Pål Ø Falnes

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Design of toxins that can be activated by cell-specific proteases and their potential use in targeted cell killing
    P O Falnes
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Med Microbiol 290:471-6. 2000
  2. ncbi request reprint AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
    Pål Ø Falnes
    Centre for Molecular Biology and Neuroscience, and Institute of Medical Microbiology, University of Oslo, National Hospital, 0027 Oslo, Norway
    Nature 419:178-82. 2002
  3. ncbi request reprint DNA repair by bacterial AlkB proteins
    Pål Ø Falnes
    Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway
    Res Microbiol 154:531-8. 2003
  4. pmc Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
    Erwin van den Born
    Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, 0316 Oslo, Norway
    Nucleic Acids Res 37:7124-36. 2009
  5. pmc The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage
    Trine J Meza
    Department of Molecular Biosciences, University of Oslo, P O Box 1041 Blindern, N 0316 Oslo, Norway
    Nucleic Acids Res 40:6620-31. 2012
  6. doi request reprint ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
    Erwin van den Born
    Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, Oslo 0316, Norway
    Nat Commun 2:172. 2011
  7. pmc Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA
    Vibeke Leihne
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Nucleic Acids Res 39:7688-701. 2011
  8. ncbi request reprint The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N6-ethenoadenine as preferred substrates
    Randi M Aamodt
    Department of Molecular Biology, Institute of Medical Microbiology, University of Oslo, National Hospital, N 0027 Oslo, Norway
    J Biol Chem 279:13601-6. 2004
  9. ncbi request reprint AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
    Rune Ougland
    Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Rikshospitalet University Hospital, NO 0027 Oslo, Norway
    Mol Cell 16:107-16. 2004
  10. doi request reprint AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA
    Jeanette Ringvoll
    Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Rikshospitalet HF and University of Oslo, Blindern, Oslo, Norway
    Cancer Res 68:4142-9. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Design of toxins that can be activated by cell-specific proteases and their potential use in targeted cell killing
    P O Falnes
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Med Microbiol 290:471-6. 2000
    ..Alternative strategies for the construction of toxins that can be activated by proteases are discussed...
  2. ncbi request reprint AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
    Pål Ø Falnes
    Centre for Molecular Biology and Neuroscience, and Institute of Medical Microbiology, University of Oslo, National Hospital, 0027 Oslo, Norway
    Nature 419:178-82. 2002
    ..This mechanism represents a new pathway for DNA repair and the third type of DNA damage reversal mechanism so far discovered...
  3. ncbi request reprint DNA repair by bacterial AlkB proteins
    Pål Ø Falnes
    Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway
    Res Microbiol 154:531-8. 2003
    ..AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins. AlkB also repairs lesions in RNA, and the biological significance of RNA repair is discussed...
  4. pmc Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
    Erwin van den Born
    Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, 0316 Oslo, Norway
    Nucleic Acids Res 37:7124-36. 2009
    ..Our data indicate that the majority, if not all, of the bacterial AlkB proteins are DNA repair enzymes, and that some of these proteins do not primarily target methylated bases...
  5. pmc The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage
    Trine J Meza
    Department of Molecular Biosciences, University of Oslo, P O Box 1041 Blindern, N 0316 Oslo, Norway
    Nucleic Acids Res 40:6620-31. 2012
    ..The present study establishes ALKBH2 as an important enzyme for protecting Arabidopsis against methylation damage in DNA, and suggests its homologues in other plants to have a similar function...
  6. doi request reprint ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
    Erwin van den Born
    Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, Oslo 0316, Norway
    Nat Commun 2:172. 2011
    ..These findings expand the function of the ALKBH oxygenases beyond nucleic acid repair and increase the current knowledge on mammalian wobble uridine modifications and their biogenesis...
  7. pmc Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA
    Vibeke Leihne
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Nucleic Acids Res 39:7688-701. 2011
    ..The present study reveals a role in for several hitherto uncharacterized Arabidopsis proteins in the formation of modified wobble uridines...
  8. ncbi request reprint The Bacillus subtilis counterpart of the mammalian 3-methyladenine DNA glycosylase has hypoxanthine and 1,N6-ethenoadenine as preferred substrates
    Randi M Aamodt
    Department of Molecular Biology, Institute of Medical Microbiology, University of Oslo, National Hospital, N 0027 Oslo, Norway
    J Biol Chem 279:13601-6. 2004
    ..It thus appears that bAag has a minor role in the repair of DNA alkylation damage and an important role in preventing the mutagenic effects of deaminated purines and cyclic etheno adducts in Bacillus subtilis...
