P E R Brandtzaeg

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Current understanding of gastrointestinal immunoregulation and its relation to food allergy
    P E R Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Ann N Y Acad Sci 964:13-45. 2002
  2. ncbi request reprint The traffic of mucosal lymphocytes to extraintestinal sites
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Pediatr Gastroenterol Nutr 39:S725-6. 2004
  3. ncbi request reprint Role of mucosal immunity in influenza
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Dev Biol (Basel) 115:39-48. 2003
  4. ncbi request reprint Immunology of tonsils and adenoids: everything the ENT surgeon needs to know
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
    Int J Pediatr Otorhinolaryngol 67:S69-76. 2003
  5. ncbi request reprint Mucosal immunity: integration between mother and the breast-fed infant
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Vaccine 21:3382-8. 2003
  6. ncbi request reprint Role of secretory antibodies in the defence against infections
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Int J Med Microbiol 293:3-15. 2003
  7. ncbi request reprint The secretory immunoglobulin system: regulation and biological significance. Focusing on human mammary glands
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Adv Exp Med Biol 503:1-16. 2002
  8. ncbi request reprint Regional specialization in the mucosal immune system: primed cells do not always home along the same track
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Immunol Today 20:267-77. 1999
  9. ncbi request reprint Inflammatory bowel disease: clinics and pathology. Do inflammatory bowel disease and periodontal disease have similar immunopathogeneses?
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Acta Odontol Scand 59:235-43. 2001
  10. ncbi request reprint The increasing power of immunohistochemistry and immunocytochemistry
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway
    J Immunol Methods 216:49-67. 1998

Detail Information

Publications47

  1. ncbi request reprint Current understanding of gastrointestinal immunoregulation and its relation to food allergy
    P E R Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Ann N Y Acad Sci 964:13-45. 2002
    ..Altogether, the intestinal immune system normally seems rather fit for tolerance induction against innocuous antigens because most children with food allergy "outgrow" their problems, whereas airway allergy tends to persist...
  2. ncbi request reprint The traffic of mucosal lymphocytes to extraintestinal sites
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Pediatr Gastroenterol Nutr 39:S725-6. 2004
  3. ncbi request reprint Role of mucosal immunity in influenza
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Dev Biol (Basel) 115:39-48. 2003
    ..However, infection models in knockout mice support the notion that SIgA exerts a decisive role in protection and cross-protection against influenza...
  4. ncbi request reprint Immunology of tonsils and adenoids: everything the ENT surgeon needs to know
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
    Int J Pediatr Otorhinolaryngol 67:S69-76. 2003
    ....
  5. ncbi request reprint Mucosal immunity: integration between mother and the breast-fed infant
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Vaccine 21:3382-8. 2003
    ..A beneficial clinical effect is also apparent in the industrialized world, even in relation to relatively common diseases such as otitis media and acute lower respiratory tract infections...
  6. ncbi request reprint Role of secretory antibodies in the defence against infections
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Int J Med Microbiol 293:3-15. 2003
    ..However, infection models in knockout mice strongly support the notion that SIgA exerts a decisive role in protection and cross-protection against a variety of infectious agents...
  7. ncbi request reprint The secretory immunoglobulin system: regulation and biological significance. Focusing on human mammary glands
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Adv Exp Med Biol 503:1-16. 2002
  8. ncbi request reprint Regional specialization in the mucosal immune system: primed cells do not always home along the same track
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Immunol Today 20:267-77. 1999
    ..However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut...
  9. ncbi request reprint Inflammatory bowel disease: clinics and pathology. Do inflammatory bowel disease and periodontal disease have similar immunopathogeneses?
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Acta Odontol Scand 59:235-43. 2001
    ..Several targets for new therapy have tentatively been identified to block immunopathological mechanisms in IBD, and inhibition of TNF has a striking beneficial effect in CD, supporting a central role of this cytokine...
  10. ncbi request reprint The increasing power of immunohistochemistry and immunocytochemistry
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway
    J Immunol Methods 216:49-67. 1998
    ..All these aspects of immunohistochemistry are briefly reviewed in this historical perspective coloured by the author's own experience...
  11. ncbi request reprint Regional specialization in the mucosal immune system: what happens in the microcompartments?
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    Immunol Today 20:141-51. 1999
    ..Here, Per Brandtzaeg and colleagues discuss compartmentalized regulation of mucosal B cells and mechanisms that might explain the strikingly regionalized effector disparity of the human mucosal immune system...
  12. ncbi request reprint Nature and function of gastrointestinal antigen-presenting cells
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Allergy 56:16-20. 2001
    ..Thus, APCs are involved in active immunity as well as in induction of oral tolerance. However, their precise role in food allergy remains to be defined...
