J Dahle

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi Automated counting of mammalian cell colonies by means of a flat bed scanner and image processing
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cytometry A 60:182-8. 2004
  2. ncbi Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Radiat Res 163:289-95. 2005
  3. ncbi Increased level of oxidative stress in genomically unstable cell clones
    Jostein Dahle
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 74:23-8. 2004
  4. ncbi Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
    Jostein Dahle
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HE, Montebello, 0310 Oslo, Norway
    Nucl Med Biol 33:271-9. 2006
  5. ncbi Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation
    Jostein Dahle
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Cancer Res 63:1464-9. 2003
  6. ncbi Bystander effects in cell death induced by photodynamic treatment UVA radiation and inhibitors of ATP synthesis
    J Dahle
    Department of Biophysics, Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol 73:378-87. 2001
  7. ncbi The bystander effect in photodynamic inactivation of cells
    J Dahle
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Biochim Biophys Acta 1475:273-80. 2000
  8. ncbi The mode of cell death induced by photodynamic treatment depends on cell density
    J Dahle
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Photochem Photobiol 70:363-7. 1999
  9. ncbi Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol 81:114-9. 2005
  10. pmc Cooperative effects of photodynamic treatment of cells in microcolonies
    J Dahle
    Department of Biophysics, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo
    Proc Natl Acad Sci U S A 94:1773-8. 1997

