Research Topics
Genomes and Genes | Clive R BramhamSummaryAffiliation: University of Bergen Country: Norway Publications
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Publications
Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivoElhoucine Messaoudi
Department of Physiology and Locus on Neuroscience, University of Bergen, N-5009 Bergen, Norway
J Neurosci 22:7453-61. 2002..In contrast, BDNF-LTP was completely occluded during the late phase. The results strongly support a role for BDNF in triggering transcription-dependent, late phase LTP in the intact adult brain...- BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesisClive R Bramham
Department of Biomedicine, Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
Prog Neurobiol 76:99-125. 2005..The biochemical mechanisms by which BDNF regulates local translation are also discussed. Elucidation of these mechanisms should shed light on a range of adaptive brain responses including memory and mood resilience... - Dendritic mRNA: transport, translation and functionClive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
Nat Rev Neurosci 8:776-89. 2007.... 
Local protein synthesis, actin dynamics, and LTP consolidationClive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
Curr Opin Neurobiol 18:524-31. 2008..Regulation of actin pools within dendritic spines modulates spine size and enlargement, organization of the postsynaptic density, receptor trafficking, and localization of the translational machinery...
The immediate early gene arc/arg3.1: regulation, mechanisms, and functionClive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
J Neurosci 28:11760-7. 2008..In sum, Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to diverse forms of synaptic plasticity, thereby optimizing information storage in active networks...- Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implicationsClive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
Prog Brain Res 163:453-71. 2007..Therapeutics strategies targeting synaptic consolidation hold promise for the future... - The Arc of synaptic memoryClive R Bramham
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
Exp Brain Res 200:125-40. 2010..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated... - Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation controlTambudzai Kanhema
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
J Neurochem 99:1328-37. 2006..Furthermore, the results suggest a compartment-specific regulation in which initiation is selectively enhanced by BDNF at synapses, while both initiation and elongation are modulated at non-synaptic sites... - Novel translational control in Arc-dependent long term potentiation consolidation in vivoDebabrata Panja
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
J Biol Chem 284:31498-511. 2009..In contrast, mTORC1 signaling is activated but nonessential for Arc synthesis and LTP. The work, thus, identifies translational control mechanisms uniquely tuned to Arc-dependent LTP consolidation in live rats... - Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivoElhoucine Messaoudi
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, N 5009 Bergen, Norway
J Neurosci 27:10445-55. 2007..Furthermore, Arc synthesis is required for both the induction and consolidation of LTP elicited by local BDNF infusion, thus identifying Arc as a key molecular effector of BDNF in synaptic plasticity... - MicroRNA regulation of the synaptic plasticity-related gene ArcKarin Wibrand
Department of Biomedicine and K G Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway
PLoS ONE 7:e41688. 2012..Furthermore, we show that, in contrast to miR-132, steady state levels of Arc-targeting miRNAs do not change in response to activity-dependent expression of Arc in hippocampal neurons in vitro or during LTP in vivo... - Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivoKarin Wibrand
Department of Biomedicine and Bergen Mental Health Research Center, Section for Physiology, University of Bergen, Jonas Liens vei 91, N 5009 Bergen, Norway
Eur J Neurosci 23:1501-11. 2006..These results provide novel insight into gene expression responses underlying BDNF-induced synaptic consolidation in the adult brain in vivo... - Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiationMaria Nordheim Alme
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
Neural Plast 2007:26496. 2007..These findings link chronic effects of antidepressant treatment to molecular mechanisms underlying BDNF-induced synaptic plasticity... - Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulationJonathan Soule
Department of Biomedicine, KG Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
J Biol Chem 287:22354-66. 2012.... - Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1Sjoukje D Kuipers
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
PLoS ONE 4:e4885. 2009..These results suggest an unexpected early role for Arc in adult-born DGCs, distinct from its functions in LTP, LTD, and homeostatic synaptic plasticity... - Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrusJonathan Soule
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
Neural Plast 2008:269097. 2008.... - Bursts of high-frequency stimulation trigger rapid delivery of pre-existing alpha-CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long-term potentiation in adult awake ratsBjarte Håvik
Department of Physiology, Locus on Neuroscience, Jonas Lies vei 91, University of Bergen, N 5009 Bergen, Norway
