Research Topics
| Carl Henrik GörbitzSummaryAffiliation: University of Oslo Country: Norway Publications
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Publications
Solid-state phase transitions of DL-aminobutyric acidCarl Henrik Görbitz
Department of Chemistry, University of Oslo, N 0315 Oslo, Norway
J Phys Chem B 116:10715-21. 2012..The nonroutine refinement of the crystallographic data was performed with a specially adapted version of the program JANA2006. The observed polymorphs are compared with those found for DL-norvaline, DL-norleucine, and DL-methionine...
Single-crystal investigation of L-tryptophan with Z' = 16Carl Henrik Görbitz
Department of Chemistry, University of Oslo, Oslo, Norway
Acta Crystallogr B 68:549-57. 2012....- Pearls on a string: a Z' = 7 structure for glycyl-L-valineCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 63:o58-60. 2007.... - Template-directed supramolecular assembly of a new type of nanoporous peptide-based materialCarl Henrik Görbitz
Department of Chemistry, University of Oslo, Blindern, N 0315 Oslo, Norway
J Pept Sci 14:210-6. 2008.... - The monohydrates of the four polar dipeptides L-seryl-L-asparagine, L-seryl-L-tyrosine, L-tryptophanyl-L-serine and L-tyrosyl-L-tryptophanCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 64:o171-6. 2008..These four dipeptide structures greatly expand our knowledge on dipeptides incorporating polar residues such as serine, asparagine, threonine, tyrosine and tryptophan... - A solution to the observed Z' = 2 preference in the crystal structures of hydrophobic amino acidsCarl Henrik Görbitz
Department of Chemistry, University of Oslo, Norway
Acta Crystallogr B 65:393-400. 2009..Additionally, the (not unexpected) observation that amino acids usually form racemates in the solid phase rather than undergoing racemic separation upon crystallization is rationalized on the basis of energy calculations... - Molecular aggregation in selected crystalline 1:1 complexes of hydrophobic D- and L-amino acids. IV. The L-phenylalanine seriesCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 65:o267-72. 2009.... - Structures of dipeptides: the head-to-tail storyCarl Henrik Görbitz
Department of Chemistry, University of Oslo, Norway
Acta Crystallogr B 66:84-93. 2010..Upon crystallization, the choice of pattern for a specific dipeptide is not random, but follows from the amino acid sequence... - L-2-aminobutyric acid: two fully ordered polymorphs with Z' = 4Carl Henrik Görbitz
Department of Chemistry, University of Oslo, 1033 Blindern, Oslo N 0315, Norway
Acta Crystallogr B 66:253-9. 2010..Uniquely, the four molecules in the asymmetric unit can be divided into two pairs that each forms an independent hydrogen-bond network... - Pseudoracemic amino acid complexes: blind predictions for flexible two-component crystalsCarl Henrik Görbitz
Department of Chemistry, University of Oslo, Norway
Phys Chem Chem Phys 12:8466-77. 2010..The results highlight the significant recent advances that have been made in computational methods for crystal structure prediction... - L-isoleucyl-L-asparagine 1.094-hydrate: a hybrid hydrogen-bonding patternCarl Henrik Görbitz
Department of Chemistry, University of Oslo, Oslo, Norway
Acta Crystallogr C 66:o349-52. 2010..Instead, a rare hybrid pattern is formed... - L-histidyl-L-serine 3.7-hydrate: water channels in the crystal structure of a polar dipeptideCarl Henrik Görbitz
Department of Chemistry, University of Oslo, Oslo, Norway
Acta Crystallogr C 66:o531-4. 2010..7H(2)O, with two hydrophilic residues, forms large polar channels filled with ordered as well as disordered water molecules... - Solid-state phase transitions in DL-norvaline studied by single-crystal X-ray diffractionCarl Henrik Görbitz
Department of Chemistry, University of Oslo, Norway
J Phys Chem B 115:2447-53. 2011..The observed polymorphs are compared with those found for DL-aminobutyric acid, DL-norleucine, and DL-methionine... - Microporous organic materials from hydrophobic dipeptidesCarl Henrik Görbitz
University of Oslo, Department of Chemistry, P O Box 1033 Blindern, 0315 Oslo, Norway
Chemistry 13:1022-31. 2007..The present review summarizes the structural properties of the microporous dipeptides and discusses their potential applications... - L-methionyl-L-alanine: a dipeptide with hexagonal symmetry and Z' = 7Carl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 59:O589-92. 2003..Acta Cryst. C52, 1764-1767] and other related dipeptides in space group P6(1), but there are seven molecules in the asymmetric unit. The Z value of 42 is the highest ever observed for a chiral molecule... - Nanotube formation by hydrophobic dipeptidesC H Gorbitz
Department of Chemistry, University of Oslo, Norway
