Research Topics
| B BogenSummaryAffiliation: University of Oslo Country: Norway Publications
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Detail Information
Publications
A mouse model for immunotherapy of myelomaBjarne Bogen
Institute of Immunology, Faculty of Medicine, University of Oslo, Rikshospitalet, Norway
Hematol J 3:224-9. 2002..Based on these results, it is suggested that Id-vaccination in humans should be reserved for eradication of minimal residual disease, eg after high dose chemotherapy and stem cell transplantation...- Deletion of idiotype (Id)-specific T cells in multiple myelomaB Bogen
Institute of Immunology, The National Hospital, University of Oslo, Norway
Acta Oncol 39:783-8. 2000..We suggest that Id-vaccination should be reserved for eradication of minimal residual disease, e.g. after high-dose chemotherapy and stem-cell transplantation... - Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cellsE Lunde
Institute of Immunology and Rheumatology, University of Oslo, Norway
Nat Biotechnol 17:670-5. 1999..In vivo, the antibodies turn B cells of the spleen into potent stimulators of T cells. This approach may be useful for the generation of new vaccines... - 'Troy-bodies': antibodies as vector proteins for T cell epitopesE Lunde
Institute of Immunology, The National Hospital, N 0027, Oslo, Norway
Biomol Eng 18:109-16. 2001..Using this technology, specific reagents can be designed that target selected antigenic peptides to an APC of choice. Troy-bodies may therefore be useful for manipulation of immune responses, and in particular for vaccination purposes... 
Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cellsZ Dembic
Institute of Immunology and the Department of Oral Biology, University of Oslo, The National Hospital, 0027 Oslo, Norway
Proc Natl Acad Sci U S A 97:2697-702. 2000..Thus, a TSA can be transferred in vivo from myeloma, and possibly other types of cancer cells to APC for MHC class II presentation to CD4(+) T cells...- The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: implications for peptide vaccinationI B Rasmussen
Department of Biology, University of Oslo, Post Box 1050, N-0316 Oslo, Norway
Proc Natl Acad Sci U S A 98:10296-301. 2001..It might thus be possible to load the Ab with several different epitopes in loops in different domains and thereby make a targeted multisubunit vaccine... - Anti-class II antibodies, but not cytotoxic T-lymphocyte antigen 4-immunoglobulin hybrid molecules, prevent rejection of major histocompatibility complex class II-negative myeloma in T-cell receptor-transgenic miceZ Dembic
Institute of Immunology, University of Oslo, PB 1052 Blindern, N 0316 Oslo, Norway
Scand J Immunol 60:143-52. 2004..While Id presentation on class II molecules is absolutely required for tumour rejection, costimulatory CD80/CD86 molecules might be dispensible in this process... - Resting small B cells present endogenous immunoglobulin variable-region determinants to idiotope-specific CD4(+) T cells in vivoL A Munthe
Institut of Immunology, University of Oslo, National Hospital, Oslo, Norway
Eur J Immunol 29:4043-52. 1999..The results suggest that B cells presenting Id self-peptides generated by V(D)J recombinations or somatic mutations may directly stimulate T cell in vivo in the absence of conventional antigen... - Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell levelZ Dembic
Institute of Immunology, Department of Physiology, and Department of Oral Biology, University of Oslo, Norway
Blood 97:2808-14. 2001..A considerable fraction (> or = 15%) of DCs is spontaneously primed with tumor-specific antigen... - T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: critical role for asparagine deamidationS N McAdam
Institute of Immunology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
J Exp Med 193:1239-46. 2001.... - "Troy-bodies": recombinant antibodies that target T cell epitopes to antigen presenting cellsE Lund
Institute of Immunology, University of Oslo, Norway
Int Rev Immunol 20:647-73. 2001..Using this technology, specific reagents can be designed that target selected antigenic peptides to an APC of choice. Troy-bodies may therefore be useful for manipulation of immune responses, and in particular for vaccination purposes... 
