P Brandtzaeg

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi Do salivary antibodies reliably reflect both mucosal and systemic immunity?
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Department and Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Norway
    Ann N Y Acad Sci 1098:288-311. 2007
  2. pmc Intraepithelial γδ T cells remain increased in the duodenum of AIDS patients despite antiretroviral treatment
    Dag E Nilssen
    Laboratory for Immunohistochemistry and Immunopathology, Centre for Immune Regulation, University of Oslo, and Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    PLoS ONE 7:e29066. 2012
  3. doi Gate-keeper function of the intestinal epithelium
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation CIR, University of Oslo Department of Pathology, Oslo University Hospital, Rikshospitalet, P O Box 4950, 0424 Oslo, Norway
    Benef Microbes 4:67-82. 2013
  4. ncbi Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Immunol Rev 206:32-63. 2005
  5. doi 'ABC' of mucosal immunology
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Division of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Nestle Nutr Workshop Ser Pediatr Program 64:23-38; discussion 38-43, 251-7. 2009
  6. ncbi The changing immunological paradigm in coeliac disease
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, N 0027 Oslo, Norway
    Immunol Lett 105:127-39. 2006
  7. doi Terminology: nomenclature of mucosa-associated lymphoid tissue
    P Brandtzaeg
    Department of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Mucosal Immunol 1:31-7. 2008
  8. ncbi Induction of secretory immunity and memory at mucosal surfaces
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, N 0027 Oslo, Norway
    Vaccine 25:5467-84. 2007
  9. doi Mucosal immunity: induction, dissemination, and effector functions
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation, University of Oslo, Division and Institute of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Scand J Immunol 70:505-15. 2009
  10. doi The mucosal immune system and its integration with the mammary glands
    Per Brandtzaeg
    Centre of Immune Regulation, Institute and Division of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Pediatr 156:S8-15. 2010

Detail Information

Publications117 found, 100 shown here

  1. ncbi Do salivary antibodies reliably reflect both mucosal and systemic immunity?
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Department and Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Norway
    Ann N Y Acad Sci 1098:288-311. 2007
    ..Despite such problems, saliva remains an interesting biological fluid with great scientific and clinical potentials...
  2. pmc Intraepithelial γδ T cells remain increased in the duodenum of AIDS patients despite antiretroviral treatment
    Dag E Nilssen
    Laboratory for Immunohistochemistry and Immunopathology, Centre for Immune Regulation, University of Oslo, and Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    PLoS ONE 7:e29066. 2012
    ....
  3. doi Gate-keeper function of the intestinal epithelium
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation CIR, University of Oslo Department of Pathology, Oslo University Hospital, Rikshospitalet, P O Box 4950, 0424 Oslo, Norway
    Benef Microbes 4:67-82. 2013
    ..This shows that the intestinal epithelial barrier is a cross-road between defence and nutrition, and that SIgA is essential to keep the balance between these two functions...
  4. ncbi Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Immunol Rev 206:32-63. 2005
    ....
  5. doi 'ABC' of mucosal immunology
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Division of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Nestle Nutr Workshop Ser Pediatr Program 64:23-38; discussion 38-43, 251-7. 2009
    ..Their microbe-sensing function is influenced by both microbial products and dietary constituents, including vitamin A and lipids such as polyunsaturated n-3 fatty acids...
  6. ncbi The changing immunological paradigm in coeliac disease
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, N 0027 Oslo, Norway
    Immunol Lett 105:127-39. 2006
    ..Hence, there is currently an increased focus on immune activation in the epithelial compartment rather than on changes in the microvasculature as a basis for classical inflammation...
  7. doi Terminology: nomenclature of mucosa-associated lymphoid tissue
    P Brandtzaeg
    Department of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Mucosal Immunol 1:31-7. 2008
    ..In addition, we recommend and justify standard nomenclature and abbreviations for discrete mucosal immune-cell compartments, belonging to, and beyond, mucosa-associated lymphoid tissue...
