Samer Al-Saad

Summary

Affiliation: University Hospital of North Norway
Country: Norway

Publications

  1. ncbi The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer
    S Al-Saad
    Institute of Medical Biology, University of Tromso Norway, Tromso, Norway
    Br J Cancer 99:1476-83. 2008
  2. ncbi Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer
    Samer Al-Saad
    Institute of Medical Biology, University of Tromso, Norway
    Anticancer Res 29:4175-83. 2009
  3. ncbi Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients
    Samer Al-Saad
    Institute of Medical Biology, Faculty of Health Sciences, University of Tromso, Norway
    J Thorac Oncol 5:1536-43. 2010
  4. ncbi Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Cancer 117:3193-200. 2011
  5. ncbi Correlation and coexpression of HIFs and NOTCH markers in NSCLC
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Anticancer Res 31:1603-6. 2011
  6. ncbi Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 3:963-70. 2008
  7. ncbi Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, University Hospital of Northern Norway, Tromso, Norway
    Clin Cancer Res 13:6649-57. 2007
  8. ncbi VEGF-A and VEGFR-3 correlate with nodal status in operable non-small cell lung cancer: inverse correlation between expression in tumor and stromal cells
    Tom Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Lung Cancer 63:277-83. 2009
  9. ncbi Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: correlation with a favorable clinical outcome
    Helge Stenvold
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 75:235-41. 2012
  10. ncbi Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e23847. 2011

Detail Information

Publications18

  1. ncbi The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer
    S Al-Saad
    Institute of Medical Biology, University of Tromso Norway, Tromso, Norway
    Br J Cancer 99:1476-83. 2008
    ..In stromal cells, high expressions of NF-kappaB p105 and Par6 are both favourable independent prognostic indicators...
  2. ncbi Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer
    Samer Al-Saad
    Institute of Medical Biology, University of Tromso, Norway
    Anticancer Res 29:4175-83. 2009
    ..By tissue microarray methodology, the expression of altered Akt isoforms, PTEN and PI3K and their prognostic significance in 335 non-small cell lung cancer (NSCLC) tumors were investigated...
  3. ncbi Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients
    Samer Al-Saad
    Institute of Medical Biology, Faculty of Health Sciences, University of Tromso, Norway
    J Thorac Oncol 5:1536-43. 2010
    ....
  4. ncbi Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Cancer 117:3193-200. 2011
    ..miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression with VEGF-A in nonsmall cell lung cancer (NSCLC) patients...
  5. ncbi Correlation and coexpression of HIFs and NOTCH markers in NSCLC
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Anticancer Res 31:1603-6. 2011
    ..NOTCH and hypoxia pathways are both known to be highly involved in cancer. Because of the close interplay between both of these pathways, we investigated correlation and co-expression of molecules in these pathways...
  6. ncbi Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 3:963-70. 2008
    ..This study investigates the prognostic impact of these molecular markers in tumor cells and tumor stroma of resected non-small cell lung cancer (NSCLC) tumors...
  7. ncbi Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, University Hospital of Northern Norway, Tromso, Norway
    Clin Cancer Res 13:6649-57. 2007
    ..This study elucidates the prognostic significance of these molecular markers in tumor cells as well as in the tumor stroma of resected non-small cell lung cancer tumors...
  8. ncbi VEGF-A and VEGFR-3 correlate with nodal status in operable non-small cell lung cancer: inverse correlation between expression in tumor and stromal cells
    Tom Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Lung Cancer 63:277-83. 2009
    ..We aimed to explore the correlations between nodal metastasis and the expression of VEGFs and VEGFRs in tumor cells and in tumor-related stroma...
  9. ncbi Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: correlation with a favorable clinical outcome
    Helge Stenvold
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 75:235-41. 2012
    ..As both malignant cells and cells of the surrounding stroma contribute to tumor growth, we have explored the impact of MMP-2, -7 and -9 expression in both the tumor and stromal compartment of non-small-cell lung cancers (NSCLC)...
  10. ncbi Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e23847. 2011
    ..HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC...
  11. ncbi Diverging prognostic impacts of hypoxic markers according to NSCLC histology
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 72:294-302. 2011
    ....
  12. ncbi Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
    ..This study evaluates the prognostic impact of all known human angiopoietins (Ang-1, Ang-2 and Ang-4) and their receptor Tie-2, as well as their relation to the prognostic expression of VEGF-A...
  13. ncbi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
    ..This study investigates the prognostic impact of FGF2 and FGFR-1 in tumor cells and tumor stroma of resected non-small cell lung carcinomas (NSCLC) and explores the importance of their coexpression with VEGFR-3 or PDGF-B...
  14. ncbi Angiogenic markers show high prognostic impact on survival in marginally operable non-small cell lung cancer patients treated with adjuvant radiotherapy
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    J Thorac Oncol 4:463-71. 2009
    ..Both expression and its prognostic impact may be associated with patient selection. Data addressing the prognostic relevance of angiogenic marker expression in NSCLC patients treated with postoperative radiotherapy (PORT) is warranted...
  15. ncbi Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Cancer 116:4318-25. 2010
    ..The authors of this report investigated the prognostic role of angiogenic markers in coexpression with immune system markers in patients with nonsmall cell lung cancer (NSCLC)...
  16. ncbi Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Cancer 116:5676-85. 2010
    ..The authors aimed to study the prognostic role of the angiogenesis-related Notch ligands and receptors and investigate the prognostic impact of the coexpression of vascular endothelial growth factor-A (VEGF-A) and Notch signaling...
  17. ncbi Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    J Transl Med 9:6. 2011
    ..MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 in non-small cell lung cancer (NSCLC) patients...
  18. ncbi Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer
    T Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Ann Oncol 21:223-31. 2010
    ..We aimed to study the PDGFs/PDGFRs and correlations with lymph node metastasis (LNM) and investigate the prognostic impact of the co-expression of PDGF-B and VEGFR-3 and its correlation with LNM...