Are Martin Holm
Affiliation: University of Oslo
- Occurrence and clinical presentation of systemic pneumococcal infections in an unselected population in Oslo, Norway, between 1993 and 1997A M Holm
Department of Medicine, Aker University Hospital, 0514 Oslo, Norway
Eur J Clin Microbiol Infect Dis 21:465-7. 2002..This study emphasizes the importance of continuing efforts to prevent systemic pneumococcal infections...
- Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type IAre Martin Holm
Research Institute for Internal Medicine, National Hospital, Oslo, Norway
J Immunol 170:5772-7. 2003..The involvement of the cAMP/PKAI system in this defect suggests a novel target for therapeutic immunomodulation in CVID...
- Polyclonal expansion of large granular lymphocytes in common variable immunodeficiency - association with neutropeniaA M Holm
Section of Clinical Immunology and Infectious Diseases, Medical Department, Research Institute for Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway
Clin Exp Immunol 144:418-24. 2006..Furthermore, our findings suggest common pathogenic mechanisms of granulocytopenia in CVID and lymphoproliferative disease of granular lymphocytes...
- Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7(-) effector-memory T cellsA M Holm
Section for Clinical Immunology and Infectious Diseases, Medical Department, The National Hospital, Oslo, Norway
Clin Exp Immunol 138:278-89. 2004..Our observations indicate that a predominance of CCR7(-) T cells with effector-memory cell features and with reduced proliferative capacity may characterize a subgroup of CVID...
- Abnormal interleukin-7 function in common variable immunodeficiencyAre Martin Holm
Section of Clinical Immunology and Infectious Diseases, Medical Center, Oslo, Norway
Blood 105:2887-90. 2005..These findings suggest novel pathogenic mechanisms and specific targets for further research in CVID...
- Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factorsStina Gregersen
University of Oslo, Department of Respiratory Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
Ann Allergy Asthma Immunol 104:503-10. 2010..It is unclear to what extent IgG replacement treatment prevents further pulmonary damage and how factors beside infections may contribute to progression of disease...
- Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in vivoB Fevang
Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
Clin Exp Immunol 147:521-5. 2007..Decreased proportions of TReg are suggested to be pathogenetically important in autoimmunity, and our results suggest that TReg may have a similar role in CVID...
- Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequencesL Heggelund
Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet University Hospital, Univerity of Oslo, Oslo, Norway
Clin Exp Immunol 138:116-21. 2004..While increased levels of beta-chemokines possibly have antiviral effects, TLR2 stimulation may also promote a chemokine-driven inflammatory loop, potentially contributing to the immunopathogenesis of HIV infection...
- Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulationB Fevang
Research Institute for Internal Medicine, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
Clin Exp Immunol 158:237-45. 2009..Because CCR7, CCL19 and CCL21 are key mediators balancing immunity and tolerance in the immune system, the abnormalities of these mediators might contribute to the profound immune dysregulation seen in CVID...
- Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasisB Fevang
Research Institute for Internal Medicine, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
Clin Exp Immunol 142:576-84. 2005..Our findings suggest that mannose-binding lectin and the lectin complement pathway may protect against lower respiratory tract infection and bronhiectasis in patients with common variable immunodeficiency...