Rune Blomhoff

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter
    Mari C W Myhrstad
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Free Radic Biol Med 32:386-93. 2002
  2. ncbi request reprint Dietary antioxidants and cardiovascular disease
    Rune Blomhoff
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, N 0316 Oslo, Norway
    Curr Opin Lipidol 16:47-54. 2005
  3. doi request reprint Degree of roasting is the main determinant of the effects of coffee on NF-kappaB and EpRE
    Ingvild Paur
    Department of Nutrition, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
    Free Radic Biol Med 48:1218-27. 2010
  4. pmc Supplementation of a western diet with golden kiwifruits (Actinidia chinensis var.'Hort 16A':) effects on biomarkers of oxidation damage and antioxidant protection
    Asgeir Brevik
    Department of Chemical Toxicology, Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    Nutr J 10:54. 2011
  5. ncbi request reprint Overview of retinoid metabolism and function
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Neurobiol 66:606-30. 2006
  6. ncbi request reprint Health benefits of nuts: potential role of antioxidants
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Br J Nutr 96:S52-60. 2006
  7. doi request reprint Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD
    Anette Karlsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, 0316 Oslo, Norway
    Eur J Nutr 49:345-55. 2010
  8. pmc The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide
    Monica H Carlsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Nutr J 9:3. 2010
  9. pmc Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice
    Aase Ertesvag
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Immunology 126:514-22. 2009
  10. doi request reprint Extract of oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice
    Ingvild Paur
    Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway
    Cancer Prev Res (Phila) 3:653-63. 2010

Detail Information

Publications85

  1. ncbi request reprint Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter
    Mari C W Myhrstad
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Free Radic Biol Med 32:386-93. 2002
    ..This effect may be exerted in part through GCS gene regulation, and may also contribute to the disease-preventing effect of fruits and vegetables...
  2. ncbi request reprint Dietary antioxidants and cardiovascular disease
    Rune Blomhoff
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, N 0316 Oslo, Norway
    Curr Opin Lipidol 16:47-54. 2005
    ..Intervention with alpha-tocopherol, ascorbic acid and beta-carotene does not appear to reduce pathogenesis. The purpose of this review is to describe alternative antioxidant mechanisms that may be involved...
  3. doi request reprint Degree of roasting is the main determinant of the effects of coffee on NF-kappaB and EpRE
    Ingvild Paur
    Department of Nutrition, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway
    Free Radic Biol Med 48:1218-27. 2010
    ..7-fold increase. Our results demonstrate that dark-roasted coffee dampens a crucial mechanism in inflammation and induces a pivotal mechanism in oxidative stress defense...
  4. pmc Supplementation of a western diet with golden kiwifruits (Actinidia chinensis var.'Hort 16A':) effects on biomarkers of oxidation damage and antioxidant protection
    Asgeir Brevik
    Department of Chemical Toxicology, Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
    Nutr J 10:54. 2011
    ....
  5. ncbi request reprint Overview of retinoid metabolism and function
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Neurobiol 66:606-30. 2006
    ..This insight has improved our view of retinoids as critical molecules in vision, normal embryonic development, and in control of cellular growth, differentiation, and death throughout life...
  6. ncbi request reprint Health benefits of nuts: potential role of antioxidants
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Br J Nutr 96:S52-60. 2006
    ..Further studies are needed to clarify whether antioxidants contribute to this apparent beneficial health effect of nuts...
  7. doi request reprint Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD
    Anette Karlsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, 0316 Oslo, Norway
    Eur J Nutr 49:345-55. 2010
    ..We investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD)...
  8. pmc The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide
    Monica H Carlsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Nutr J 9:3. 2010
    ..This database is intended for use in a wide range of nutritional research, from in vitro and cell and animal studies, to clinical trials and nutritional epidemiological studies...
  9. pmc Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice
    Aase Ertesvag
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Immunology 126:514-22. 2009
    ....
  10. doi request reprint Extract of oregano, coffee, thyme, clove, and walnuts inhibits NF-kappaB in monocytes and in transgenic reporter mice
    Ingvild Paur
    Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway
    Cancer Prev Res (Phila) 3:653-63. 2010
    ....
