P Aukrust

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    P Aukrust
    Medical Department A, University of Oslo, Rikshospitalet, Norway
    Am J Cardiol 83:376-82. 1999
  2. ncbi Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: indication of normalization of the bone-remodeling process during highly active antiretroviral therapy
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, Rikshospitalet, Oslo, Norway
    J Clin Endocrinol Metab 84:145-50. 1999
  3. ncbi Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, Rikshospitalet, Oslo, Norway
    J Immunol 162:1178-85. 1999
  4. ncbi Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure
    P Aukrust
    Section of Clinical Immunology, Research Institute of Nuclear Medicine, Oslo, Norway
    J Infect Dis 179:74-82. 1999
  5. ncbi Elevated circulating levels of C-C chemokines in patients with congestive heart failure
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, University of Oslo, Rikshospitalet, Norway
    Circulation 97:1136-43. 1998
  6. ncbi Circulating levels of RANTES in human immunodeficiency virus type 1 infection: effect of potent antiretroviral therapy
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, University of Oslo, Rikshospitalet, Norway
    J Infect Dis 177:1091-6. 1998
  7. ncbi Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses
    P Aukrust
    University of Oslo, Oslo University of Bergen, Bergen, Norway
    Eur J Clin Invest 30:252-9. 2000
  8. pmc Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication
    J K Damas
    Research Institute for Internal Medicine, University of Oslo, Oslo, Norway
    Clin Exp Immunol 157:400-7. 2009
  9. ncbi Virological and immunological effects of antioxidant treatment in patients with HIV infection
    F Muller
    University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Eur J Clin Invest 30:905-14. 2000
  10. ncbi CXCL16 in HIV infection - a link between inflammation and viral replication
    L Landrø
    University of Oslo, 0027 Oslo, Norway
    Eur J Clin Invest 39:1017-24. 2009

Collaborators

Detail Information

Publications74

  1. ncbi Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    P Aukrust
    Medical Department A, University of Oslo, Rikshospitalet, Norway
    Am J Cardiol 83:376-82. 1999
    ..The present study analyzing the complexity of the cytokine network in CHF, demonstrates profound disturbances in the levels of both inflammatory and anti-inflammatory mediators with a marked dysbalance favoring inflammatory effects...
  2. ncbi Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: indication of normalization of the bone-remodeling process during highly active antiretroviral therapy
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, Rikshospitalet, Oslo, Norway
    J Clin Endocrinol Metab 84:145-50. 1999
    ....
  3. ncbi Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, Rikshospitalet, Oslo, Norway
    J Immunol 162:1178-85. 1999
    ....
  4. ncbi Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure
    P Aukrust
    Section of Clinical Immunology, Research Institute of Nuclear Medicine, Oslo, Norway
    J Infect Dis 179:74-82. 1999
    ..The persistent activation of the TNF system in a subgroup of persons may be involved in treatment failure...
  5. ncbi Elevated circulating levels of C-C chemokines in patients with congestive heart failure
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, University of Oslo, Rikshospitalet, Norway
    Circulation 97:1136-43. 1998
    ....
  6. ncbi Circulating levels of RANTES in human immunodeficiency virus type 1 infection: effect of potent antiretroviral therapy
    P Aukrust
    Research Institute for Internal Medicine, Medical Department A, University of Oslo, Rikshospitalet, Norway
    J Infect Dis 177:1091-6. 1998
    ..The increase in RANTES levels during protease inhibitor-containing regimens may represent a previously unrecognized immunologic effect of such therapy...
  7. ncbi Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses
    P Aukrust
    University of Oslo, Oslo University of Bergen, Bergen, Norway
    Eur J Clin Invest 30:252-9. 2000
    ..In the present study we examined the possible role of vitamin A deficiency in CVI...
  8. pmc Homeostatic chemokines CCL19 and CCL21 promote inflammation in human immunodeficiency virus-infected patients with ongoing viral replication
    J K Damas
    Research Institute for Internal Medicine, University of Oslo, Oslo, Norway
    Clin Exp Immunol 157:400-7. 2009
    ..These findings link a dysregulated CCL19/CCL21/CCR7 system in HIV-infected patients to persistent inflammation and HIV replication, not only in untreated HIV infection, but also in treatment failure during HAART...