  8. ncbi Induction of secretory immunity and memory at mucosal surfaces
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, N 0027 Oslo, Norway
    Vaccine 25:5467-84. 2007
    ..Nevertheless, relatively few mucosal vaccines have been approved for human use, and more basic work is needed in vaccine and adjuvant design, including particulate or live-vectored combinations...
  9. doi Mucosal immunity: induction, dissemination, and effector functions
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation, University of Oslo, Division and Institute of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Scand J Immunol 70:505-15. 2009
    ..The airways also receive such cells from nasopharynx-associated lymphoid tissue - but by different homing receptors. Such compartmentalization is a challenge for development of mucosal vaccines...
  10. doi The mucosal immune system and its integration with the mammary glands
    Per Brandtzaeg
    Centre of Immune Regulation, Institute and Division of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Pediatr 156:S8-15. 2010
    ..Therefore breast-feeding represents an ingenious immunologic integration of mother and child...
  11. doi Function of mucosa-associated lymphoid tissue in antibody formation
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation, University of Oslo, Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Immunol Invest 39:303-55. 2010
    ....
  12. doi Food allergy: separating the science from the mythology
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Centre for Immune Regulation CIR, University of Oslo and Department and Institute of Pathology, Oslo University Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Nat Rev Gastroenterol Hepatol 7:380-400. 2010
    ..It is not easy to dissect the immunoregulatory network and identify variables that lead to food allergy. This Review discusses efforts to this end and outlines the scientific basis for future food allergy prevention...
  13. doi Update on mucosal immunoglobulin A in gastrointestinal disease
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Centre for Immune Regulation, Department and Institute of Pathology, Oslo University Hospital, University of Oslo, Rikshospitalet, Oslo, Norway
    Curr Opin Gastroenterol 26:554-63. 2010
    ..New information will be discussed in the context of previous knowledge in this field...
  14. doi Potential of nasopharynx-associated lymphoid tissue for vaccine responses in the airways
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Centre for Immune Regulation, University of Oslo, Olso, Norway
    Am J Respir Crit Care Med 183:1595-604. 2011
    ..This interaction is central in the formation of secretory IgA and secretory IgM. Accumulating evidence suggests a major role for NALT in antibody immunity of the respiratory tract and associated glands...
  15. doi The gut as communicator between environment and host: immunological consequences
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Centre for Immune Regulation, University of Oslo, and Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Eur J Pharmacol 668:S16-32. 2011
    ....
  16. doi Immune functions of nasopharyngeal lymphoid tissue
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Centre for Immune Regulation, University of Oslo, and Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Adv Otorhinolaryngol 72:20-4. 2011
    ..In this context, the potential immunological consequences of removing both the tonsils and the adenoids have to be considered...
  17. ncbi Let's go mucosal: communication on slippery ground
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Trends Immunol 25:570-7. 2004
  18. ncbi Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease
    E M Nilsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
    Gastroenterology 115:551-63. 1998
    ..Duodenal biopsy specimens from patients with celiac disease and histologically normal controls were investigated to see if cytokine expression is related to disease activity...
  19. ncbi Maternal allergy influences the proliferation of neonatal T cells expressing CCR4, CXCR5 or CD103
    U Haddeland
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Department and Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Clin Exp Allergy 37:856-64. 2007
    ..Elevated proliferative response to allergen in cord blood mononuclear cells (CBMCs) is related to subsequent allergy development of the neonate and has been suggested as a screening marker for high allergy risk...
  20. ncbi A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor
    H Schjerven
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Immunol 167:6412-20. 2001
    ..Several intronic DNA elements found to be functionally important in the human gene are highly conserved between the human and mouse pIgR/SC genes, suggesting the presence of a conserved cytokine-responsive enhancer region...
  21. ncbi Regional specialization in the mucosal immune system: primed cells do not always home along the same track
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, N 0027 Oslo, Norway
    Immunol Today 20:267-77. 1999
    ..However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut...