Review: to what extent are T cells tolerant to immunoglobulin variable regions?B Bogen
Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway
Scand J Immunol 70:526-30. 2009....- Surface expression of transglutaminase 2 by dendritic cells and its potential role for uptake and presentation of gluten peptides to T cellsM Raki
Institute of Immunology, The Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
Scand J Immunol 65:213-20. 2007..However, we were unable to obtain evidence for a role of surface TG2 in the loading and subsequent generation of deamidated gluten peptides in these cells... - Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptorE Blichfeldt
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
Eur J Immunol 26:2876-84. 1996..Eur. J. Immunol. 1994. 24: 851]. Surprisingly small reductions in TCR expression per cell reduce T cell responsiveness. This suggests that dual-TCR T cells are immunologically less effective than single-TCR T cells... - Tumour necrosis factor receptor superfamily member 6 gene mutation detection by denaturing high-performance liquid chromatographyG E Etokebe
Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
Scand J Immunol 59:496-503. 2004..In conclusion, DHPLC is a suitable method for the detection of genetic variation in the TNFRSF6 gene... - Liver metastasis of cancer facilitated by chemokine receptor CCR6J Dellacasagrande
Institute of Immunology; and Department of Oral Biology, University of Oslo, The National Hospital, Oslo, Norway
Scand J Immunol 57:534-44. 2003..As metastasis in patients with cancer poses the biggest peril for survival, inhibition of CCR6 signalling, either during or after medical or surgical treatment, might be useful in preventing liver metastasis... - Generation of antibody-producing hybridomas following one single immunization with a targeted DNA vaccineI Øynebråten
Centre for Immune Regulation, Department of Immunology, University of Oslo, Oslo, Norway
Scand J Immunol 75:379-88. 2012..The data suggest that the targeted DNA vaccine format can be utilized to enhance the number of Ab-producing hybridomas and thereby be a tool to improve the B cell hybridoma technology... - Is secretion of tumour-specific antigen important for cancer eradication by CD4(+) T cells?--Implications for cancer immunotherapy by adoptive T cell transferA Corthay
Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
Scand J Immunol 73:527-30. 2011..Thus, it is anticipated that secreted TSA will be more readily detected in vivo by transferred CD4(+) T cells, resulting in more efficient tumour eradication... - T cells from multiple sclerosis patients recognize multiple epitopes on Self-IgGA L K Hestvik
Institute of Immunology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
Scand J Immunol 66:393-401. 2007..These results suggest that mutated CSF IgG from MS patients carry several T-cell epitopes, which could mediate intrathecal IgG production and inflammation in MS through idiotope-driven T-B-cell collaboration... - No recombinations between Tcra-V and Tcra-C gene segments in 669 backcross miceL Gleditsch
Institute of Immunology and Rheumatology, University of Oslo, Norway
Immunogenetics 32:297-303. 1990..This finding agrees with the conclusion from our backcross studies; namely that Tcra-V and Tcra-C gene segments are tightly linked... - A Tcra congenic mouse: V alpha epitope expression is influenced by both Tcra haplotypes and background genesL Gleditsch
Institute of Immunology and Rheumatology, University of Oslo, Norway
Immunogenetics 35:153-60. 1992..However, BALB/c mice have fewer V beta 11+ T cells than B10.D2 and B10.D2-Tcraa, therefore, the BALB/c genome must harbor a V beta 11 deleting gene(s) in addition to those described so far... - Functional phage display of two murine alpha/beta T-cell receptors is strongly dependent on fusion format, mode and periplasmic folding assistanceG A Løset
Department of Molecular Biosciences, University of Oslo, N 0316 Oslo, Norway
Protein Eng Des Sel 20:461-72. 2007..Furthermore, successful display may be obtained both in phagemid and phage versions. Importantly, improvement of poor display can be achieved by over-expressing the periplasmic chaperone FkpA... - Delivery of antigen to CD40 induces protective immune responses against tumorsKaroline W Schjetne
Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