Chemistry 7:5153-9. 2001..The resulting structures have chiral hydrophilic channels with a van der Waals' diameter up to 10 A... - Water polymers in L-alanyl-L-methionine hemihydrateCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 59:o730-2. 2003..0.5H(2)O, form hydrophobic columns within a three-dimensional hydrogen-bond network that includes extended polymers of cocrystallized water molecules and C(alpha)-H.S interactions... - L-Isoleucyl-L-phenylalanine dihydrateCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 60:o371-3. 2004..The peptide molecule is in a rare conformation normally associated with hydrophobic dipeptides that form nanotubes. Nevertheless, the present structure is divided into hydrophobic and hydrophilic layers... - Selective solvent inclusion as a tool for mapping molecular properties in crystal structures: a diethylstilbestrol exampleC H Gorbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr B 56:1094-102. 2000..Molecular conformations in the crystal structures compare favorably with results from molecular mechanics calculations... - A crystallographic titration of the dipeptide L-isoleucyl-L-isoleucineCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr B 60:569-77. 2004..The crystallization of L-Ile-L-Ile as an anion was achieved by slow evaporation from an NH(3)(l) solution to give the first ever ammonium salt of a peptide (or amino acid)... - N-(L-2-Aminobutyryl)-L-alanine and 2-(L-alanylamino)-L-butyric acid 0.33-hydrateCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 58:o533-6. 2002..33-hydrate, C(7)H(14)N(2)O(3).0.33H(2)O, forms a new type of molecular columnar structure with three peptide molecules in the asymmetric unit... - L-Phenylalanyl-L-isoleucine 0.88-hydrateCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 60:o810-2. 2004..0.88H(2)O, contains two peptide molecules with completely different conformations. The structure is divided into hydrophobic and hydrophilic layers, with channels of water molecules at the layer interface... - An NH3+...phenyl interaction in L-phenylalanyl-L-valineC H Gorbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 56:1496-8. 2000..The phenyl group is also a donor in a weak hydrogen bond to the peptide carbonyl group... - L-Phenylalanyl-L-alanine dihydrateC H Gorbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 57:575-6. 2001..Two L-Phe and two L-Ala side chains aggregate into large hydrophobic columns within a three-dimensional hydrogen-bond network... - L-Isoleucyl-L-serine 0.33-hydrate, L-phenylalanyl-L-serine and L-methionyl-L-serine 0.34-hydrateCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 62:o22-5. 2006.... - L-Seryl-L-phenylalanineIna Høydal Helle
Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, N 0316 Oslo, Norway
Acta Crystallogr C 60:o771-2. 2004 - The crystal structure of peroxymyoglobin generated through cryoradiolytic reduction of myoglobin compound III during data collectionHans Petter Hersleth
University of Oslo, Department of Molecular Biosciences, P O Box 1041 Blindern, N 0316 Oslo, Norway
Biochem J 412:257-64. 2008..Additionally, we have observed that the Xe1 site is occupied by a water molecule, which might be the leaving group in the compound II to compound III reaction... - N-(tert-butoxycarbonyl)-L-valyl-L-valine methyl ester: a twisted parallel β-sheet in the crystal structure of a protected dipeptideØyvind Jacobsen
School of Pharmacy, University of Oslo, Oslo, Norway
Acta Crystallogr C 67:o278-82. 2011..Additionally, a comparison of the backbone conformation is made with that of the Val141-Val142 segment of the water channel aquaporin-4 (AQP4)... - N-(tert-butoxycarbonyl)-α-aminoisobutyryl-α-aminoisobutyric acid methyl ester: two polymorphic forms in the space group P2(1)/nHadgu Girmay Gebreslasie
Department of Chemistry, University of Oslo, Oslo, Norway
Acta Crystallogr C 67:o283-7. 2011..This seems to represent an unusual packing for a protected dipeptide containing at least one α,α-disubstituted residue... - Crystallographic and spectroscopic studies of peroxide-derived myoglobin compound II and occurrence of protonated FeIV OHans Petter Hersleth
Department of Chemistry, University of Oslo, PO Box 1033, Blindern, Oslo N 0315, Norway
J Biol Chem 282:23372-86. 2007.... - N-(tert-butoxycarbonyl)-O-allyl-L-seryl-α-aminoisobutyryl-L-valine methyl ester: a protected tripeptide with an allylated serine residueHadgu Girmay Gebreslasie
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 67:o359-63. 2011..The crystal packing of the title compound is divided into one-molecule-thick layers, each layer having a hydrophilic core and distinct hydrophobic interfaces on either side... - L-Phenylalanyl-L-tryptophan 0.75-hydrateCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr C 62:o328-30. 2006.... - Stapling of a 3(10)-helix with click chemistryØyvind Jacobsen
School of Pharmacy, University of Oslo, P O Box 1068 Blindern, 0316 Oslo, Norway
J Org Chem 76:1228-38. 2011..Side chain-to-side chain stapling by CuAAC should prove useful when applied to 3(10)-helical peptides and protein segments of interest in biomedicine... 