  22. ncbi Role of J chain in secretory immunoglobulin formation
    F E Johansen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Scand J Immunol 52:240-8. 2000
    ..Therefore, both the J chain and the pIgR/SC are key proteins in secretory immunity...
  23. ncbi Identification of residues within the extracellular domain 1 of bovine Fc gamma 2R essential for binding bovine IgG2
    H C Morton
    Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Biol Chem 276:47794-800. 2001
    ..Furthermore, single amino acid mutational analysis of this region identified Phe-82 and Trp-87 as being critical for bIgG2 binding...
  24. ncbi Different regulatory pathways employed in cytokine-enhanced expression of secretory component and epithelial HLA class I genes
    E M Nilsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Norway
    Eur J Immunol 29:168-79. 1999
    ..Our observations in vitro likely parallel events in vivo by which activated mucosal T cells and macrophages enhance pIg receptor-mediated external transport of secretory IgA and IgM and up-regulate epithelial HLA expression...
  25. ncbi The B-cell system of human mucosae and exocrine glands
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    Immunol Rev 171:45-87. 1999
    ..Rational design of local vaccines will depend on better knowledge of both inductive and migratory properties of human mucosal B cells...
  26. ncbi Regional specialization in the mucosal immune system: what happens in the microcompartments?
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    Immunol Today 20:141-51. 1999
    ..Here, Per Brandtzaeg and colleagues discuss compartmentalized regulation of mucosal B cells and mechanisms that might explain the strikingly regionalized effector disparity of the human mucosal immune system...
  27. ncbi Domain deletions in the human polymeric Ig receptor disclose differences between its dimeric IgA and pentameric IgM interaction
    I N Norderhaug
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Eur J Immunol 29:3401-9. 1999
    ..Moreover, our studies imply that dimeric human IgA binds differently to pIgR from various species. This observation cautions against interpretation of functional studies performed with non-homologous receptor-ligand pairs...
  28. ncbi Ontogeny of the mucosal immune system and IgA deficiency
    P Brandtzaeg
    University of Oslo, Norway
    Gastroenterol Clin North Am 20:397-439. 1991
    ..The immaturity of the IgA system revealed in this disorder bears a striking resemblance to that seen in newborn infants. It may therefore be worthwhile to consider IgA deficiency in relation to the ontogeny of mucosal immunity...
  29. doi Hypersensitivity and oral tolerance in the absence of a secretory immune system
    M R Karlsson
    Centre for Immune Regulation, Oslo University Hospital, University of Oslo, Rikshospitalet, Norway
    Allergy 65:561-70. 2010
    ..Lack of secretory antibodies may cause immune dysfunction and affect mucosally induced (oral) tolerance against food antigens...
  30. ncbi Inflammatory bowel disease: clinics and pathology. Do inflammatory bowel disease and periodontal disease have similar immunopathogeneses?
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Acta Odontol Scand 59:235-43. 2001
    ..Several targets for new therapy have tentatively been identified to block immunopathological mechanisms in IBD, and inhibition of TNF has a striking beneficial effect in CD, supporting a central role of this cytokine...
  31. ncbi Cellular activating properties and morphology of membrane-bound and purified meningococcal lipopolysaccharide
    A Bjerre
    Department of Pediatrics, Ulleval University Hospital, Oslo, Norway
    J Endotoxin Res 6:437-45. 2000
    ..However, LAL activity was significantly higher for nOMV than for purified Nm-LPS and dOMV. The cellular responses of purified Nm-LPS and nOMV were reduced (>95%) by a specific anti-CD14-antibody...
  32. ncbi Phenotypic distribution of T cells in human nasal mucosa differs from that in the gut
    F L Jahnsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet, Oslo, Norway
    Am J Respir Cell Mol Biol 18:392-401. 1998
    ....
  33. ncbi Culture characterization of differentiated high endothelial venule cells from human tonsils
    E S Baekkevold
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Norway
    Lab Invest 79:327-36. 1999
    ..Our rapid and reproducible method to establish HEVEC cultures provides a useful mechanistic tool for identification of the factors that induce and maintain the HEV phenotype, as well as a source for isolation of HEV-specific genes...