  9. ncbi Virological and immunological effects of antioxidant treatment in patients with HIV infection
    F Muller
    University of Oslo, The National Hospital, Rikshospitalet, Oslo, Norway
    Eur J Clin Invest 30:905-14. 2000
    ..The aim of the present study was to assess whether short-term, high-dose antioxidant treatment might have effects on immunological and virological parameters in patients with HIV infection...
  10. ncbi CXCL16 in HIV infection - a link between inflammation and viral replication
    L Landrø
    University of Oslo, 0027 Oslo, Norway
    Eur J Clin Invest 39:1017-24. 2009
    ..Here, we examined the regulation and the effects of CXCL16, a newly discovered chemokine of the CXC family, in HIV-infected patients...
  11. ncbi Enhanced gene expression of chemokines and their corresponding receptors in mononuclear blood cells in chronic heart failure--modulatory effect of intravenous immunoglobulin
    J K Damas
    Department of Cardiology, University of Oslo, The National Hospital, Norway
    J Am Coll Cardiol 38:187-93. 2001
    ....
  12. ncbi Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients
    T Holm
    Department of Cardiology, Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, Norway
    Am J Cardiol 87:815-8, A9. 2001
    ....
  13. ncbi Peripheral endothelial dysfunction in heart transplant recipients: possible role of proinflammatory cytokines
    T Holm
    Department of Cardiology, University of Oslo, Rikshospitalet, Norway
    Clin Transplant 14:218-25. 2000
    ..This endothelial dysfunction may be related to enhanced levels of proinflammatory cytokines in these patients...
  14. ncbi Enhanced interleukin-10 production in response to Mycobacterium avium products in mononuclear cells from patients with human immunodeficiency virus infection
    F Muller
    Medical Department A, University of Oslo, and Rikshospitalet, Norway
    J Infect Dis 177:586-94. 1998
    ..Elevated monocyte/macrophage-derived IL-10 production may contribute to the high susceptibility to MAC infection seen in patients with advanced HIV disease...
  15. ncbi Immunologic parameters as predictive factors of cytomegalovirus disease in renal allograft recipients
    I Nordøy
    Section of Clinical Immunology and Infectious Diseases, Research Institute for Internal Medicine, Medical Dept A, Rikshospitalet, N 0027 Oslo, Norway
    J Infect Dis 180:195-8. 1999
    ..Interleukin-8 and MIP-1alpha may be predictive markers of CMV disease and could be of potential use in selecting patients for prophylactic treatment...
  16. ncbi Increased serum osteoprotegerin in disorders characterized by persistent immune activation or glucocorticoid excess--possible role in bone homeostasis
    T Ueland
    Section of Endocrinology, Medical Department, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    Eur J Endocrinol 145:685-90. 2001
    ....
  17. ncbi Enhancement of lymphocyte proliferation induced by interleukin-12 and anti-interleukin-10 in HIV-infected patients during highly active antiretroviral therapy
    E Stylianou
    Section of Clinical Immunology and Infectious Diseases and Research Institute for Internal Medicine, Medical Department, Rikshopitalet, Oslo, Norway
    APMIS 108:601-7. 2000
    ..These results suggest that further exploration of both IL-10 and IL-12 as targets for immunomodulating therapy in HIV-infected patients in addition to HAART might be important...
  18. ncbi Increased levels of biochemical markers of bone turnover in relation to persistent immune activation in common variable immunodeficiency
    T Ueland
    Research Institute for Internal Medicine, National University Hospital, Oslo, Norway
    Eur J Clin Invest 31:72-8. 2001
    ....
  19. ncbi Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure
    J K Damas
    Department of Cardiology, Division of Heart and Lung Diseases, The National Hospital, Oslo, Norway
    Cardiovasc Res 47:778-87. 2000
    ..The objective of this study was to examine mRNA levels and cellular localisation of chemokines and chemokine receptors in human CHF...
  20. ncbi Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure
    L Gullestad
    Section of Clinical Immunology and Infectious Diseases and Research Institute for Internal Medicine, Medical Department A, Rikshospitalet University Hosptial, Oslo, Norway
    J Am Coll Cardiol 34:2061-7. 1999
    ..We examined the effect of long-term treatment with two doses of the angiotensin converting enzyme (ACE) inhibitor enalapril on various immunological variables in patients with chronic congestive heart failure (CHF)...
