L A Akslen

Summary

Affiliation: University of Bergen
Country: Norway

Publications

  1. doi request reprint Tumor dormancy--from basic mechanisms to clinical practice
    Lars A Akslen
    Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    APMIS 116:545-7. 2008
  2. pmc Lymphatic vessel density and prognosis in cutaneous melanoma
    O Straume
    Br J Cancer 91:1224-5. 2004
  3. pmc Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas
    Tor A Klingen
    Department of Pathology, Vestfold Hospital Trust, Tønsberg, Norway
    Diagn Pathol 8:80. 2013
  4. pmc Lipocalin 2 expression is associated with aggressive features of endometrial cancer
    Monica Mannelqvist
    The Gade Institute, Section for Pathology, University of Bergen, Bergen, Norway
    BMC Cancer 12:169. 2012
  5. pmc Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation
    Ingrid Moen
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    BMC Cancer 12:21. 2012
  6. pmc Early detection of breast cancer based on gene-expression patterns in peripheral blood cells
    Praveen Sharma
    DiaGenic ASA, Oslo, Norway
    Breast Cancer Res 7:R634-44. 2005
  7. pmc Tumor necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas
    Ingeborg M Bachmann
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital Bergen, Norway
    BMC Cancer 8:362. 2008
  8. pmc Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma
    Rita G Ladstein
    The Gade Institute, Section for Pathology, University of Bergen, Bergen, Norway
    BMC Cancer 10:140. 2010
  9. pmc Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas
    Ove Bruland
    Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    BMC Cancer 9:425. 2009
  10. pmc Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
    Marc Tischkowitz
    Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada
    BMC Cancer 7:134. 2007

Detail Information

Publications101 found, 100 shown here

  1. doi request reprint Tumor dormancy--from basic mechanisms to clinical practice
    Lars A Akslen
    Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    APMIS 116:545-7. 2008
  2. pmc Lymphatic vessel density and prognosis in cutaneous melanoma
    O Straume
    Br J Cancer 91:1224-5. 2004
  3. pmc Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas
    Tor A Klingen
    Department of Pathology, Vestfold Hospital Trust, Tønsberg, Norway
    Diagn Pathol 8:80. 2013
    ..However, positive cases have recently been reported among primary breast carcinomas...
  4. pmc Lipocalin 2 expression is associated with aggressive features of endometrial cancer
    Monica Mannelqvist
    The Gade Institute, Section for Pathology, University of Bergen, Bergen, Norway
    BMC Cancer 12:169. 2012
    ..The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, markers of epithelial-mesenchymal transition (EMT), and patient survival...
  5. pmc Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation
    Ingrid Moen
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    BMC Cancer 12:21. 2012
    ..Finally, we aimed to identify differences in gene expression and key molecular mechanisms, both in the native state and following treatment...
  6. pmc Early detection of breast cancer based on gene-expression patterns in peripheral blood cells
    Praveen Sharma
    DiaGenic ASA, Oslo, Norway
    Breast Cancer Res 7:R634-44. 2005
    ..In this study, we investigated whether early detection of breast cancer is possible by analyzing gene-expression patterns in peripheral blood cells...
  7. pmc Tumor necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas
    Ingeborg M Bachmann
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital Bergen, Norway
    BMC Cancer 8:362. 2008
    ..We proposed that these tumor characteristics might be associated with changes in expression of cell adhesion proteins leading to increased invasive capacity and reduced patient survival...
  8. pmc Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma
    Rita G Ladstein
    The Gade Institute, Section for Pathology, University of Bergen, Bergen, Norway
    BMC Cancer 10:140. 2010
    ....
  9. pmc Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas
    Ove Bruland
    Center of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
    BMC Cancer 9:425. 2009
    ..Finally, we investigated potential influence on PDGF mRNA levels by the presence of tumour-infiltrating lymphocytes...
  10. pmc Use of immunohistochemical markers can refine prognosis in triple negative breast cancer
    Marc Tischkowitz
    Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada
    BMC Cancer 7:134. 2007
    ..The IHC pattern that best defines basal-like tumors is under investigation and various combinations of ER, PR, HER2-, CK5/6+ and EGFR+ have been tested...
