Aslaug Helland

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Radiation-induced effects on gene expression: an in vivo study on breast cancer
    Aslaug Helland
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Radiother Oncol 80:230-5. 2006
  2. pmc Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
    Vilde D Haakensen
    Dept of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Norway
    BMC Med Genomics 4:77. 2011
  3. pmc Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    BMC Cancer 11:332. 2011
  4. doi request reprint Increasing age and carcinoma not otherwise specified: a 20-year population study of 40,118 lung cancer patients
    Camilla Maria T Sagerup
    University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Oslo, Norway
    J Thorac Oncol 7:57-63. 2012
  5. ncbi request reprint Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas
    Yun Wang
    Department of Gynecologic Oncology, the Norwegian Radium Hospital and the University of Oslo, Oslo, Norway
    Am J Clin Pathol 124:392-401. 2005
  6. doi request reprint Clinicopathological characteristics of 11 NSCLC patients with EGFR-exon 20 mutations
    Marius Lund-Iversen
    Department of Pathology, Oslo University Hospital Norwegian Radium Hospital, Oslo, Norway
    J Thorac Oncol 7:1471-3. 2012
  7. pmc High levels of genomic aberrations in serous ovarian cancers are associated with better survival
    Lars O Baumbusch
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 8:e54356. 2013
  8. pmc Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
    Vessela N Kristensen
    Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 109:2802-7. 2012
  9. doi request reprint Dosimetric impact of a frame-based strategy in stereotactic radiotherapy of lung tumors
    Einar Waldeland
    Department of Medical Physics, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, Oslo, Norway
    Acta Oncol 51:603-9. 2012
  10. doi request reprint Incidence and survival of malignant pleural mesothelioma in norway: a population-based study of 1686 cases
    Aslaug Helland
    Department of Oncology, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway
    J Thorac Oncol 7:1858-61. 2012