  34. ncbi Recombinant expression of polymeric IgA: incorporation of J chain and secretory component of human origin
    F E Johansen
    Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Eur J Immunol 29:1701-8. 1999
    ..Development of production systems for human antigen-specific recombinant SIgA may be important for applications in passive mucosal vaccination...
  35. pmc Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice
    F E Johansen
    Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Exp Med 190:915-22. 1999
    ..Production of SIgA might therefore be a variable in the initiation of human immunopathology such as inflammatory bowel disease or gluten-sensitive enteropathy...
  36. pmc Cloning and characterization of an immunoglobulin A Fc receptor from cattle
    H Craig Morton
    Laboratory of Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Immunology 111:204-11. 2004
    ..Identification of the bFcalphaR will aid in the understanding of IgA-FcalphaR interactions, and may facilitate the isolation of FcalphaR from other species...
  37. ncbi Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease
    T S Halstensen
    Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Scand J Immunol 30:665-72. 1989
    ..Our results suggested that increase of the intraepithelial TcR gamma/delta+ CD8- subset of T cells is particularly related to coeliac disease...
  38. pmc Mac 387 antibody and detection of formalin resistant myelomonocytic L1 antigen
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    J Clin Pathol 41:963-70. 1988
    ..In addition, squamous epithelium of mucous membranes was strongly positive, in contrast to normal epidermis...
  39. ncbi Immunology of tonsils and adenoids: everything the ENT surgeon needs to know
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
    Int J Pediatr Otorhinolaryngol 67:S69-76. 2003
    ....
  40. ncbi CD4+ T cells with specific reactivity against astrovirus isolated from normal human small intestine
    O Molberg
    Institute of Transplantation Immunology, Rikshospitalet, Oslo, Norway
    Gastroenterology 114:115-22. 1998
    ..Serum antibodies against astrovirus are prevalent, indicating frequent viral exposure and postinfectious induction of systemic immune responses. Mucosal immune responses may conceivably mediate protection on astroviral reinfections...
  41. pmc The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis
    M Hvatum
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
    Gut 55:1240-7. 2006
    ....
  42. ncbi Mucosal immunity in the female genital tract
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    J Reprod Immunol 36:23-50. 1997
    ..In addition, paracellular diffusion of serum-derived and locally produced IgG through epithelia is an important part of humoral immunity in the female genital tract...
  43. ncbi Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease
    R W Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Scand J Immunol 56:652-64. 2002
    ..We conclude that isolated T cells spontaneously secreting IFN-gamma localize preferentially in the epithelium of patients with classical and refractory CD...
  44. pmc Heterogeneity of intraepithelial lymphocytes in refractory sprue: potential implications of CD30 expression
    I N Farstad
    Department of Pathology, and Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Gut 51:372-8. 2002
    ..Refractory sprue is defined as primary or secondary failure to respond to a gluten free diet in patients with coeliac disease-like enteropathy and may signify cryptic or overt enteropathy associated T cell lymphoma...
  45. pmc Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis
    A E Berstad
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    Gut 40:196-203. 1997
    ..Mucosal deposition of various activation products of the complement system may contribute to the pathogenesis of chronic gastritis and was therefore studied by immunohistochemistry...
  46. ncbi Age-related changes in CCR9+ circulating lymphocytes: are CCR9+ naive T cells recent thymic emigrants?
    R W Olaussen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Scand J Immunol 54:435-9. 2001
    ....
  47. ncbi The J chain is essential for polymeric Ig receptor-mediated epithelial transport of IgA
    F E Johansen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Immunol 167:5185-92. 2001
    ..Nevertheless, these polymers bound free SC with nearly the same affinity as pIgA containing wild-type J chain, but were transcytosed by pIgR-expressing polarized epithelial cells at a reduced efficiency...