Collaborators

Detail Information

Publications23

  1. ncbi Automated counting of mammalian cell colonies by means of a flat bed scanner and image processing
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cytometry A 60:182-8. 2004
    ..However, several commercial automatic colony counters are available. Based on CCD video imaging and image analysis they are relatively expensive and can analyze only one petri dish at a time...
  2. ncbi Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Radiat Res 163:289-95. 2005
    ..In conclusion, the results suggest that a bystander effect is involved in ultraviolet-radiation-induced genomic instability and that it may be mediated in part by gap junctional intercellular communication...
  3. ncbi Increased level of oxidative stress in genomically unstable cell clones
    Jostein Dahle
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Photochem Photobiol B 74:23-8. 2004
    ..The unstable clones had elevated levels of oxidants, supporting the hypothesis that intermediate reactive oxygen species might have a role in the maintenance of genomic instability induced by ultraviolet radiation...
  4. ncbi Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
    Jostein Dahle
    Department of Radiation Biology, Rikshospitalet Radiumhospitalet HE, Montebello, 0310 Oslo, Norway
    Nucl Med Biol 33:271-9. 2006
    ..4 days. Incubation of lymphoma cells with (227)Th-DOTA-p-benzyl-rituximab resulted in a significant antigen-dependent inhibition of cell growth. The data presented here warrant further studies of (227)Th-DOTA-p-benzyl-rituximab...
  5. ncbi Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation
    Jostein Dahle
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Cancer Res 63:1464-9. 2003
    ..Thus, the mechanism of UVA-induced chromosomal instability is apparently different from that of UVB and X-radiation...
  6. ncbi Bystander effects in cell death induced by photodynamic treatment UVA radiation and inhibitors of ATP synthesis
    J Dahle
    Department of Biophysics, Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol 73:378-87. 2001
    ....
  7. ncbi The bystander effect in photodynamic inactivation of cells
    J Dahle
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Biochim Biophys Acta 1475:273-80. 2000
    ..The degree of bystander effect was higher for cells dying by necrosis than for cell dying by apoptosis...
  8. ncbi The mode of cell death induced by photodynamic treatment depends on cell density
    J Dahle
    Department of Biophysics, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Photochem Photobiol 70:363-7. 1999
    ..The difference in mode of cell death for the different cell densities was not related to any observable difference in subcellular localization pattern of TPPS4 at equitoxic doses of photodynamic treatment...
  9. ncbi Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Photochem Photobiol 81:114-9. 2005
    ..Therefore, the present results support the hypothesis that persistent increase in oxidative stress is involved in the mechanism of UV-induced genomic instability...
  10. pmc Cooperative effects of photodynamic treatment of cells in microcolonies
    J Dahle
    Department of Biophysics, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo
    Proc Natl Acad Sci U S A 94:1773-8. 1997
    ..Our findings clearly indicate some kind of cooperativity between cells treated with Photofrin and light...
  11. ncbi Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Oslo, Norway
    Blood 110:2049-56. 2007
    ..Thorium-227 based constructs may provide a novel approach for targeted therapy against a wide variety of cancers...
  12. doi Assessment of long-term radiotoxicity after treatment with the low-dose-rate alpha-particle-emitting radioimmunoconjugate (227)Th-rituximab
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    Eur J Nucl Med Mol Imaging 37:93-102. 2010
    ..To evaluate possible late side effects of (227)Th-rituximab, the long-term radiotoxicity of this potential radiopharmaceutical was investigated...
  13. doi Overexpression of human OGG1 in mammalian cells decreases ultraviolet A induced mutagenesis
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Cancer Lett 267:18-25. 2008
    ..The results suggest a link between the 8-oxoG lesion and UVA-induced mutagenesis. We propose that hOGG1 has a role in maintaining genomic stability in mammalian cells after oxidative stress...
  14. doi In vitro cytotoxicity of low-dose-rate radioimmunotherapy by the alpha-emitting radioimmunoconjugate Thorium-227-DOTA-rituximab
    Jostein Dahle
    Department of Radiation Biology, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 75:886-95. 2009
    ....
  15. ncbi The pheomelanin precursor 5-S-cysteinyldopa protects melanocytes from membrane damage induced by ultraviolet A radiation
    Egil Kvam
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Cancer Lett 221:131-4. 2005
    ..Thus, 5-S-cysteinyldopa, may at the same time sensitise DNA and protect membranes from damage induced by ultraviolet radiation...
  16. ncbi Pigmented melanocytes are protected against ultraviolet-A-induced membrane damage
    Egil Kvam
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Invest Dermatol 121:564-9. 2003
    ..Thus, pigmented melanocytes apparently contain antioxidants more potent than glutathione, protecting them from ultraviolet-A-induced membrane damage...
  17. ncbi Evaluation of the binding of radiolabeled rituximab to CD20-positive lymphoma cells: an in vitro feasibility study concerning low-dose-rate radioimmunotherapy with the alpha-emitter 227Th
    Katrine B Melhus
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Cancer Biother Radiopharm 22:469-79. 2007
    ..These results were confirmed using flow cytometry. Rituximab was found to be localized in patches on the cell membrane. The findings indicated that 227Th-labeled rituximab has relevant antigen-targeting properties for radioimmunotherapy...
  18. ncbi Relative biologic effects of low-dose-rate alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab versus external beam X-radiation
    Jostein Dahle
    Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Radiat Oncol Biol Phys 72:186-92. 2008
    ..To determine the relative biologic effects (RBE) of alpha-particle radiation from 227Th-rituximab and of beta-radiation from 90Y-tiuexetan-ibritumomab (Zevalin) compared with external beam X-radiation in the Raji lymphoma xenograft model...
  19. ncbi A one-step method for determining the maximum number of bound antibodies, and the affinity and association rate constants for antibody binding
    Jostein Dahle
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Nucl Med Commun 28:742-7. 2007
    ..The on and off rate constants are determined by kinetic binding experiments. However, it is necessary to perform two to three different types of experiment in order to determine these parameters...
  20. ncbi Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability
    Roy H Larsen
    Department of Radiation Biology, University of Oslo and The Norwegian Radium Hospital, Oslo, Norway
    Cancer Biother Radiopharm 22:431-7. 2007
    ..The overall labeling yield spanned from 6% to 17%. The radioimmunoconjugates demonstrated a relevant stability in serum and showed appropriate antigen-binding abilities...
  21. doi A (238)Pu irradiator for exposure of cultured cells with alpha-radiation: construction, calibration and dosimetry
    Nikolai Tisnek
    Department of Radiation Biology, The Norwegian Radium Hospital, Oslo, Norway
    Appl Radiat Isot 67:1998-2002. 2009
    ..2 Gy/s. The (238)Pu alpha-particle irradiator is feasible for irradiation of cells and it can be used for studies of both direct effects and bystander effects of alpha-radiation...
  22. ncbi Melanin synthesis may sensitize melanocytes to oxidative DNA damage by ultraviolet A radiation and protect melanocytes from direct DNA damage by ultraviolet B radiation
    Egil Kvam
    Pigment Cell Res 17:549-50. 2004