Bodil Bjerkehagen

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint [Molecular genetics in the diagnosis of bone and soft tissue tumours]
    Bodil Bjerkehagen
    Fagområde patologi, Rikshospitalet Radiumhospitalet HF, Montebello, 0310 Oslo
    Tidsskr Nor Laegeforen 125:3286-9. 2005
  2. doi request reprint Radiation-induced sarcoma: 25-year experience from the Norwegian Radium Hospital
    Bodil Bjerkehagen
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Acta Oncol 47:1475-82. 2008
  3. pmc DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
    Stine H Kresse
    Department of Tumor Biology, Radiumhospitalet, Rikshospitalet, Oslo, Norway
    Mol Cancer 7:48. 2008
  4. doi request reprint t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 48:1051-6. 2009
  5. doi request reprint LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
    Stine H Kresse
    Department of Tumor Biology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 48:679-93. 2009
  6. doi request reprint Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 47:558-64. 2008
  7. pmc Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
    Kaja B Nyquist
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e49705. 2012
  8. doi request reprint Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Acta Oncol 48:1165-72. 2009
  9. doi request reprint Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
    Helge R Brekke
    Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    J Clin Oncol 28:1573-82. 2010
  10. doi request reprint Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Genes Chromosomes Cancer 52:610-8. 2013

Collaborators

Detail Information

Publications34

  1. ncbi request reprint [Molecular genetics in the diagnosis of bone and soft tissue tumours]
    Bodil Bjerkehagen
    Fagområde patologi, Rikshospitalet Radiumhospitalet HF, Montebello, 0310 Oslo
    Tidsskr Nor Laegeforen 125:3286-9. 2005
    ..Bone and soft tissue tumours are relatively rare; they make up about 1% of all new cancer cases, but around 10% among children and adolescents...
  2. doi request reprint Radiation-induced sarcoma: 25-year experience from the Norwegian Radium Hospital
    Bodil Bjerkehagen
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Acta Oncol 47:1475-82. 2008
    ..The aim of this study was to determine the prevalence and outcome of radiation-induced sarcomas (RISs) among sarcoma patients referred to the Norwegian Radium Hospital (NRH)...
  3. pmc DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
    Stine H Kresse
    Department of Tumor Biology, Radiumhospitalet, Rikshospitalet, Oslo, Norway
    Mol Cancer 7:48. 2008
    ....
  4. doi request reprint t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 48:1051-6. 2009
    ..How the new fusion gene contributes to tumorigenesis is unknown, but the finding of an EWSR1 rearrangement suggests that this, possibly even the EWSR1-ZNF444, is a defining pathogenetic feature of at least a subset of these tumors...
  5. doi request reprint LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
    Stine H Kresse
    Department of Tumor Biology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 48:679-93. 2009
    ..4-p15.3 and low expression of LSAMP (both P = 0.011) were significantly associated with poor survival. Our results show that LSAMP is a novel candidate tumor suppressor gene in osteosarcomas...
  6. doi request reprint Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Genes Chromosomes Cancer 47:558-64. 2008
    ..Based on the structure of the novel fusion gene detected, its transforming mechanism is thought to be the same as for other fusion genes involving EWSR1 or PBX1...
  7. pmc Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
    Kaja B Nyquist
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e49705. 2012
    ..This demonstrates that genetic heterogeneity exists in mesenchymal chondrosarcoma...
  8. doi request reprint Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience
    Petter Brandal
    Department of Oncology, Division of Cancer Medicine and Radiotherapy, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Acta Oncol 48:1165-72. 2009
    ..Revealing a possible clonal relationship between these tumors, e.g., by karyotyping, may be of interest for estimating prognosis and guide therapy intensiveness...
  9. doi request reprint Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
    Helge R Brekke
    Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    J Clin Oncol 28:1573-82. 2010
    ..The purpose of this study was to identify genetic aberrations contributing to clinical aggressiveness of malignant peripheral nerve sheath tumors (MPNSTs)...
