Rebecca J Cox

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi request reprint The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice
    Rebecca Jane Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 24:6585-7. 2006
  2. doi request reprint A(H1N1)pdm09 vaccination of health care workers: improved immune responses in low responders following revaccination
    Rishi Delan Pathirana
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    J Infect Dis 206:1660-9. 2012
  3. ncbi request reprint The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man
    Rebecca Jane Cox
    Influenza Centre, The Gade Institute, University of Bergen, Norway
    Vaccine 24:6577-80. 2006
  4. doi request reprint Evaluation of a virosomal H5N1 vaccine formulated with Matrix M™ adjuvant in a phase I clinical trial
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 29:8049-59. 2011
  5. doi request reprint A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:1889-97. 2009
  6. doi request reprint A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 3:107-17. 2009
  7. pmc A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice
    Arnt Ove Hovden
    The Influenza Centre, The Gade Institute, University of Bergen, Bergen, UK
    Influenza Other Respi Viruses 3:21-8. 2009
  8. doi request reprint Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:7367-76. 2009
  9. pmc The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants
    Asne Jul-Larsen
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Hum Vaccin Immunother 8:653-61. 2012
  10. doi request reprint An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 29:266-73. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice
    Rebecca Jane Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 24:6585-7. 2006
    ..The two vaccine formulations induced different T helper profiles particularly after one dose of vaccine; split virus vaccine induced a type 2 bias response, whereas whole virus vaccine elicited a dominant type 1 response...
  2. doi request reprint A(H1N1)pdm09 vaccination of health care workers: improved immune responses in low responders following revaccination
    Rishi Delan Pathirana
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    J Infect Dis 206:1660-9. 2012
    ..By 2 weeks after vaccination, 97% had protective hemagglutinin inhibition (HI) titers (≥ 40) however, 16% were low responders (LR) and failed to maintain a protective response 90 days after vaccination...
  3. ncbi request reprint The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man
    Rebecca Jane Cox
    Influenza Centre, The Gade Institute, University of Bergen, Norway
    Vaccine 24:6577-80. 2006
    ..In the tonsils and blood, parenteral vaccination results in a significant decrease in CD4(+) cells upon vaccination, which are probably recruited to the draining lymph node...
  4. doi request reprint Evaluation of a virosomal H5N1 vaccine formulated with Matrix M™ adjuvant in a phase I clinical trial
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 29:8049-59. 2011
    ..In conclusion, Matrix M™ adjuvant was well tolerated and augmented the antibody response allowing considerable dose sparing down to 1.5 μg HA...
  5. doi request reprint A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:1889-97. 2009
    ..In conclusion, our study shows that producing effective H7 pandemic vaccines is as challenging as has been observed for H5 vaccines...
  6. doi request reprint A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models
    Rebecca J Cox
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 3:107-17. 2009
    ..In recent years, several avian influenza subtypes (H5, H7 and H9) have transmitted directly from birds to man, posing a pandemic threat...
  7. pmc A pilot study of the immune response to whole inactivated avian influenza H7N1 virus vaccine in mice
    Arnt Ove Hovden
    The Influenza Centre, The Gade Institute, University of Bergen, Bergen, UK
    Influenza Other Respi Viruses 3:21-8. 2009
    ..In 1999, an HPAI outbreak of H7N1 virus occurred in domestic poultry in Italy, and a wild-type virus isolate from this outbreak was chosen as a pandemic vaccine candidate...
  8. doi request reprint Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 27:7367-76. 2009
    ..Our results highlight that Matrix-M adjuvant is a promising parenteral adjuvant for formulating pandemic candidate vaccines...
  9. pmc The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants
    Asne Jul-Larsen
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Hum Vaccin Immunother 8:653-61. 2012
    ..We conclude that the tobacco derived recombinant HAC1 antigen is a promising vaccine candidate recognized by both B- and T cells...
  10. doi request reprint An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 29:266-73. 2010
    ..A rapid induction of protective antibody is important in reducing community spread of pandemic influenza and in helping maintain the integrity of the health care system during the pandemic...
  11. doi request reprint T-helper 1 cells elicited by H5N1 vaccination predict seroprotection
    Gabriel K Pedersen
    The Gade Institute, Haukeland University Hospital, Bergen, Norway
    J Infect Dis 206:158-66. 2012
    ..An immunological marker for H5N1 vaccine effectiveness is needed for early identification of the best vaccine candidate...
  12. doi request reprint Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model
    Gabriel Pedersen
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 5:426-37. 2011
    ..As regulatory authorities have not yet approved a surrogate correlate of protection for H5N1 vaccines, it is important to test the protective efficacy of candidate H5N1 vaccines in a viral challenge study...
  13. doi request reprint The mucosal and systemic immune responses elicited by a chitosan-adjuvanted intranasal influenza H5N1 vaccine
    Signe C Svindland
    Influenza Centre, The Gade Institute, University of Bergen, Bergen, Norway
    Influenza Other Respi Viruses 6:90-100. 2012
    ..Dose-sparing strategies and an efficient mass-vaccination regime will be paramount to reduce the morbidity and mortality of a future H5N1 pandemic...
  14. doi request reprint Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice
    Abdullah S Madhun
    Influenza Centre, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Vaccine 29:4973-82. 2011
    ..Our results highlight that c-di-GMP is a promising mucosal adjuvant for pandemic influenza vaccine development...
  15. pmc Influenza: the virus and prophylaxis with inactivated influenza vaccine in "at risk" groups, including COPD patients
    Arnt Ove Hovden
    The Influenza Centre, The Gade Institute, Faculty of Medicine, University of Bergen, Bergen, Norway
    Int J Chron Obstruct Pulmon Dis 2:229-40. 2007
    ..This review will focus on influenza virus and prophylaxis with inactivated influenza vaccines in COPD patients and other "at risk" groups to reduce morbidity, save lives, and reduce health care costs...
  16. pmc Quality and kinetics of the antibody response in mice after three different low-dose influenza virus vaccination strategies
    Solveig Hauge
    Influenza Center, The Gade Institute, University of Bergen, Armauer Hansen Building, N 5021 Bergen, Norway
    Clin Vaccine Immunol 14:978-83. 2007
    ..However, the low-dose aluminum-adjuvanted vaccine could present a feasible alternative in case of limited vaccine supply...
  17. ncbi request reprint Parenteral vaccination against influenza does not induce a local antigen-specific immune response in the nasal mucosa
    Karl Albert Brokstad
    Broegelmann Research Laboratory, University of Bergen, Bergen, Norway
    J Infect Dis 185:878-84. 2002
    ....