  11. doi request reprint Retinoic acid dampens LPS-induced NF-kappaB activity: results from human monoblasts and in vivo imaging of NF-kappaB reporter mice
    Liv M Austenaa
    Department of Nutrition Research, Institute of Basic Medical Sciences, University of Oslo, Norway
    J Nutr Biochem 20:726-34. 2009
    ..This provides more evidence for retinoic acid's anti-inflammatory potential, which may have clinical implications in terms of fighting microbial infections...
  12. pmc Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers
    Siv K Bøhn
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway
    BMC Med 8:54. 2010
    ..We have tested the hypothesis that intake of antioxidant-rich foods can affect groups of genes associated with cellular stress defence in human blood cells. Trial registration number: NCT00520819 http://clinicaltrials.gov...
  13. doi request reprint Compliance, tolerability and safety of two antioxidant-rich diets: a randomised controlled trial in male smokers
    Anette Karlsen
    Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Br J Nutr 106:557-71. 2011
    ..Such diets may be useful in future studies investigating whether dietary antioxidants may reduce oxidative stress and related diseases...
  14. doi request reprint Plant extracts of spices and coffee synergistically dampen nuclear factor-κB in U937 cells
    Marit Kolberg
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, 0317 Oslo, Norway
    Nutr Res 33:817-30. 2013
    ..Such complex mechanistic interactions between phytochemicals are likely to underlie the protective effects of a plant-based diet on life-style related diseases. ..
  15. pmc Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study
    Amrit K Sakhi
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0316 Oslo, Norway
    BMC Cancer 9:458. 2009
    ..Furthermore, the effect of radiotherapy on these biomarkers and their association with survival in HNSCC patients were investigated...
  16. pmc Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
    Siv K Bøhn
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo 0316, Norway
    BMC Cancer 12:426. 2012
    ..The aim of the present study was to compare stress associated blood cell gene expression between two sub-groups of HNSCC patients with different biochemical responses to radiotherapy...
  17. ncbi request reprint Whole-grain consumption is associated with a reduced risk of noncardiovascular, noncancer death attributed to inflammatory diseases in the Iowa Women's Health Study
    David R Jacobs
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 85:1606-14. 2007
    ..It has recently been shown that oxidative stress, infection, and inflammation are predominant pathophysiologic factors for several major diseases...
  18. ncbi request reprint Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States
    Bente L Halvorsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 84:95-135. 2006
    ..We suggest that other redox-active phytochemicals may be more effective and that a combination of different redox-active compounds (ie, antioxidants or reductants) may be needed for proper protection against oxidative damage...
  19. doi request reprint Relative validity of fruit and vegetable intake estimated from an FFQ, using carotenoid and flavonoid biomarkers and the method of triads
    Monica H Carlsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Br J Nutr 105:1530-8. 2011
    ....
  20. doi request reprint Postradiotherapy plasma lutein, alpha-carotene, and beta-carotene are positively associated with survival in patients with head and neck squamous cell carcinoma
    Amrit Kaur Sakhi
    Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Nutr Cancer 62:322-8. 2010
    ..Increasing plasma carotenoid concentration should be done by increasing intake of carotenoid-rich fruits and vegetables, as other studies have shown either no or negative effects due to use of carotenoid supplements...
  21. ncbi request reprint Antioxidant activity in the newborn brain: a luciferase mouse model
    Gaute Dohlen
    Department of Pediatric Research, Rikshospitalet Medical Center, Oslo, Norway
    Neonatology 93:125-31. 2008
    ..The aim of this study is to present a model that can monitor genetic activity in vivo during pregnancy and the first 10 days of life...
  22. ncbi request reprint Dietary polyphenols identified as intracellular protein kinase A inhibitors
    Jan Øivind Moskaug
    Dept of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Eur J Nutr 47:460-9. 2008
    ..A few polyphenols have been shown to be potent inhibitors of protein kinases...
  23. ncbi request reprint Molecular imaging of the transcription factor NF-kappaB, a primary regulator of stress response
    Harald Carlsen
    Department of Nutrition, Faculty of Medicine, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Mutat Res 551:199-211. 2004
    ....
  24. doi request reprint Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo - studies in electrophile response element transgenic mice
    Trude Rakel Balstad
    Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway
    Mol Nutr Food Res 55:185-97. 2011
    ..A common feature of these genes is binding sites for transcription factor nuclear factor erythroid-2-related factor 2 (Nrf2), named electrophile response elements (EpREs) within their promoters...