2-Diazo-1-(1,1-dioxothio-morpholin-4-yl)ethanoneAsmund Kaupang
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr E Struct Rep Online 67:o1844-5. 2011..89 (14)% in the boat conformation. In the crystal structure, there are five inter-molecular C-H⋯O=C and C-H⋯O=S contacts less than 2.6 Å, as well as a weak C-H⋯N=N inter-action to the diazo group...- (1S,5R)-1-(3,4-Dichloro-phen-yl)-3-oxa-bicyclo-[3.1.0]hexan-2-oneCarl Henrik Görbitz
Department of Chemistry, University of Oslo, P O Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr E Struct Rep Online 65:o686. 2009..208 (2) Å below the plane formed by the other four atoms. A weak intermolecular C-H⋯O hydrogen bond is present in the crystal structure... - L-valyl-L-serine trihydrateArne Johansen
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N-0315 Oslo, Norway
Acta Crystallogr C 61:o198-200. 2005..The peptide molecules in each layer are related only by translation, and generate a very rare pattern. This is rendered possible through the formation of the shortest C(alpha)-H...O(carboxylate) interaction ever recorded... - (Acetonitrile){2-[bis-(pyridin-2-ylmethyl-κ(2)N)amino-κN]-N-(2,6-dimethyl-phen-yl)acetamide-κO}(perchlorato-κO)zinc (acetonitrile){2-[bis-(pyridin-2-ylmethyl-κ(2)N)amino-κN]-N-(2,6-dimethyl-phen-yl)acetamide-κO}zinc tris-(perchlorate)Ove Alexander Høgmoen Astrand
School of Pharmacy, University of Oslo, PO Box 1068 Blindern, N 0316 Oslo, Norway
Acta Crystallogr Sect E Struct Rep Online 69:m112-3. 2013..Disordered solvent mol-ecules occupy about 11% of the unit-cell volume; their contribution to the scattering was removed with the SQUEEZE routine of the PLATON program [Spek (2009 ▶). Acta Cryst. D65, 148-155.]... - tert-Butyl 4-(2-diazo-acet-yl)piperazine-1-carboxyl-ateAsmund Kaupang
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr E Struct Rep Online 66:o1299. 2010..8 (2) and 357.7 (2)°. In the crystal structure, the O atom of the diazo-acetyl group accepts two H atoms from C-H donors, thus generating chains of weak hydrogen-bonded R(2) (1)(7) rings... - 1,1'-(4,4'-Bipiperidine-1,1'-di-yl)bis-(2,2,2-trifluoro-ethanone)Vitthal N Yadav
Department of Chemistry, University of Oslo, Oslo, Norway
Acta Crystallogr E Struct Rep Online 67:o1691. 2011..Even though the structure is fairly compact with no sizable voids, the shortest H⋯O distance is as long as 2.58 Å... - (1S,5R)-1-(4-Fluoro-phen-yl)-3-azonia-bicyclo-[3.1.0]hexane chlorideCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr E Struct Rep Online 65:o677. 2009..The five-membered ring has an envelope conformation with the N atom at the flap position. In the crystal structure, the Cl(-) anion links with the organic cation via N-H⋯Cl hydrogen bonding... - Cyclo(l-tyrosyl-l-tryptophanyl) dimethylformamide solvateCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr E Struct Rep Online 64:o436. 2008..The structure is stabilized by strong inter-molecular inter-actions of the types O-H⋯O and N-H⋯O involving the dipeptide and the solvent mol-ecules. The absolute configuration was known from the starting materials... - Benzene-1,3,5-triol at 105 KCarl Henrik Görbitz
Department of Chemistry, University of Oslo, PO Box 1033 Blindern, N 0315 Oslo, Norway
Acta Crystallogr E Struct Rep Online 64:o2023. 2008..The mol-ecule is planar with approximate D(3h) point symmetry, yet it crystallizes in the chiral ortho-rhom-bic space group P2(1)2(1)2(1) with a three-dimensional hydrogen-bonding network containing infinite O-H⋯O-H⋯O-H chains... - Crystal structural studies of changes in the native dinuclear iron center of ribonucleotide reductase protein R2 from mouseKari R Strand
Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, Oslo NO 0316, Norway
J Biol Chem 279:46794-801. 2004..Together, this might contribute to the lower affinity and cooperative binding of iron in mouse R2... - Structures of the high-valent metal-ion haem-oxygen intermediates in peroxidases, oxygenases and catalasesHans-Petter Hersleth
Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, N-0315 Oslo, Norway
J Inorg Biochem 100:460-76. 2006..86-1.92A) in agreement with a single-bond character where the oxygen-atom is protonated...