  21. pmc Raised serum levels of interleukin-18 is associated with disease progression and may contribute to virological treatment failure in HIV-1-infected patients
    E Stylianou
    Section of Clinical Immunology and Infectious Diseases, Rikshospitalet University Hospital, Oslo, Norway
    Clin Exp Immunol 132:462-6. 2003
    ....
  22. ncbi Chemokines and leukocyte activation in the fetal circulation during preeclampsia
    J R Mellembakken
    Departments of Pediatric Research and Obstetrics and Gynecology, The National Hospital, University of Oslo, Oslo, Norway
    Hypertension 38:394-8. 2001
    ..Our findings suggest the activation of neutrophils and monocytes in the fetus during preeclampsia involving enhanced chemokine activation, possibly contributing to the fetal morbidity of this disorder...
  23. ncbi Complex effects of interferon-alpha on the cytokine network in HIV infection--possible contribution to immunosuppression
    E Stylianou
    Section of Clinical Immunology and Infectious Diseases and Research Institute for Internal Medicine, Medical Department, Rikshospitalet, Oslo, N 0027, Norway
    Cytokine 14:56-62. 2001
    ....
  24. ncbi Myocardial gene expression of leukaemia inhibitory factor, interleukin-6 and glycoprotein 130 in end-stage human heart failure
    H G Eiken
    University of Oslo, The National Hospital, Ullevål Hospital Oslo, Norway
    Eur J Clin Invest 31:389-97. 2001
    ..Accordingly, we have examined IL-6-related cytokines in chronic CHF in humans by analysing gene and protein expression in myocardium derived from patients with end-stage heart failure and donor hearts...
  25. pmc Stimulation of toll-like receptor 2 in mononuclear cells from HIV-infected patients induces chemokine responses: possible pathogenic consequences
    L Heggelund
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet University Hospital, Univerity of Oslo, Oslo, Norway
    Clin Exp Immunol 138:116-21. 2004
    ..While increased levels of beta-chemokines possibly have antiviral effects, TLR2 stimulation may also promote a chemokine-driven inflammatory loop, potentially contributing to the immunopathogenesis of HIV infection...
  26. ncbi Persistently elevated levels of von Willebrand factor antigen in HIV infection. Downregulation during highly active antiretroviral therapy
    P Aukrust
    Section of Clinical Immunology and Infectious Diseases, and Research Institute for Internal Medicine, Rikshospitalet, University of Oslo, Norway
    Thromb Haemost 84:183-7. 2000
    ..The persistent elevation of functionally normal vWf during HIV infection, most probably reflecting a persistent endothelial cell activation, may have an important role in the pathogenesis of HIV infection...
  27. pmc Chemokines and common variable immunodeficiency; possible contribution of CCL19, CCL21 and CCR7 to immune dysregulation
    B Fevang
    Research Institute for Internal Medicine, Rikshospitalet University Hospital and University of Oslo, Oslo, Norway
    Clin Exp Immunol 158:237-45. 2009
    ..Because CCR7, CCL19 and CCL21 are key mediators balancing immunity and tolerance in the immune system, the abnormalities of these mediators might contribute to the profound immune dysregulation seen in CVID...
  28. ncbi Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality
    E Øie
    Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    J Intern Med 270:263-72. 2011
    ..The aim of this study was to investigate whether total levels and composition of FAs and FFAs in plasma are altered in clinical heart failure (HF) and whether any alterations in these parameters are correlated with the severity of HF...
  29. pmc Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy
    L Landrø
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, Unviersity of Oslo, Oslo, Norway
    Clin Exp Immunol 152:57-63. 2008
    ..These abnormalities were reversed by successful HAART. Our findings underscore further the involvement of neutrophils and innate immunity in HIV-related immunodeficiency...
  30. ncbi Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure
    L Gullestad
    Department of Cardiology, Medical Department, Rikshospitalet, Oslo, Norway
    Circulation 103:220-5. 2001
    ..This effect was significantly correlated with an improvement in LVEF, suggesting a potential for immunomodulating therapy in addition to optimal conventional cardiovascular treatment regimens in CHF patients...
