Lars Gullestad

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo N 0027, Norway
    Eur Heart J 33:2290-6. 2012
  2. doi request reprint Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Int J Cardiol 168:212-8. 2013
  3. pmc Endomyocardial, intralymphocyte, and whole blood concentrations of ciclosporin A in heart transplant recipients
    Ida Robertsen
    Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P, O, Box 1068, Blindern, Oslo, 0316, Norway
    Transplant Res 2:5. 2013
  4. doi request reprint The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)
    Lars Gullestad
    Deparment of Cardiology, Oslo University Hospital, Rikshospitalet, Norway
    Am Heart J 164:878-83. 2012
  5. doi request reprint Inflammatory cytokines in heart failure: mediators and markers
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Oslo, Norway
    Cardiology 122:23-35. 2012
  6. doi request reprint Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, Oslo, Norway
    Scand Cardiovasc J 46:23-31. 2012
  7. pmc Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in type 2 diabetes mellitus
    Jonas Hallén
    Department of Cardiology, Oslo University Hospital, Faculty of Medicine, University of Oslo, Oslo, Norway
    Cardiovasc Diabetol 9:52. 2010
  8. ncbi request reprint Effect of thalidomide on cardiac remodeling in chronic heart failure: results of a double-blind, placebo-controlled study
    Lars Gullestad
    Department of Cardiology, Rikshospitalet, 0027 Oslo, Norway
    Circulation 112:3408-14. 2005
  9. ncbi request reprint Agents targeting inflammation in heart failure
    Lars Gullestad
    Department of Cardiology, University of Oslo, N 0027 Oslo, Norway
    Expert Opin Investig Drugs 14:557-66. 2005
  10. doi request reprint Two-year outcomes in thoracic transplant recipients after conversion to everolimus with reduced calcineurin inhibitor within a multicenter, open-label, randomized trial
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Transplantation 90:1581-9. 2010

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo N 0027, Norway
    Eur Heart J 33:2290-6. 2012
    ..To investigate whether plasma galectin-3, a mediator of fibrogenesis, can identify patients with chronic heart failure (HF) for whom statins are effective...
  2. doi request reprint Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Int J Cardiol 168:212-8. 2013
    ..Our hypothesis was that the immunomodulating effects of intravenous immunoglobulin (IVIg) would be beneficial in patients with impaired myocardial function after MI by reducing myocardial remodeling and improving myocardial function...
  3. pmc Endomyocardial, intralymphocyte, and whole blood concentrations of ciclosporin A in heart transplant recipients
    Ida Robertsen
    Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, P, O, Box 1068, Blindern, Oslo, 0316, Norway
    Transplant Res 2:5. 2013
    ..The aims of this study were to evaluate the relationships between CsA concentrations at different target sites as potential therapeutic drug monitoring (TDM) tools in heart transplant recipients...
  4. doi request reprint The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)
    Lars Gullestad
    Deparment of Cardiology, Oslo University Hospital, Rikshospitalet, Norway
    Am Heart J 164:878-83. 2012
    ..We examined the prognostic value of baseline galectin-3 in a substudy involving approximately 30% of participants in the CORONA study...
  5. doi request reprint Inflammatory cytokines in heart failure: mediators and markers
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Oslo, Norway
    Cardiology 122:23-35. 2012
    ..In this review article, these issues are thoroughly discussed, and we also argue for the possibility of future therapeutic targets such as mediators in innate immunity, chemokines and mediators in matrix remodeling...
  6. doi request reprint Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Nydalen, Oslo, Norway
    Scand Cardiovasc J 46:23-31. 2012
    ..To explore possible differential effects between metoprolol and atenolol in patients with coronary artery disease...
  7. pmc Determinants and prognostic implications of cardiac troponin T measured by a sensitive assay in type 2 diabetes mellitus
    Jonas Hallén
    Department of Cardiology, Oslo University Hospital, Faculty of Medicine, University of Oslo, Oslo, Norway
    Cardiovasc Diabetol 9:52. 2010
    ..Accordingly, we aimed to understand the prevalence, determinants, and prognostic implications of cardiac troponin T (cTnT) elevations measured with a high-sensitivity assay in patients with T2DM...
  8. ncbi request reprint Effect of thalidomide on cardiac remodeling in chronic heart failure: results of a double-blind, placebo-controlled study
    Lars Gullestad
    Department of Cardiology, Rikshospitalet, 0027 Oslo, Norway
    Circulation 112:3408-14. 2005
    ....
