Karen B, Helle

Summary

Affiliation: University of Norway
Location: Bergen, Norway

Publications

  1. pmc Regulatory peptides from chromogranin A and secretogranin II
    Karen B Helle
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Cell Mol Neurobiol 30:1145-6. 2010
  2. ncbi Formate assay in body fluids: application in methanol poisoning
    A B Makar
    Biochem Med 13:117-26. 1975
  3. ncbi A clinical method for the determination of serum gamma-glutamyl transpeptidase
    H Tamaoki
    Clin Chim Acta 65:21-7. 1975
  4. ncbi Effects of graded infusions of monomethylmethacrylate on coagulation, blood lipids, respiration and circulation. An experimental study in dogs
    J Modig
    Clin Orthop Relat Res . 1975
  5. ncbi Immunotherapy for cancer: an overview
    J W Proctor
    Can J Surg 19:12-9. 1976
  6. ncbi Use of the latent image technique to develop and evaluate problem-solving skills
    M L Schwabbauer
    Am J Med Technol 41:457-62. 1975
  7. ncbi Review of drug treatment for Down's syndrome persons
    J B Share
    Am J Ment Defic 80:388-93. 1976
  8. doi The chromogranin A- derived N-terminal peptide vasostatin-I: In vivo effects on cardiovascular variables in the rabbit
    Silvestro Roatta
    Dept of Neurosciences, Physiology, Medical School, Torino, Italy
    Regul Pept 168:10-20. 2011
  9. pmc Human catestatin peptides differentially regulate infarct size in the ischemic-reperfused rat heart
    Bhawanjit K Brar
    Department of Medicine, UCSD, La Jolla, California, USA
    Regul Pept 165:63-70. 2010
  10. ncbi Specificity studies on alpha-mannosidases using oligosaccharides from mannosidosis urine as substrates
    B Hultberg
    Biochim Biophys Acta 410:156-63. 1975

Collaborators

  • Anne K Jonassen
  • Silvestro Roatta
  • DANIEL T O'CONNOR
  • T Sato
  • Angelo Corti
  • D R Phillips
  • B Tota
  • Sushil Mahata
  • Anna Blois
  • Maurizio Mandala
  • Bhawanjit K Brar
  • Daniela Belloni
  • Marie Hélène Metz-Boutigue
  • Guldborg Serck-Hanssen
  • Sandra Imbrogno
  • Per Gøran Krüger
  • P G Krüuger
  • Johan F Brekke
  • Kuixing Zhang
  • Erik Helgeland
  • Silvia Scabini
  • Maria Elena Ferrero
  • Alessio Giazzon
  • Barbara Colombo
  • Chiara Foglieni
  • Elisabetta Ferrero
  • Alessandro Fulgenzi
  • Lorenzo Veschini
  • Guglielmo Martino
  • Holm Holmsen
  • Boleslaw Srebro
  • Johan Fredrik Brekke
  • Tommaso Angelone
  • Cristina Adamo
  • George J Osol
  • A Schmoldt
  • M Ardenne
  • K Moroi
  • M L Schwabbauer
  • T R Anderson
  • T Galliard
  • B Hultberg
  • J W Proctor
  • Y W Chow
  • J B Share
  • W Barthel
  • R J Smith
  • A E Halaris
  • P D Mier
  • H Tamaoki
  • A B Makar
  • J Modig
  • P W Mansell
  • T R Tephly
  • G Waernbaum
  • H F Benthe
  • T A Slotkin
  • A Mukerji
  • S Takei
  • J A Matthew
  • M G Lewis
  • A Lundblad
  • R G Bryant
  • C Busch
  • M Palese
  • J J van den Hurk
  • F Markwardt
  • S Minato
  • P G Reitnauer
  • K Fujisawa
  • P A Ockerman
  • K E McMartin
  • K T Belendiuk
  • P K Masson
  • D X Freedman
  • R Pietranico
  • G Haberland

