Paula M De Angelis

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. pmc Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
    P M De Angelis
    Norwegian National Hospital, Institute for Pathology University of Oslo, Norway
    Mol Pathol 51:254-61. 1998
  2. ncbi Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer
    P M De Angelis
    Institute of Pathology, Norwegian National Hospital, 0027 Oslo, Norway
    Int J Colorectal Dis 16:38-45. 2001
  3. ncbi Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil
    Paula M De Angelis
    Institute of Pathology, Norwegian National Hospital, N 0027 Oslo, Norway
    Int J Oncol 24:1279-88. 2004
  4. pmc Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols
    Paula M De Angelis
    Institute of Pathology, Rikshospitalet, 0027 Oslo, Norway
    Mol Cancer 3:11. 2004
  5. pmc Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
    Paula M De Angelis
    Institute of Pathology, Section for Molecular Chemoresistance, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
    Mol Cancer 5:20. 2006
  6. doi DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status
    Birgitte L Adamsen
    Department of Pathology, Clinic for Diagnostics and Intervention, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Int J Oncol 39:673-82. 2011
  7. doi Cellular response to chemoradiotherapy, radiotherapy and chemotherapy in two colorectal cancer cell lines
    Birgitte Lid Adamsen
    The Pathology Clinic, Rikshospital University Hospital, 0027 Oslo, Norway
    Radiat Res 171:562-71. 2009
  8. ncbi Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil
    Kristiane Haug
    The Pathology Clinic, Rikshospitalet Medical Center, 0027 Oslo, Norway
    Anticancer Res 28:583-92. 2008
  9. ncbi Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas
    Paula M De Angelis
    The Pathology Clinic, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Int J Cancer 120:2734-8. 2007
  10. doi Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas
    Kirsten Hannisdal
    Department of Otorhinolaryngology Head and Neck Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Head Neck 32:1354-62. 2010

Collaborators

Detail Information

Publications14

  1. pmc Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
    P M De Angelis
    Norwegian National Hospital, Institute for Pathology University of Oslo, Norway
    Mol Pathol 51:254-61. 1998
    ..The p53 genotypes/phenotypes and BAX genotypes were also determined, and possible associations of these with apoptosis and/or with expression of the different apoptotic regulatory proteins were studied...
  2. ncbi Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer
    P M De Angelis
    Institute of Pathology, Norwegian National Hospital, 0027 Oslo, Norway
    Int J Colorectal Dis 16:38-45. 2001
    ..Loss of chromosome arm 1p, 4q, 8p, 14q, or 18q or gain of chromosome arm 20q thus results in shortened survival times in colorectal cancer patients. 1p loss and 8p loss were shown to be independent predictors of poor prognosis...
  3. ncbi Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil
    Paula M De Angelis
    Institute of Pathology, Norwegian National Hospital, N 0027 Oslo, Norway
    Int J Oncol 24:1279-88. 2004
    ..Development of 5-FU resistance thus appears to encompass deregulation of apoptosis-, proliferation-, DNA repair-, and metastasis-associated regulatory pathways...
  4. pmc Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols
    Paula M De Angelis
    Institute of Pathology, Rikshospitalet, 0027 Oslo, Norway
    Mol Cancer 3:11. 2004
    ....
  5. pmc Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
    Paula M De Angelis
    Institute of Pathology, Section for Molecular Chemoresistance, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
    Mol Cancer 5:20. 2006
    ....
  6. doi DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status
    Birgitte L Adamsen
    Department of Pathology, Clinic for Diagnostics and Intervention, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Int J Oncol 39:673-82. 2011
    ..DNA repair and cell cycle responses to 5-FU-induced DNA damage were distinctly affected by MMR and TP53 (role in BER/NER) functionalities, but MMR deficiency especially seemed to confer less overall sensitivity to 5-FU...
  7. doi Cellular response to chemoradiotherapy, radiotherapy and chemotherapy in two colorectal cancer cell lines
    Birgitte Lid Adamsen
    The Pathology Clinic, Rikshospital University Hospital, 0027 Oslo, Norway
    Radiat Res 171:562-71. 2009
    ....
  8. ncbi Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil
    Kristiane Haug
    The Pathology Clinic, Rikshospitalet Medical Center, 0027 Oslo, Norway
    Anticancer Res 28:583-92. 2008
    ..Cross-resistance to both drugs may however be a potential clinical problem. The cellular response to CPT-11 was investigated in two human colon cancer cell lines that demonstrate a differential response to 5-FU...
  9. ncbi Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas
    Paula M De Angelis
    The Pathology Clinic, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
    Int J Cancer 120:2734-8. 2007
    ..2 and by KRAS mutations, but not by TP53 deletions or losses of large chromosomal regions such as 4q, 8p and 18q...
  10. doi Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas
    Kirsten Hannisdal
    Department of Otorhinolaryngology Head and Neck Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Head Neck 32:1354-62. 2010
    ..The aim of the present study was to examine their possible impact on prognosis in tonsillar carcinomas and their relation to clinical variables, the prevalence of human papillomavirus (HPV), p53 status, and Ki-67 positivity...
  11. pmc Reduced hTERT protein levels are associated with DNA aneuploidy in the colonic mucosa of patients suffering from longstanding ulcerative colitis
    Mariann Friis-Ottessen
    Division of Diagnostics and Intervention, Department of Pathology, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway
    Int J Mol Med 33:1477-83. 2014
    ....
  12. ncbi Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer
    Aasa R Schjølberg
    The Pathology Clinic, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway
    Anticancer Res 29:4381-7. 2009
    ..Defective expression of genes involved in mitotic chromosome segregation (e.g. AURKA, BUB1B), DNA damage response (e.g. TP53, BRCA1), and telomere function (e.g. TERT) may play a role in the development of tumor aneuploidy...
  13. pmc Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis
    Mariann Friis-Ottessen
    Department of Pathology, Division of Diagnostics and Intervention, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    BMC Gastroenterol 14:8. 2014
    ..Specifically, the abrupt shortening of one or more telomeres to a critical length, rather than bulk shortening of telomeres, seems to be associated with chromosomal instability...
  14. ncbi Keratoacanthomas frequently show chromosomal aberrations as assessed by comparative genomic hybridization
    Ole Petter F Clausen
    Institute and Department of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Invest Dermatol 119:1367-72. 2002
    ....