  25. doi request reprint Reduced antioxidant defense and increased oxidative stress in spinal cord injured patients
    Nasser Ezzathkah Bastani
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Arch Phys Med Rehabil 93:2223-8.e2. 2012
    ..To determine the plasma and urine levels of antioxidants and oxidative stress biomarkers in subjects with spinal cord injury (SCI) the first year after injury...
  26. pmc Retinoic acid signalling is activated in the postischemic heart and may influence remodelling
    Dusan Bilbija
    Department of Physiology, University of Oslo, Oslo, Norway
    PLoS ONE 7:e44740. 2012
    ..We hypothesized that the retinoic acid (RA) signalling pathway is activated in myocardial ischemia and postischemic remodelling...
  27. ncbi request reprint Corneal NF-kappaB activity is necessary for the retention of transparency in the cornea of UV-B-exposed transgenic reporter mice
    George Alexander
    Department of Nutrition, Faculty of Medicine, University of Oslo, P O Box 1046, Blindern, 0316 Oslo, Norway
    Exp Eye Res 82:700-9. 2006
    ....
  28. ncbi request reprint Bilberry extracts induce gene expression through the electrophile response element
    Mari Charlotte Wik Myhrstad
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Nutr Cancer 54:94-101. 2006
    ..We further provide evidence that this induction is mediated through EpREs...
  29. pmc Intakes of culinary herbs and spices from a food frequency questionnaire evaluated against 28-days estimated records
    Monica H Carlsen
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Norway
    Nutr J 10:50. 2011
    ..Thus we compared the intake estimates from the FFQ with 28 days of estimated records of herb and spice consumption as a reference method...
  30. ncbi request reprint Simultaneous and trace determination of reduced and oxidized glutathione in minute plasma samples using dual mode fluorescence detection and column switching high performance liquid chromatography
    Amrit K Sakhi
    Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, PO Box 1046 Blindern, N 0316 Oslo, Norway
    J Chromatogr A 1142:178-84. 2007
    ....
  31. doi request reprint Evolution of transcription factor binding sites in mammalian gene regulatory regions: handling counterintuitive results
    James E Balmer
    Institute of Basic Medical Sciences, School of Medicine, University of Oslo, Box 1046 Blindern, Oslo, Norway
    J Mol Evol 68:654-64. 2009
    ..However, after the data set is carefully vetted against binding site overloading, and after the likelihood of a specific type of compensatory evolution is evaluated, conservation rates as high as 94% appear reasonable...
  32. ncbi request reprint Apple, cherry, and blackcurrant increases nuclear factor kappa B activation in liver of transgenic mice
    Trude R Balstad
    Department of Nutrition, Faculty of Medicine, University of Oslo, Oslo, Norway
    Nutr Cancer 62:841-8. 2010
    ....
  33. ncbi request reprint In vivo imaging of NF-kappa B activity
    Harald Carlsen
    Institute for Nutrition Research, University of Oslo, Blindern, 0316 Oslo, Norway
    J Immunol 168:1441-6. 2002
    ..Thus, we have developed a versatile model for monitoring NF-kappaB activation in vivo...
  34. doi request reprint Expression of retinoic acid target genes in coronary artery disease
    Dusan Bilbija
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Int J Mol Med 33:677-86. 2014
    ..ATRA accumulated in the failing human heart. All investigated cell types present in the heart had induced expression of RA target genes when stimulated with ATRA, which also influenced cell proliferation. ..
  35. ncbi request reprint Polyphenols and glutathione synthesis regulation
    Jan Ø Moskaug
    Institute for Nutrition Research, University of Oslo, Norway
    Am J Clin Nutr 81:277S-283S. 2005
    ....
  36. ncbi request reprint Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults
    Anette Karlsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway N 0316
    J Nutr 137:1951-4. 2007
    ....
  37. ncbi request reprint Simultaneous quantification of reduced and oxidized glutathione in plasma using a two-dimensional chromatographic system with parallel porous graphitized carbon columns coupled with fluorescence and coulometric electrochemical detection
    Amrit K Sakhi
    Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    J Chromatogr A 1104:179-89. 2006
    ..The method is fully validated and is currently used for determination of GSH, GSSG and its redox potential in different clinical studies...
