Paula M De Angelis
Affiliation: University of Oslo
- Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotypeP M De Angelis
Norwegian National Hospital, Institute for Pathology University of Oslo, Norway
Mol Pathol 51:254-61. 1998..The p53 genotypes/phenotypes and BAX genotypes were also determined, and possible associations of these with apoptosis and/or with expression of the different apoptotic regulatory proteins were studied...
- Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancerP M De Angelis
Institute of Pathology, Norwegian National Hospital, 0027 Oslo, Norway
Int J Colorectal Dis 16:38-45. 2001..Loss of chromosome arm 1p, 4q, 8p, 14q, or 18q or gain of chromosome arm 20q thus results in shortened survival times in colorectal cancer patients. 1p loss and 8p loss were shown to be independent predictors of poor prognosis...
- Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracilPaula M De Angelis
Institute of Pathology, Norwegian National Hospital, N 0027 Oslo, Norway
Int J Oncol 24:1279-88. 2004..Development of 5-FU resistance thus appears to encompass deregulation of apoptosis-, proliferation-, DNA repair-, and metastasis-associated regulatory pathways...
- Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocolsPaula M De Angelis
Institute of Pathology, Rikshospitalet, 0027 Oslo, Norway
Mol Cancer 3:11. 2004....
- Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recoveryPaula M De Angelis
Institute of Pathology, Section for Molecular Chemoresistance, Rikshospitalet Radiumhospitalet HF, Oslo, Norway
Mol Cancer 5:20. 2006....
- DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 statusBirgitte L Adamsen
Department of Pathology, Clinic for Diagnostics and Intervention, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Int J Oncol 39:673-82. 2011..DNA repair and cell cycle responses to 5-FU-induced DNA damage were distinctly affected by MMR and TP53 (role in BER/NER) functionalities, but MMR deficiency especially seemed to confer less overall sensitivity to 5-FU...
- TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitisMariann Friis-Ottessen
Division of Diagnostics and Intervention, Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Int J Mol Med 35:24-30. 2015..Furthermore, a decreased Aurora A expression is associated with the development of DNA aneuploidy, as well as with dysplasia in UC progressors...
- Cellular response to chemoradiotherapy, radiotherapy and chemotherapy in two colorectal cancer cell linesBirgitte Lid Adamsen
The Pathology Clinic, Rikshospital University Hospital, 0027 Oslo, Norway
Radiat Res 171:562-71. 2009....
- Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracilKristiane Haug
The Pathology Clinic, Rikshospitalet Medical Center, 0027 Oslo, Norway
Anticancer Res 28:583-92. 2008..Cross-resistance to both drugs may however be a potential clinical problem. The cellular response to CPT-11 was investigated in two human colon cancer cell lines that demonstrate a differential response to 5-FU...
- Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomasPaula M De Angelis
The Pathology Clinic, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, 0027 Oslo, Norway
Int J Cancer 120:2734-8. 2007..2 and by KRAS mutations, but not by TP53 deletions or losses of large chromosomal regions such as 4q, 8p and 18q...
- Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomasKirsten Hannisdal
Department of Otorhinolaryngology Head and Neck Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Head Neck 32:1354-62. 2010..The aim of the present study was to examine their possible impact on prognosis in tonsillar carcinomas and their relation to clinical variables, the prevalence of human papillomavirus (HPV), p53 status, and Ki-67 positivity...
- Reduced hTERT protein levels are associated with DNA aneuploidy in the colonic mucosa of patients suffering from longstanding ulcerative colitisMariann Friis-Ottessen
Division of Diagnostics and Intervention, Department of Pathology, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway
Int J Mol Med 33:1477-83. 2014....
- Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancerAasa R Schjølberg
The Pathology Clinic, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway
Anticancer Res 29:4381-7. 2009..Defective expression of genes involved in mitotic chromosome segregation (e.g. AURKA, BUB1B), DNA damage response (e.g. TP53, BRCA1), and telomere function (e.g. TERT) may play a role in the development of tumor aneuploidy...
- Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitisMariann Friis-Ottessen
Department of Pathology, Division of Diagnostics and Intervention, Oslo University Hospital, Rikshospitalet, Oslo, Norway
BMC Gastroenterol 14:8. 2014..Specifically, the abrupt shortening of one or more telomeres to a critical length, rather than bulk shortening of telomeres, seems to be associated with chromosomal instability...
- Keratoacanthomas frequently show chromosomal aberrations as assessed by comparative genomic hybridizationOle Petter F Clausen
Institute and Department of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
J Invest Dermatol 119:1367-72. 2002....