  13. ncbi request reprint The B-cell system of human mucosae and exocrine glands
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    Immunol Rev 171:45-87. 1999
    ..Rational design of local vaccines will depend on better knowledge of both inductive and migratory properties of human mucosal B cells...
  14. pmc Cloning and characterization of equine CD89 and identification of the CD89 gene in chimpanzees and rhesus macaques
    H Craig Morton
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, University Hospital, Oslo, Norway
    Immunology 115:74-84. 2005
    ..The identification and characterization of CD89 in different species will contribute to a greater understanding of the biological role of IgA and CD89 in mucosal and systemic immunity throughout evolution...
  15. ncbi request reprint Characterization of the ligand binding site of the bovine IgA Fc receptor (bFc alpha R)
    H Craig Morton
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Biol Chem 279:54018-22. 2004
    ..We show that, in common with CD89, Tyr-35 in the B-C loop is essential for IgA binding. However, in contrast to earlier observations on CD89, mutation of residues in the F-G loop did not significantly inhibit IgA binding...
  16. ncbi request reprint Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition
    Ranveig Braathen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 281:7075-81. 2006
    ..This implied that the C9A peptide sequence may be exploited for pIgR-mediated epithelial transport without interfering with secretory immunity...
  17. ncbi request reprint Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils
    Finn Eirik Johansen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Norway
    Blood 106:593-600. 2005
    ..However, immunization of nasopharynx-associated lymphoid tissue clearly appears preferable to target respiratory pathogens and may to some extent also protect against infections of the female genital tract...
  18. ncbi request reprint Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation
    Richard W Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
    Gastroenterology 132:2371-82. 2007
    ..Because CCR9 expression appears to be activation dependent, we examined CCR9 on duodenal T cells from untreated and treated (gluten-free diet) patients with celiac disease and healthy controls...
  19. pmc Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
    Malin R Karlsson
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Exp Med 199:1679-88. 2004
    ..Collectively, our study provides human data to suggest that mucosal induction of tolerance against dietary antigens is associated with the development of CD4(+)CD25(+) Treg cells...
  20. ncbi request reprint Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments
    Inger Øynebråten
    LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
    Blood 104:314-20. 2004
    ..In conclusion, we propose that rapid release of chemokines is restricted to those primarily recruiting leukocytes of the innate immune system, and that their storage in ECs is not restricted to the WPB compartment...
  21. ncbi request reprint Transcriptional regulation of the mucosal IgA system
    Finn Eirik Johansen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Trends Immunol 25:150-7. 2004
  22. pmc Cloning and characterization of an immunoglobulin A Fc receptor from cattle
    H Craig Morton
    Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Immunology 111:204-11. 2004
    ..Identification of the bFcalphaR will aid in the understanding of IgA-FcalphaR interactions, and may facilitate the isolation of FcalphaR from other species...
  23. ncbi request reprint Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes
    Frode L Jahnsen
    LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
    Am J Respir Cell Mol Biol 30:31-7. 2004
    ..How these two cell populations regulate the tone of the local adaptive immune system should be the focus of further studies...
  24. ncbi request reprint Involvement of plasmacytoid dendritic cells in human diseases
    Frode L Jahnsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Hum Immunol 63:1201-5. 2002
    ....
  25. ncbi request reprint The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor
    Ranveig Braathen
    Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Biol Chem 277:42755-62. 2002
    ..This recombinant molecule formed J chain-containing pentamers that could, like IgA, efficiently form covalent complexes with the human pIgR ectodomain, known as secretory component...
  26. doi request reprint The mucosal immune system and its integration with the mammary glands
    Per Brandtzaeg
    Centre of Immune Regulation, Institute and Division of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Pediatr 156:S8-15. 2010
    ..Therefore breast-feeding represents an ingenious immunologic integration of mother and child...
  27. ncbi request reprint CD38 is a marker of human lacteals
    Inger Nina Farstad
    Laboratory for Immunohistochemistry and Immunopathology, Rikshospitalet, University of Oslo, Norway
    Virchows Arch 441:605-13. 2002
    ..CD38 was not detected on lymphatics in other organs or in rodent lacteals. We propose that CD38 is a novel marker of human small intestinal lymphatic vessels...
  28. ncbi request reprint The proportion of CD40+ mucosal macrophages is increased in inflammatory bowel disease whereas CD40 ligand (CD154)+ T cells are relatively decreased, suggesting differential modulation of these costimulatory molecules in human gut lamina propria
    Hege S Carlsen
    Laboratory for Immunohistochemistry and Immunopathology, Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Inflamm Bowel Dis 12:1013-24. 2006
    ....