  38. ncbi request reprint Gene deletion of NF-kappaB p105 enhances neointima formation in a mouse model of carotid artery injury
    Arno Ruusalepp
    Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, Norway
    Cardiovasc Drugs Ther 20:103-11. 2006
    ..These data indicate that the p105 subunit of NF-kappaB plays an essential role in vascular healing, and defects in NF-kappaB p105 promote neointima hyperplasia...
  39. doi request reprint Both base excision repair and nucleotide excision repair in humans are influenced by nutritional factors
    Asgeir Brevik
    Division of Environmental Medicine, Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Cell Biochem Funct 29:36-42. 2011
    ..Here we have demonstrated that DNA repair is affected by diet and that modified versions of the comet assay can be used to assess activity of different DNA repair pathways in human biomonitoring studies...
  40. doi request reprint Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice
    Gabor Czibik
    Department of Physiology, IMB, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103, Blindern, NO 0317 Oslo, Norway
    Cardiovasc Res 82:107-14. 2009
    ..The present study investigates whether the cardioprotection achieved by gene delivery of hypoxia-inducible factor-1 alpha (HIF-1 alpha) depends on the downstream factor haem oxygenase (HMOX)-1...
  41. doi request reprint Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study
    Kjell M Russnes
    Department of Epidemiology, Harvard School of Public Health, Boston, MA Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Oslo, Norway Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Int J Cancer 134:1156-65. 2014
    ..The indication of increased risk for lethal and advanced prostate cancers with high TAC intake from supplements warrants further investigation. ..
  42. ncbi request reprint Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma
    Siv Kjølsrud Bøhn
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P O Box 1046, Blindern N 0316, Oslo, Norway
    Cancer Lett 238:240-7. 2006
    ..Systemic oxidative stress as assessed by low GSH in post-radiotherapy plasma is associated to outcome in HNSCC patients...
  43. doi request reprint Dried blood spot (DBS) sample collection for determination of the oxidative stress biomarker 8-epi-PGF(2α) in humans using liquid chromatography/tandem mass spectrometry
    Nasser E Bastani
    Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316, Oslo, Norway
    Rapid Commun Mass Spectrom 26:645-52. 2012
    ..In this study we have developed an analytical tool for finger-tip blood sampling and analysis of 8-epi-PGF(2α) from dried blood spots (DBS)...
  44. pmc Evaluation of energy and dietary intake estimates from a food frequency questionnaire using independent energy expenditure measurement and weighed food records
    Monica H Carlsen
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway
    Nutr J 9:37. 2010
    ..The aim of the present study was to evaluate the relative validity of the intakes of energy, food and nutrients from the FFQ...
  45. doi request reprint In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012
    Anders Kielland
    Department of Nutrition, Institute of Basic Medical Sciences, The Medical Faculty, University of Oslo, P O Box 1046 Blindern, 0316 Oslo, Norway
    Free Radic Biol Med 47:760-6. 2009
    ..In conclusion, L-012 is well distributed in the mouse body and mediates a strong ROS/RNS-dependent luminescent signal in vivo and is useful for monitoring the development and regulation of inflammation in living organisms...
  46. ncbi request reprint Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women's Health Study
    Lene Frost Andersen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 83:1039-46. 2006
    ..Coffee is the major source of dietary antioxidants. The association between coffee consumption and risk of death from diseases associated with inflammatory or oxidative stress has not been studied...
  47. ncbi request reprint Reoxygenation of hypoxic mice with 100% oxygen induces brain nuclear factor-kappa B
    Gaute Døhlen
    Department of Pediatric Research, Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Pediatr Res 58:941-5. 2005
    ..However, when reoxygenation occurs with 21% O2 (room air), no elevation in NF-kappaB activity is observed. Thus, reoxygenation with room air may induce less brain inflammation than reoxygenation with pure oxygen...
  48. ncbi request reprint Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans
    Arne Svilaas
    Lipid Clinic, Medical Department, Rikshospitalet, University of Oslo, Oslo, Norway
    J Nutr 134:562-7. 2004
    ..These data agree with the hypothesis that dietary antioxidants other than the well-known antioxidants contribute to our antioxidant defense. Surprisingly, the single greatest contributor to the total antioxidant intake was coffee...
  49. ncbi request reprint A systematic screening of total antioxidants in dietary plants
    Bente L Halvorsen
    Institute for Nutrition Research, Faculty of Medicine, University of Oslo, Blindern, 0316 Oslo, Norway
    J Nutr 132:461-71. 2002
    ..Vegetables contributed only 8.9%. The systematic analysis presented here will facilitate research into the nutritional role of the combined effect of antioxidants in dietary plants...