  31. ncbi Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients
    T Holm
    Department of Cardiology, Research Institute for Internal Medicine, University of Oslo, Rikshospitalet, Norway
    Transplantation 72:706-11. 2001
    ..In this study, we examined plasma levels of tumor necrosis factor alpha (TNF-alpha), interleukin (IL) 10, and their relations to antioxidant vitamins in 45 HTx recipients before and after treatment with omega-3 fatty acids or placebo...
  32. ncbi CXC-chemokines in coronary artery disease: possible pathogenic role of interactions between oxidized low-density lipoprotein, platelets and peripheral blood mononuclear cells
    T Holm
    Department of Cardiology, Rikshospitalet, Oslo, Norway
    J Thromb Haemost 1:257-62. 2003
    ..Our findings suggest enhanced inflammatory interactions between ox-LDL, platelets and PBMC in CAD patients involving CXC-chemokine related mechanisms, possible contributing to atherogenesis in these and other CAD patients...
  33. ncbi The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients
    I Nordøy
    Section of Clinical Immunology, Research Institute of Internal Medicine, Medical Dept, Rikshospitalet, N 0027 Oslo, Norway
    J Infect Dis 181:51-7. 2000
    ..Thus, the balance between TNF-alpha and IL-10 may be important in the development of CMV infection and CMV-related disease...
  34. pmc Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7(-) effector-memory T cells
    A M Holm
    Section for Clinical Immunology and Infectious Diseases, Medical Department, The National Hospital, Oslo, Norway
    Clin Exp Immunol 138:278-89. 2004
    ..Our observations indicate that a predominance of CCR7(-) T cells with effector-memory cell features and with reduced proliferative capacity may characterize a subgroup of CVID...
  35. ncbi Monocyte chemoattractant protein-1 enhances and interleukin-10 suppresses the production of inflammatory cytokines in adult rat cardiomyocytes
    J K Damas
    Department of Cardiology, Research Institute for Internal Medicine, Rikshospitalet, Oslo, Norway
    Basic Res Cardiol 96:345-52. 2001
    ....
  36. ncbi Modulatory effect of mannose-binding lectin on cytokine responses: possible roles in HIV infection
    L Heggelund
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Research Institute for Internal Medicine, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    Eur J Clin Invest 35:765-70. 2005
    ..Mannose-binding lectin (MBL) is a soluble receptor of the innate immune system, probably contributing to antimicrobial defence. The possible role of MBL in HIV infection is unclear...
  37. ncbi Effect of smoking cessation on markers of inflammation and endothelial cell activation among individuals with high risk for cardiovascular disease
    B Halvorsen
    Institute for Internal Medicine Research, University of Oslo, Oslo, Norway
    Scand J Clin Lab Invest 67:604-11. 2007
    ..To prospectively determine the effect of smoking cessation on markers of inflammation and endothelial cell activation...
  38. ncbi Clopidogrel increases expression of chemokines in peripheral blood mononuclear cells in patients with coronary artery disease: results of a double-blind placebo-controlled study
    T Waehre
    Research Institute of Internal Medicine, Rikshospitalet, University of Oslo, Oslo, Norway
    J Thromb Haemost 4:2140-7. 2006
    ..Platelet inhibitors are widely used in coronary artery disease (CAD), and we hypothesized that the platelet inhibitor clopidogrel could modify chemokines in CAD patients...
  39. ncbi Effect of folic acid treatment on endothelium-dependent vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects
    K B Holven
    Lipid Clinic, University Hospital, Rikshospitalet, Oslo, Norway
    Am J Med 110:536-42. 2001
    ..CONCLUSIONS: Homocysteine appears to induce its atherogenic effect, at least in part, by depressing endothelial function, possibly through nitric oxide-dependent mechanisms. This effect can be reversed by folic acid supplementation...
  40. ncbi Complement activation in patients with congestive heart failure: effect of high-dose intravenous immunoglobulin treatment
    P Aukrust
    Section of Clinical Immunology and Infectious Diseases, Research Institute for Internal Medicine, Rikshospitalet, University of Oslo, Norway
    Circulation 104:1494-500. 2001
    ..Increasing evidence implicates innate immunity in the pathogenesis of congestive heart failure (CHF). In the present study, we examined the possible role of complement, an important part of innate immunity, in CHF...
  41. doi Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis
    T Ueland
    Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Intern Med 270:452-60. 2011
    ..To examine the prognostic value of osteoprotegerin (OPG) levels in relation to all-cause mortality in patients with symptomatic severe aortic stenosis (AS)...