  29. ncbi request reprint Let's go mucosal: communication on slippery ground
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Trends Immunol 25:570-7. 2004
  30. ncbi request reprint Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians
    Ranveig Braathen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Immunol 178:1589-97. 2007
    ..These results showed that the functional site of interaction between pIgR, J chain and Ig H chains is conserved in these species and suggests that SIgs originated in an ancestor common to tetrapods...
  31. ncbi request reprint De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor
    Hilde Schjerven
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    J Immunol 173:1849-57. 2004
    ..Thus, TNF-induced signaling pathways required for up-regulated pIgR expression appear to differ from those of the proinflammatory gene repertoire...
  32. ncbi request reprint Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Immunol Rev 206:32-63. 2005
    ....
  33. pmc Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules
    Espen S Baekkevold
    Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Am J Pathol 163:69-79. 2003
    ....
  34. doi request reprint 'ABC' of mucosal immunology
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Division of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Nestle Nutr Workshop Ser Pediatr Program 64:23-38; discussion 38-43, 251-7. 2009
    ..Their microbe-sensing function is influenced by both microbial products and dietary constituents, including vitamin A and lipids such as polyunsaturated n-3 fatty acids...
  35. pmc Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice
    Dag K Skovseth
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Am J Pathol 160:1629-37. 2002
    ..In conclusion, isolated human endothelial cells can integrate with the murine vascular system to form functional capillaries and regain in vivo properties...
  36. ncbi request reprint Effect of elemental diet on mucosal immunopathology and clinical symptoms in type 1 refractory celiac disease
    Richard Willfred Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
    Clin Gastroenterol Hepatol 3:875-85. 2005
    ..Both conditions are difficult to treat. Here we describe the effects of a nonimmunogenic elemental diet on clinical symptoms and mucosal immunopathology in type 1 RCD...
  37. ncbi request reprint Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules
    Hege S Carlsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Norway
    Blood 106:444-6. 2005
    ....
  38. ncbi request reprint Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches
    Takeshi Yamanaka
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    J Immunol 170:816-22. 2003
    ....
  39. ncbi request reprint Immune response to Mycoplasma pulmonis in nasal mucosa is modulated by the normal microbiota
    Gert Henriksson
    Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Am J Respir Cell Mol Biol 31:657-62. 2004
    ..2-fold in GF rats versus 2.6-fold in CV rats. Collectively, our results demonstrated that the normal microbiota modulated markedly the nasal immune response elicited by monoinfection with M. pulmonis...
  40. doi request reprint Function of mucosa-associated lymphoid tissue in antibody formation
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation, University of Oslo, Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Immunol Invest 39:303-55. 2010
    ....
  41. ncbi request reprint Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4
    Hilde Schjerven
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Immunol 170:6048-56. 2003
    ..Thus, several transcription factors cooperate in this enhanceosome to mediate IL-4 responsiveness in HT-29 epithelial cells...
  42. ncbi request reprint Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis
    Hege S Carlsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Department of Surgery, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Blood 104:3021-7. 2004
    ..Circulating monocytes are therefore potential candidates for future targeted therapy of chronic inflammation...
  43. ncbi request reprint Do salivary antibodies reliably reflect both mucosal and systemic immunity?
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Department and Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Norway
    Ann N Y Acad Sci 1098:288-311. 2007
    ..Despite such problems, saliva remains an interesting biological fluid with great scientific and clinical potentials...
  44. ncbi request reprint Induction of secretory immunity and memory at mucosal surfaces
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, N 0027 Oslo, Norway
    Vaccine 25:5467-84. 2007
    ..Nevertheless, relatively few mucosal vaccines have been approved for human use, and more basic work is needed in vaccine and adjuvant design, including particulate or live-vectored combinations...
  45. ncbi request reprint Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk
    Unni Haddeland
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Pediatr Allergy Immunol 16:104-12. 2005
    ..This capacity was impaired in neonates with hereditary allergy risk, but clinical follow-up will be required to determine a possible effect on allergy emergence...
  46. ncbi request reprint Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
    Espen O Kvale
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
    Blood 109:3369-76. 2007
    ..Our results show that DCs can regulate memory responses and that PDCs rapidly induce regulatory cytokines in effector T cells that can suppress bystander activity...
  47. doi request reprint Food allergy: separating the science from the mythology
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation CIR, University of Oslo and Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Nat Rev Gastroenterol Hepatol 7:380-400. 2010
    ..It is not easy to dissect the immunoregulatory network and identify variables that lead to food allergy. This Review discusses efforts to this end and outlines the scientific basis for future food allergy prevention...