  50. ncbi request reprint Noninvasive in vivo imaging of protein kinase A activity
    Jan Øivind Moskaug
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Mol Imaging 7:35-41. 2008
    ..This study shows that luciferase can be used for in vivo measurements of kinase activity, suggesting that different kinase target sequences in luciferase can monitor kinase activity modulation...
  51. ncbi request reprint Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants
    Kristin Braekke
    Pediatric Intensive Care Unit, Ulleval University Hospital, Oslo, Norway
    J Pediatr 151:23-8. 2007
    ..To evaluate whether our current practice of giving iron 18 mg daily to 6-week-old infants with very low birth weight (VLBW) was associated with increased oxidative stress markers or decreased antioxidant status...
  52. doi request reprint Determination of 8-epi PGF(2alpha) concentrations as a biomarker of oxidative stress using triple-stage liquid chromatography/tandem mass spectrometry
    Nasser E Bastani
    Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Rapid Commun Mass Spectrom 23:2885-90. 2009
    ..The mass limit of detection (mLOD) was 1 pg of analyte eluting from the column. The assay has been successfully applied to the analysis of human plasma, whole blood, erythrocytes and urine samples...
  53. pmc Anecdotes, data and regulatory modules
    James E Balmer
    Institute of Basic Medical Sciences, School of Medicine, University of Oslo, 0316 Oslo, Norway
    Biol Lett 2:431-4. 2006
    ..5% of cases. Based on this particular sample, we found a mean module length of 609 nucleotides containing, on an average, 24.5 presumptive regulatory signals of length greater than 5 and averaging 8.5 nucleotides each...
  54. doi request reprint NF-κB activity in perinatal brain during infectious and hypoxic-ischemic insults revealed by a reporter mouse
    Anders Kielland
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
    Brain Pathol 22:499-510. 2012
    ..In conclusion, by using this transgenic reporter mouse in experimental models of perinatal complications, we could assess NF-κB activity in vivo and subsequently determine the cellular origin in the tissues...
  55. ncbi request reprint Vitamin A distribution and content in tissues of the lamprey, Lampetra japonica
    Heidi L Wold
    Institute for Nutrition Research, Faculty of Medicine, University of Oslo, Oslo, Norway
    Anat Rec A Discov Mol Cell Evol Biol 276:134-42. 2004
    ..Stellate cells derived from the splanchnic and intermediate mesoderm have high capacity and fibroblasts derived from the somatic and dorsal mesoderm have low capacity for the storage of vitamin A in the lamprey...
  56. ncbi request reprint Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging
    Liv M I Austenaa
    Department of Nutrition, Faculty of Medicine, University of Oslo, Norway
    FASEB J 18:1255-7. 2004
    ..Our results suggest that vitamin A status, and vitamin A itself, affects NF-kappaB activity in vivo and that the elevated NF-kappaB activity in VAD may be a mechanism underlying some of the features of VAD syndrome...
  57. ncbi request reprint All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3
    Nikolai Engedal
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Immunol 177:2851-61. 2006
    ..In conclusion, our results indicate that RA, via RAR, stimulates IL-2-induced signaling in a JAK-dependent manner to enhance cyclin D3 expression and thereby promote T cell proliferation...
  58. ncbi request reprint Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors
    George Alexander
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Invest Ophthalmol Vis Sci 44:2683-8. 2003
    ..To examine the in vivo activation of nuclear factor (NF)-kappaB in mouse lens epithelia by using bacterial lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, and UV-B radiation...
  59. ncbi request reprint Quantitative high-throughput determination of endogenous retinoids in human plasma using triple-stage liquid chromatography/tandem mass spectrometry
    Thomas E Gundersen
    Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Rapid Commun Mass Spectrom 21:1176-86. 2007
    ..1-0.2 ng/mL and the mass limit of detection (mLOD) was in the range 1-4 pg on column for the retinoic acids. The assay has been successfully applied to the analysis of 1700 plasma samples...
  60. pmc Food items contributing most to variation in antioxidant intake; a cross-sectional study among Norwegian women
    Samera Azeem Qureshi
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    BMC Public Health 14:45. 2014
    ..We used food frequency data from a population-based sample of women to identify the food items that contributed most to the variation in antioxidant intake in Norwegian diet...
