B Bogen

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint A mouse model for immunotherapy of myeloma
    Bjarne Bogen
    Institute of Immunology, Faculty of Medicine, University of Oslo, Rikshospitalet, Norway
    Hematol J 3:224-9. 2002
  2. ncbi request reprint Deletion of idiotype (Id)-specific T cells in multiple myeloma
    B Bogen
    Institute of Immunology, The National Hospital, University of Oslo, Norway
    Acta Oncol 39:783-8. 2000
  3. ncbi request reprint Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells
    E Lunde
    Institute of Immunology and Rheumatology, University of Oslo, Norway
    Nat Biotechnol 17:670-5. 1999
  4. ncbi request reprint 'Troy-bodies': antibodies as vector proteins for T cell epitopes
    E Lunde
    Institute of Immunology, The National Hospital, N 0027, Oslo, Norway
    Biomol Eng 18:109-16. 2001
  5. pmc Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells
    Z Dembic
    Institute of Immunology and the Department of Oral Biology, University of Oslo, The National Hospital, 0027 Oslo, Norway
    Proc Natl Acad Sci U S A 97:2697-702. 2000
  6. pmc The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: implications for peptide vaccination
    I B Rasmussen
    Department of Biology, University of Oslo, Post Box 1050, N-0316 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10296-301. 2001
  7. ncbi request reprint Anti-class II antibodies, but not cytotoxic T-lymphocyte antigen 4-immunoglobulin hybrid molecules, prevent rejection of major histocompatibility complex class II-negative myeloma in T-cell receptor-transgenic mice
    Z Dembic
    Institute of Immunology, University of Oslo, PB 1052 Blindern, N 0316 Oslo, Norway
    Scand J Immunol 60:143-52. 2004
  8. ncbi request reprint Resting small B cells present endogenous immunoglobulin variable-region determinants to idiotope-specific CD4(+) T cells in vivo
    L A Munthe
    Institut of Immunology, University of Oslo, National Hospital, Oslo, Norway
    Eur J Immunol 29:4043-52. 1999
  9. ncbi request reprint Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level
    Z Dembic
    Institute of Immunology, Department of Physiology, and Department of Oral Biology, University of Oslo, Norway
    Blood 97:2808-14. 2001
  10. pmc T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: critical role for asparagine deamidation
    S N McAdam
    Institute of Immunology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
    J Exp Med 193:1239-46. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint A mouse model for immunotherapy of myeloma
    Bjarne Bogen
    Institute of Immunology, Faculty of Medicine, University of Oslo, Rikshospitalet, Norway
    Hematol J 3:224-9. 2002
    ..Based on these results, it is suggested that Id-vaccination in humans should be reserved for eradication of minimal residual disease, eg after high dose chemotherapy and stem cell transplantation...
  2. ncbi request reprint Deletion of idiotype (Id)-specific T cells in multiple myeloma
    B Bogen
    Institute of Immunology, The National Hospital, University of Oslo, Norway
    Acta Oncol 39:783-8. 2000
    ..We suggest that Id-vaccination should be reserved for eradication of minimal residual disease, e.g. after high-dose chemotherapy and stem-cell transplantation...
  3. ncbi request reprint Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells
    E Lunde
    Institute of Immunology and Rheumatology, University of Oslo, Norway
    Nat Biotechnol 17:670-5. 1999
    ..In vivo, the antibodies turn B cells of the spleen into potent stimulators of T cells. This approach may be useful for the generation of new vaccines...
  4. ncbi request reprint 'Troy-bodies': antibodies as vector proteins for T cell epitopes
    E Lunde
    Institute of Immunology, The National Hospital, N 0027, Oslo, Norway
    Biomol Eng 18:109-16. 2001
    ..Using this technology, specific reagents can be designed that target selected antigenic peptides to an APC of choice. Troy-bodies may therefore be useful for manipulation of immune responses, and in particular for vaccination purposes...