Detail Information

Publications35

  1. pmc Regulatory peptides from chromogranin A and secretogranin II
    Karen B Helle
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Cell Mol Neurobiol 30:1145-6. 2010
    ....
  2. ncbi Formate assay in body fluids: application in methanol poisoning
    A B Makar
    Biochem Med 13:117-26. 1975
  3. ncbi A clinical method for the determination of serum gamma-glutamyl transpeptidase
    H Tamaoki
    Clin Chim Acta 65:21-7. 1975
    ..Serum transpeptidase activity was assayed in 1080 healthy adults, the normal mean value being 14.8 mU/ml. The diagnostic evaluation of the enzyme in various hepatobiliary diseases is also discussed...
  4. ncbi Effects of graded infusions of monomethylmethacrylate on coagulation, blood lipids, respiration and circulation. An experimental study in dogs
    J Modig
    Clin Orthop Relat Res . 1975
    ..Monomethylmethacrylate in whole blood was associated with both blood cells and plasma...
  5. ncbi Immunotherapy for cancer: an overview
    J W Proctor
    Can J Surg 19:12-9. 1976
    ..Despite the lack of success in general, immunotherapy still appears to have a future as an adjunct to existing therapy in order to control as much as to cure residual tumour...
  6. ncbi Use of the latent image technique to develop and evaluate problem-solving skills
    M L Schwabbauer
    Am J Med Technol 41:457-62. 1975
    ..Target learner populations included medical technology students, physician assistant students, and pathology residents. Members of all three groups participated in the evaluation of the module and responded to its use in varied settings...
  7. ncbi Review of drug treatment for Down's syndrome persons
    J B Share
    Am J Ment Defic 80:388-93. 1976
    ..There have not been any drugs that have demonstrated remarkable improvement in the status of Down's syndrome individuals that have been widely accepted as effective...
  8. doi The chromogranin A- derived N-terminal peptide vasostatin-I: In vivo effects on cardiovascular variables in the rabbit
    Silvestro Roatta
    Dept of Neurosciences, Physiology, Medical School, Torino, Italy
    Regul Pept 168:10-20. 2011
    ..This initial vasoconstriction masked a persistent adrenoceptor-independent vasodilatation, consistent with previous reports from in vitro models...
  9. pmc Human catestatin peptides differentially regulate infarct size in the ischemic-reperfused rat heart
    Bhawanjit K Brar
    Department of Medicine, UCSD, La Jolla, California, USA
    Regul Pept 165:63-70. 2010
    ..3%) increased myocardial infarct size via a mechanism involving dephosphorylation of Akt and the two downstream targets during ischemic reperfusion in the isolated rat heart...
  10. ncbi Specificity studies on alpha-mannosidases using oligosaccharides from mannosidosis urine as substrates
    B Hultberg
    Biochim Biophys Acta 410:156-63. 1975
    ..Human alpha-mannosidase C, which has a neutral pH optimum when assayed with a synthetic substrate, did not hydrolyse any of the oligosaccharides at neutral pH, but was found to be active at an acidic pH...
  11. ncbi Enzymic reactions of fatty acid hydroperoxides in extracts of potato tuber. II. Conversion of 9- and 13-hydroperoxy-octadecadienoic acids to monohydroxydienoic acid, epoxyhydroxy- and trihydroxymonoenoic acid derivatives
    T Galliard
    Biochim Biophys Acta 409:157-71. 1975
    ..6. This system is compared with the 9-hydroperoxide-specific enzymic formation of divinyl ether derivatives by potato extracts...
  12. ncbi Lysosomal hydrolases of the epidermis. I. Glycosidases
    P D Mier
    Br J Dermatol 93:1-10. 1975
    ....
  13. ncbi Studies of oxygen binding energy to hemoglobin molecule
    Y W Chow
    Biochem Biophys Res Commun 66:1424-31. 1975
  14. ncbi Metal substitutions incarbonic anhydrase: a halide ion probe study
    R J Smith
    Biochem Biophys Res Commun 66:1281-6. 1975
  15. ncbi Maturation of the adrenal medulla--IV. Effects of morphine
    T R Anderson
    Biochem Pharmacol 24:1469-74. 1975
  16. ncbi Comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase
    K Moroi
    Biochem Pharmacol 24:1517-21. 1975
  17. ncbi Digitoxin metabolism by rat liver microsomes
    A Schmoldt
    Biochem Pharmacol 24:1639-41. 1975
  18. ncbi Antidepressant drugs affect dopamine uptake
    A E Halaris
    Biochem Pharmacol 24:1896-7. 1975
  19. ncbi Aggregation of blood platelets by adrenaline and its uptake
    W Barthel
    Biochem Pharmacol 24:1903-4. 1975
  20. ncbi [Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a
    M Ardenne
    Arzneimittelforschung 25:1369-79. 1975
    ..v. application of BA 1. The thus obtained numerical values clearly show that further research work on the prophylactic use of this substance seems to be necessary and very promising...
  21. ncbi Catestatin (CgA344-364) stimulates rat mast cell release of histamine in a manner comparable to mastoparan and other cationic charged neuropeptides
    Per Gøran Krüger
    Department of Anatomy, University of Bergen, Bergen, Norway
    Regul Pept 114:29-35. 2003
    ....
  22. ncbi N-terminal chromogranin-derived peptides as dilators of bovine coronary resistance arteries