  9. ncbi request reprint Agents targeting inflammation in heart failure
    Lars Gullestad
    Department of Cardiology, University of Oslo, N 0027 Oslo, Norway
    Expert Opin Investig Drugs 14:557-66. 2005
    ..In addition, further research in this area will have to be more precise in identifying the most important 'actors' in the immunopathogenesis of chronic HF...
  10. doi request reprint Two-year outcomes in thoracic transplant recipients after conversion to everolimus with reduced calcineurin inhibitor within a multicenter, open-label, randomized trial
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Transplantation 90:1581-9. 2010
    ....
  11. ncbi request reprint The role of statins in heart failure
    Lars Gullestad
    Department of Cardiology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, 0027 Oslo, Norway
    Fundam Clin Pharmacol 21:35-40. 2007
    ..For the moment there are several large-scale prospective outcome studies in HF which probably will give us more definitive answers...
  12. doi request reprint Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling
    Christen Peder Dahl
    Research Institute for Internal Medicine, Department of Cardiology, Section of Clinical Immunology and Infectious Diseases, Section of Endocrinology, and Institute for Surgical Research, Rikshospitalet University Hospital, University of Oslo, Norway
    Circ Heart Fail 2:624-32. 2009
    ..On the basis of its role in vascular inflammation, vascular proliferation, and matrix degradation, we hypothesized a role for the chemokine CXCL16 in the pathogenesis of myocardial remodeling and development of HF...
  13. doi request reprint High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
    Camilla Smith
    Research Institute for Internal Medicine, Rikshospitalet Medical Center, University of Oslo, Oslo, Norway
    Cardiovasc Res 79:195-203. 2008
    ..CXC ligand 16 (CXCL16) may be involved in inflammation and lipid metabolism, and we hypothesized a role for this chemokine in coronary artery disease (CAD)...
  14. ncbi request reprint Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure
    Thor Ueland
    Research Institute for Internal Medicine, Medical Department, Rikshospitalet University Hospital, Oslo, Norway
    Circulation 111:2461-8. 2005
    ..We hypothesized that the OPG/RANK/RANKL axis could be involved in the pathogenesis of heart failure (HF), and this hypothesis was investigated in both experimental and clinical studies...
  15. doi request reprint Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
    Arne Yndestad
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    Eur Heart J 30:1229-36. 2009
    ..Growing evidence suggests that NGAL may also be involved in cell survival, inflammation, and matrix degradation. We therefore aimed to investigate the role of NGAL in heart failure (HF)...
  16. doi request reprint Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology
    Kaspar Broch
    Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    Eur J Heart Fail 14:268-77. 2012
    ..We assessed the association between sST2 and cause-specific outcome in 1449 patients enrolled in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA study)...
  17. ncbi request reprint Increased expression of interleukin-1 in coronary artery disease with downregulatory effects of HMG-CoA reductase inhibitors
    Torgun Waehre
    Research Institute of Internal Medicine, Rikshospitalet, N 0027 Oslo, Norway
    Circulation 109:1966-72. 2004
    ..We hypothesized a dysbalance between inflammatory and anti-inflammatory mediators in the IL-1 family in coronary artery disease (CAD) and a possible modulation of these mediators by HMG-CoA inhibitors (statins)...
  18. doi request reprint Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis
    Wiggo J Sandberg
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Norway
    Circ Res 104:60-8. 2009
    ..Our findings suggest that LIGHT/PAR-2-driven inflammation could be a pathogenic loop in atherogenesis potentially representing a target for therapy in this disorder...
  19. ncbi request reprint The role of intravenous immunoglobulin in the treatment of chronic heart failure
    Pal Aukrust
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, N 0027 Oslo, Norway
    Int J Cardiol 112:40-5. 2006
    ..So far, few patients have been included in clinical trials, and there is clearly a need for larger placebo-controlled mortality studies involving a diverse group of patients with regard to cause and severity of HF...
  20. ncbi request reprint Enhanced plasma levels of LIGHT in unstable angina: possible pathogenic role in foam cell formation and thrombosis
    Hanne Scholz
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway
    Circulation 112:2121-9. 2005
    ..In the present study, we used microarrays to identify genes in THP-1 macrophages that were upregulated by oxLDL...
  21. ncbi request reprint Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation
    Camilla Smith
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Am Coll Cardiol 48:1591-9. 2006
    ..We sought to investigate the role of the CXC chemokine neutrophil-activating peptide-2 (NAP-2) in atherogenesis and plaque destabilization...
  22. ncbi request reprint Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
    Jan K Damås
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
    Arterioscler Thromb Vasc Biol 27:614-20. 2007
    ..Based on their role in T-cell homing into nonlymphoid tissue, we examined the role of the homeostatic chemokines CCL19 and CCL21 and their common receptor CCR7 in coronary artery disease (CAD)...