  48. pmc Increased mucosal production of monomeric IgA1 but no IgA1 protease activity in Helicobacter pylori gastritis
    A E Berstad
    Laboratory for Immunohistochemistry, Institute of Pathology, University of Oslo, Oslo, Norway
    Am J Pathol 155:1097-104. 1999
    ..7% versus 87.9% (P = 0.0002), and for IgA2 cells to 48.9% versus 87.8% (P = 0.0002). This down-regulation of the J chain suggested that a large fraction of IgA monomers is produced in gastritis...
  49. ncbi Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissue
    R Hamre
    The Laboratory of Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, Rikshospitalet, Oslo, Norway
    Scand J Immunol 57:506-16. 2003
    ..The implications of our current findings on the biological functioning of CD89 are discussed...
  50. pmc The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment
    E S Baekkevold
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Exp Med 193:1105-12. 2001
    ..We conclude that perivascular ELC is transcytosed to the luminal surfaces of HEVs and participates in CCR7-mediated triggering of lymphocyte arrest...
  51. pmc Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies
    D E Nilssen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Norway
    Clin Exp Immunol 83:17-24. 1991
    ..The possible clinical consequences of such variable mucosal expression of IgG subclass deficiencies remain to be studied...
  52. pmc Impaired interleukin (IL)-4-associated generation of CCR4-expressing T cells in neonates with hereditary allergy risk
    U Haddeland
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Clin Exp Immunol 139:314-22. 2005
    ..Conversely, Th1 responses to antigen in the presence of LPS did not appear to be reduced compared with controls...
  53. ncbi Mechanism of IL-4-mediated up-regulation of the polymeric Ig receptor: role of STAT6 in cell type-specific delayed transcriptional response
    H Schjerven
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    J Immunol 165:3898-906. 2000
    ..This mechanism may represent a general strategy for how pleiotropic cytokines elicit cell type-specific transcriptional responses...
  54. pmc Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions
    L Farkas
    Laboratory for Immunohistochemistry and Immunopathology, University of Oslo, Rikshospitalet, Oslo, Norway
    Am J Pathol 159:237-43. 2001
    ..Together, our findings suggested that P-DCs are an important source of IFN-alpha/beta in cutaneous LE lesions and may therefore be of pathogenic importance...
  55. pmc Heterogeneous epithelial expression of class II (HLA-DR) determinants and secretory component related to dysplasia in ulcerative colitis
    T O Rognum
    Institute of Forensic Medicine, Oslo, Norway
    Br J Cancer 56:419-24. 1987
    ..Decreased SC and increased DR expression thus seemed to be related to intensified inflammatory activity, whereas heterogeneous expression of these markers was significantly more related to dysplasia...
  56. doi Bronchial response pattern of antigen presenting cells and regulatory T cells in children less than 2 years of age
    I Heier
    LIIPAT, The Pathology Clinic, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Thorax 63:703-9. 2008
    ....
  57. pmc Depletion of CD4+ CD25+ regulatory T cells inhibits local tumour growth in a mouse model of B cell lymphoma
    I Heier
    LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Clin Exp Immunol 152:381-7. 2008
    ....
  58. pmc Intestinal B cell hyperactivity in AIDS is controlled by highly active antiretroviral therapy
    D E Nilssen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    Gut 53:487-93. 2004
    ..It is well documented that highly active antiretroviral therapy (HAART) restores systemic immunity to human immunodeficiency virus (HIV) but the effect of this treatment on the mucosal immune system is less clear...
  59. ncbi Proinflammatory cytokines upregulate expression of calprotectin (L1 protein, MRP-8/MRP-14) in cultured human keratinocytes
    G Mørk
    Department of Dermatology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Br J Dermatol 149:484-91. 2003
    ..Normal skin contains no epidermal calprotectin. In biopsies from various inflammatory skin disorders, however, this antimicrobial protein occurs in the cytoplasm of keratinocytes...
