Clive R Bramham

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. ncbi request reprint Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo
    Elhoucine Messaoudi
    Department of Physiology and Locus on Neuroscience, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 22:7453-61. 2002
  2. ncbi request reprint BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis
    Clive R Bramham
    Department of Biomedicine, Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Prog Neurobiol 76:99-125. 2005
  3. ncbi request reprint Dendritic mRNA: transport, translation and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Nat Rev Neurosci 8:776-89. 2007
  4. pmc Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1
    Sjoukje D Kuipers
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
    PLoS ONE 4:e4885. 2009
  5. pmc Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus
    Jonathan Soule
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
    Neural Plast 2008:269097. 2008
  6. pmc Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation
    Maria Nordheim Alme
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Neural Plast 2007:26496. 2007
  7. pmc MicroRNA regulation of the synaptic plasticity-related gene Arc
    Karin Wibrand
    Department of Biomedicine and K G Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway
    PLoS ONE 7:e41688. 2012
  8. pmc The Arc of synaptic memory
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Exp Brain Res 200:125-40. 2010
  9. pmc The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
  10. doi request reprint Local protein synthesis, actin dynamics, and LTP consolidation
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
    Curr Opin Neurobiol 18:524-31. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo
    Elhoucine Messaoudi
    Department of Physiology and Locus on Neuroscience, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 22:7453-61. 2002
    ..In contrast, BDNF-LTP was completely occluded during the late phase. The results strongly support a role for BDNF in triggering transcription-dependent, late phase LTP in the intact adult brain...
  2. ncbi request reprint BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis
    Clive R Bramham
    Department of Biomedicine, Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Prog Neurobiol 76:99-125. 2005
    ..The biochemical mechanisms by which BDNF regulates local translation are also discussed. Elucidation of these mechanisms should shed light on a range of adaptive brain responses including memory and mood resilience...
  3. ncbi request reprint Dendritic mRNA: transport, translation and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Nat Rev Neurosci 8:776-89. 2007
    ....
  4. pmc Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1
    Sjoukje D Kuipers
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
    PLoS ONE 4:e4885. 2009
    ..These results suggest an unexpected early role for Arc in adult-born DGCs, distinct from its functions in LTP, LTD, and homeostatic synaptic plasticity...
  5. pmc Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus
    Jonathan Soule
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
    Neural Plast 2008:269097. 2008
    ....
  6. pmc Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation
    Maria Nordheim Alme
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Neural Plast 2007:26496. 2007
    ..These findings link chronic effects of antidepressant treatment to molecular mechanisms underlying BDNF-induced synaptic plasticity...
  7. pmc MicroRNA regulation of the synaptic plasticity-related gene Arc
    Karin Wibrand
    Department of Biomedicine and K G Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway
    PLoS ONE 7:e41688. 2012
    ..Furthermore, we show that, in contrast to miR-132, steady state levels of Arc-targeting miRNAs do not change in response to activity-dependent expression of Arc in hippocampal neurons in vitro or during LTP in vivo...
  8. pmc The Arc of synaptic memory
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
    Exp Brain Res 200:125-40. 2010
    ..Arc holds considerable promise as a "master regulator" of protein synthesis-dependent forms of synaptic plasticity, but the mechanisms that modulate and switch Arc function are only beginning to be elucidated...
  9. pmc The immediate early gene arc/arg3.1: regulation, mechanisms, and function
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, 5009 Bergen, Norway
    J Neurosci 28:11760-7. 2008
    ..In sum, Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to diverse forms of synaptic plasticity, thereby optimizing information storage in active networks...
  10. doi request reprint Local protein synthesis, actin dynamics, and LTP consolidation
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
    Curr Opin Neurobiol 18:524-31. 2008
    ..Regulation of actin pools within dendritic spines modulates spine size and enlargement, organization of the postsynaptic density, receptor trafficking, and localization of the translational machinery...
  11. ncbi request reprint Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications
    Clive R Bramham
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Prog Brain Res 163:453-71. 2007
    ..Therapeutics strategies targeting synaptic consolidation hold promise for the future...
  12. ncbi request reprint Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control
    Tambudzai Kanhema
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Bergen, Norway
    J Neurochem 99:1328-37. 2006
    ..Furthermore, the results suggest a compartment-specific regulation in which initiation is selectively enhanced by BDNF at synapses, while both initiation and elongation are modulated at non-synaptic sites...
  13. pmc Novel translational control in Arc-dependent long term potentiation consolidation in vivo
    Debabrata Panja
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    J Biol Chem 284:31498-511. 2009
    ..In contrast, mTORC1 signaling is activated but nonessential for Arc synthesis and LTP. The work, thus, identifies translational control mechanisms uniquely tuned to Arc-dependent LTP consolidation in live rats...
  14. ncbi request reprint Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo
    Karin Wibrand
    Department of Biomedicine and Bergen Mental Health Research Center, Section for Physiology, University of Bergen, Jonas Liens vei 91, N 5009 Bergen, Norway
    Eur J Neurosci 23:1501-11. 2006
    ..These results provide novel insight into gene expression responses underlying BDNF-induced synaptic consolidation in the adult brain in vivo...
  15. ncbi request reprint Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo
    Elhoucine Messaoudi
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 27:10445-55. 2007
    ..Furthermore, Arc synthesis is required for both the induction and consolidation of LTP elicited by local BDNF infusion, thus identifying Arc as a key molecular effector of BDNF in synaptic plasticity...
  16. ncbi request reprint Bursts of high-frequency stimulation trigger rapid delivery of pre-existing alpha-CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long-term potentiation in adult awake rats
    Bjarte Håvik
    Department of Physiology, Locus on Neuroscience, Jonas Lies vei 91, University of Bergen, N 5009 Bergen, Norway
    Eur J Neurosci 17:2679-89. 2003
    ..The results support a model in which locally stored camkII messenger ribonucleic acid is rapidly transported to dendritic spines and translated during long-term potentiation in behaving rats...
