Research Topics
| P E R BrandtzaegSummaryAffiliation: University of Oslo Country: Norway Publications
| Collaborators
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Detail Information
Publications
Current understanding of gastrointestinal immunoregulation and its relation to food allergyP E R Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
Ann N Y Acad Sci 964:13-45. 2002..Altogether, the intestinal immune system normally seems rather fit for tolerance induction against innocuous antigens because most children with food allergy "outgrow" their problems, whereas airway allergy tends to persist...- The traffic of mucosal lymphocytes to extraintestinal sitesPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, N-0027 Oslo, Norway
J Pediatr Gastroenterol Nutr 39:S725-6. 2004 - Role of mucosal immunity in influenzaP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet University Hospital, Oslo, Norway
Dev Biol (Basel) 115:39-48. 2003..However, infection models in knockout mice support the notion that SIgA exerts a decisive role in protection and cross-protection against influenza... - Immunology of tonsils and adenoids: everything the ENT surgeon needs to knowP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
Int J Pediatr Otorhinolaryngol 67:S69-76. 2003.... - Mucosal immunity: integration between mother and the breast-fed infantPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
Vaccine 21:3382-8. 2003..A beneficial clinical effect is also apparent in the industrialized world, even in relation to relatively common diseases such as otitis media and acute lower respiratory tract infections... - Role of secretory antibodies in the defence against infectionsPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
Int J Med Microbiol 293:3-15. 2003..However, infection models in knockout mice strongly support the notion that SIgA exerts a decisive role in protection and cross-protection against a variety of infectious agents... - The secretory immunoglobulin system: regulation and biological significance. Focusing on human mammary glandsPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
Adv Exp Med Biol 503:1-16. 2002 - Regional specialization in the mucosal immune system: primed cells do not always home along the same trackP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, N 0027 Oslo, Norway
Immunol Today 20:267-77. 1999..However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut... - Inflammatory bowel disease: clinics and pathology. Do inflammatory bowel disease and periodontal disease have similar immunopathogeneses?P Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
Acta Odontol Scand 59:235-43. 2001..Several targets for new therapy have tentatively been identified to block immunopathological mechanisms in IBD, and inhibition of TNF has a striking beneficial effect in CD, supporting a central role of this cytokine... - The increasing power of immunohistochemistry and immunocytochemistryP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway
J Immunol Methods 216:49-67. 1998..All these aspects of immunohistochemistry are briefly reviewed in this historical perspective coloured by the author's own experience... - Regional specialization in the mucosal immune system: what happens in the microcompartments?P Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
Immunol Today 20:141-51. 1999..Here, Per Brandtzaeg and colleagues discuss compartmentalized regulation of mucosal B cells and mechanisms that might explain the strikingly regionalized effector disparity of the human mucosal immune system... - Nature and function of gastrointestinal antigen-presenting cellsP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Allergy 56:16-20. 2001..Thus, APCs are involved in active immunity as well as in induction of oral tolerance. However, their precise role in food allergy remains to be defined... - The B-cell system of human mucosae and exocrine glandsP Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
Immunol Rev 171:45-87. 1999..Rational design of local vaccines will depend on better knowledge of both inductive and migratory properties of human mucosal B cells... 
Cloning and characterization of equine CD89 and identification of the CD89 gene in chimpanzees and rhesus macaquesH Craig Morton
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, University Hospital, Oslo, Norway
Immunology 115:74-84. 2005..The identification and characterization of CD89 in different species will contribute to a greater understanding of the biological role of IgA and CD89 in mucosal and systemic immunity throughout evolution...- Characterization of the ligand binding site of the bovine IgA Fc receptor (bFc alpha R)H Craig Morton
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Biol Chem 279:54018-22. 2004..We show that, in common with CD89, Tyr-35 in the B-C loop is essential for IgA binding. However, in contrast to earlier observations on CD89, mutation of residues in the F-G loop did not significantly inhibit IgA binding... - Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competitionRanveig Braathen
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
J Biol Chem 281:7075-81. 2006..This implied that the C9A peptide sequence may be exploited for pIgR-mediated epithelial transport without interfering with secretory immunity... - Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsilsFinn-Eirik Johansen
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Norway
Blood 106:593-600. 2005..However, immunization of nasopharynx-associated lymphoid tissue clearly appears preferable to target respiratory pathogens and may to some extent also protect against infections of the female genital tract... - Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activationRichard W Olaussen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
Gastroenterology 132:2371-82. 2007..Because CCR9 expression appears to be activation dependent, we examined CCR9 on duodenal T cells from untreated and treated (gluten-free diet) patients with celiac disease and healthy controls... - Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergyMalin R Karlsson
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
J Exp Med 199:1679-88. 2004..Collectively, our study provides human data to suggest that mucosal induction of tolerance against dietary antigens is associated with the development of CD4(+)CD25(+) Treg cells... - Rapid chemokine secretion from endothelial cells originates from 2 distinct compartmentsInger Øynebråten
LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
Blood 104:314-20. 2004..In conclusion, we propose that rapid release of chemokines is restricted to those primarily recruiting leukocytes of the innate immune system, and that their storage in ECs is not restricted to the WPB compartment... - Transcriptional regulation of the mucosal IgA systemFinn-Eirik Johansen
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT, Institute and Department of Pathology, Rikshospitalet University Hospital, N-0027 Oslo, Norway
Trends Immunol 25:150-7. 2004 - Cloning and characterization of an immunoglobulin A Fc receptor from cattleH Craig Morton
Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Immunology 111:204-11. 2004..Identification of the bFcalphaR will aid in the understanding of IgA-FcalphaR interactions, and may facilitate the isolation of FcalphaR from other species... - Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypesFrode L Jahnsen
LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
Am J Respir Cell Mol Biol 30:31-7. 2004..How these two cell populations regulate the tone of the local adaptive immune system should be the focus of further studies... - Involvement of plasmacytoid dendritic cells in human diseasesFrode L Jahnsen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
Hum Immunol 63:1201-5. 2002.... - The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptorRanveig Braathen
Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
J Biol Chem 277:42755-62. 2002..This recombinant molecule formed J chain-containing pentamers that could, like IgA, efficiently form covalent complexes with the human pIgR ectodomain, known as secretory component... 