  60. pmc Early detection of liver metastasis in patients with colorectal carcinoma by increased levels of circulating IgA- and IgM-associated secretory component
    D Kvale
    Institute of Pathology, University of Oslo, National Hospital, Norway
    Br J Cancer 56:629-32. 1987
    ..5 months median lead time from the first positive serum sample to clinically manifest liver disease. These data are interesting in view of the promising results reported for liver resection in patients with colorectal carcinoma...
  61. ncbi Fulminant meningococcal septicemia: dissociation between plasma thrombopoietin levels and platelet counts
    A Bjerre
    Department of Pediatrics and the Research and Development Group, Ulleval University Hospital, Oslo, Norway
    Clin Infect Dis 30:643-7. 2000
    ..In patients with fulminant septicemia, TPO level increases significantly whereas the level of circulating platelets does not...
  62. ncbi Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy
    F L Jahnsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    J Immunol 165:4062-8. 2000
    ..Together, our findings suggested that P-DCs are involved in the triggering of airway allergy and that they are directed to allergic lesions by adhesion molecules that normally mediate leukocyte extravasation in organized lymphoid tissue...
  63. ncbi The proportion of CD40+ mucosal macrophages is increased in inflammatory bowel disease whereas CD40 ligand (CD154)+ T cells are relatively decreased, suggesting differential modulation of these costimulatory molecules in human gut lamina propria
    Hege S Carlsen
    Laboratory for Immunohistochemistry and Immunopathology, Department of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Inflamm Bowel Dis 12:1013-24. 2006
    ....
  64. ncbi Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians
    Ranveig Braathen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Immunol 178:1589-97. 2007
    ..These results showed that the functional site of interaction between pIgR, J chain and Ig H chains is conserved in these species and suggests that SIgs originated in an ancestor common to tetrapods...
  65. ncbi Transcriptional regulation of the mucosal IgA system
    Finn Eirik Johansen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Trends Immunol 25:150-7. 2004
  66. ncbi CD89: the human myeloid IgA Fc receptor
    H C Morton
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway
    Arch Immunol Ther Exp (Warsz) 49:217-29. 2001
    ..Here we review current knowledge concerning the genetics, structure and biological function of CD89...
  67. ncbi Mucosal immunity
    P Brandtzaeg
    Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Dev Biol (Basel) 115:111-7. 2003
  68. ncbi A composite DNA element in the promoter of the polymeric immunoglobulin receptor regulates its constitutive expression
    F E Johansen
    Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway
    Eur J Immunol 28:1161-71. 1998
    ..Finally, a mutation in the pIgR promoter that inhibited protein binding to the E-box and the formation of the larger complex, abolished activated transcription from the reporter gene...
  69. pmc B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue
    H S Carlsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, and Department of Surgery, University of Oslo, Rikshospitalet, Oslo, Norway
    Gut 51:364-71. 2002
    ..Hence to elucidate the potential role of this chemokine and its receptor in human gut associated lymphoid tissue (GALT), we analysed their expression in normal intestine and ulcerative colitis (UC)...
  70. ncbi Systemic meningococcal disease: a model infection to study acute endotoxinemia in man
    P Brandtzaeg
    Department of Infectious Diseases, Ulleval University Hospital, Oslo, Norway
    Prog Clin Biol Res 272:263-71. 1988
    ..The results suggest that plasma LPS are quantitatively related to the development of septic shock, multiple organ failure and death from these complications in SMD, making LPS measurement a direct prognostic marker...
  71. ncbi M cell pockets of human Peyer's patches are specialized extensions of germinal centers
    T Yamanaka
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Eur J Immunol 31:107-17. 2001
    ..We propose that this M cell-associated event contributes to memory B cell survival and diversification of intestinal immunity, representing a specialized limb of GC function...
  72. pmc Secretory component mRNA and protein expression in colorectal adenomas and carcinomas
    P Krajci
    Laboratory for Immunohistochemisty and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, University of Oslo, Norway
    Br J Cancer 73:1503-10. 1996
    ....
  73. ncbi Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition
    Ranveig Braathen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 281:7075-81. 2006
    ..This implied that the C9A peptide sequence may be exploited for pIgR-mediated epithelial transport without interfering with secretory immunity...