  5. pmc Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells
    Z Dembic
    Institute of Immunology and the Department of Oral Biology, University of Oslo, The National Hospital, 0027 Oslo, Norway
    Proc Natl Acad Sci U S A 97:2697-702. 2000
    ..Thus, a TSA can be transferred in vivo from myeloma, and possibly other types of cancer cells to APC for MHC class II presentation to CD4(+) T cells...
  6. pmc The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: implications for peptide vaccination
    I B Rasmussen
    Department of Biology, University of Oslo, Post Box 1050, N-0316 Oslo, Norway
    Proc Natl Acad Sci U S A 98:10296-301. 2001
    ..It might thus be possible to load the Ab with several different epitopes in loops in different domains and thereby make a targeted multisubunit vaccine...
  7. ncbi request reprint Anti-class II antibodies, but not cytotoxic T-lymphocyte antigen 4-immunoglobulin hybrid molecules, prevent rejection of major histocompatibility complex class II-negative myeloma in T-cell receptor-transgenic mice
    Z Dembic
    Institute of Immunology, University of Oslo, PB 1052 Blindern, N 0316 Oslo, Norway
    Scand J Immunol 60:143-52. 2004
    ..While Id presentation on class II molecules is absolutely required for tumour rejection, costimulatory CD80/CD86 molecules might be dispensible in this process...
  8. ncbi request reprint Resting small B cells present endogenous immunoglobulin variable-region determinants to idiotope-specific CD4(+) T cells in vivo
    L A Munthe
    Institut of Immunology, University of Oslo, National Hospital, Oslo, Norway
    Eur J Immunol 29:4043-52. 1999
    ..The results suggest that B cells presenting Id self-peptides generated by V(D)J recombinations or somatic mutations may directly stimulate T cell in vivo in the absence of conventional antigen...
  9. ncbi request reprint Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level
    Z Dembic
    Institute of Immunology, Department of Physiology, and Department of Oral Biology, University of Oslo, Norway
    Blood 97:2808-14. 2001
    ..A considerable fraction (> or = 15%) of DCs is spontaneously primed with tumor-specific antigen...
  10. pmc T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: critical role for asparagine deamidation
    S N McAdam
    Institute of Immunology, University of Oslo, Rikshospitalet, Oslo N 0027, Norway
    J Exp Med 193:1239-46. 2001
    ....
  11. ncbi request reprint "Troy-bodies": recombinant antibodies that target T cell epitopes to antigen presenting cells
    E Lund
    Institute of Immunology, University of Oslo, Norway
    Int Rev Immunol 20:647-73. 2001
    ..Using this technology, specific reagents can be designed that target selected antigenic peptides to an APC of choice. Troy-bodies may therefore be useful for manipulation of immune responses, and in particular for vaccination purposes...
  12. doi request reprint Review: to what extent are T cells tolerant to immunoglobulin variable regions?
    B Bogen
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway
    Scand J Immunol 70:526-30. 2009
    ....
  13. ncbi request reprint Surface expression of transglutaminase 2 by dendritic cells and its potential role for uptake and presentation of gluten peptides to T cells
    M Raki
    Institute of Immunology, The Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Scand J Immunol 65:213-20. 2007
    ..However, we were unable to obtain evidence for a role of surface TG2 in the loading and subsequent generation of deamidated gluten peptides in these cells...
  14. ncbi request reprint Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor
    E Blichfeldt
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Eur J Immunol 26:2876-84. 1996
    ..Eur. J. Immunol. 1994. 24: 851]. Surprisingly small reductions in TCR expression per cell reduce T cell responsiveness. This suggests that dual-TCR T cells are immunologically less effective than single-TCR T cells...
  15. ncbi request reprint Tumour necrosis factor receptor superfamily member 6 gene mutation detection by denaturing high-performance liquid chromatography
    G E Etokebe
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Scand J Immunol 59:496-503. 2004
    ..In conclusion, DHPLC is a suitable method for the detection of genetic variation in the TNFRSF6 gene...