  11. doi request reprint Mutation analysis of the EGFR-NRAS-BRAF pathway in melanomas from black Africans and other subgroups of cutaneous melanoma
    Lars A Akslen
    Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Melanoma Res 18:29-35. 2008
    ..Thus, the frequencies of BRAF and NRAS mutations were particularly low in melanomas from black Africans, supporting a different pathogenesis of these tumors...
  12. ncbi request reprint BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival
    Lars A Akslen
    The Gade Institute, Section of Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    J Invest Dermatol 125:312-7. 2005
    ..Although BRAF and NRAS mutations are likely to be important for the initiation and maintenance of some melanomas, other factors might be more significant for proliferation and prognosis in subgroups of aggressive melanoma...
  13. pmc Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer
    L A Akslen
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen N 5021, Norway
    Br J Cancer 105:9-12. 2011
    ..Glomeruloid microvascular proliferation (GMP), a novel histology-based angiogenesis marker, has been associated with decreased survival in several human cancers...
  14. ncbi request reprint Frequent mutations of the p53 gene in cutaneous melanoma of the nodular type
    L A Akslen
    Department of Pathology, The Gade Institute, University of Bergen, Norway
    Int J Cancer 79:91-5. 1998
    ..Our results indicate that point mutations in exons 7 and 8 are more frequent than previously reported in primary melanomas, and such changes may be important for the development of certain melanoma subgroups...
  15. ncbi request reprint Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer
    S Geisler
    Department of Medicine, Haukeland University Hospital, Bergen, Norway
    Cancer Res 61:2505-12. 2001
    ..Our findings are consistent with the hypothesis that other defects may act in concert with loss of p53 function, causing resistance to doxorubicin in breast cancers...
  16. ncbi request reprint Methylation of hMLH1 in a population-based series of endometrial carcinomas
    H B Salvesen
    Department of Pathology, The Gade Institute, Bergen, Norway
    Clin Cancer Res 6:3607-13. 2000
    ..In contrast, hMSH2 methylation was infrequent in this prospective and population-based series of endometrial carcinomas...
  17. pmc KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
    E Birkeland
    Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen 5021, Norway
    Br J Cancer 107:1997-2004. 2012
    ....
  18. pmc Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma
    I B Engelsen
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen 5021, Norway
    Br J Cancer 98:1662-9. 2008
    ..Loss of BMI-1 seems to be associated with an aggressive phenotype in endometrial carcinomas...
  19. ncbi request reprint Independent prognostic importance of microvessel density in clinically localized prostate cancer
    O J Halvorsen
    Department of Pathology, Gade Institute, Haukeland University Hospital, N 5021 Bergen, Norway
    Anticancer Res 20:3791-9. 2000
    ..The purpose of this study was to assess the prognostic value of MVD in clinically localized prostatic adenocarcinomas, focusing on moderately-differentiated tumours...
  20. pmc Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
    H B Salvesen
    Department of Obstetrics and Gynecology, Haukeland University Hospital, 5021 Bergen, Norway
    Proc Natl Acad Sci U S A 106:4834-9. 2009
    ..The results affirm the utility of systematic characterization of the cancer genome in clinically annotated specimens and suggest the particular importance of the PI3K pathway in patients who have aggressive endometrial cancer...
  21. pmc Expression of c-erbB-2 protein in papillary thyroid carcinomas
    D R Haugen
    Department of Biochemistry, University of Bergen, Norway
    Br J Cancer 65:832-7. 1992
    ....
  22. pmc Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer
    H Nalwoga
    Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, N 5021, Bergen, Norway
    Br J Cancer 102:369-75. 2010
    ..The aim of this study was to explore the expression of these proteins in breast cancers from an African population and their associations with the basal-like phenotype (BLP) and other molecular characteristics...
  23. ncbi request reprint Expression of heregulins and associations with the ErbB family of tyrosine kinase receptors in papillary thyroid carcinomas
    O Fluge
    Department of Molecular Biology, University of Bergen, Bergen, Norway
    Int J Cancer 87:763-70. 2000
    ..The overexpression and nuclear localization of the Hrg precursor isoform were not associated with the expression of ErbB-receptors. This may reflect an unknown mechanism of action, possibly independent of the ErbB receptor system...
  24. ncbi request reprint Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas
    H B Salvesen
    Department of Pathology, The Gade Institute, Bergen, Norway
    Int J Cancer 84:538-43. 1999
    ..High TAM density was significantly associated with reduced survival in univariate analysis...