  74. ncbi Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
    Espen O Kvale
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
    Blood 109:3369-76. 2007
    ..Our results show that DCs can regulate memory responses and that PDCs rapidly induce regulatory cytokines in effector T cells that can suppress bystander activity...
  75. pmc Cloning and characterization of equine CD89 and identification of the CD89 gene in chimpanzees and rhesus macaques
    H Craig Morton
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, University Hospital, Oslo, Norway
    Immunology 115:74-84. 2005
    ..The identification and characterization of CD89 in different species will contribute to a greater understanding of the biological role of IgA and CD89 in mucosal and systemic immunity throughout evolution...
  76. doi Increased number and activation of colonic macrophages in pediatric patients with untreated Crohn's disease
    Gøri Perminow
    Department of Pediatrics, Akershus University Hospital, Nordbyhagen and Oslo University Hospital, Ulleval, Oslo, Norway
    Inflamm Bowel Dis 15:1368-78. 2009
    ..Here, mucosal macrophages were studied in selected untreated pediatric patients compared with adults from a population-based Norwegian cohort of IBD patients. Age-matched non-IBD controls were also included...
  77. ncbi The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor
    Ranveig Braathen
    Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Biol Chem 277:42755-62. 2002
    ..This recombinant molecule formed J chain-containing pentamers that could, like IgA, efficiently form covalent complexes with the human pIgR ectodomain, known as secretory component...
  78. ncbi Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis
    Hege S Carlsen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Department of Surgery, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Blood 104:3021-7. 2004
    ..Circulating monocytes are therefore potential candidates for future targeted therapy of chronic inflammation...
  79. ncbi Characterization of the ligand binding site of the bovine IgA Fc receptor (bFc alpha R)
    H Craig Morton
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Biol Chem 279:54018-22. 2004
    ..We show that, in common with CD89, Tyr-35 in the B-C loop is essential for IgA binding. However, in contrast to earlier observations on CD89, mutation of residues in the F-G loop did not significantly inhibit IgA binding...
  80. ncbi Mucosal immunity: integration between mother and the breast-fed infant
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Vaccine 21:3382-8. 2003
    ..A beneficial clinical effect is also apparent in the industrialized world, even in relation to relatively common diseases such as otitis media and acute lower respiratory tract infections...
  81. ncbi The secretory immunoglobulin system: regulation and biological significance. Focusing on human mammary glands
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    Adv Exp Med Biol 503:1-16. 2002
  82. ncbi Role of mucosal immunity in influenza
    P Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Dev Biol (Basel) 115:39-48. 2003
    ..However, infection models in knockout mice support the notion that SIgA exerts a decisive role in protection and cross-protection against influenza...
  83. ncbi Hepatocyte NF-1 and STAT6 cooperate with additional DNA-binding factors to activate transcription of the human polymeric Ig receptor gene in response to IL-4
    Hilde Schjerven
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Immunol 170:6048-56. 2003
    ..Thus, several transcription factors cooperate in this enhanceosome to mediate IL-4 responsiveness in HT-29 epithelial cells...
  84. ncbi De novo synthesized RelB mediates TNF-induced up-regulation of the human polymeric Ig receptor
    Hilde Schjerven
    Laboratory for Immunohistochemistry and Immunopathology, Institute and Department of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    J Immunol 173:1849-57. 2004
    ..Thus, TNF-induced signaling pathways required for up-regulated pIgR expression appear to differ from those of the proinflammatory gene repertoire...
  85. ncbi Effect of elemental diet on mucosal immunopathology and clinical symptoms in type 1 refractory celiac disease
    Richard Willfred Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
    Clin Gastroenterol Hepatol 3:875-85. 2005
    ..Both conditions are difficult to treat. Here we describe the effects of a nonimmunogenic elemental diet on clinical symptoms and mucosal immunopathology in type 1 RCD...