    Johan F Brekke
    Department of Physiology, University of Bergen, Arstadveien 19, 5009, Bergen, Norway
    Regul Pept 105:93-100. 2002
    ..We propose that CGA(1-40) and the naturally occurring vasostatin I are regulatory peptides of relevance for the coronary microcirculation and that a G(alphai) sub-unit and K(+) channel activation may be involved in the signal pathway...
  23. ncbi The chromogranin A peptide vasostatin-I inhibits gap formation and signal transduction mediated by inflammatory agents in cultured bovine pulmonary and coronary arterial endothelial cells
    Anna Blois
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Regul Pept 135:78-84. 2006
    ..Furthermore, the inhibitory activity of vasostatin-I may be associated with the p38MAPK signalling cascade via a pertussis toxin sensitive, presumably Galphai coupled mechanism...
  24. ncbi Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine
    Anna Blois
    Department of Biomedicine, Section of Physiology, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Regul Pept 134:30-7. 2006
    ....
  25. ncbi Chromogranin A-derived peptides: interaction with the rat posterior cerebral artery
    Maurizio Mandala
    Department of Biomedicine, Division of Physiology, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Regul Pept 124:73-80. 2005
    ....
  26. ncbi The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects
    Karen B Helle
    Department of Biomedicine, Division of Physiology, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Biol Rev Camb Philos Soc 79:769-94. 2004
    ....
  27. doi Chromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system
    Karen B Helle
    Department of Biomedicine, Division of Physiology, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Results Probl Cell Differ 50:21-44. 2010
    ..Most of their effects fit into patterns of direct or indirect modulations of major functions, in particular associated with inflammatory conditions...
  28. doi Regulatory peptides from chromogranin A and secretogranin II: putative modulators of cells and tissues involved in inflammatory conditions
    Karen B Helle
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Regul Pept 165:45-51. 2010
    ..Oppositely directed effects of vasostatin-I and secretoneurin on formation of blood vessels are also indicated, vasostatin-I inhibiting angiogenetic parameters while secretoneurin activates not only angiogenesis but also vascularization...
  29. doi The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions
    Karen B Helle
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen, Norway
    Cardiovasc Res 85:9-16. 2010
    ..The accumulated evidence provides convincing support for vasostatin-I and catestatin as regulatory peptides for the cardiovascular system, converging on alleviation of significant dysfunctions as part of several inflammatory conditions...
  30. ncbi The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties
    K B Helle
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Cell Mol Life Sci 64:2863-86. 2007
    ....
  31. ncbi Catestatin (chromogranin A344-358) stimulates release of histamine from rat pleural and peritoneal mast cells
    P G Krüuger
    Department of Anatomy and Cell Biology, University of Bergen, Bergen, Norway
    Ann N Y Acad Sci 971:349-51. 2002
  32. ncbi Chromogranin A: osmotically active fragments and their susceptibility to proteolysis during lysis of the bovine chromaffin granules
    K B Helle
    Department of Physiology, PKI, University of Bergen, Norway
    Acta Physiol Scand 138:565-74. 1990
    ..The functional roles of these osmotically active intermediates in the processing of Chr A are not yet known...
  33. ncbi The vasostatin-I fragment of chromogranin A inhibits VEGF-induced endothelial cell proliferation and migration
    Daniela Belloni
    Department of Oncology and IIT Network Research Unit of Molecular Neurosciences, DIBIT, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    FASEB J 21:3052-62. 2007
    ..Conclusion: These findings suggest that vasostatin I may play a novel role as a regulator of endothelial cell function and homeostasis...
  34. ncbi Influence of vasostatins, the chromogranin A-derived peptides, on the working heart of the eel (Anguilla anguilla): negative inotropy and mechanism of action
    Sandra Imbrogno
    Department of Cellular Biology, University of Calabria, Via P Bucci, Arcavacata di Rende 87030, CS, Italy
    Gen Comp Endocrinol 139:20-8. 2004
    ..These findings provide the first evidence that vasostatins exert cardiotropic action in fish, thus suggesting their long evolutionary history as well as their species-specific mechanisms of action...
  35. ncbi Peptides from the N-terminal domain of chromogranin A (vasostatins) exert negative inotropic effects in the isolated frog heart
    Bruno Tota
    Department of Cell Biology, University of Calabria, 87030 Arcavata di Rende CS, Italy
    Regul Pept 114:123-30. 2003
    ..Taken together, these results extend the first evidence for a cardiosuppressive role of the N-terminal domain of chromogranin A known for its co-storage with catecholamines in the sympathoadrenal system of vertebrates...