Eur J Neurosci 17:2679-89. 2003..The results support a model in which locally stored camkII messenger ribonucleic acid is rapidly transported to dendritic spines and translated during long-term potentiation in behaving rats... - Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivoKarin Wibrand
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
Eur J Neurosci 31:636-45. 2010..This study demonstrates differential regulation of primary and mature miRNA expression by mGluR and NMDAR signaling following LTP induction, the function of which remains to be defined... - Activity-dependent local translation of matrix metalloproteinase-9Magdalena Dziembowska
Laboratory of Neurobiology, The Nencki Institute, 02 093 Warsaw, Poland, Department of Biomedicine and KG Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, N 5009 Bergen, Norway, and Department of Biophysics, Warsaw University of Life Sciences SGGW, 02 787 Warsaw, Poland
J Neurosci 32:14538-47. 2012..Acting in concert with other dendritically synthesized proteins, locally secreted MMP-9 may contribute to the structural and functional plasticity of the activated synapses... - Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilitiesStephanie Le Hellard
Bergen Mental Health Research Center, Department of Clinical Medicine, University of Bergen, Bergen, Norway
PLoS ONE 4:e7534. 2009..CONCLUSION: These data present DCLK1 as a functionally pertinent gene involved in human memory and cognitive functions... - DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorderBjarte Håvik
Dr E Martens Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, Norway
PLoS ONE 7:e35424. 2012..Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity... - Chronic fluoxetine induces region-specific changes in translation factor eIF4E and eEF2 activity in the rat brainGrethe Dagestad
Department of Biomedicine, University of Bergen, and Bergen Mental Health Research Center, Jonas Lies vei 91, N-5009 Bergen, Norway
Eur J Neurosci 23:2814-8. 2006..Acute fluoxetine treatment had no effect on translational factor activity. These findings suggest that region-specific regulation of translation contributes to the delayed action of antidepressant drugs such as fluoxetine... - Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylationJanne Grønli
Department of Biological and Medical Psychology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
Behav Brain Res 235:251-62. 2012..We conclude that CMS and acute sleep deprivation have interactive and brain region-specific effects on translational regulators of relevance to mechanisms of stress responsiveness and sleep homeostasis... - Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapySjoukje D Kuipers
Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway
Curr Opin Drug Discov Devel 9:580-6. 2006..This review discusses findings that link BDNF mechanisms in synaptic plasticity to disease mechanisms and possible future therapies... - Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesisShui-Wang Ying
Department of Physiology and Locus on Neuroscience, University of Bergen, N-5009 Bergen, Norway
J Neurosci 22:1532-40. 2002..U0126 blocked Arc upregulation in parallel with BDNF-LTP. The results support a model in which BDNF triggers long-lasting synaptic strengthening through MEK-ERK and selective induction of the dendritic mRNA species Arc... - The complement control-related genes CSMD1 and CSMD2 associate to schizophreniaBjarte Håvik
Department of Clinical Medicine, University of Bergen, Bergen, Norway
Biol Psychiatry 70:35-42. 2011..We therefore aimed to examine whether key regulators of these processes are genetic susceptibility factors in schizophrenia... - Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell linesBjarte Håvik
Department of Biomedicine, Section of Physiology, University of Bergen, N 5009 Bergen, Norway
Oncol Rep 17:1501-10. 2007..The results suggest that targeting both the Hsp70 family, as well as the Hsp90 protein will have an additive negative effect on cancer cell survival, even though their pathways of action are separate... - BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling eventsMartina Gooney
Department of Physiology, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
Neurobiol Aging 25:1323-31. 2004..These results suggest a cascade of presynaptic changes contributing to the expression of BDNF-induced LTP and show that BDNF-induced transduction mechanisms are attenuated with age... - Modulation of neuronal calcium signaling by neurotrophic factorsMary Eve McCutchen
Department of Neurobiology, CIRC-429, University of Alabama at Birmingham, Birmingham, AL 35294-0021, USA
Int J Dev Neurosci 20:199-207. 2002.... - The coupling of a trkB tyrosine residue to LTPPatrik Ernfors
Unit of Molecular Neurobiology, MBB, Karolinska Institute, S 171 77 Stockholm, Sweden
Trends Neurosci 26:171-3. 2003..A recent study using mice carrying a mutation in a specific tyrosine residue of trkB pinpoints a necessary role for the phospholipase-Cgamma (PLCgamma) pathway in CREB activation and LTP maintenance... - From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learningWilliam J Tyler
Departments of Neurobiology and Psychology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-0021, USA
Learn Mem 9:224-37. 2002..Here we review recent literature showing the involvement of BDNF/TrkB signaling in hippocampal-dependent learning paradigms, as well as in the types of cellular plasticity proposed to underlie learning and memory...