  16. ncbi request reprint Liver metastasis of cancer facilitated by chemokine receptor CCR6
    J Dellacasagrande
    Institute of Immunology and Department of Oral Biology, University of Oslo, The National Hospital, Oslo, Norway
    Scand J Immunol 57:534-44. 2003
    ..As metastasis in patients with cancer poses the biggest peril for survival, inhibition of CCR6 signalling, either during or after medical or surgical treatment, might be useful in preventing liver metastasis...
  17. pmc Generation of antibody-producing hybridomas following one single immunization with a targeted DNA vaccine
    I Øynebråten
    Centre for Immune Regulation, Department of Immunology, University of Oslo, Oslo, Norway
    Scand J Immunol 75:379-88. 2012
    ..The data suggest that the targeted DNA vaccine format can be utilized to enhance the number of Ab-producing hybridomas and thereby be a tool to improve the B cell hybridoma technology...
  18. doi request reprint Is secretion of tumour-specific antigen important for cancer eradication by CD4(+) T cells?--Implications for cancer immunotherapy by adoptive T cell transfer
    A Corthay
    Centre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway
    Scand J Immunol 73:527-30. 2011
    ..Thus, it is anticipated that secreted TSA will be more readily detected in vivo by transferred CD4(+) T cells, resulting in more efficient tumour eradication...
  19. ncbi request reprint T cells from multiple sclerosis patients recognize multiple epitopes on Self-IgG
    A L K Hestvik
    Institute of Immunology, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Scand J Immunol 66:393-401. 2007
    ..These results suggest that mutated CSF IgG from MS patients carry several T-cell epitopes, which could mediate intrathecal IgG production and inflammation in MS through idiotope-driven T-B-cell collaboration...
  20. ncbi request reprint No recombinations between Tcra-V and Tcra-C gene segments in 669 backcross mice
    L Gleditsch
    Institute of Immunology and Rheumatology, University of Oslo, Norway
    Immunogenetics 32:297-303. 1990
    ..This finding agrees with the conclusion from our backcross studies; namely that Tcra-V and Tcra-C gene segments are tightly linked...
  21. ncbi request reprint A Tcra congenic mouse: V alpha epitope expression is influenced by both Tcra haplotypes and background genes
    L Gleditsch
    Institute of Immunology and Rheumatology, University of Oslo, Norway
    Immunogenetics 35:153-60. 1992
    ..However, BALB/c mice have fewer V beta 11+ T cells than B10.D2 and B10.D2-Tcraa, therefore, the BALB/c genome must harbor a V beta 11 deleting gene(s) in addition to those described so far...
  22. ncbi request reprint Functional phage display of two murine alpha/beta T-cell receptors is strongly dependent on fusion format, mode and periplasmic folding assistance
    G A Løset
    Department of Molecular Biosciences, University of Oslo, N 0316 Oslo, Norway
    Protein Eng Des Sel 20:461-72. 2007
    ..Furthermore, successful display may be obtained both in phagemid and phage versions. Importantly, improvement of poor display can be achieved by over-expressing the periplasmic chaperone FkpA...
  23. ncbi request reprint Delivery of antigen to CD40 induces protective immune responses against tumors
    Karoline W Schjetne
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
    J Immunol 178:4169-76. 2007
    ..These results highlight the importance of agonistic targeting of Ag to CD40 for induction of long-lasting and protective immune responses...
  24. ncbi request reprint Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of research
    Bjarne Bogen
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital N 0027 Oslo, Norway
    Haematologica 91:941-8. 2006
    ..This review focuses on tolerance mechanisms that might hinder Id-specific immune responses in MM patients. New strategies for Id vaccination in MM are discussed...
  25. ncbi request reprint A mouse C kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation
    Karoline W Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway
    Int Immunol 14:1423-30. 2002
    ..These results strongly argue that DC-SIGN-specific mAb are channeled into the MHC class II presentation pathway. Thus, DC-SIGN could be an efficient target for antibody-mediated delivery of T cell epitopes in vaccine development...