  42. ncbi CD4+ and CD8+ lymphocytes and HIV RNA in HIV infection: high baseline counts and in particular rapid decrease of CD8+ lymphocytes predict AIDS
    D Kvale
    Medical Department A and Research Institute for Internal Medicine, The National Hospital, Oslo, Norway
    AIDS 13:195-201. 1999
    ..To study the progression of HIV infection in relation to immunological and virological variables with emphasis on the role of CD8+ lymphocytes...
  43. ncbi Immunomodulating effects of 3-thia fatty acids in activated peripheral blood mononuclear cells
    P Aukrust
    Section of Clinical Immunology and Infectious Diseases, Research Institute for Internal Medicine, Rikshospitalet, Oslo, Norway
    Eur J Clin Invest 33:426-33. 2003
    ..Based on the suggested role of inflammation in atherogenesis, any immunomodulating effects of TTA would be of particular interest for the potential use of this fatty acid in atherosclerotic disorders...
  44. ncbi Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapy
    J Fredriksen
    Rikshospitalet, Oslo, Norway
    Eur J Clin Invest 34:709-15. 2004
    ....
  45. pmc Low numbers of regulatory T cells in common variable immunodeficiency: association with chronic inflammation in vivo
    B Fevang
    Research Institute for Internal Medicine, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Clin Exp Immunol 147:521-5. 2007
    ..Decreased proportions of TReg are suggested to be pathogenetically important in autoimmunity, and our results suggest that TReg may have a similar role in CVID...
  46. ncbi Dysregulation of membrane-bound tumor necrosis factor-alpha and tumor necrosis factor receptors on mononuclear cells in human immunodeficiency virus type 1 infection: low percentage of p75-tumor necrosis factor receptor positive cells in patients with adv
    K Hestdal
    Department of Pediatric Research, University of Oslo, The National Hospital, Norway
    Blood 90:2670-9. 1997
    ....
  47. pmc Polyclonal expansion of large granular lymphocytes in common variable immunodeficiency - association with neutropenia
    A M Holm
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Research Institute for Internal Medicine, Rikshospitalet University Hospital, Oslo, Norway
    Clin Exp Immunol 144:418-24. 2006
    ..Furthermore, our findings suggest common pathogenic mechanisms of granulocytopenia in CVID and lymphoproliferative disease of granular lymphocytes...
  48. ncbi Immunophenotypic analyses of CD34(+) cell subsets in bone marrow from HIV-infected patients during highly- active antiretroviral therapy
    F Muller
    The National Hospital, University of Oslo, Norway
    Eur J Clin Invest 32:535-40. 2002
    ....
  49. ncbi Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10
    T Waehre
    Research Institute for Internal Medicine, Rikshospitalet, Oslo, Norway
    Eur J Clin Invest 32:803-10. 2002
    ..We hypothesized that patients with unstable angina may have an imbalance between inflammatory and anti-inflammatory cytokines...
  50. ncbi Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
    E M Aandahl
    Institute of Medical Biochemistry, University of Oslo, Norway
    FASEB J 12:855-62. 1998
    ..These observations imply that increased activation of PKA type I may contribute to the progressive T cell dysfunction in HIV infection and that PKA type I may be a potential target for immunomodulating therapy...
  51. pmc Chemokines and soluble adhesion molecules in renal transplant recipients with cytomegalovirus infection
    I Nordøy
    Section of Clinical Immunology and Infectious Diseases, Research Institute of Internal Medicine, Medical Department, Rikshospitalet, Oslo, Norway
    Clin Exp Immunol 120:333-7. 2000
    ..This could suggest a role for these molecules in the pathogenesis of CMV infection...
  52. pmc Increased expression of chemokines in patients with Wegener's granulomatosis - modulating effects of methylprednisolone in vitro
    E A Torheim
    Research Institute for Internal Medicine, Medical Department Rikshospitalet, University of Oslo, N 0027 Oslo, Norway
    Clin Exp Immunol 140:376-83. 2005
    ..The diminished MP-mediated suppression of chemokines in PBMC from WG patients suggests that more specific modulators of chemokine levels should be investigated in this disorder...