  23. ncbi request reprint Potential anti-inflammatory role of activin A in acute coronary syndromes
    Camilla Smith
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    J Am Coll Cardiol 44:369-75. 2004
    ..We sought to investigate whether activin A could be involved in the immunopathogenesis of acute coronary syndromes...
  24. doi request reprint Osteoprotegerin predicts progression of chronic heart failure: results from CORONA
    Thor Ueland
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    Circ Heart Fail 4:145-52. 2011
    ..Our primary goal was to determine whether OPG provided independent prognostic information in patients with chronic HF, and to examine its potential interactions with statin therapy...
  25. doi request reprint Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure
    Christen Peder Dahl
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Centre, University of Oslo, Norway
    Eur J Heart Fail 10:352-9. 2008
    ..Clinical and experimental studies suggest a pathogenic role for inflammation in chronic heart failure (HF). LIGHT is a member of the tumour necrosis factor superfamily involved in innate and adaptive immune responses...
  26. doi request reprint Everolimus with reduced calcineurin inhibitor in thoracic transplant recipients with renal dysfunction: a multicenter, randomized trial
    Lars Gullestad
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, and Faculty of Medicine, University of Oslo, Oslo, Norway
    Transplantation 89:864-72. 2010
    ..The proliferation signal inhibitor everolimus offers the potential to reduce calcineurin inhibitor (CNI) exposure and alleviate CNI-related nephrotoxicity. Randomized trials in maintenance thoracic transplant patients are lacking...
  27. doi request reprint Elevated serum uric acid levels following heart transplantation predict all-cause and cardiac mortality
    Satish Arora
    Department of Cardiology, Rikshospitalet Medical Centre, N 0027 Oslo, Norway
    Eur J Heart Fail 11:1005-13. 2009
    ..We also measured inflammatory, neurohormonal, and oxidative stress markers to explore pathophysiological mechanisms...
  28. ncbi request reprint Hydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery disease
    Torgun Waehre
    Research Institute of Internal Medicine, Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
    J Am Coll Cardiol 41:1460-7. 2003
    ..We sought to investigate whether the activation of the chemokine network observed in patients with coronary artery disease (CAD) could be modified by treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins)...
  29. ncbi request reprint Decreased endomyocardial RANKL expression in transplant coronary artery disease
    Thor Ueland
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet University Hospital, Oslo, Norway
    Transplantation 81:1467-70. 2006
    ..Our findings may suggest an unrecognized role RANKL in maintaining myocardial and/or endothelial integrity and suggest that RANKL should be further investigated as a parameter that may predict development of TxCAD...
  30. ncbi request reprint Probrain natriuretic peptide and C-reactive protein as markers of acute rejection, allograft vasculopathy, and mortality in heart transplantation
    Satish Arora
    Department of Cardiology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Transplantation 83:1308-15. 2007
    ..They could also be markers of distinctly altered hormonal and immunological milieus, but the combined prognostic value of these biomarkers in heart transplant (HTx) recipients has not been assessed previously...
  31. doi request reprint NT-proBNP predicts myocardial recovery after non-ST-elevation acute coronary syndrome
    Kaspar Broch
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Scand Cardiovasc J 46:65-71. 2012
    ..Our aim was to investigate the associations between B-type natriuretic peptide (NT-proBNP), troponin T (TnT) and C-reactive protein (CRP) and changes in left ventricular function and size after acute coronary syndrome...
  32. doi request reprint Improvement in renal function after everolimus introduction and calcineurin inhibitor reduction in maintenance thoracic transplant recipients: the significance of baseline glomerular filtration rate
    Satish Arora
    Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Heart Lung Transplant 31:259-65. 2012
    ..Nevertheless, introduction of everolimus is not recommended for patients with advanced renal failure. We evaluated NOCTET data to assess everolimus introduction amongst TTx recipients with advanced renal failure...
  33. doi request reprint Benefit of early conversion from CNI-based to everolimus-based immunosuppression in heart transplantation
    Einar Gude
    Department of Cardiology, Oslo University Hospital, Oslo, Norway
    J Heart Lung Transplant 29:641-7. 2010
    ....
  34. doi request reprint Chemokines and cardiovascular risk
    Pal Aukrust
    Section of Clinical Immunology and InfectiousDiseases, Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Norway
    Arterioscler Thromb Vasc Biol 28:1909-19. 2008
    ....
  35. ncbi request reprint Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization
    Wiggo J Sandberg
    Research Institute for Internal Medicine, Rikshospitalet, University of Oslo, N 0027 Oslo, Norway
    Arterioscler Thromb Vasc Biol 26:857-63. 2006
    ..Based on its role in inflammation and matrix degradation, we hypothesized a role for osteoprotegerin (OPG), RANK, and RANK ligand (RANKL) in coronary artery disease...
