Genomes and Genes
Affiliation: University of Oslo
- Radiation-induced effects on gene expression: an in vivo study on breast cancerAslaug Helland
Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
Radiother Oncol 80:230-5. 2006..The purpose of this study was to investigate the molecular basis underlying response to radiotherapy in breast cancer tissue...
- Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low featuresVilde D Haakensen
Dept of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Norway
BMC Med Genomics 4:77. 2011..Increased understanding of the variability in normal breast biology will enable us to identify mechanisms of breast cancer initiation and the origin of different subtypes, and to better predict breast cancer risk...
- Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomasVilde D Haakensen
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
BMC Cancer 11:332. 2011..High serum levels of estradiol are associated with increased risk of postmenopausal breast cancer. Little is known about the gene expression in normal breast tissue in relation to levels of circulating serum estradiol...
- Increasing age and carcinoma not otherwise specified: a 20-year population study of 40,118 lung cancer patientsCamilla Maria T Sagerup
University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Oslo, Norway
J Thorac Oncol 7:57-63. 2012..We aimed to assess how the incidence and prognosis of carcinoma not otherwise specified (NOS) coincide with an aging patient population, disease stage, and diagnostic methods used...
- Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomasYun Wang
Department of Gynecologic Oncology, the Norwegian Radium Hospital and the University of Oslo, Oslo, Norway
Am J Clin Pathol 124:392-401. 2005..The PI3K/AKT and RAS/MEK/ERK pathways seem to be activated in some cases of advanced ovarian carcinomas, although PIK3CA, p-AKT, p-ERK, and PTEN do not seem to be independent prognostic markers in this group of patients...
- Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signalingVessela N Kristensen
Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
Proc Natl Acad Sci U S A 109:2802-7. 2012..In conclusion, by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, we demonstrate that we can stratify immune signatures that predict patient survival...
- Dosimetric impact of a frame-based strategy in stereotactic radiotherapy of lung tumorsEinar Waldeland
Department of Medical Physics, The Norwegian Radium Hospital, Oslo University Hospital, Nydalen, Oslo, Norway
Acta Oncol 51:603-9. 2012..In this study, cone beam computed tomography (CBCT) images acquired prior to SBRT of patients with lung tumors was used to study the dosimetric impact of a pure frame-based strategy...
- PIK3CA mutations in advanced ovarian carcinomasYun Wang
Department of Gynecologic Oncology, The Norwegian Radium Hospital, N 0310, Oslo, Norway
Hum Mutat 25:322. 2005..Two of the cases with mutations were mucinous and clear cell tumors, suggesting that PIK3CA mutations are more common in these rare histological types...
- Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapyHege Edvardsen
Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
Int J Radiat Oncol Biol Phys 67:1163-71. 2007..To explore whether certain glutathione S-transferase (GST) polymorphisms are associated with an increased risk of breast cancer or the level of radiation-induced adverse effects after two fractionation patterns of adjuvant radiotherapy...
- EGFR gene alterations in a Norwegian cohort of lung cancer patients selected for surgeryAslaug Helland
Department of Clinical Oncology, Oslo University Hospital Radiumhospitalet, Oslo, Norway
J Thorac Oncol 6:947-50. 2011..The frequency of these mutations is largely unknown in unselected Caucasian patients...
- Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic densityVilde D Haakensen
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, NO 0310, Norway
Breast Cancer Res 12:R65. 2010..However, the biologic correlates of density are little known...
- Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progressionIvan O Potapenko
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
Mol Oncol 4:98-118. 2010....
- Clinicopathological characteristics of 11 NSCLC patients with EGFR-exon 20 mutationsMarius Lund-Iversen
Department of Pathology, Oslo University Hospital Norwegian Radium Hospital, Oslo, Norway
J Thorac Oncol 7:1471-3. 2012..We present clinicopathological characteristics of patients with EGFR mutations in the four exons, with emphasis on exon 20 positive patients...
- Incidence and survival of malignant pleural mesothelioma in norway: a population-based study of 1686 casesAslaug Helland
Department of Oncology, Oslo University Hospital The Norwegian Radium Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway and Department of Thoracic Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
J Thorac Oncol 7:1858-61. 2012..The advent of antimetabolite treatment as pemetrexed, introduced in the early 2000s, may have increased survival on a population basis. In this study, we have analyzed population-based incidence and survival data over the last 40 years...
- Dynamic respiratory gated (18)FDG-PET of lung tumors - a feasibility studyIngerid Skjei Knudtsen
Section for Diagnostic Physics, The Intervention Centre, Oslo University Hospital, Oslo, Norway
Acta Oncol 50:889-96. 2011..In this study we explore the feasibility of a combined dynamic and respiratory gated (DR) PET protocol...
- Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancersAslaug Helland
Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
PLoS ONE 6:e18064. 2011..By defining the drivers of a molecular subtype of serous ovarian cancers we provide a novel strategy for targeted therapeutic intervention...
- Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinomaYun Wang
Department of Gynecologic Oncology, The Norwegian Radium Hospital, Oslo, Norway
Hum Mutat 24:21-34. 2004..008) and tended to increase with increasing FIGO stages (P=0.05), but had no significant effect on survival. No association between p63 protein accumulation and TP53 protein accumulation was seen...
- Stereotactic body radiation therapy is effective and safe in patients with early-stage non-small cell lung cancer with low performance status and severe comorbidityMartin Turzer
Department of Clinical Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Case Rep Oncol 4:25-34. 2011..The purpose of this study was to assess stereotactic body radiation therapy (SBRT) results and toxicity for stage I non-small cell lung cancer patients with low performance status and severe comorbidity...
- Sex-specific trends in lung cancer incidence and survival: a population study of 40,118 casesCamilla M T Sagerup
University of Oslo, Institute of Clinical Medicine, and Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
Thorax 66:301-7. 2011..Lung cancer is increasingly affecting women. The aim of this study was to identify sex-specific trends in lung cancer incidence and survival...