  53. pmc Interferons and interferon (IFN)-inducible protein 10 during highly active anti-retroviral therapy (HAART)-possible immunosuppressive role of IFN-alpha in HIV infection
    E Stylianou
    Section of Clinical Immunology and Infectious Diseases and Research Institute for Internal Medicine, Medical Department, Rikshospitalet, Oslo, Norway
    Clin Exp Immunol 119:479-85. 2000
    ..Our findings suggest a pathogenic role of IFN-alpha in HIV infection, which may be a potential target for immunomodulating therapy in combination with HAART...
  54. pmc Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
    E Taraldsrud
    Department of Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway K G Jebsen Center for Cancer Immunotherapy and K G Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Clin Exp Immunol 175:439-48. 2014
    ..In conclusion, it seems unlikely that CVID is secondary to insufficient production of naturally occurring DCs or a defect in their signalling through TLR-7 or TLR-9. ..
  55. ncbi Cytokine responses to fungal pathogens in Kupffer Cells are Toll-like receptor 4 independent and mediated by tyrosine kinases
    G Overland
    University of Oslo, Institute for Surgical Research, Rikshospitalet University Hospital, Oslo, Norway
    Scand J Immunol 62:148-54. 2005
    ..albicans conidia involves Src tyrosine kinases. The experiments with TLR4-deficient Kupffer cells suggest that the cytokine response in these cells to fungal component is not mediated by TLR4...
  56. ncbi Effect of metoprolol on cytokine levels in chronic heart failure--a substudy in the Metoprolol Controlled-Release Randomised Intervention Trial in Heart Failure (MERIT-HF)
    L Gullestad
    Division of Heart and Lung Diseases, Department of Cardiology, Rikshospitalet, Sognsvannsveien 20, 0027 Oslo, Norway
    Am Heart J 141:418-21. 2001
    ..However, an enhanced immune activation also persisted in the metoprolol group, suggesting a potential for more specific immunomodulatory therapy in CHF...
  57. doi C-reactive protein; a potential marker of second cancer and cardiovascular disease in testicular cancer survivors?
    T Wethal
    Department of Cardiology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Eur J Cancer 46:3425-33. 2010
    ..There is conflicting evidence regarding CRP as a marker of future cancer. We studied whether CRP predicts CVD and consecutive cancer in testicular cancer survivors (TCSs)...
  58. ncbi Systemic markers of inflammation are associated with cardiac allograft vasculopathy and an increased intimal inflammatory component
    S Arora
    Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Am J Transplant 10:1428-36. 2010
    ..Forthcoming studies should clarify if routine measurements of these markers can accurately identify HTx recipients at risk of developing advanced CAV and vulnerable lesions...
  59. ncbi Sustained retention of tetradecylthioacetic acid after local delivery reduces angioplasty-induced coronary stenosis in the minipig
    R J Pettersen
    Department of Heart Disease, Haukeland University Hospital, N 5021, Bergen, Norway
    Cardiovasc Res 52:306-13. 2001
    ..This study examined the possible modulatory effects of TTA, delivered locally, on coronary stenosis in minipigs and the underlying mechanisms of action...
  60. ncbi Biochemical markers for cardiovascular risk following treatment in endogenous Cushing's syndrome
    C Kristo
    Section of Endocrinology, Research Institute of Internal Medicine, University of Oslo, Oslo, Norway
    J Endocrinol Invest 31:400-5. 2008
    ..To further elucidate these issues we measured several markers of inflammation in CS patients at baseline and following operative treatment and potential cure...
  61. pmc Expression of matrix metalloproteinases in patients with Wegener's granulomatosis
    V Bjerkeli
    Research Institute for Internal Medicine, Medical Department, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Ann Rheum Dis 63:1659-63. 2004
    ..Enhanced activity of matrix metalloproteinases (MMPs) has been reported to have a pathogenic role in several diseases such as cancer and cardiovascular disorders, and seems also to play a part in certain autoimmune diseases...
  62. doi Oxidized LDL level is related to gene expression of tumour necrosis factor super family members in children and young adults with familial hypercholesterolaemia
    I Narverud
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Intern Med 273:69-78. 2013
    ....
  63. ncbi Cytomegalovirus infection induces production of human interleukin-10 in macrophages
    I Nordøy
    Institute of Microbiology, Rikshospitalet, 0027 Oslo, Norway
    Eur J Clin Microbiol Infect Dis 22:737-41. 2003
    ..In conclusion, human cytomegalovirus infection of macrophages induces production of human interleukin-10. This requires viral entry, but not full viral replication...