  36. ncbi request reprint Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization
    Tuva B Dahl
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center and University of Oslo, N 0027 Oslo, Norway
    Circulation 115:972-80. 2007
    ..In particular, the role of inflammation in plaque destabilization is not fully understood...
  37. ncbi request reprint Effects of conventional and aggressive statin treatment on markers of endothelial function and inflammation
    Aina Hognestad
    Department of Cardiology, Rikshospitalet, Oslo, Norway
    Clin Cardiol 27:199-203. 2004
    ..Several large-scale clinical studies demonstrate that markers of inflammation, such as high-sensitivity C-reactive protein (hsCRP), fibrinogen, and soluble CD40 ligand, are potent and independent predictors of vascular risk...
  38. ncbi request reprint Enhanced expression of inflammatory cytokines and activation markers in T-cells from patients with chronic heart failure
    Arne Yndestad
    Research Institute for Internal Medicine, Rikshospitalet, University of Oslo, N 0027, Oslo, Norway
    Cardiovasc Res 60:141-6. 2003
    ..To address this issue we investigated the gene expression of cytokines and the surface expression of activity markers in T-cells and monocytes from CHF patients and healthy controls...
  39. ncbi request reprint Inflammatory and anti-inflammatory cytokines in chronic heart failure: potential therapeutic implications
    Pal Aukrust
    Research Institute for Internal Medicine, University of Oslo, N 0027 Oslo, Norway
    Ann Med 37:74-85. 2005
    ..Further research will have to identify more precisely the most important actors in the immunopathogenesis of chronic HF in order to develop more specific immunomodulating agents for this disorder...
  40. doi request reprint Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
    Erik Øie
    Department of Cardiology, Rikshospitalet University Hospital, University of Oslo, 0027 Oslo, Norway
    Basic Res Cardiol 105:89-98. 2010
    ..Finally, a net release of AM from the lungs into the circulation was only found in patients with severe systolic dysfunction...
  41. ncbi request reprint The complex role of T-cell-based immunity in atherosclerosis
    Pal Aukrust
    Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Curr Atheroscler Rep 10:236-43. 2008
    ..This research is not only of interest for the basic research field, but may also have relevance for clinical cardiology, potentially leading to new targets for therapy in atherosclerotic disorders...
  42. doi request reprint Acute renal failure early after heart transplantation: risk factors and clinical consequences
    Einar Gude
    Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway
    Clin Transplant 24:E207-13. 2010
    ..As ARF is associated with short-term survival, post-operative strategies of preserving renal function have the potential of reducing mortality. Of avoidable risk factors, the use of intravenous CsA should be discouraged...
  43. ncbi request reprint Plasma levels of soluble tumor necrosis factor receptor type I during the acute phase following complicated myocardial infarction predicts survival in high-risk patients
    Thor Ueland
    Section of Endocrinology, National University Hospital, Oslo, Norway
    J Am Coll Cardiol 46:2018-21. 2005
    ..We sought to determine the relationship between circulating cytokine levels and clinical outcomes in patients with heart failure (HF) following acute myocardial infarction (AMI)...
  44. doi request reprint Activin A and cardiovascular disease in type 2 diabetes mellitus
    Thor Ueland
    Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway
    Diab Vasc Dis Res 9:234-7. 2012
    ..Based on its multiple roles in inflammation, atherogenesis and glucose homeostasis, we hypothesised that activin A could be related to coronary atherosclerosis in T2DM...
  45. ncbi request reprint Elevated levels of activin A in heart failure: potential role in myocardial remodeling
    Arne Yndestad
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, N 0027 Oslo, Norway
    Circulation 109:1379-85. 2004
    ....
  46. doi request reprint Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
    Cathrine Husberg
    Institute for Experimental Medical Research, Ullevaal University Hospital, Oslo, Norway
    J Mol Cell Cardiol 45:261-9. 2008
    ..Given the increased CX3CL1 production in both an experimental HF model and in patients with chronic HF as well as its direct effects on cardiomyocytes, we suggest a role for CX3CL1 and its receptor CX3CR1 in the pathogenesis of HF...
  47. doi request reprint A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins
    Unni M Breland
    Research Institute for Internal Medicine, Rikshospitalet, University of Oslo, Norway
    Arterioscler Thromb Vasc Biol 28:1005-11. 2008
    ..We examined the role of the CXCR2 ligand growth-related oncogene (GRO) alpha in human atherosclerosis...