  25. ncbi request reprint Prognostic significance of p16 and CDK4 proteins in localized prostate carcinoma
    O J Halvorsen
    Department of Pathology, The Gade Institute, Haukeland Hospital, University of Bergen, Bergen, Norway
    Cancer 88:416-24. 2000
    ..In the current study the authors evaluated the expression of p16 and CDK4 proteins and their prognostic significance in patients with clinically localized prostate carcinoma...
  26. ncbi request reprint Identification of high-risk patients by assessment of nuclear Ki-67 expression in a prospective study of endometrial carcinomas
    H B Salvesen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 4:2779-85. 1998
    ..Ki-67 expression is assessed on the histological specimens taken routinely, with no separate sampling technique; this should make it easy to use in a routine setting...
  27. ncbi request reprint Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis
    H B Salvesen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 6:153-9. 2000
    ..Methylation of the promoter region seems to be an uncommon mechanism of p16 inactivation in endometrial carcinoma...
  28. doi request reprint Microvessel proliferation by co-expression of endothelial nestin and Ki-67 is associated with a basal-like phenotype and aggressive features in breast cancer
    K Kruger
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Breast 22:282-8. 2013
    ..Immature endothelial cells express nestin, and when co-expressed with the proliferation marker Ki-67, the number of proliferating immature blood vessels can be measured...
  29. ncbi request reprint Primary systemic treatment with weekly doxorubicin monotherapy in women with locally advanced breast cancer; clinical experience and parameters predicting outcome
    T Aas
    Department of Surgery, Haukeland University Hospital, Bergen, Norway
    Acta Oncol 35:5-8. 1996
    ..Recent studies have demonstrated a correlation between p53-mutations and chemotherapy response...
  30. pmc Loss of GPER identifies new targets for therapy among a subgroup of ERα-positive endometrial cancer patients with poor outcome
    C Krakstad
    Department of Clinical Medicine, Section for Gynecology and Obstetrics, University of Bergen, Jonas Lies vei 72, Bergen 5020, Norway
    Br J Cancer 106:1682-8. 2012
    ..Our purpose was to investigate the potential of GPER as a prognostic and predictive marker in endometrial carcinoma and to search for new drug candidates to improve treatment of aggressive disease...
  31. pmc Prognostic impact of EGF-receptor in papillary thyroid carcinoma
    L A Akslen
    Department of Pathology, Gade Institute, Bergen, Norway
    Br J Cancer 68:808-12. 1993
    ..0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas...
  32. pmc High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer
    K K Mauland
    Department of Obstetrics and Gynaecology, Haukeland University Hospital, 5021 Bergen, Norway
    Br J Cancer 104:921-6. 2011
    ..We wanted to investigate if BMI is related to clinico-pathological characteristics, hormone receptor status in primary tumour, and disease outcome in endometrial cancer...
  33. doi request reprint Expression of epidermal growth factor receptor in relation to BRCA1 status, basal-like markers and prognosis in breast cancer
    J B Arnes
    The Gade Institute, Section for Pathology, Haukeland University Hospital, Bergen, Norway
    J Clin Pathol 62:139-46. 2009
    ....
  34. ncbi request reprint Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma
    O Straume
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 6:1845-53. 2000
    ..Cases without p53 expression had improved survival...
  35. pmc Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma
    O Straume
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Br J Cancer 93:933-8. 2005
    ..An inverse relation between ID1 and TSP-1 expression support an important role of ID1 in the regulation of this complex multitarget protein...
  36. pmc Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas
    O Straume
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Am J Pathol 159:223-35. 2001
    ..These data suggest that MVD is associated with prognosis in cutaneous melanomas, and that the VEGF system and particularly TSP-1 seem to be involved in the regulation of angiogenesis and progression of these tumors...
  37. ncbi request reprint Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1
    J B Arnes
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Histopathology 52:370-80. 2008
    ..To study the relationship between basal-like breast cancers, epidermal growth factor receptor (EGFR) and candidate stem cell markers (BMI-1, EZH2, Oct-4) in a population-based setting...
  38. ncbi request reprint Maximum Ki-67 staining in prostate cancer provides independent prognostic information after radical prostatectomy
    O J Halvorsen
    Department of Pathology, The Gade Institute, Bergen, Norway
    Anticancer Res 21:4071-6. 2001
    ..We have evaluated the prognostic value of Ki-67 growth fraction after radical prostatectomy, especially focusing on intermediate grade carcinomas...