  26. ncbi request reprint Efficient delivery of T cell epitopes to APC by use of MHC class II-specific Troybodies
    Elin Lunde
    Institute of Immunology, University of Oslo, National Hospital, P O Box 1050 Blindern, N 0316 Oslo, Norway
    J Immunol 168:2154-62. 2002
    ..The study shows that class II-specific Troybodies can deliver a variety of T cell epitopes to professional APC for efficient presentation, in vitro as well as in vivo. Thus, Troybodies may be useful as tools in vaccine development...
  27. pmc Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
    Michael M Zangani
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    J Exp Med 204:1181-91. 2007
    ..Eventually, B lymphomas grew independent of T cells. Thus, T cells do not only eliminate cancers as currently believed. In fact, Id-specific Th2 cells can induce B lymphomas...
  28. ncbi request reprint A VH4-34+ myeloma protein with weak autoreactivity
    Marianne Frøyland
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Haematologica 92:690-3. 2007
    ..Thus, counter-selection of VH4-34 is pronounced but not absolute in MM. Mechanisms of how VH4-34 can occasionally be expressed in MM and clinical implications are discussed...
  29. ncbi request reprint Human receptors of innate immunity (CD14, TLR2) are promising targets for novel recombinant immunoglobulin-based vaccine candidates
    Gro Tunheim
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Sognsvannsveien 20, Rikshospitalet, Oslo, Norway
    Vaccine 25:4723-34. 2007
    ..The results show that TLR2 and CD14 are efficient targets for delivery of antigen to APC for stimulation of HLA class II-restricted CD4(+) T cells. Thus, receptors of innate immunity should be further explored as targets for vaccines...
  30. ncbi request reprint Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic sequences
    Agnete Brunsvik Fredriksen
    Institute of Immunology, University of Oslo, Oslo, Norway
    Blood 110:1797-805. 2007
    ..The results suggest that bivalency and foreign sequences combine to increase the efficiency of chemokine-Id DNA vaccines...
  31. ncbi request reprint MHC-restricted Ig V region-driven T-B lymphocyte collaboration: B cell receptor ligation facilitates switch to IgG production
    Ludvig A Munthe
    Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, N 0027 Oslo, Norway
    J Immunol 172:7476-84. 2004
    ..Taken together, V region-driven T-B collaboration may explain induction of natural IgM Abs (absence of BCR ligation) and IgG autoantibodies (BCR ligation by autoantigen) and may be involved in the development of autoimmunity...
  32. pmc Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
    Harald Husebye
    Institute of Cancer Research and Molecular Medicine, The Norwegian University of Science and Technology, Trondheim, Norway
    EMBO J 25:683-92. 2006
    ..Our results show that endosomal trafficking of the LPS receptor complex is essential for signal termination and LPS-associated antigen presentation, thus controlling both innate and adaptive immunity through TLR4...
  33. ncbi request reprint DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen-presenting cells
    Agnete B Fredriksen
    Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, Sognsvannsvn 20, 0027 Oslo, Norway
    Mol Ther 13:776-85. 2006
    ..Targeting to APC was essential for these effects. The results show that immunogenicity of plasmid DNA vaccines can be increased by inducing muscle to secrete proteins that target antigen to APC...
  34. ncbi request reprint Genetic fusions with viral chemokines target delivery of nonimmunogenic antigen to trigger antitumor immunity independent of chemotaxis
    Pier Adelchi Ruffini
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Leukoc Biol 76:77-85. 2004
    ....
  35. ncbi request reprint Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models
    Alexandre Corthay
    University of Oslo, Institute of Immunology, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Cancer Immunol Immunother 53:759-69. 2004
    ....
  36. ncbi request reprint Antibody-mediated delivery of antigen to chemokine receptors on antigen-presenting cells results in enhanced CD4+ T cell responses
    Karoline W Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Eur J Immunol 33:3101-8. 2003
    ..Targeting T cell epitopes to chemokine receptors by recombinant antibody should be a useful vaccine strategy for the induction of strong CD4+ T cell responses...
