Granum S, Sundvold Gjerstad V, Gopalakrishnan R, Berge T, Koll L, Abrahamsen G, et al. The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. Sci Signal. 2014;7:ra118 pubmed publisher
..Our data suggest that phosphorylation transiently alters SH2 domain specificity and provide a potential mechanism whereby SFKs may be rewired from one signaling program to another to enable appropriate cell activation. ..
Granum S, Sundvold Gjerstad V, Dai K, Kolltveit K, Hildebrand K, Huitfeldt H, et al. Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7. BMC Immunol. 2006;7:15 pubmed
..Whether TSAd is regulated through differential alternative splicing of the SH2D2A transcript remains to be determined. ..
Granum S, Andersen T, Sørlie M, Jørgensen M, Koll L, Berge T, et al. Modulation of Lck function through multisite docking to T cell-specific adapter protein. J Biol Chem. 2008;283:21909-19 pubmed publisher
..We propose that through multivalent interactions with Lck, TSAd diverts Lck from phosphorylating other substrates, thus modulating its functional activity through substrate competition. ..