  39. ncbi request reprint PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma
    H B Salvesen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Int J Cancer 91:22-6. 2001
    ..Its association with metastatic disease and microsatellite instability implicates its importance in the development of this tumor type...
  40. ncbi request reprint EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    Ingeborg M Bachmann
    Gade Institute, Section of Pathology, Bergen, Norway
    J Clin Oncol 24:268-73. 2006
    ..The purpose of this study was to validate previous findings in a population-based setting, also including tumors that have not been studied previously...
  41. ncbi request reprint Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas
    Ingeborg M Bachmann
    Department of Pathology, The Gade Institute, Bergen, Norway
    Int J Oncol 25:1559-65. 2004
    ..005). Our results seem to confirm that the p16-Rb pathway plays an important role in tumour progression and prognosis in vertical growth phase melanomas, whereas alterations in the p14-p53 pathway might be less important...
  42. doi request reprint GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival
    Ingeborg B Engelsen
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    Am J Obstet Gynecol 199:543.e1-7. 2008
    ..We investigated this marker in relation to clinicopathologic characteristics, hormone receptors, other biomarkers, and survival in endometrial carcinoma...
  43. pmc Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas
    I S Haldorsen
    1 Department of Radiology, Haukeland University Hospital, Jonas Liesvei 65, Postbox 7800, 5021 Bergen, Norway 2 Section for Radiology, Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, 5020 Bergen, Norway
    Br J Cancer 110:107-14. 2014
    ....
  44. ncbi request reprint Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy
    T Aas
    Department of Surgery, Haukeland University Hospital, N 5021 Bergen, Norway
    Eur J Cancer 39:438-46. 2003
    ..001 and P = 0.001, respectively). A key reason for this difference with respect to the factors predicting chemotherapy resistance could be due to the adjuvant use of tamoxifen in all patients harbouring ER-positive tumours...
  45. ncbi request reprint Enhanced expression of EGF receptor and low frequency of ras mutations in X-ray-induced rat thyroid tumours
    D R Haugen
    Department of Biochemistry and Molecular Biology, University of Bergen, Norway
    Virchows Arch 435:434-41. 1999
    ..Increased expression of EGF receptor in the tumours parallels the situation in human thyroid cancer...
  46. pmc Independent prognostic importance of microvessel density in endometrial carcinoma
    H B Salvesen
    Department of Gynaecology and Obstetrics, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Br J Cancer 77:1140-4. 1998
    ....
  47. pmc Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis
    Xi Song Ke
    The Gade Institute, University of Bergen, Bergen, Norway
    PLoS ONE 4:e4687. 2009
    ..However, the relationship between epigenetic switches and more dynamic patterns of gene activation and repression has remained largely unknown...
  48. ncbi request reprint Gene expression in poorly differentiated papillary thyroid carcinomas
    Øystein Fluge
    Department of Molecular Biology, University of Bergen, and Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital, Norway
    Thyroid 16:161-75. 2006
    ..These data are interpreted to be consistent with altered cell motility, extracellular matrix remodeling and increased cell proliferation, as important processes in PTC tumor progression...
  49. ncbi request reprint HER-2/neu expression is associated with high tumor cell proliferation and aggressive phenotype in a population based patient series of endometrial carcinomas
    Ingeborg B Engelsen
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    Int J Oncol 32:307-16. 2008
    ..These results motivate further clinical trials with trastuzumab based on HER-2/neu status in endometrial carcinomas...
  50. ncbi request reprint Loss of BMI-1 expression is associated with clinical progress of malignant melanoma
    Ingeborg M Bachmann
    Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Mod Pathol 21:583-90. 2008
    ..Low BMI-1 expression was associated with low p14 and CDK4 but not with p16 expression. Low levels of BMI-1 expression were also significantly associated with decreased patient survival...
  51. ncbi request reprint Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer?
    Bjørn O Maehle
    Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Bergen, Norway
    APMIS 117:644-50. 2009
    ..The role of ERbeta needs to be further evaluated especially in this group of breast cancers...
  52. ncbi request reprint Low frequency of BRAF and CDKN2A mutations in endometrial cancer
    Helga B Salvesen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Int J Cancer 115:930-4. 2005
    ..However, the mechanism of p16 inactivation remains unclear for the majority of cases exhibiting loss of expression, but the interactions with K-ras and p53 should be further studied...