J Immunol 178:4169-76. 2007..These results highlight the importance of agonistic targeting of Ag to CD40 for induction of long-lasting and protective immune responses... - Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of researchBjarne Bogen
Institute of Immunology, University of Oslo, Rikshospitalet University Hospital N 0027 Oslo, Norway
Haematologica 91:941-8. 2006..This review focuses on tolerance mechanisms that might hinder Id-specific immune responses in MM patients. New strategies for Id vaccination in MM are discussed... - A mouse C kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentationKaroline W Schjetne
Institute of Immunology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway
Int Immunol 14:1423-30. 2002..These results strongly argue that DC-SIGN-specific mAb are channeled into the MHC class II presentation pathway. Thus, DC-SIGN could be an efficient target for antibody-mediated delivery of T cell epitopes in vaccine development... - Efficient delivery of T cell epitopes to APC by use of MHC class II-specific TroybodiesElin Lunde
Institute of Immunology, University of Oslo, National Hospital, P O Box 1050 Blindern, N 0316 Oslo, Norway
J Immunol 168:2154-62. 2002..The study shows that class II-specific Troybodies can deliver a variety of T cell epitopes to professional APC for efficient presentation, in vitro as well as in vivo. Thus, Troybodies may be useful as tools in vaccine development... - Lymphomas can develop from B cells chronically helped by idiotype-specific T cellsMichael M Zangani
Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
J Exp Med 204:1181-91. 2007..Eventually, B lymphomas grew independent of T cells. Thus, T cells do not only eliminate cancers as currently believed. In fact, Id-specific Th2 cells can induce B lymphomas... - A VH4-34+ myeloma protein with weak autoreactivityMarianne Frøyland
Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
Haematologica 92:690-3. 2007..Thus, counter-selection of VH4-34 is pronounced but not absolute in MM. Mechanisms of how VH4-34 can occasionally be expressed in MM and clinical implications are discussed... - Human receptors of innate immunity (CD14, TLR2) are promising targets for novel recombinant immunoglobulin-based vaccine candidatesGro Tunheim
Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Sognsvannsveien 20, Rikshospitalet, Oslo, Norway
Vaccine 25:4723-34. 2007..The results show that TLR2 and CD14 are efficient targets for delivery of antigen to APC for stimulation of HLA class II-restricted CD4(+) T cells. Thus, receptors of innate immunity should be further explored as targets for vaccines... - Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic sequencesAgnete Brunsvik Fredriksen
Institute of Immunology, University of Oslo, Oslo, Norway
Blood 110:1797-805. 2007..The results suggest that bivalency and foreign sequences combine to increase the efficiency of chemokine-Id DNA vaccines... - MHC-restricted Ig V region-driven T-B lymphocyte collaboration: B cell receptor ligation facilitates switch to IgG productionLudvig A Munthe
Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, N 0027 Oslo, Norway
J Immunol 172:7476-84. 2004..Taken together, V region-driven T-B collaboration may explain induction of natural IgM Abs (absence of BCR ligation) and IgG autoantibodies (BCR ligation by autoantigen) and may be involved in the development of autoimmunity... - Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunityHarald Husebye
Institute of Cancer Research and Molecular Medicine, The Norwegian University of Science and Technology, Trondheim, Norway
EMBO J 25:683-92. 2006..Our results show that endosomal trafficking of the LPS receptor complex is essential for signal termination and LPS-associated antigen presentation, thus controlling both innate and adaptive immunity through TLR4... - DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen-presenting cellsAgnete B Fredriksen
Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, Sognsvannsvn 20, 0027 Oslo, Norway
Mol Ther 13:776-85. 2006..Targeting to APC was essential for these effects. The results show that immunogenicity of plasmid DNA vaccines can be increased by inducing muscle to secrete proteins that target antigen to APC... - Genetic fusions with viral chemokines target delivery of nonimmunogenic antigen to trigger antitumor immunity independent of chemotaxisPier Adelchi Ruffini
Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
J Leukoc Biol 76:77-85. 2004.... - Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal modelsAlexandre Corthay