  61. ncbi request reprint Coffee and cancer risk, epidemiological evidence, and molecular mechanisms
    Siv Kjølsrud Bøhn
    Department of Nutrition, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Norway
    Mol Nutr Food Res 58:915-30. 2014
    ..The experimental evidence for effects of coffee and coffee constituents on each of these processes is discussed. ..
  62. doi request reprint Vitamin D, season, and risk of prostate cancer: a nested case-control study within Norwegian health studies
    Haakon E Meyer
    Department of Community Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Am J Clin Nutr 97:147-54. 2013
    ....
  63. ncbi request reprint Molecular imaging of the biological effects of quercetin and quercetin-rich foods
    Jan Øivind Moskaug
    Institute for Nutrition Research, Faculty of Medicine, University of Oslo, P O Box 1046, Blindern, 0316 Oslo, Norway
    Mech Ageing Dev 125:315-24. 2004
    ..We utilize these in vivo models to elucidate the role of various flavonoids, such as quercetin, for modulating gene expression related to oxidative stress and the antioxidant defence system...
  64. pmc Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model
    Virginie Follin-Arbelet
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    BMC Cancer 11:301. 2011
    ..We have elucidated the potential for manipulating the cAMP signaling pathway as a target for inhibiting the growth of multiple myeloma cells...
  65. ncbi request reprint Capillary high-performance liquid chromatographic determination of lutein and zeaxanthin in aqueous humor from a single mouse eye
    Anette Karlsen
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    J Chromatogr B Analyt Technol Biomed Life Sci 795:17-23. 2003
    ..In this paper we present a rapid, sensitive and robust packed capillary high-performance liquid chromatographic visible detection method for the quantification of lutein and zeaxanthin in the aqueous humor of single mouse eyes...
  66. pmc Diet-induced obesity increases NF-kappaB signaling in reporter mice
    Harald Carlsen
    Department of Nutrition, The Medical Faculty, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046, Blindern, 0316, Oslo, Norway
    Genes Nutr 4:215-22. 2009
    ..In conclusion, HFD increased NF-kappaB activity in both female and male mice. However, HFD differentially increased activity in males and females. The moderate increase in abdomen of male mice may be linked to glucose intolerance...
  67. ncbi request reprint Berry intake increases the activity of the gamma-glutamylcysteine synthetase promoter in transgenic reporter mice
    Harald Carlsen
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    J Nutr 133:2137-40. 2003
    ..Our results demonstrate for the first time that berry extracts rich in polyphenols and EA can induce GCS(h) in vivo. The induction of protective enzymes may be important for the chemopreventive effects of fruits and vegetables...
  68. doi request reprint Validation of a quantitative assay for the total content of lipophilic and hydrophilic antioxidants in foods
    Bente L Halvorsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, 0316 Oslo, Norway
    Food Chem 127:761-8. 2011
    ..We conclude that the FRAP assay, with 4min reaction time, is suitable for high-throughput screening of total antioxidant content of edible items...
  69. ncbi request reprint High-throughput analysis of vitamin C in human plasma with the use of HPLC with monolithic column and UV-detection
    Anette Karlsen
    Institute of Basic Medical Sciences, Department of Nutrition Research, University of Oslo, P O Box 1046, Blindern, N 0316 Oslo, Norway
    J Chromatogr B Analyt Technol Biomed Life Sci 824:132-8. 2005
    ..The method was used for the assessment of ascorbic acid and total ascorbic acid during several clinical studies...
  70. ncbi request reprint Retinoids: essential nutrients for the central nervous system
    Rune Blomhoff
    Institute for Nutrition Research, University of Oslo, Norway
    Nutr Health 16:35-9. 2002
  71. ncbi request reprint Gene expression regulation by retinoic acid
    James E Balmer
    Institute for Nutrition Research, School of Medicine, University of Oslo, Oslo, Norway
    J Lipid Res 43:1773-808. 2002
    ..Most of the remaining 133 targets seem to be regulated indirectly, usually through a transcriptional intermediary, in the contexts studied so far (Category 0)...
  72. ncbi request reprint Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations
    Anne M Myhre
    Sogn Center for Child and Adolescent Psychiatry, University Hospital, University of Oslo, Blindern, 0316 Oslo, Norway
    Am J Clin Nutr 78:1152-9. 2003
    ..It is well established that an excessive intake of retinol (vitamin A) is toxic; however, it has been > 25 y since the last extensive treatise of case reports on this subject...