  53. ncbi request reprint A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation
    Anders Molven
    Section for Pathology, The Gade Institute, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Genes Chromosomes Cancer 44:10-8. 2005
    ..In addition to resulting from selection pressure, this observation may be explained by the CG dinucleotide of codon 24 representing a mutational hot spot in the CDK4 gene...
  54. ncbi request reprint Prognostic importance of glomeruloid microvascular proliferation indicates an aggressive angiogenic phenotype in human cancers
    Oddbjørn Straume
    Department of Pathology, The Gade Institute, University of Bergen, Bergen 5021, Norway
    Cancer Res 62:6808-11. 2002
    ..02), and was a better predictor of outcome than was microvessel density. In conclusion, GMPs might indicate a more aggressive vascular phenotype associated with poor prognosis and could be a novel prognostic marker in human cancer...
  55. ncbi request reprint Prognostic impact of histological grade and vascular invasion compared with tumour cell proliferation in endometrial carcinoma of endometrioid type
    I M Stefansson
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Histopathology 44:472-9. 2004
    ..The recently proposed binary architectural grade was also evaluated, in addition to age, depth of myometrial infiltration and FIGO stage in our population-based series of 237 endometrioid carcinomas...
  56. pmc Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis
    Ø Fluge
    Department of Oncology, Haukeland University Hospital, Bergen, Norway
    Br J Cancer 101:1282-9. 2009
    ..Enhancer of zeste homologue 2 (EZH2) is a member of the Polycomb group of genes that is involved in epigenetic silencing and cell cycle regulation...
  57. ncbi request reprint Expression and alternative splicing of c-ret RNA in papillary thyroid carcinomas
    O Fluge
    Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway
    Oncogene 20:885-92. 2001
    ..Transcriptional up-regulation and post-transcriptional mechanisms of c-ret RNA processing may contribute to differences in expression of Ret protein observed in PTC compared to non-neoplastic thyroid tissue...
  58. ncbi request reprint Loss of hMSH2 and hMSH6 expression is frequent in sporadic endometrial carcinomas with microsatellite instability: a population-based study
    Ingunn Stefansson
    Department of Pathology, The Gade Institute, Bergen, Norway
    Clin Cancer Res 8:138-43. 2002
    ..Our data indicate that the other mismatch repair genes hMSH2 and hMSH6 are also involved, especially in cases with intermediate MSI...
  59. pmc Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival
    Christine Gjerdrum
    Department of Biomedicine, University of Bergen, N 5009 Bergen, Norway
    Proc Natl Acad Sci U S A 107:1124-9. 2010
    ..Thus, the detection and targeted treatment of Axl-expressing tumors represents an important new therapeutic strategy for breast cancer...
  60. ncbi request reprint Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma
    Ingeborg M Bachmann
    The Gade Institute, Section for Pathology, University of Bergen, Bergen, Norway
    Clin Cancer Res 11:8606-14. 2005
    ..We therefore wanted to investigate the role of cadherin subtypes, beta-catenin, and Wnt5a/Frizzled in melanocytic tumors, with focus on prognosis in nodular melanomas...
  61. ncbi request reprint Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer
    Ingunn M Stefansson
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    J Clin Oncol 22:1242-52. 2004
    ..We wanted to examine the expression pattern and prognostic value of these molecules in a population-based series of endometrial carcinoma patients...
  62. ncbi request reprint Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma
    Oddbjørn Straume
    Department of Pathology, The Gade Institute, University of Bergen, N 5021 Bergen, Norway
    Clin Cancer Res 9:250-6. 2003
    ..In addition, our data suggest the presence of low-grade intra-tumoral lymphangiogenesis in melanoma and a stimulating role of bFGF in lymphangiogenesis...
  63. ncbi request reprint Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer
    Ole J Halvorsen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, N 5021 Bergen, Norway
    Clin Cancer Res 9:1474-9. 2003
    ....
  64. pmc Seasonal variations in the presentation and growth of thyroid cancer
    L A Akslen
    Department of Pathology, The Gade Institute, University of Bergen, Norway
    Br J Cancer 77:1174-9. 1998
    ..When further clarified, this might be of relevance for the planning of diagnostic and therapeutic strategies...