  10. doi request reprint Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
    Genes Chromosomes Cancer 52:610-8. 2013
    ..Whether or not the (patho)genetic subsets JAZF1-SUZ12, PHF1 rearrangements, and ZC3H7B-BCOR correspond to any phenotypic, let alone clinically important, differences in ESS remain unknown. © 2013 Wiley Periodicals, Inc...
  11. pmc DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
    Stine H Kresse
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 5:e15378. 2010
    ....
  12. pmc Novel fusion of MYST/Esa1-associated factor 6 and PHF1 in endometrial stromal sarcoma
    Ioannis Panagopoulos
    Section for Cancer Cytogenetics, Institute for Medical Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    PLoS ONE 7:e39354. 2012
    ....
  13. ncbi request reprint Deregulation of HMGA2 in an aggressive angiomyxoma with t(11;12)(q23;q15)
    Francesca Micci
    Department of Medical Genetics, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Virchows Arch 448:838-42. 2006
    ..FISH analyses demonstrated no structural alteration of HMGA2 at the cytogenetic level; however, expression of the full-length gene was detected molecularly...
  14. doi request reprint Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrations
    Ludmila Gorunova
    Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 48:583-602. 2009
    ..Nor did we find any association between cytogenetic features and adverse clinical outcome. Thus, local recurrences probably depend more on the adequacy of surgical treatment than on the intrinsic biology of the tumors...
  15. doi request reprint Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma
    Hege O Ohnstad
    Department of Tumor Biology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway
    Cancer 119:1013-22. 2013
    ..Relatively few sarcomas harbor TP53 (tumor protein p53) mutations, but in many cases, amplification of MDM2 (murine double minute 2) effectively inactivate p53. The p53 pathway activity can also be affected by normal genetic variation...
  16. ncbi request reprint Trisomy 7 in postoperative spindle cell nodules
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, Ullernchaussen 70, 0310 Oslo, Norway
    Cancer Genet Cytogenet 174:147-50. 2007
    ..The other case, from the urinary bladder, showed presence of trisomy 7 by interphase-FISH performed on nuclei extracted from paraffin-embedded tissue...
  17. ncbi request reprint Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology
    Petter Brandal
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    J Pathol 208:388-94. 2006
    ..When selective therapies tailor-made against the specific pathogenetic rearrangement become available, it will become mandatory to pay more attention to the genetic constitution of the tumour cells than to their phenotypic appearance...
  18. pmc Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern
    Heidi M Namløs
    Department of Tumour Biology, The Norwegian Radium Hospital, Oslo University Hospital, 0310 Oslo, Norway
    Sarcoma 2012:639038. 2012
    ..Increased knowledge of mechanisms and interactions between specified molecular signalling pathways in osteosarcomas could lead to a more rational strategy for development of targeted therapy...
  19. pmc Molecular cytogenetic characterization of tenosynovial giant cell tumors
    Petter Brandal
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Neoplasia 6:578-83. 2004
    ..The IP-FISH studies showed trisomy 7 in 56% of the tumors (15/27), whereas chromosomes 1 and 5 seemed to be disomic in all TSGCTs. All informative tumors were wild-type by microsatellite instability analysis...
  20. doi request reprint Paratesticular leiomyoma with a der(14)t(12;14)(q15;q24)
    Ludmila Gorunova
    Section for Cancer Cytogenetics, Institute for Medical Informatics, Oslo University Hospital, and Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Cancer Genet 204:465-8. 2011
    ..The finding of this abnormality may help identify a scrotal tumor of uncertain biologic potential but with smooth muscle differentiation as benign...
  21. ncbi request reprint Chromosome 7 abnormalities are common in chordomas
    Petter Brandal
    Department of Cancer Genetics, The Norwegian Radium Hospital, Montebello, Oslo 0310, Norway
    Cancer Genet Cytogenet 160:15-21. 2005
    ..IP-FISH confirmed the CGH findings and showed that chromosome 7 was polysomic in four of the tumors. All these samples had trisomic and tetrasomic clones for chromosome 7, and two of them had pentasomic clones as well...
  22. ncbi request reprint Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
    Leonardo A Meza-Zepeda