Detail Information

Publications20

  1. ncbi request reprint Radiation-induced effects on gene expression: an in vivo study on breast cancer
    Aslaug Helland
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Radiother Oncol 80:230-5. 2006
    ..The purpose of this study was to investigate the molecular basis underlying response to radiotherapy in breast cancer tissue...
  2. pmc Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
    Vilde D Haakensen
    Dept of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Norway
    BMC Med Genomics 4:77. 2011
    ..Increased understanding of the variability in normal breast biology will enable us to identify mechanisms of breast cancer initiation and the origin of different subtypes, and to better predict breast cancer risk...
  3. pmc Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    BMC Cancer 11:332. 2011
    ..High serum levels of estradiol are associated with increased risk of postmenopausal breast cancer. Little is known about the gene expression in normal breast tissue in relation to levels of circulating serum estradiol...
  4. doi request reprint Increasing age and carcinoma not otherwise specified: a 20-year population study of 40,118 lung cancer patients
    Camilla Maria T Sagerup
    University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Oslo, Norway
    J Thorac Oncol 7:57-63. 2012
    ..We aimed to assess how the incidence and prognosis of carcinoma not otherwise specified (NOS) coincide with an aging patient population, disease stage, and diagnostic methods used...
  5. ncbi request reprint Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas
    Yun Wang
    Department of Gynecologic Oncology, the Norwegian Radium Hospital and the University of Oslo, Oslo, Norway
    Am J Clin Pathol 124:392-401. 2005
    ..The PI3K/AKT and RAS/MEK/ERK pathways seem to be activated in some cases of advanced ovarian carcinomas, although PIK3CA, p-AKT, p-ERK, and PTEN do not seem to be independent prognostic markers in this group of patients...
  6. doi request reprint Clinicopathological characteristics of 11 NSCLC patients with EGFR-exon 20 mutations
    Marius Lund-Iversen
    Department of Pathology, Oslo University Hospital Norwegian Radium Hospital, Oslo, Norway
    J Thorac Oncol 7:1471-3. 2012
    ..We present clinicopathological characteristics of patients with EGFR mutations in the four exons, with emphasis on exon 20 positive patients...
  7. pmc High levels of genomic aberrations in serous ovarian cancers are associated with better survival
    Lars O Baumbusch
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 8:e54356. 2013
    ....
  8. pmc Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
    Vessela N Kristensen
    Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 109:2802-7. 2012
    ..In conclusion, by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, we demonstrate that we can stratify immune signatures that predict patient survival...
  9. doi request reprint Dosimetric impact of a frame-based strategy in stereotactic radiotherapy of lung tumors
    Einar Waldeland
    Department of Medical Physics, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, Oslo, Norway
    Acta Oncol 51:603-9. 2012
    ..In this study, cone beam computed tomography (CBCT) images acquired prior to SBRT of patients with lung tumors was used to study the dosimetric impact of a pure frame-based strategy...
  10. doi request reprint Incidence and survival of malignant pleural mesothelioma in norway: a population-based study of 1686 cases
    Aslaug Helland
    Department of Oncology, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway
    J Thorac Oncol 7:1858-61. 2012
    ..The advent of antimetabolite treatment as pemetrexed, introduced in the early 2000s, may have increased survival on a population basis. In this study, we have analyzed population-based incidence and survival data over the last 40 years...
  11. ncbi request reprint PIK3CA mutations in advanced ovarian carcinomas
    Yun Wang
    Department of Gynecologic Oncology, The Norwegian Radium Hospital, N 0310, Oslo, Norway
    Hum Mutat 25:322. 2005
    ..Two of the cases with mutations were mucinous and clear cell tumors, suggesting that PIK3CA mutations are more common in these rare histological types...
  12. doi request reprint EGFR gene alterations in a Norwegian cohort of lung cancer patients selected for surgery
    Aslaug Helland
    Department of Clinical Oncology, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    J Thorac Oncol 6:947-50. 2011
    ..The frequency of these mutations is largely unknown in unselected Caucasian patients...
  13. pmc Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, NO 0310, Norway
    Breast Cancer Res 12:R65. 2010
    ..However, the biologic correlates of density are little known...
  14. ncbi request reprint Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy
    Hege Edvardsen
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Int J Radiat Oncol Biol Phys 67:1163-71. 2007
    ..To explore whether certain glutathione S-transferase (GST) polymorphisms are associated with an increased risk of breast cancer or the level of radiation-induced adverse effects after two fractionation patterns of adjuvant radiotherapy...
  15. doi request reprint Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
    Ivan O Potapenko
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Mol Oncol 4:98-118. 2010
    ....
  16. doi request reprint Dynamic respiratory gated (18)FDG-PET of lung tumors - a feasibility study
    Ingerid Skjei Knudtsen
    Section for Diagnostic Physics, The Intervention Centre, Oslo University Hospital, Oslo, Norway
    Acta Oncol 50:889-96. 2011
    ..In this study we explore the feasibility of a combined dynamic and respiratory gated (DR) PET protocol...
  17. pmc Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers
    Aslaug Helland
    Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e18064. 2011
    ..By defining the drivers of a molecular subtype of serous ovarian cancers we provide a novel strategy for targeted therapeutic intervention...
  18. ncbi request reprint Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
    Yun Wang
    Department of Gynecologic Oncology, The Norwegian Radium Hospital, Oslo, Norway
    Hum Mutat 24:21-34. 2004
    ..008) and tended to increase with increasing FIGO stages (P=0.05), but had no significant effect on survival. No association between p63 protein accumulation and TP53 protein accumulation was seen...
  19. pmc Stereotactic body radiation therapy is effective and safe in patients with early-stage non-small cell lung cancer with low performance status and severe comorbidity
    Martin Turzer
    Department of Clinical Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Case Rep Oncol 4:25-34. 2011
    ..The purpose of this study was to assess stereotactic body radiation therapy (SBRT) results and toxicity for stage I non-small cell lung cancer patients with low performance status and severe comorbidity...
  20. doi request reprint Sex-specific trends in lung cancer incidence and survival: a population study of 40,118 cases
    Camilla M T Sagerup
    University of Oslo, Institute of Clinical Medicine, and Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
    Thorax 66:301-7. 2011
    ..Lung cancer is increasingly affecting women. The aim of this study was to identify sex-specific trends in lung cancer incidence and survival...