  73. ncbi request reprint Preconditioning with estradiol abolishes its neuroprotection in cerebellar neurons
    Asa B Fallgren
    Department of Pharmaceutical Biosciences, University of Oslo, P O Box 1068 Blindern, N 0316 Oslo, Norway
    Biochem Biophys Res Commun 352:966-72. 2007
    ..Thus, vitamins C+E and progesterone were more effective long-term neuroprotectors, since preconditioning did not reduce glutathione...
  74. ncbi request reprint Molecular imaging of NF-kappaB in prostate tissue after systemic administration of IL-1 beta
    Eugene V Vykhovanets
    Department of Urology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Prostate 68:34-41. 2008
    ..A wide range of human cancers and inflammatory disorders express inappropriate regulation of NF-kappaB. The role of NF-kappaB in intraprostatic inflammation has not been elucidated...
  75. ncbi request reprint [Antioxidants and oxidative stress]
    Rune Blomhoff
    Institutt for medisinske basalfag, Universitetet i Oslo, Postboks 1046 Blindern, 0316 Oslo
    Tidsskr Nor Laegeforen 124:1643-5. 2004
    ..An improved antioxidant defence may therefore protect against these diseases. Recent studies have demonstrated that dietary plants contain several hundred different antioxidants...
  76. doi request reprint Hepatic nuclear factor kappa B regulates neutrophil recruitment to the injured brain
    Sandra J Campbell
    Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    J Neuropathol Exp Neurol 67:223-30. 2008
    ..In conclusion, acute brain injury is associated with rapid and robust activation of hepatic NF-kappa B, which is required for efficient mobilization of circulating leukocytes to the brain...
  77. doi request reprint In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection
    Sofie Notebaert
    Laboratory of Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Cell Microbiol 10:1249-58. 2008
    ....
  78. ncbi request reprint Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells
    Jason Partridge
    BHF Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
    FASEB J 21:3553-61. 2007
    ..Thus modulation of NF-kappaB function may underlie the atheroprotective effects of laminar shear stress...
  79. ncbi request reprint Several culinary and medicinal herbs are important sources of dietary antioxidants
    Steinar Dragland
    The Norwegian Crop Research Institute, Apelsvold Research Station Div Kise, N 2350 Nes, Norway
    J Nutr 133:1286-90. 2003
    ..It is tempting to speculate that several of the effects due to these herbs are mediated by their antioxidant activities...
  80. ncbi request reprint Is serum gamma glutamyltransferase a marker of oxidative stress?
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Free Radic Res 38:535-9. 2004
    ..Even though studies on serum and/or cellular GGT is at a beginning stage, our epidemiological findings suggest that serum GGT might be useful in studying oxidative stress-related issues in both epidemiological and clinical settings...
  81. ncbi request reprint Caught in the act: in vivo molecular imaging of the transcription factor NF-kappaB after myocardial infarction
    Jochen Tillmanns
    Medizinische Klinik der Universität Würzburg, Germany
    Biochem Biophys Res Commun 342:773-4. 2006
    ..Thus, in vivo measurement of the activation of NF-kappaB is feasible. NF-kappaB activity might play an important role for the remodeling process...
  82. ncbi request reprint Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds
    Dirk Kluth
    German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Free Radic Biol Med 42:315-25. 2007
    ..It is concluded that individual polyphenols as well as polyphenol-rich plant extracts may affect phase 1 and 2 enzyme expression by distinct mechanisms that must be elucidated, before potential health effects can reliably be predicted...
  83. ncbi request reprint Lutein effect on retina and hippocampus of diabetic mice
    Maria Muriach
    Departamento de Fisiologia, Farmacología and Toxicología, Universidad CEU Cardenal Herrera, Valencia, Spain
    Free Radic Biol Med 41:979-84. 2006
    ..Lutein could be an appropriate coadjuvant treatment for the changes observed in this study...
  84. ncbi request reprint Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen
    B Rhiannon Noble
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol Lung Cell Mol Physiol 293:L1079-87. 2007
    ..Retinoid signaling perturbations do not appear to involve oxidative effects of nitrofen. Any substantial roles of nitrofen-induced perturbations of thyroid hormone signaling or receptor function are not supported...