Lars R Haaheim

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. doi request reprint Immune correlates of protection against influenza: challenges for licensure of seasonal and pandemic influenza vaccines, Miami, FL, USA, March 1-3, 2010
    Lars R Haaheim
    University of Bergen, Myrdalskogen, Ulset, Norway
    Influenza Other Respi Viruses 5:288-95. 2011
  2. ncbi request reprint Original antigenic sin. A confounding issue?
    L R Haaheim
    University of Bergen, Department of Microbiology and Immunology, The Gade Institute, Bergen High Technology Centre, Bergen, Norway
    Dev Biol (Basel) 115:49-53. 2003
  3. doi request reprint Vaccines for an influenza pandemic: scientific and political challenges
    Lars R Haaheim
    Influenza Centre, Section for Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 1:55-60. 2007
  4. ncbi request reprint Identification of genetic diversity by cultivating influenza A(H3N2) virus in vitro in the presence of post-infection sera from small children
    L R Haaheim
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, VIC 3052, Australia
    Vaccine 24:6708-11. 2006
  5. doi request reprint A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:1889-97. 2009
  6. doi request reprint Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:7367-76. 2009
  7. doi request reprint A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 3:107-17. 2009
  8. ncbi request reprint Non-lethal viral challenge of influenza haemagglutinin and nucleoprotein DNA vaccinated mice results in reduced viral replication
    R J Cox
    Department of Molecular Biology, University of Bergen, N 5020 Bergen, Norway
    Scand J Immunol 55:14-23. 2002
  9. ncbi request reprint The effect of zanamivir treatment on the early immune response to influenza vaccination
    R J Cox
    Department of Molecular Biology, University of Bergen, N 5020, Bergen, Norway
    Vaccine 19:4743-9. 2001
  10. ncbi request reprint Impact of influenza vaccine formulation with a detailed analysis of the cytokine response
    E Szyszko
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Scand J Immunol 64:467-75. 2006