  64. ncbi Different effect of 1,25-dihydroxyvitamin D3 on replication of Mycobacterium avium in monocyte-derived macrophages from human immunodeficiency virus-infected subjects and healthy controls
    C J Haug
    Institute for Internal Medicine, Medical Department A, University of Oslo, The National Hospital Rikshospitalet, Norway
    Immunol Lett 63:107-12. 1998
    ..These findings suggest that HIV infection may significantly modulate the macrophage response to 1,25D stimulation, and that 1,25D may have inhibitory effects on MAC replication in macrophages from HIV-infected patients...
  65. pmc Common variable immunodeficiency and the complement system; low mannose-binding lectin levels are associated with bronchiectasis
    B Fevang
    Research Institute for Internal Medicine, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    Clin Exp Immunol 142:576-84. 2005
    ..Our findings suggest that mannose-binding lectin and the lectin complement pathway may protect against lower respiratory tract infection and bronhiectasis in patients with common variable immunodeficiency...
  66. ncbi Increased inflammatory markers in children with familial hypercholesterolaemia
    T Ueland
    Research Institute for Internal Medicine, Section of Endocrinology, Rikshospitalet, University of Oslo, Norway
    Eur J Clin Invest 36:147-52. 2006
    ....
  67. pmc Effects of interferon-alpha on gene expression of chemokines and members of the tumour necrosis factor superfamily in HIV-infected patients
    E Stylianou
    Section of Clinical Immunology and Infectious Diseases, Research Institute for Internal Medicine, Rikshospitalet, Oslo, Norway
    Clin Exp Immunol 130:279-85. 2002
    ....
  68. ncbi Interleukin-1 receptor antagonist is associated with fat distribution in endogenous Cushing's syndrome: a longitudinal study
    T Ueland
    Section of Endocrinology, Research Institute for Internal Medicine, Medical Department, National University Hospital, N 0027 Oslo, Norway
    J Clin Endocrinol Metab 88:1492-6. 2003
    ..We also show that circulating IL-1Ra is strongly associated with these changes, signifying a relationship among the hypothalamic-pituitary-adrenal axis, IL-1 system, and regional fat distribution in these patients...
  69. ncbi Increased levels of C-reactive protein and interleukin-6 in hyperhomocysteinemic subjects
    K B Holven
    The Lipid Clinic, Rikshospitalet University Hospital, NO 0027 Oslo, Norway
    Scand J Clin Lab Invest 66:45-54. 2006
    ..The aim of this study was to investigate whether individuals with increased plasma homocysteine concentrations have altered levels of serum CRP and IL-6...
  70. ncbi The insulin-like growth factor system in human immunodeficiency virus infection: relations to immunological parameters, disease progression, and antiretroviral therapy
    S I Helle
    Department of Oncology, Haukeland University Hospital, N 5021 Bergen, Norway
    J Clin Endocrinol Metab 86:227-33. 2001
    ..Our results reveal several alterations in the IGF system during HIV infection with decreased IGF-II levels, increased concentration of IGFBP-2, and an increased IGFBP-3 protease activity in advanced disease...
  71. ncbi 8-isoprostane increases scavenger receptor A and matrix metalloproteinase activity in THP-1 macrophages, resulting in long-lived foam cells
    H Scholz
    Rikshospitalet University Hospital, University of Oslo, Norway
    Eur J Clin Invest 34:451-8. 2004
    ....
  72. ncbi Increased concentrations of soluble CD40 ligand, RANTES and GRO-alpha in preeclampsia--possible role of platelet activation
    J R Mellembakken
    Department of Pediatric Research, Medical Department, The National Hospital, University of Oslo, Norway
    Thromb Haemost 86:1272-6. 2001
    ....
  73. ncbi Expression of matrix metalloproteinase-9 in mononuclear cells of hyperhomocysteinaemic subjects
    K B Holven
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, 0027 Oslo, Norway
    Eur J Clin Invest 33:555-60. 2003
    ..Moreover, our findings suggest that folic acid supplementation may down-regulate these inappropriate responses in these patients...
  74. ncbi Enhanced platelet activation in hyperhomocysteinemic individuals
    K B Holven
    J Thromb Haemost 5:193-5. 2007