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer Res 66:8984-93. 2006
    ..Our results show the potential of using array comparative genomic hybridization to classify histologically similar tumors such as GISTs and leiomyosarcomas...
  23. ncbi request reprint Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice
    Mona Elisabeth Revheim
    Department of Nuclear Medicine, Rikshospitalet, Oslo University Hospital, 0027 Oslo, Norway
    Anticancer Res 29:4331-6. 2009
    ..The aim of this study was to establish and characterize a human GIST xenograft that could be used for evaluating various molecularly targeted therapies...
  24. pmc Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
    Helge R Brekke
    Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Neuro Oncol 11:514-28. 2009
    ..Patients in complete remission with a primary p53-positive MPNST diagnosis may be considered in a high-risk subgroup and candidates for adjuvant treatment...
  25. ncbi request reprint Pairwise comparison of genomic imbalances between primary and recurrent well differentiated liposarcomas
    Francesca Micci
    Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Centre, Ullernchausseen 70, Montebello, Oslo, Norway
    Cancer Genet Cytogenet 178:163-7. 2007
    ..The findings illustrate that the phenotypic changes some WDL undergo with time may have a genomic correlate, and that a pathogenetic continuum exists between WDL and dedifferentiated, more malignant liposarcomas...
  26. ncbi request reprint Management of high-grade bone sarcomas over two decades: the Norwegian Radium Hospital experience
    Liv Hege Aksnes
    Department of Oncology, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway
    Acta Oncol 45:38-46. 2006
    ..Improved formalized organisation of the sarcoma group and annual audited reports of its patient and research activity may also have contributed to improved focus and performance...
  27. ncbi request reprint Molecular cytogenetic characterization of desmoid tumors
    Petter Brandal
    Institute for Cancer Research, The Norwegian Radium Hospital Montebello, Oslo, Norway
    Cancer Genet Cytogenet 146:1-7. 2003
    ....
  28. ncbi request reprint Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17)
    Francesca Micci
    Department of Cancer Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Cancer Genet Cytogenet 144:119-24. 2003
    ..Evidently, karyotypic, and hence pathogenetic, heterogeneity exists for tumors classified as endometrial stromal sarcomas based on their phenotypic features...
  29. ncbi request reprint [Bone and soft tissue sarcomas treated at the Norwegian Radium Hospital 1980-99]
    Gunnar Saeter
    Onkologisk avdeling, Det Norske Radiumhospital 0310 Oslo
    Tidsskr Nor Laegeforen 122:2089-94. 2002
    ..The Norwegian Radium Hospital's sarcoma group is a multidisciplinary group with a leading role in the diagnosis and treatment of bone and soft tissue sarcomas in Norway...
  30. ncbi request reprint Expression profiling using tissue microarray in 211 malignant fibrous histiocytomas confirms the prognostic value of Ki-67
    Jacob Engellau
    Department of Oncology, Jubileum Institution, Lund University, 22185 Lund, Sweden
    Virchows Arch 445:224-30. 2004
    ..Hence, we suggest that proliferation, as measured by Ki-67 index, should be considered as a prognostic marker in clinical management of pleomorphic soft tissue sarcomas...
  31. ncbi request reprint Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway
    Sonja E Steigen
    Department of Pathology, Institute of Medical Biology, University of Tromsø, Norway
    Mod Pathol 21:46-53. 2008
    ..Expression of p16 was significantly correlated with unfavorable prognosis, whereas L1 expression was not...
  32. pmc Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential
    Princy Francis
    Department of Oncology, Institute of Clinical Sciences, Lund University, Lund, Sweden
    BMC Genomics 8:73. 2007
    ..We assessed the diagnostic and prognostic value of array-based gene expression profiles using 27 k cDNA microarrays in 177, mainly high-grade, STS of 13 histopathological subtypes...
  33. ncbi request reprint Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group
    Catarina Svarvar
    Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    Cancer 109:282-91. 2007
    ..This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15-year period (from 1986 to 2001). Follow-up information was available for all patients...
  34. ncbi request reprint Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma
    Ioannis Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 35:340-52. 2002
    ....