  17. pmc Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation
    Jonathan Soule
    Department of Biomedicine, KG Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    J Biol Chem 287:22354-66. 2012
    ....
  18. ncbi request reprint Chronic fluoxetine induces region-specific changes in translation factor eIF4E and eEF2 activity in the rat brain
    Grethe Dagestad
    Department of Biomedicine, University of Bergen, and Bergen Mental Health Research Center, Jonas Lies vei 91, N 5009 Bergen, Norway
    Eur J Neurosci 23:2814-8. 2006
    ..Acute fluoxetine treatment had no effect on translational factor activity. These findings suggest that region-specific regulation of translation contributes to the delayed action of antidepressant drugs such as fluoxetine...
  19. pmc Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo
    Karin Wibrand
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Eur J Neurosci 31:636-45. 2010
    ..This study demonstrates differential regulation of primary and mature miRNA expression by mGluR and NMDAR signaling following LTP induction, the function of which remains to be defined...
  20. pmc Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats
    Karin Wibrand
    Department of Biomedicine and KG Jebsen Centre for Research onNeuropsychiatric Disorders, University of Bergen, Jonas Lies vei 91, BergenNO 5009, Norway
    Lipids Health Dis 12:6. 2013
    ..The purpose of the study was to evaluate the effects of krill oil (KO) on cognition and depression-like behaviour in rats...
  21. doi request reprint Activity-dependent local translation of matrix metalloproteinase-9
    Magdalena Dziembowska
    Laboratory of Neurobiology, The Nencki Institute, 02 093 Warsaw, Poland
    J Neurosci 32:14538-47. 2012
    ..Acting in concert with other dendritically synthesized proteins, locally secreted MMP-9 may contribute to the structural and functional plasticity of the activated synapses...
  22. pmc Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities
    Stephanie Le Hellard
    Bergen Mental Health Research Center, Department of Clinical Medicine, University of Bergen, Bergen, Norway
    PLoS ONE 4:e7534. 2009
    ..Human memory and general cognitive abilities are complex functions of high heritability and wide variability in the population. The brain-derived neurotrophic factor (BDNF) plays an important role in mammalian memory formation...
  23. ncbi request reprint Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis
    Shui Wang Ying
    Department of Physiology and Locus on Neuroscience, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 22:1532-40. 2002
    ..U0126 blocked Arc upregulation in parallel with BDNF-LTP. The results support a model in which BDNF triggers long-lasting synaptic strengthening through MEK-ERK and selective induction of the dendritic mRNA species Arc...
  24. pmc DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder
    Bjarte Håvik
    Dr E Martens Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, Norway
    PLoS ONE 7:e35424. 2012
    ..Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity...
  25. ncbi request reprint BDNF mechanisms in late LTP formation: A synthesis and breakdown
    Debabrata Panja
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway KG Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Neuropharmacology 76:664-76. 2014
    ..This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'...
  26. doi request reprint Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation
    Janne Grønli
    Department of Biological and Medical Psychology, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Behav Brain Res 235:251-62. 2012
    ..We conclude that CMS and acute sleep deprivation have interactive and brain region-specific effects on translational regulators of relevance to mechanisms of stress responsiveness and sleep homeostasis...
  27. ncbi request reprint Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy
    Sjoukje D Kuipers
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Curr Opin Drug Discov Devel 9:580-6. 2006
    ..This review discusses findings that link BDNF mechanisms in synaptic plasticity to disease mechanisms and possible future therapies...
  28. ncbi request reprint Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines
    Bjarte Håvik
    Department of Biomedicine, Section of Physiology, University of Bergen, N 5009 Bergen, Norway
    Oncol Rep 17:1501-10. 2007
    ..The results suggest that targeting both the Hsp70 family, as well as the Hsp90 protein will have an additive negative effect on cancer cell survival, even though their pathways of action are separate...
  29. doi request reprint The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia
    Bjarte Håvik
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Biol Psychiatry 70:35-42. 2011
    ..We therefore aimed to examine whether key regulators of these processes are genetic susceptibility factors in schizophrenia...
  30. ncbi request reprint The coupling of a trkB tyrosine residue to LTP
    Patrik Ernfors
    Unit of Molecular Neurobiology, MBB, Karolinska Institute, S 171 77 Stockholm, Sweden
    Trends Neurosci 26:171-3. 2003
    ..A recent study using mice carrying a mutation in a specific tyrosine residue of trkB pinpoints a necessary role for the phospholipase-Cgamma (PLCgamma) pathway in CREB activation and LTP maintenance...
  31. ncbi request reprint BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events
    Martina Gooney
    Department of Physiology, Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland
    Neurobiol Aging 25:1323-31. 2004
    ..These results suggest a cascade of presynaptic changes contributing to the expression of BDNF-induced LTP and show that BDNF-induced transduction mechanisms are attenuated with age...
  32. pmc Modulation of neuronal calcium signaling by neurotrophic factors
    Mary Eve McCutchen
    Department of Neurobiology, CIRC 429, University of Alabama at Birmingham, Birmingham, AL 35294 0021, USA
    Int J Dev Neurosci 20:199-207. 2002
    ....
  33. pmc From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning
    William J Tyler
    Departments of Neurobiology and Psychology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294 0021, USA
    Learn Mem 9:224-37. 2002
    ..Here we review recent literature showing the involvement of BDNF/TrkB signaling in hippocampal-dependent learning paradigms, as well as in the types of cellular plasticity proposed to underlie learning and memory...