Clin Microbiol Infect Dis 21:465-7. 2002
  2. ncbi request reprint Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I
    Are Martin Holm
    Research Institute for Internal Medicine, National Hospital, Oslo, Norway
    J Immunol 170:5772-7. 2003
  3. pmc Polyclonal expansion of large granular lymphocytes in common variable immunodeficiency - association with neutropenia
    A M Holm
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Research Institute for Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway
    Clin Exp Immunol 144:418-24. 2006
  4. pmc Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7(-) effector-memory T cells
    A M Holm
    Section for Clinical Immunology and Infectious Diseases, Medical Department, The National Hospital, Oslo, Norway
    Clin Exp Immunol 138:278-89. 2004
  5. ncbi request reprint Abnormal interleukin-7 function in common variable immunodeficiency
    Are Martin Holm
    Section of Clinical Immunology and Infectious Diseases, Medical Center, Oslo, Norway
    Blood 105:2887-90. 2005
  6. doi request reprint Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors
    Stina Gregersen
    University of Oslo, Department of Respiratory Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Ann Allergy Asthma Immunol 104:503-10. 2010
  7. pmc Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in vivo
    B Fevang
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Clin Exp Immunol 147:521-5. 2007
  8. pmc Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences
    L Heggelund
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet University Hospital, Univerity of Oslo, Oslo, Norway
    Clin Exp Immunol 138:116-21. 2004
  9. pmc Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation
    B Fevang
    Research Institute for Internal Medicine, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
    Clin Exp Immunol 158:237-45. 2009
  10. pmc Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis
    B Fevang
    Research Institute for Internal Medicine, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Clin Exp Immunol 142:576-84. 2005

Detail Information

Publications10

  1. ncbi request reprint Occurrence and clinical presentation of systemic pneumococcal infections in an unselected population in Oslo, Norway, between 1993 and 1997
    A M Holm
    Department of Medicine, Aker University Hospital, 0514 Oslo, Norway
    Eur J Clin Microbiol Infect Dis 21:465-7. 2002
    ..This study emphasizes the importance of continuing efforts to prevent systemic pneumococcal infections...
  2. ncbi request reprint Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I
    Are Martin Holm
    Research Institute for Internal Medicine, National Hospital, Oslo, Norway
    J Immunol 170:5772-7. 2003
    ..The involvement of the cAMP/PKAI system in this defect suggests a novel target for therapeutic immunomodulation in CVID...
  3. pmc Polyclonal expansion of large granular lymphocytes in common variable immunodeficiency - association with neutropenia
    A M Holm
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Research Institute for Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway
    Clin Exp Immunol 144:418-24. 2006
    ..Furthermore, our findings suggest common pathogenic mechanisms of granulocytopenia in CVID and lymphoproliferative disease of granular lymphocytes...
  4. pmc Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7(-) effector-memory T cells
    A M Holm
    Section for Clinical Immunology and Infectious Diseases, Medical Department, The National Hospital, Oslo, Norway
    Clin Exp Immunol 138:278-89. 2004
    ..Our observations indicate that a predominance of CCR7(-) T cells with effector-memory cell features and with reduced proliferative capacity may characterize a subgroup of CVID...
  5. ncbi request reprint Abnormal interleukin-7 function in common variable immunodeficiency
    Are Martin Holm
    Section of Clinical Immunology and Infectious Diseases, Medical Center, Oslo, Norway
    Blood 105:2887-90. 2005
    ..These findings suggest novel pathogenic mechanisms and specific targets for further research in CVID...
  6. doi request reprint Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors
    Stina Gregersen
    University of Oslo, Department of Respiratory Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Ann Allergy Asthma Immunol 104:503-10. 2010
    ..It is unclear to what extent IgG replacement treatment prevents further pulmonary damage and how factors beside infections may contribute to progression of disease...
  7. pmc Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in vivo
    B Fevang
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Clin Exp Immunol 147:521-5. 2007
    ..Decreased proportions of TReg are suggested to be pathogenetically important in autoimmunity, and our results suggest that TReg may have a similar role in CVID...
  8. pmc Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences
    L Heggelund
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet University Hospital, Univerity of Oslo, Oslo, Norway
    Clin Exp Immunol 138:116-21. 2004
    ..While increased levels of beta-chemokines possibly have antiviral effects, TLR2 stimulation may also promote a chemokine-driven inflammatory loop, potentially contributing to the immunopathogenesis of HIV infection...
  9. pmc Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation
    B Fevang
    Research Institute for Internal Medicine, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
    Clin Exp Immunol 158:237-45. 2009
    ..Because CCR7, CCL19 and CCL21 are key mediators balancing immunity and tolerance in the immune system, the abnormalities of these mediators might contribute to the profound immune dysregulation seen in CVID...
  10. pmc Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis
    B Fevang
    Research Institute for Internal Medicine, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Clin Exp Immunol 142:576-84. 2005
    ..Our findings suggest that mannose-binding lectin and the lectin complement pathway may protect against lower respiratory tract infection and bronhiectasis in patients with common variable immunodeficiency...