University of Oslo, Institute of Immunology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
Cancer Immunol Immunother 53:759-69. 2004.... - Antibody-mediated delivery of antigen to chemokine receptors on antigen-presenting cells results in enhanced CD4+ T cell responsesKaroline W Schjetne
Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Eur J Immunol 33:3101-8. 2003..Targeting T cell epitopes to chemokine receptors by recombinant antibody should be a useful vaccine strategy for the induction of strong CD4+ T cell responses... - Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine targetKaroline W Schjetne
Institute of Immunology, University of Oslo, Rikshospitalet, Oslo, Norway
J Immunol 171:32-6. 2003..This novel function of TLR2 represents a link between innate and adaptive immunity and indicates that TLR2 could be a promising target for vaccines... - Therapeutic effect of idiotype-specific CD4+ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodiesKatrin U Lundin
Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Blood 102:605-12. 2003..The results show that Id-specific CD4+ T cells, in the absence of antibodies home to subcutaneous Id+ B lymphoma, become activated, induce inflammation, and prevent tumor development... - Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopesGro Tunheim
University of Oslo and Rikshospitalet University Hospital, N 0027 Oslo, Norway
J Leukoc Biol 77:303-10. 2005..The results show that CD14, a receptor of innate immunity, may be a promising target of recombinant Ig-based vaccines for elicitation of T cell responses in humans... - CD4+ T cells kill Id+ B-lymphoma cells: FasLigand-Fas interaction is dominant in vitro but is redundant in vivoKatrin U Lundin
Institute of Immunology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
Cancer Immunol Immunother 53:1135-45. 2004..These results suggest that there are several redundant pathways by which Id-specific CD4+ T cells eliminate Id+ B-lymphoma cells in vivo, of which FasL-Fas interaction is only one... - Primary antitumor immune response mediated by CD4+ T cellsAlexandre Corthay
Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, 0027 Oslo, Norway
Immunity 22:371-83. 2005..These data indicate a mechanism for immunosurveillance of MHC-II-negative cancer cells by tumor-specific CD4+ T cells through collaboration with macrophages... - Cerebrospinal fluid T cell clones from patients with multiple sclerosis: recognition of idiotopes on monoclonal IgG secreted by autologous cerebrospinal fluid B cellsTrygve Holmøy
Institute of Immunology, Rikshospitalet University Hospital, and University of Oslo, Rikshospitalet, Oslo, Norway
Eur J Immunol 35:1786-94. 2005..The finding of Id-specific T cells and Id-bearing B cells in the CSF indicates that they coexist within the diseased organ, and provide a basis for the study of Id-driven T-B cell collaboration in a human autoimmune disease... - Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig V region-specific T cellsLudvig André Munthe
Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
J Immunol 175:2391-400. 2005.... - Induction of central T cell tolerance: recombinant antibodies deliver peptides for deletion of antigen-specific (CD4+)8+ thymocytesKaroline Western Schjetne
Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
Eur J Immunol 35:3142-52. 2005..These experiments suggest that Troybodies constructed to target specifically thymic APC could be useful tools for induction and maintenance of central T cell tolerance in autoimmune diseases... - Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational levelKristin Melkevik Kolltveit
The Institute of Oral Biology, University of Oslo, Sognsvannsvn 10, N 0372 Oslo, Norway
Mol Immunol 45:2380-90. 2008..Our study thus points to a novel mechanism for how cAMP signaling may modulate T-cell activation through transcriptional priming of resting cells... - [DNA--the future in vaccine technology?]Rune Kjeken
Inovio Biomedical Corporation, 11494 Sorrento Valley Road, San Diego, CA, USA
Tidsskr Nor Laegeforen 126:2964-8. 2006.... - Monoclonal antibodies produced by muscle after plasmid injection and electroporationTorunn Elisabeth Tjelle
Inovio AS, Forskningsveien 2a, 0373 Oslo, Norway
Mol Ther 9:328-36. 2004..Sustained levels of serum mAb, induced by single injection of Ig genes and electroporation of muscle cells, may offer significant advantages in the treatment of human diseases...