  86. ncbi Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches
    Takeshi Yamanaka
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway
    J Immunol 170:816-22. 2003
    ....
  87. pmc Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
    Malin R Karlsson
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Exp Med 199:1679-88. 2004
    ..Collectively, our study provides human data to suggest that mucosal induction of tolerance against dietary antigens is associated with the development of CD4(+)CD25(+) Treg cells...
  88. ncbi Fine specificity of ligand-binding domain 1 in the polymeric Ig receptor: importance of the CDR2-containing region for IgM interaction
    M Røe
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    J Immunol 162:6046-52. 1999
    ....
  89. ncbi The traffic of mucosal lymphocytes to extraintestinal sites
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Pediatr Gastroenterol Nutr 39:S725-6. 2004
  90. ncbi Role of secretory antibodies in the defence against infections
    Per Brandtzaeg
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Int J Med Microbiol 293:3-15. 2003
    ..However, infection models in knockout mice strongly support the notion that SIgA exerts a decisive role in protection and cross-protection against a variety of infectious agents...
  91. ncbi Regional induction of adhesion molecules and chemokine receptors explains disparate homing of human B cells to systemic and mucosal effector sites: dispersion from tonsils
    Finn Eirik Johansen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Norway
    Blood 106:593-600. 2005
    ..However, immunization of nasopharynx-associated lymphoid tissue clearly appears preferable to target respiratory pathogens and may to some extent also protect against infections of the female genital tract...
  92. ncbi Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation
    Richard W Olaussen
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Oslo, Norway
    Gastroenterology 132:2371-82. 2007
    ..Because CCR9 expression appears to be activation dependent, we examined CCR9 on duodenal T cells from untreated and treated (gluten-free diet) patients with celiac disease and healthy controls...
  93. ncbi Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes
    Frode L Jahnsen
    LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
    Am J Respir Cell Mol Biol 30:31-7. 2004
    ..How these two cell populations regulate the tone of the local adaptive immune system should be the focus of further studies...
  94. ncbi Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk
    Unni Haddeland
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Pediatr Allergy Immunol 16:104-12. 2005
    ..This capacity was impaired in neonates with hereditary allergy risk, but clinical follow-up will be required to determine a possible effect on allergy emergence...
  95. pmc Cytokine profiles of cultured microvascular endothelial cells from the human intestine
    E M Nilsen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, University of Oslo, National Hospital, Oslo, Norway
    Gut 42:635-42. 1998
    ....
  96. ncbi Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues
    P Krajci
    Laboratory for Immunohistochemistry and Immunopathology, and University of Oslo, Rikshospitalet, Norway
    Biochem Biophys Res Commun 158:783-9. 1989
    ..2). Northern blot analysis showed mRNA expression in various human exocrine tissues in good agreement with our previous immunohistochemical studies of SC...
  97. ncbi Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia
    F L Jahnsen
    Laboratory for Immunohistochemistry, Institute of Pathology, Department of Ear, Nose, and Throat, University of Oslo, The National Hospital, Rikshospitalet, Norway
    J Immunol 163:1545-51. 1999
    ....
  98. ncbi Neisseria meningitidis lipopolysaccharides in human pathology
    P Brandtzaeg
    Departments of Pediatrics, Ulleval University Hospital, University of Oslo, Oslo, Norway
    J Endotoxin Res 7:401-20. 2001
    ..Early antibiotic treatment is mandatory. Three intervention trials to block lipid A have not significantly reduced the mortality of meningococcal septicemia...
  99. pmc Immunoglobulin-binding sites of human FcalphaRI (CD89) and bovine Fcgamma2R are located in their membrane-distal extracellular domains
    H C Morton
    Laboratory of Immunohistochemistry and Immunopathology LIIPAT, The National Hospital, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Exp Med 189:1715-22. 1999
    ..In terms of FcR-Ig interactions characterized thus far, this location is unique and surprising because it has been shown previously that leukocyte FcgammaRs and FcepsilonRI bind Ig via sites principally located in their EC2 domains...