  65. ncbi request reprint Clinicopathological characteristics of melanomas of the hand
    L M Hove
    Department of Orthopaedic Surgery, University of Bergen, Norway
    J Hand Surg Br 24:460-4. 1999
    ..The subungual melanomas were thicker and the patients were older at presentation compared with the non-subungual sites. Review of our patients emphasized the need for early diagnosis...
  66. pmc Reproductive factors and risk of thyroid cancer. A prospective study of 63,090 women from Norway
    L A Akslen
    Department of Pathology, Gade Institute, Bergen, Norway
    Br J Cancer 65:772-4. 1992
    ..Our results are consistent with a modest effect of certain reproductive factors upon thyroid cancer development...
  67. ncbi request reprint Risk of primary childhood brain tumors related to birth characteristics: a Norwegian prospective study
    J M Heuch
    Section for Medical Statistics, University of Bergen, Norway
    Int J Cancer 77:498-503. 1998
    ..Among 5-10-year-old children, birth weight was also inversely related to risk of astrocytoma. Our results suggest that risk factors may differ over age intervals and histological subgroups...
  68. ncbi request reprint Significance of PTEN alterations in endometrial carcinoma: a population-based study of mutations, promoter methylation and PTEN protein expression
    Helga B Salvesen
    Department of Gynaecology and Obstetrics, Haukeland University Hospital, Bergen, Norway
    Int J Oncol 25:1615-23. 2004
    ..A pathway in endometrial carcinogenesis involving PTEN mutation and microsatellite instability is confirmed, and this study also indicates the importance of PTEN and hMLH1 methylation in this pathway...
  69. ncbi request reprint Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer
    Jarle B Arnes
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 11:4003-11. 2005
    ..BRCA1-related breast cancer frequently has a basal epithelial phenotype, and P-cadherin is a basal marker. We undertook a detailed evaluation of the relationship among P-cadherin, prognostic markers in breast cancer, and outcome...
  70. ncbi request reprint Expression of EGFR and c-kit is associated with the basal-like phenotype in breast carcinomas of African women
    Hawa Nalwoga
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    APMIS 116:515-25. 2008
    ..More studies are required to assess the clinical significance of EGFR and c-kit in breast cancer patients in Uganda...
  71. ncbi request reprint Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
    Karin Collett
    Section for Pathology, The Gade Institute, Haukeland University Hospital, Norway
    Clin Cancer Res 12:1168-74. 2006
    ..These findings might be practically important and relevant because the polycomb group proteins have recently been suggested as candidates for targeted therapy...
  72. ncbi request reprint Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas
    Helga B Salvesen
    Department of Pathology, The Gade Institute, Bergen, Norway
    APMIS 111:1011-8. 2003
    ..In conclusion, CD105/endoglin-MVD is significantly associated with FIGO stage, tumour proliferation and prognosis in endometrial carcinoma, indicating that this is a better angiogenic marker in these tumours...
  73. ncbi request reprint Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting
    Elisabeth Wik
    Institute of Clinical Medicine, University of Bergen, and Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    Am J Obstet Gynecol 201:603.e1-7. 2009
    ..The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series...
  74. ncbi request reprint Expression of bFGF/FGFR-1 and vascular proliferation related to clinicopathologic features and tumor progress in localized prostate cancer
    Karsten Gravdal
    Section for Pathology, The Gade Institute, Haukeland University Hospital, 5021 Bergen, Norway
    Virchows Arch 448:68-74. 2006
    ..Our findings indicate a complex relationship between bFGF/FGFR-1 expression and prognosis of prostate cancer. Vascular proliferation revealed no prognostic impact in this study...
  75. ncbi request reprint Loss of p63 and cytokeratin 5/6 expression is associated with more aggressive tumors in endometrial carcinoma patients
    Ingunn M Stefansson
    Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, N 5021 Bergen, Norway
    Int J Cancer 118:1227-33. 2006
    ..Thus, loss of p63 or CK5/6 was associated with features of aggressive tumors, and lack of CK5/6 was significantly associated with reduced survival in multivariate analysis...