  48. pmc Secreted Wnt modulators in symptomatic aortic stenosis
    Erik Tandberg Askevold
    Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Am Heart Assoc 1:e002261. 2012
    ..The Wnt pathways have been linked to inflammation, bone metabolism, angiogenesis, and heart valve formation. We hypothesized that soluble Wnt modulators may be dysregulated in symptomatic AS...
  49. doi request reprint High-sensitive troponin T and N-terminal-brain-natriuretic-peptide predict outcome in symptomatic aortic stenosis
    Ole Geir Solberg
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Scand Cardiovasc J 46:278-85. 2012
    ....
  50. doi request reprint Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure: analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)
    Erik Tandberg Askevold
    Department of Cardiology, University of Oslo, Oslo, Norway
    Circ Heart Fail 6:91-8. 2013
    ..We hypothesized that soluble gp130 would provide prognostic information beyond that of IL-6 in a population with HF from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)...
  51. pmc The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure
    Arne Yndestad
    Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    PLoS ONE 7:e33038. 2012
    ..Based on their role in concerting immunological responses and their proposed involvement in tissue remodeling, we hypothesized that these chemokines could play a pathogenic role in heart failure (HF)...
  52. doi request reprint The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis
    Wiggo J Sandberg
    Research Institute for Internal Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Thromb Haemost 102:704-10. 2009
    ..The enhanced expression of APRIL in atherosclerotic disorders, both systemically and within the lesion, may suggest a potential involvement of APRIL in atherogenesis...
  53. ncbi request reprint Soluble CD40 ligand in acute and chronic heart failure
    Thor Ueland
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Eur Heart J 26:1101-7. 2005
    ..Inflammatory cytokines may play a pathogenic role in heart failure (HF). CD40-CD40 ligand (CD40L) interactions are important in atherogenesis and based on its role in inflammation we sought to evaluate the role of CD40L in human HF...
  54. ncbi request reprint Anti-inflammatory trials in chronic heart failure
    Pal Aukrust
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    Heart Fail Monit 5:2-9. 2006
    ....
  55. ncbi request reprint Systemic inflammation in heart failure--the whys and wherefores
    Arne Yndestad
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Norway
    Heart Fail Rev 11:83-92. 2006
    ....
  56. doi request reprint Peak oxygen uptake during cardiopulmonary exercise testing determines response to cardiac resynchronization therapy
    Satish Arora
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Faculty of Medicine, University of Oslo, Oslo, Norway
    J Cardiol 60:228-35. 2012
    ..Hence, in this study we aimed to investigate whether baseline cardiopulmonary exercise testing (CPX) can help improve the prediction of a positive functional CRT response...
  57. ncbi request reprint Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets
    Jan Kristian Damas
    Research Institute for Internal Medicine, Rikshospitalet, Sognsvannsveien 20, 0027 Oslo, Norway
    Circulation 107:2670-6. 2003
    ..Interleukin (IL)-7 is a regulator of T-cell homeostasis but also may be involved in inflammation. We hypothesized that IL-7 could be involved in the inflammatory processes observed in atherosclerosis and acute coronary syndromes...
  58. doi request reprint Early postoperative left ventricular function by echocardiographic strain is a predictor of 1-year mortality in heart transplant recipients
    Sebastian Imre Sarvari
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    J Am Soc Echocardiogr 25:1007-14. 2012
    ..The aim of this study was to test the hypothesis that LVGLS could predict 1-year mortality in heart transplant recipients...
  59. pmc Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure
    Liv I Bjoner Sikkeland
    Department of Respiratory Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    PLoS ONE 7:e36815. 2012
    ..We investigated whether expression of different factors known to be increased in the myocardium and/or the circulation in HF is also increased in alveolar macrophages in HF...
  60. ncbi request reprint Effect of thalidomide in patients with chronic heart failure
    Lars Gullestad
    Department of Internal Medicine, Baerum Hospital, Aker Hospital, Oslo, Norway
    Am Heart J 144:847-50. 2002
    ..We therefore examined whether immunomodulation with thalidomide could improve cardiac performance in patients with CHF...
  61. ncbi request reprint Potential mechanisms of benefit with thalidomide in chronic heart failure
    Pal Aukrust
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo N 0027, Norway
    Am J Cardiovasc Drugs 7:127-34. 2007
    ..Such studies should include experiments in animal models of HF as well as further preclinical trials, attempting to identify the potential mechanisms by which thalidomide may be beneficial in human HF...
