- Cytotoxicity of atorvastatin and simvastatin on primary rainbow trout (Oncorhynchus mykiss) hepatocytesKathrin Sabine Ellesat
Department of Biology, University of Oslo, Oslo, Norway
Toxicol In Vitro 24:1610-8. 2010..Simvastatin was more toxic than atorvastatin and the lactone form more toxic than the acid form. Exposure time affected atorvastatin and ortho-hydroxy atorvastatin lactone but not simvastatin toxicity...
- Atorvastatin up-regulate toxicologically relevant genes in rainbow trout gillsKathrin Sabine Ellesat
Department of Biology, University of Oslo, P O Box 1066, Blindern, 0316, Oslo, Norway
Ecotoxicology 21:1841-56. 2012..The pattern of differentially expressed genes in rainbow trout gills differ from responses previously observed in mammalian tissues following statin exposure...
- Species-dependent sensitivity to contaminants: an approach using primary hepatocyte cultures with three marine fish speciesKathrin Sabine Ellesat
Department of Biology, University of Oslo, P O Box 1066 Blindern, N 0316 Oslo, Norway
Mar Environ Res 72:216-24. 2011..Flatfish hepatocytes were more susceptible to copper and statin exposure than hepatocytes from cod. This study has shown that species-dependent differences in contaminant sensitivity can be investigated using primary hepatocyte cultures...