  76. doi request reprint Peritoneal carcinosis in apparently benign cortisol producing adrenal adenoma ≥ 5 cm in diameter: the need of regular postoperative surveillance
    M Brauckhoff
    Department of Surgery, Haukeland University Hospital, Bergen, Norway michael brauckhoff kir uib no
    Exp Clin Endocrinol Diabetes 120:472-6. 2012
    ..Report on 2 patients with cortisol producing apparently benign adrenal adenomas ≥ 5 cm in diameter with local malignant recurrence and peritoneal carcinomatosis after endoscopic surgery...
  77. doi request reprint Biologic markers in endometrial cancer treatment
    Ingeborg B Engelsen
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    APMIS 117:693-707. 2009
    ..Ongoing molecular-based clinical trials and newly reported molecular alterations with a potential for development of new targeted therapy are discussed...
  78. doi request reprint TMPRSS2:ERG fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosis
    Kari Rostad
    The Gade Institute, University of Bergen, Bergen, Norway
    APMIS 117:575-82. 2009
    ..Our findings contribute to the increasing elucidation of the role of TMPRSS2:ERG in the development of prostate cancer...
  79. doi request reprint Proliferation of immature tumor vessels is a novel marker of clinical progression in prostate cancer
    Karsten Gravdal
    The Gade Institute, Section for Pathology, and Department of Surgical Sciences, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Cancer Res 69:4708-15. 2009
    ..The castration-resistant tumors exhibited weak VEGF-A but strong HIF-1alpha expression. These novel data might have an effect on clinical evaluation and treatment of prostate cancer patients...
  80. doi request reprint Secondary breast cancer: a 5-year population-based study with review of the literature
    Tor Audun Klingen
    Department of Pathology, Vestfold County Hospital, Halvdan Wilhelmsens Allè 17, Tønsberg, Norway
    APMIS 117:762-7. 2009
    ....
  81. ncbi request reprint NATH, a novel gene overexpressed in papillary thyroid carcinomas
    Øystein Fluge
    Department of Molecular Biology, University of Bergen, N 5020 Bergen, Norway
    Oncogene 21:5056-68. 2002
    ....
  82. ncbi request reprint Increased expression of VEGF-receptors (FLT-1, KDR, NRP-1) and thrombospondin-1 is associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype, in malignant melanoma
    Oddbjørn Straume
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Angiogenesis 6:295-301. 2003
    ..In contrast, GMP expression of bFGF was decreased. Our findings suggest an important role of VEGF-A and its receptors in GMP formation in human cutaneous melanoma...
  83. ncbi request reprint Vascular proliferation is important for clinical progress of endometrial cancer
    Ingunn M Stefansson
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Cancer Res 66:3303-9. 2006
    ..In conclusion, our study indicates that vascular proliferation is a meaningful variable in assessing the angiogenic phenotype of endometrial carcinoma...
  84. ncbi request reprint Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
    Therese Sørlie
    Department of Medicine, Section of Oncology, Haukeland University Hospital, N 5021 Bergen, Norway
    Mol Cancer Ther 5:2914-8. 2006
    ..Using supervised analysis, we could not uncover a gene profile that could reliably (>70% accuracy and specificity) predict response to either treatment regimen...
  85. ncbi request reprint Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinoma
    Helga B Salvesen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    Cancer 94:2185-91. 2002
    ..The objective of this study was to assess the pattern of PTEN expression by immunohistochemistry in a large series of patients with endometrial carcinoma...
  86. ncbi request reprint A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer
    Karsten Gravdal
    The Gade Institute, Section for Pathology, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Clin Cancer Res 13:7003-11. 2007
    ..We here present novel data, with special focus on the independent relationship between an E-cadherin to N-cadherin switch (EN-switch) and patient prognosis...
  87. ncbi request reprint Molecular pathogenesis and prognostic factors in endometrial carcinoma
    Helga B Salvesen
    Department of Gynecology and Obstetrics, The Gade Institute, Haukeland University Hospital, Bergen, Norway
    APMIS 110:673-89. 2002
    ..In conclusion, several prognostic markers have been identified. It is likely that the information derived from these tumor biomarkers will reduce the need for extensive surgical staging and adjuvant treatment in endometrial carcinoma...
  88. ncbi request reprint Pathologic expression of p53 or p16 in preoperative curettage specimens identifies high-risk endometrial carcinomas
    Ingeborg B Engelsen
    Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    Am J Obstet Gynecol 195:979-86. 2006
    ..The purpose of this study was to investigate the prognostic impact of p53 and p16 expression in curettage material from patients with endometrial carcinoma...