  62. doi request reprint Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis
    Thor Ueland
    Research Institute for Internal Medicine, Rikshospitalet, Oslo University Hospital, N 0027 Oslo, Norway
    Arterioscler Thromb Vasc Biol 29:1228-34. 2009
    ..Based on the emerging importance of the wingless (Wnt) pathways in inflammation and vascular biology, we hypothesized a role for Dickkopf-1 (DKK-1), a major modulator of Wnt signaling, in atherogenesis and plaque destabilization...
  63. doi request reprint Atherosclerotic plaque stability--what determines the fate of a plaque?
    Bente Halvorsen
    Research Institute for Internal Medicine, Department of Neurology, Rikshospitalet Medical Center, Oslo, Norway
    Prog Cardiovasc Dis 51:183-94. 2008
    ..In the present study, these issues will be discussed in more detail, particularly focusing on the interactions between matrix degradation, apoptotic, and inflammatory processes in plaque destabilization...
  64. doi request reprint Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy
    Marit Aarones
    University of Oslo, Faculty of Medicine, Department of Cardiology, Oslo University Hospital, Oslo, Norway
    Am Heart J 161:1031-7. 2011
    ..We investigated whether baseline levels of hsTnT were associated with response to CRT and with severe cardiovascular events after long-term follow-up...
  65. doi request reprint Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial
    Satish Arora
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Transplantation 92:235-43. 2011
    ..Everolimus reduces the progression of cardiac allograft vasculopathy (CAV) in de novo heart transplant (HTx) recipients, but the influence on established CAV is unknown...
  66. ncbi request reprint Prognostic importance of renal function 1 year after heart transplantation for all-cause and cardiac mortality and development of allograft vasculopathy
    Satish Arora
    Department of Cardiology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Transplantation 84:149-54. 2007
    ..Hence, we assessed the relationship between glomerular filtration rate (GFR) at 1 year post-HTx and all-cause and cardiac mortality and development of cardiac allograft vasculopathy (CAV)...
  67. pmc Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
    Linn E Fosshaug
    Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway
    Lipids Health Dis 10:245. 2011
    ..Seven days post-MI, the rats were examined with echocardiography and rats in the control group were further randomised to continued control feed or krill oil feed for 7 weeks before re-examination with echocardiography and euthanization...
  68. pmc Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload
    Anne Waehre
    Institute for Experimental Medical Research, Oslo University Hospital Ulleval, Oslo, Norway
    PLoS ONE 6:e18668. 2011
    ..Based on their role in inflammation and matrix remodeling in other tissues, we hypothesized that CXCL13 and CXCR5 could be involved in cardiac remodeling during HF...
  69. ncbi request reprint Role of inflammation in the progression of heart failure
    Arne Yndestad
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet Radiumhospitalet Medical Center, Sognsvannsveien 20, N 0027 Oslo, Norway
    Curr Cardiol Rep 9:236-41. 2007
    ..However, inflammatory cytokines may also have adaptive and cardioprotective effects. This important aspect of cytokine biology must be kept in mind when designing new immunomodulatory treatment modalities in HF...
  70. ncbi request reprint Raised LIGHT levels in pulmonary arterial hypertension: potential role in thrombus formation
    Kari Otterdal
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, N 0027 Oslo, Norway
    Am J Respir Crit Care Med 177:202-7. 2008
    ....
  71. ncbi request reprint Chemokines in cardiovascular risk prediction
    Pal Aukrust
    Research Institute for Internal Medicine, University of Oslo, Oslo, Norway
    Thromb Haemost 97:748-54. 2007
    ..If successful, such new biomarker will be a useful indicator for better risk assessment, diagnosis, and prognosis, as well as monitoring pharmacological treatments for atherosclerosis...
  72. ncbi request reprint Pre-transplant Toxoplasma gondii seropositivity among heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality
    Satish Arora
    Department of Cardiology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Am Coll Cardiol 50:1967-72. 2007
    ..gondii) seropositive heart transplant (HTx) recipients and the 4 donor/recipient seropairing groups...
  73. ncbi request reprint Myocardial gene expression of inflammatory cytokines after heart transplantation in relation to the development of transplant coronary artery disease
    Thor Ueland
    Research Institute for Internal Medicine, National University Hospital, University of Oslo, N 0027 Oslo, Norway
    Am J Cardiol 92:715-7. 2003
    ....
  74. ncbi request reprint Increased gene expression of tumor necrosis factor superfamily ligands in peripheral blood mononuclear cells during chronic heart failure
    Arne Yndestad
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Norway
    Cardiovasc Res 54:175-82. 2002
    ..Inflammation may play a pathogenic role in chronic heart failure (CHF). The objective of the study was to characterise the imbalance in the cytokine network in CHF...