  37. ncbi request reprint Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target
    Karoline W Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Immunol 171:32-6. 2003
    ..This novel function of TLR2 represents a link between innate and adaptive immunity and indicates that TLR2 could be a promising target for vaccines...
  38. ncbi request reprint Therapeutic effect of idiotype-specific CD4+ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodies
    Katrin U Lundin
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Blood 102:605-12. 2003
    ..The results show that Id-specific CD4+ T cells, in the absence of antibodies home to subcutaneous Id+ B lymphoma, become activated, induce inflammation, and prevent tumor development...
  39. ncbi request reprint Human CD14 is an efficient target for recombinant immunoglobulin vaccine constructs that deliver T cell epitopes
    Gro Tunheim
    University of Oslo and Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Leukoc Biol 77:303-10. 2005
    ..The results show that CD14, a receptor of innate immunity, may be a promising target of recombinant Ig-based vaccines for elicitation of T cell responses in humans...
  40. ncbi request reprint CD4+ T cells kill Id+ B-lymphoma cells: FasLigand-Fas interaction is dominant in vitro but is redundant in vivo
    Katrin U Lundin
    Institute of Immunology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Cancer Immunol Immunother 53:1135-45. 2004
    ..These results suggest that there are several redundant pathways by which Id-specific CD4+ T cells eliminate Id+ B-lymphoma cells in vivo, of which FasL-Fas interaction is only one...
  41. ncbi request reprint Primary antitumor immune response mediated by CD4+ T cells
    Alexandre Corthay
    Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, 0027 Oslo, Norway
    Immunity 22:371-83. 2005
    ..These data indicate a mechanism for immunosurveillance of MHC-II-negative cancer cells by tumor-specific CD4+ T cells through collaboration with macrophages...
  42. ncbi request reprint Cerebrospinal fluid T cell clones from patients with multiple sclerosis: recognition of idiotopes on monoclonal IgG secreted by autologous cerebrospinal fluid B cells
    Trygve Holmøy
    Institute of Immunology, Rikshospitalet University Hospital, and University of Oslo, Rikshospitalet, Oslo, Norway
    Eur J Immunol 35:1786-94. 2005
    ..The finding of Id-specific T cells and Id-bearing B cells in the CSF indicates that they coexist within the diseased organ, and provide a basis for the study of Id-driven T-B cell collaboration in a human autoimmune disease...
  43. ncbi request reprint Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig V region-specific T cells
    Ludvig André Munthe
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    J Immunol 175:2391-400. 2005
    ....
  44. ncbi request reprint Induction of central T cell tolerance: recombinant antibodies deliver peptides for deletion of antigen-specific (CD4+)8+ thymocytes
    Karoline Western Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Eur J Immunol 35:3142-52. 2005
    ..These experiments suggest that Troybodies constructed to target specifically thymic APC could be useful tools for induction and maintenance of central T cell tolerance in autoimmune diseases...
  45. ncbi request reprint Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational level
    Kristin Melkevik Kolltveit
    The Institute of Oral Biology, University of Oslo, Sognsvannsvn 10, N 0372 Oslo, Norway
    Mol Immunol 45:2380-90. 2008
    ..Our study thus points to a novel mechanism for how cAMP signaling may modulate T-cell activation through transcriptional priming of resting cells...
  46. ncbi request reprint [DNA--the future in vaccine technology?]
    Rune Kjeken
    Inovio Biomedical Corporation, 11494 Sorrento Valley Road, San Diego, CA, USA
    Tidsskr Nor Laegeforen 126:2964-8. 2006
    ....
  47. ncbi request reprint Monoclonal antibodies produced by muscle after plasmid injection and electroporation
    Torunn Elisabeth Tjelle
    Inovio AS, Forskningsveien 2a, 0373 Oslo, Norway
    Mol Ther 9:328-36. 2004
    ..Sustained levels of serum mAb, induced by single injection of Ig genes and electroporation of muscle cells, may offer significant advantages in the treatment of human diseases...