  89. doi request reprint Importance of tumour cell invasion in blood and lymphatic vasculature among patients with endometrial carcinoma
    Monica Mannelqvist
    The Gade Institute, Section for Pathology, Haukeland University Hospital, Bergen, Norway
    Histopathology 54:174-83. 2009
    ..The aim was to examine lymphatic and blood vessel invasion separately and their associations with clinicopathological characteristics and prognosis...
  90. ncbi request reprint Is preoperative serum prostate-specific antigen level significantly related to clinical recurrence after radical retropubic prostatectomy for localized prostate cancer?
    Svein A Haukaas
    Department of Surgical Sciences, University of Bergen, Bergen, Norway
    BJU Int 97:51-5. 2006
    ....
  91. ncbi request reprint Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis
    Farhad Alexander-Sefre
    ICRF Translational Oncology Laboratory, St Bartholomew s and the Royal London Medical and Dental School, Charterhouse Square, London, EC1M 6BQ, UK
    Gynecol Oncol 91:218-25. 2003
    ..Tumor cells can evade detection by light microscopy if they are vastly outnumbered by myometrial cells. Molecular techniques have a great potential in the detection of such isolated cells...
  92. ncbi request reprint Population-based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas
    Per Helsing
    Department of Dermatology, Rikshospitalet Radiumhospitalet Medical Center, N 0027 Oslo, Norway
    Genes Chromosomes Cancer 47:175-84. 2008
    ..The frequency of CDKN2A mutations was lower than previously reported in other studies, an observation which probably is due to the population-based design of our study...
  93. pmc Drug-sensitive FGFR2 mutations in endometrial carcinoma
    Amit Dutt
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8713-7. 2008
    ..Inhibition of FGFR2 kinase activity in endometrial carcinoma cell lines bearing such FGFR2 mutations inhibits transformation and survival, implicating FGFR2 as a novel therapeutic target in endometrial carcinoma...
  94. ncbi request reprint Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch
    George N Naumov
    Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    Cell Cycle 5:1779-87. 2006
    ....
  95. doi request reprint Tumor-vascular interactions and tumor dormancy
    George N Naumov
    Department of Surgery, Harvard Medical School and Vascular Biology Program, Children s Hospital Boston, Boston, MA, USA
    APMIS 116:569-85. 2008
    ..We also review current experimental human tumor dormancy models which closely recapitulate clinically observed delay in tumor progress...
  96. ncbi request reprint [Tumour angiogenesis and therapy directed at the neovasculature]
    Hans Petter Eikesdal
    Avdeling for kreftbehandling og strålefysikk, Institutt for indremedisin, Haukeland Universitetsskehus, Bergen
    Tidsskr Nor Laegeforen 124:1919-22. 2004
    ..In this paper we highlight the central aspects of these processes and describe new therapies directed at the tumour vasculature. We also present some of our own data...
  97. ncbi request reprint Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    Torsten O Nielsen
    Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:5367-74. 2004
    ..Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a clinical assay for breast basal-like tumors...
  98. ncbi request reprint MSI-low, a real phenomenon which varies in frequency among cancer types
    Sarah E R Halford
    Molecular and Population Genetics Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Pathol 201:389-94. 2003
    ..PCR artefact was also found to masquerade as MSI-L; criteria for the assessment of MSI-L are suggested to eliminate this problem...
  99. ncbi request reprint A basal epithelial phenotype is more frequent in interval breast cancers compared with screen detected tumors
    Karin Collett
    Vascular Biology Program, Karp Family Research Labs 12 125, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 5737, USA
    Cancer Epidemiol Biomarkers Prev 14:1108-12. 2005
    ..Our data suggest that breast cancers with a basal epithelial phenotype are more likely than nonbasal breast cancers to present between regular mammograms...
  100. doi request reprint Dr. Folkman's legacy-a life of angiogenesis research
    George N Naumov
    APMIS 116:89-92. 2008
  101. ncbi request reprint WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence
    Biaoyang Lin
    Zhejiang California International Nanosystems Institute, Hangzhou, China
    Clin Cancer Res 14:1397-406. 2008
    ..We previously identified WDR19 as a prostate-specific, androgen-regulated gene. Here, we evaluate its utility as a prostate cancer tissue marker for diagnosis and prognostic evaluation...