  75. ncbi request reprint Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches
    Lars Gullestad
    Department of Cardiology, Rikshospitalet, Oslo, Norway
    Am J Cardiol 95:17C-23C; discussion 38C-40C. 2005
    ..Further research in this area will have to more precisely identify the most important "actors" in the immunopathogenesis of CHF to improve the immunomodulatory treatment regimens in this disorder...
  76. doi request reprint Baseline anemia is not a predictor of all-cause mortality in outpatients with advanced heart failure or severe renal dysfunction. Results from the Norwegian Heart Failure Registry
    Bård Waldum
    Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    J Am Coll Cardiol 59:371-8. 2012
    ....
  77. doi request reprint Intra-aortic balloon counterpulsation as a bridge to heart transplantation does not impair long-term survival
    Ola Gjesdal
    Department of Cardiology, Rikshospitalet, N 0027 Oslo, Norway
    Eur J Heart Fail 11:709-14. 2009
    ..This is the first study to compare long-term clinical and haemodynamic outcomes in IABP-treated HTx patients and electively transplanted patients...
  78. doi request reprint Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure
    John K Kjekshus
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, Oslo, Norway
    Eur J Heart Fail 11:771-8. 2009
    ..Blockade of 5-HT(4) receptors reduced left ventricular (LV) remodelling in HF rats. We evaluated the effect of piboserod, a potent, selective, 5-HT(4) serotonin receptor antagonist, on LV function in patients with HF...
  79. doi request reprint Activated platelets and atherosclerosis
    Pal Aukrust
    Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, N 0027 Oslo, Norway
    Expert Rev Cardiovasc Ther 8:1297-307. 2010
    ..This underscores the need for new therapeutic tools that more specifically target the pathways in platelet-mediated inflammation...
  80. doi request reprint Tumor necrosis factor superfamily molecules in acute coronary syndromes
    Pal Aukrust
    Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Ann Med 43:90-103. 2011
    ..These TNF-related molecules could also represent attractive new targets for therapy in this disorder...
  81. doi request reprint Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure
    Thor Ueland
    Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Clin Sci (Lond) 121:119-27. 2011
    ..In conclusion, a dysregulated MGP system could be involved in left ventricular dysfunction in patients with chronic HF...
  82. ncbi request reprint Prognostic value of osteoprotegerin in heart failure after acute myocardial infarction
    Thor Ueland
    Research Institute for Internal Medicine, Section of Endocrinology, National University Hospital, Oslo, Norway
    J Am Coll Cardiol 44:1970-6. 2004
    ..We sought to determine the relationship between osteoprotegerin (OPG) and clinical outcomes in patients with heart failure (HF) after acute myocardial infarction (AMI)...
  83. doi request reprint Pulmonary hypertension in heart transplantation: discrepant prognostic impact of pre-operative compared with 1-year post-operative right heart hemodynamics
    Einar Gude
    Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Heart Lung Transplant 29:216-23. 2010
    ....
  84. ncbi request reprint Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy
    Anne G Semb
    Cardiologic Department, Aker Hospital, Oslo, Norway
    J Am Coll Cardiol 41:275-9. 2003
    ..In the present study, we investigated the effects of statins on serum levels of soluble CD40 ligand (sCD40L) in patients with familial hypercholesterolemia (FH)...
  85. doi request reprint The prognostic importance of modifiable risk factors after heart transplantation
    Satish Arora
    Department of Cardiology, Rikshospitalet Medical Center, Oslo, Norway
    Am Heart J 158:431-6. 2009
    ..Hence, we evaluated the prognostic importance of smoking, obesity, hyperglycemia and hyperlipidemia at 1 year after HTx for all-cause and cardiac mortality...
  86. ncbi request reprint Rosuvastatin in older patients with systolic heart failure
    John Kjekshus
    Department of Cardiology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    N Engl J Med 357:2248-61. 2007
    ..Patients with systolic heart failure have generally been excluded from statin trials. Acute coronary events are uncommon in this population, and statins have theoretical risks in these patients...
  87. ncbi request reprint Effect of morning versus evening intake of simvastatin on the serum cholesterol level in patients with coronary artery disease
    Tor M Lund
    Department of Internal Medicine, Baerum Hospital, Oslo, Norway
    Am J Cardiol 90:784-6. 2002
  88. ncbi request reprint Predictors of exercise capacity and the impact of angiographic coronary artery disease in heart transplant recipients
    Lars Gullestad
    Department of Cardiology, Division of Heart and Lung Diseases, Rikshospitalet, Oslo, Norway
    Am Heart J 147:49-54. 2004
    ..Maximal exercise capacity is limited in patients after heart transplantation. The extent to which transplant coronary artery disease contributes to exercise intolerance in these patients has not been well defined...