The mucosal immune system and its integration with the mammary glandsPer Brandtzaeg
Centre of Immune Regulation, Institute and Division of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
J Pediatr 156:S8-15. 2010..Therefore breast-feeding represents an ingenious immunologic integration of mother and child...- CD38 is a marker of human lactealsInger Nina Farstad
Laboratory for Immunohistochemistry and Immunopathology, Rikshospitalet, University of Oslo, Norway
Virchows Arch 441:605-13. 2002..CD38 was not detected on lymphatics in other organs or in rodent lacteals. We propose that CD38 is a novel marker of human small intestinal lymphatic vessels... - The proportion of CD40+ mucosal macrophages is increased in inflammatory bowel disease whereas CD40 ligand (CD154)+ T cells are relatively decreased, suggesting differential modulation of these costimulatory molecules in human gut lamina propriaHege S Carlsen
Laboratory for Immunohistochemistry and Immunopathology, Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
Inflamm Bowel Dis 12:1013-24. 2006.... - Let's go mucosal: communication on slippery groundPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, N-0027 Oslo, Norway
Trends Immunol 25:570-7. 2004 - Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibiansRanveig Braathen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
J Immunol 178:1589-97. 2007..These results showed that the functional site of interaction between pIgR, J chain and Ig H chains is conserved in these species and suggests that SIgs originated in an ancestor common to tetrapods... - De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptorHilde Schjerven
Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, Rikshospitalet University Hospital, Oslo, Norway
J Immunol 173:1849-57. 2004..Thus, TNF-induced signaling pathways required for up-regulated pIgR expression appear to differ from those of the proinflammatory gene repertoire... - Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing propertiesPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Immunol Rev 206:32-63. 2005.... - Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venulesEspen S Baekkevold
Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
Am J Pathol 163:69-79. 2003.... - 'ABC' of mucosal immunologyPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology, Institute and Division of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Nestle Nutr Workshop Ser Pediatr Program 64:23-38; discussion 38-43, 251-7. 2009..Their microbe-sensing function is influenced by both microbial products and dietary constituents, including vitamin A and lipids such as polyunsaturated n-3 fatty acids... - Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient miceDag K Skovseth
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Am J Pathol 160:1629-37. 2002..In conclusion, isolated human endothelial cells can integrate with the murine vascular system to form functional capillaries and regain in vivo properties... - Effect of elemental diet on mucosal immunopathology and clinical symptoms in type 1 refractory celiac diseaseRichard Willfred Olaussen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
Clin Gastroenterol Hepatol 3:875-85. 2005..Elemental diet is a therapeutic option that can provide long-term immunopathologic and clinical improvement of this difficult condition... - Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venulesHege S Carlsen
Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Norway
Blood 106:444-6. 2005.... - Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patchesTakeshi Yamanaka
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
J Immunol 170:816-22. 2003.... - Immune response to Mycoplasma pulmonis in nasal mucosa is modulated by the normal microbiotaGert Henriksson
Institute of Pathology, Rikshospitalet University Hospital, N-0027 Oslo, Norway
Am J Respir Cell Mol Biol 31:657-62. 2004..2-fold in GF rats versus 2.6-fold in CV rats. Collectively, our results demonstrated that the normal microbiota modulated markedly the nasal immune response elicited by monoinfection with M. pulmonis... - Function of mucosa-associated lymphoid tissue in antibody formationPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation, University of Oslo, Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
Immunol Invest 39:303-55. 2010.... - Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4Hilde Schjerven
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
J Immunol 170:6048-56. 2003..Thus, several transcription factors cooperate in this enhanceosome to mediate IL-4 responsiveness in HT-29 epithelial cells... - Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesisHege S Carlsen
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Department of Surgery, Rikshospitalet University Hospital, N 0027 Oslo, Norway
Blood 104:3021-7. 2004..Circulating monocytes are therefore potential candidates for future targeted therapy of chronic inflammation... - Do salivary antibodies reliably reflect both mucosal and systemic immunity?Per Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology, Department and Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Norway
Ann N Y Acad Sci 1098:288-311. 2007..Despite such problems, saliva remains an interesting biological fluid with great scientific and clinical potentials... - Induction of secretory immunity and memory at mucosal surfacesPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, N 0027 Oslo, Norway
Vaccine 25:5467-84. 2007..Nevertheless, relatively few mucosal vaccines have been approved for human use, and more basic work is needed in vaccine and adjuvant design, including particulate or live-vectored combinations... - Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy riskUnni Haddeland
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Pediatr Allergy Immunol 16:104-12. 2005..This capacity was impaired in neonates with hereditary allergy risk, but clinical follow-up will be required to determine a possible effect on allergy emergence... - Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cellsEspen O Kvale
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
Blood 109:3369-76. 2007..Our results show that DCs can regulate memory responses and that PDCs rapidly induce regulatory cytokines in effector T cells that can suppress bystander activity... - Food allergy: separating the science from the mythologyPer Brandtzaeg
Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation CIR, University of Oslo and Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
Nat Rev Gastroenterol Hepatol 7:380-400. 2010..It is not easy to dissect the immunoregulatory network and identify variables that lead to food allergy. This Review discusses efforts to this end and outlines the scientific basis for future food allergy prevention...