Detail Information

Publications18

  1. doi request reprint Immune correlates of protection against influenza: challenges for licensure of seasonal and pandemic influenza vaccines, Miami, FL, USA, March 1-3, 2010
    Lars R Haaheim
    University of Bergen, Myrdalskogen, Ulset, Norway
    Influenza Other Respi Viruses 5:288-95. 2011
    ....
  2. ncbi request reprint Original antigenic sin. A confounding issue?
    L R Haaheim
    University of Bergen, Department of Microbiology and Immunology, The Gade Institute, Bergen High Technology Centre, Bergen, Norway
    Dev Biol (Basel) 115:49-53. 2003
    ..It is unlikely that antibodies generated under the mechanism of Antigenic Sin will have any major epidemiological relevance...
  3. doi request reprint Vaccines for an influenza pandemic: scientific and political challenges
    Lars R Haaheim
    Influenza Centre, Section for Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 1:55-60. 2007
    ..This scenario is not acceptable...
  4. ncbi request reprint Identification of genetic diversity by cultivating influenza A(H3N2) virus in vitro in the presence of post-infection sera from small children
    L R Haaheim
    WHO Collaborating Centre for Reference and Research on Influenza, 45 Poplar Road, Parkville, VIC 3052, Australia
    Vaccine 24:6708-11. 2006
    ..On a community level, it is possible that antigenic changes could be accumulated in a step-wise manner when epidemic virus is transmitted from one small child to the next, each with a restricted and possibly variant antibody repertoire...
  5. doi request reprint A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:1889-97. 2009
    ..In conclusion, our study shows that producing effective H7 pandemic vaccines is as challenging as has been observed for H5 vaccines...
  6. doi request reprint Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:7367-76. 2009
    ..Our results highlight that Matrix-M adjuvant is a promising parenteral adjuvant for formulating pandemic candidate vaccines...
  7. doi request reprint A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 3:107-17. 2009
    ..In recent years, several avian influenza subtypes (H5, H7 and H9) have transmitted directly from birds to man, posing a pandemic threat...
  8. ncbi request reprint Non-lethal viral challenge of influenza haemagglutinin and nucleoprotein DNA vaccinated mice results in reduced viral replication
    R J Cox
    Department of Molecular Biology, University of Bergen, N 5020 Bergen, Norway
    Scand J Immunol 55:14-23. 2002
    ..In conclusion, intramuscular DNA vaccination resulted in immunological memory in the systemic compartment, which was rapidly reactivated upon viral challenge...
  9. ncbi request reprint The effect of zanamivir treatment on the early immune response to influenza vaccination
    R J Cox
    Department of Molecular Biology, University of Bergen, N 5020, Bergen, Norway
    Vaccine 19:4743-9. 2001
    ..Our results suggest that during an influenza epidemic, volunteers would only need to continue zanamivir treatment for the initial 12 days after vaccination whilst the vaccine induced protective antibody response developed...
  10. ncbi request reprint Impact of influenza vaccine formulation with a detailed analysis of the cytokine response
    E Szyszko
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Scand J Immunol 64:467-75. 2006
    ....
  11. ncbi request reprint Systemic and mucosal immune responses in young children and adults after parenteral influenza vaccination
    A S El-Madhun
    Department of Molecular Biology, University of Bergen, Norway
    J Infect Dis 178:933-9. 1998
    ....
  12. pmc A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice
    Arnt Ove Hovden
    The Influenza Centre, The Gade Institute, University of Bergen, Bergen, UK
    Influenza Other Respi Viruses 3:21-8. 2009
    ..In 1999, an HPAI outbreak of H7N1 virus occurred in domestic poultry in Italy, and a wild-type virus isolate from this outbreak was chosen as a pandemic vaccine candidate...
  13. doi request reprint Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 29:4973-82. 2011
    ..Our results highlight that c-di-GMP is a promising mucosal adjuvant for pandemic influenza vaccine development...
  14. ncbi request reprint A comparison of the humoral and cellular immune responses at different immunological sites after split influenza virus vaccination of mice
    S Hauge
    Influenza Centre, The Gade Institute, University of Bergen, Armauer Hansen Building, Bergen, Norway
    Scand J Immunol 65:14-21. 2007
    ..Each of the three tissues had a different immunological pattern, suggesting that in preclinical vaccine studies, there is a case for investigating a range of immunological sites...
  15. ncbi request reprint Two doses of parenterally administered split influenza virus vaccine elicited high serum IgG concentrations which effectively limited viral shedding upon challenge in mice
    A O Hovden
    Influenza Centre, The Gade Institute, University of Bergen, Norway
    Scand J Immunol 62:342-52. 2005
    ..Therefore, serum IgG is an important factor in limiting viral replication in the upper respiratory tract upon challenge of an antigenically similar virus...
  16. ncbi request reprint Whole influenza virus vaccine is more immunogenic than split influenza virus vaccine and induces primarily an IgG2a response in BALB/c mice
    A O Hovden
    Influenza Centre, Section for Microbiology and Immunology, The Gade Institute, University of Bergen, Haukeland University Hospital, Norway
    Scand J Immunol 62:36-44. 2005
    ..The increased immunogenicity of whole virus vaccine in a naïve population could reduce the vaccine concentration needed to provide protective immunity...
  17. ncbi request reprint Systemic and local immune responses after parenteral influenza vaccination in juvenile diabetic patients and healthy controls: results from a pilot study
    A S El-Madhun
    Department for Molecular Biology, University of Bergen, Norway
    Vaccine 16:156-60. 1998
    ..Our study did not detect a difference in the humoral immune response between juvenile diabetics and healthy controls...
  18. ncbi request reprint Antibodies in sera from Norwegian multiple sclerosis patients and the general population reacting with HTLV-1. A pilot study
    L R Haaheim
    Department of Microbiology and Immunology, Haukeland Hospital, University of Bergen, Norway
    APMIS 97:767-73. 1989
    ..The results obtained in this study do not indicate an association between HTLV-I and multiple sclerosis, although at this stage we cannot rule out that another retrovirus is involved...