  89. ncbi request reprint Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension
    Torbjørn Holm
    Department of Cardiology, University of Oslo, Oslo, Norway
    Transplantation 74:1395-400. 2002
    ..Reduced levels of nitric oxide (NO) have been found in essential hypertension, and herein we investigated the possible role of altered concentrations of NO in posttransplant hypertension...
  90. ncbi request reprint Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects
    Jan K Damås
    Research Institute for Internal Medicine, Rikshospitalet, Oslo, Norway
    Circulation 106:36-42. 2002
    ..However, stromal cell-derived factor (SDF)-1 was recently found to have antiinflammatory effects, and we hypothesized that this chemokine could play a beneficial role in coronary artery disease...
  91. ncbi request reprint Inflammation and chronic heart failure-potential therapeutic role of intravenous immunoglobulin
    Pal Aukrust
    Research Institute for Internal Medicine, Rikshospitalet, University of Oslo, Norway
    Autoimmun Rev 3:221-7. 2004
    ..Although these shortcomings, we believe that the 'cytokine era' in cardiovascular research might lead to quite new treatment modalities in CHF patients potentially leading to reduced morbidity and mortality in these patients...
  92. ncbi request reprint A descriptive study of early nonspecific chest pain after PTCA: important area for the acute health care personnel
    Marit Ronnevig
    Department of Cardiology, Rikshospitalet, University of Oslo, Oslo, Norway
    Heart Lung 32:241-9. 2003
    ..Many patients report chest pain of varying intensity at various locations during the first hours after percutaneous transluminal coronary angioplasty (PTCA)...
  93. ncbi request reprint [Survival after heart transplantation in Norway]
    Svein Simonsen
    Hjertemedisinsk avdeling, Rikshospitalet Radiumhospitalet, 0027 Oslo
    Tidsskr Nor Laegeforen 127:865-8. 2007
    ..The number of transplants is limited by donor availability. Few Norwegian doctors are aware of the challenges to be expected in taking care of heart transplant recipients. In the present paper we therefore present our experience so far...
  94. ncbi request reprint Evaluation of ST-segment changes during and after maximal exercise tests in one-, two- and three-vessel coronary artery disease
    Thorvald Bjurö
    AstraZeneca R and D, Molndal, Sweden
    Scand Cardiovasc J 38:270-7. 2004
    ..To relate ECG and heart rate (HR) variables during and after exercise testing with the presence of one-, two- or three-vessel disease defined by angiography...
  95. ncbi request reprint What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF)
    Lars Gullestad
    Baerums Sykehus, Baerum, Norway
    J Am Coll Cardiol 45:252-9. 2005
    ..The goal of this study was to explore the question: what resting heart rate (HR) should one aim for when treating patients with heart failure with a beta-blocker?..
  96. ncbi request reprint Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF)
    Stephen S Gottlieb
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Circulation 105:1182-8. 2002
    ..beta-Blockade improves survival when administered over a long period of time to patients with heart failure. However, the time course of any possible deterioration during the titration phase has not been reported...
  97. ncbi request reprint Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation
    Arnt E Fiane
    Department of Thoracic and Cardiovascular Surgery, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Eur Heart J 26:1660-5. 2005
    ..Transplant-associated coronary artery disease (TxCAD) is a major cause of post-transplant graft failure. The aim of this study was to investigate a possible role of mannose-binding lectin (MBL) deficiency and complement activation in TxCAD...
  98. ncbi request reprint Potential role for immunomodulatory therapy in atherosclerotic plaque stabilisation
    Pal Aukrust
    Research Institute for Internal Medicine, Norway
    Expert Opin Pharmacother 6:2169-80. 2005
    ..It is conceivable that some of these approaches will be tested clinically and, if successful, they could provide novel treatment strategies for atherosclerotic plaque stabilisation...
  99. ncbi request reprint Mannose binding lectin and soluble Toll-like receptor 2 in heart failure following acute myocardial infarction
    Thor Ueland
    J Card Fail 12:659-63. 2006
    ..Atherogenesis and HF is associated with the altered control of inflammation by innate immune defenses that include pattern-recognition molecules such as Toll-like receptors (TLRs) and mannose-binding lectin (MBL)...
  100. ncbi request reprint Clinical and exercise test determinants of survival after cardiac transplantation
    Jonathan Myers
    Cardiology Division, Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    Chest 124:2000-5. 2003
    ..Clinical, exercise, and hemodynamic factors associated with survival after CTX have not been well established...
  101. ncbi request reprint Heart rate adjustments and analysis of recovery patterns of ST-segment depression in type 2 diabetes
    Odd Erik Johansen
    Int J Cardiol 127:129-32. 2008
    ....