  9. ncbi request reprint AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
    Rune Ougland
    Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Rikshospitalet University Hospital, NO 0027 Oslo, Norway
    Mol Cell 16:107-16. 2004
    ..AlkB-mediated repair of 1-meA in tRNA was also observed in E. coli in vivo. Our data demonstrate that AlkB proteins can mediate functional recovery of RNA exposed to methylation damage, supporting the notion that RNA repair is important...
  10. doi request reprint AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA
    Jeanette Ringvoll
    Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Rikshospitalet HF and University of Oslo, Blindern, Oslo, Norway
    Cancer Res 68:4142-9. 2008
    ....
  11. pmc Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding
    Lene Songe-Møller
    Center for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Oslo University Hospital, and Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Mol Cell Biol 30:1814-27. 2010
    ..However, the selenocysteine-specific tRNA (tRNASec) is aberrantly modified in the Alkbh8-/- mice, and for the selenoprotein Gpx1, we indeed observed reduced recoding of the UGA stop codon to selenocysteine...
  12. pmc Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins
    Pål Ø Falnes
    Department of Molecular Biosciences, University of Oslo, Postboks 1041, Blindern, 0316 Oslo, Norway
    Nucleic Acids Res 32:6260-7. 2004
    ..Our data show that 3-meT and 1-meG are repaired by AlkB, but indicate that the recognition of these substrates is different from that in the case of 1-meA and 3-meC...
  13. pmc Human ALKBH4 interacts with proteins associated with transcription
    Linn G Bjørnstad
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 7:e49045. 2012
    ..Although the molecular function of both proteins remains to be revealed, our findings suggest a role for ALKBH4 in regulation of gene expression or chromatin state...
  14. pmc Viral AlkB proteins repair RNA damage by oxidative demethylation
    Erwin van den Born
    Department of Molecular Biosciences, University of Oslo, P O Box 1041 Blindern, N 0316 Oslo, Norway
    Nucleic Acids Res 36:5451-61. 2008
    ..Our results suggest a role for viral AlkBs in maintaining the integrity of the viral RNA genome through repair of deleterious methylation damage, and support the notion that AlkB-mediated RNA repair is biologically relevant...
  15. pmc Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
    Jeanette Ringvoll
    Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Rikshospitalet Radiumhospitalet HF, University of Oslo, Oslo, Norway
    EMBO J 25:2189-98. 2006
    ..Our data suggest that mABH2 and mABH3 have different roles in the defense against alkylating agents...
  16. pmc Substrate specificities of bacterial and human AlkB proteins
    Pål Ø Falnes
    Centre for Molecular Biology and Neuroscience, Institute of Medical Microbiology, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Nucleic Acids Res 32:3456-61. 2004
    ..These results may contribute to identifying the main substrates of bacterial and human AlkB proteins in vivo...
  17. pmc Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities
    Daria Zdzalik
    Department of Biosciences, University of Oslo, Oslo, Norway Institute of Genetics and Biotechnology, University of Warsaw, Warsaw, Poland
    PLoS ONE 9:e98729. 2014
    ..The present study provides new insights on the function and evolution of the ALKBH8 family of proteins. ..
  18. doi request reprint The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity
    Hanne Korvald
    Department of Microbiology, Oslo University Hospital HF Rikshospitalet, and Centre for Molecular Biology and Neuroscience CMBN, University of Oslo, Oslo, Norway
    DNA Repair (Amst) 11:453-62. 2012
    ..It appears that in vitro AP lyase activity can be detected for a number of enzymes belonging to structurally and functionally unrelated families, but the in vivo significance of such activities may be questionable...
  19. pmc Spectroscopic and magnetic studies of wild-type and mutant forms of the Fe(II)- and 2-oxoglutarate-dependent decarboxylase ALKBH4
    Linn G Bjørnstad
    Department of Molecular Biosciences, University of Oslo, Blindern, NO 0316 Oslo, Norway
    Biochem J 434:391-8. 2011
    ..The present results demonstrate that ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination...