Ellen Aasum

Summary

Affiliation: University of Troms
Country: Norway

Publications

  1. ncbi request reprint Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR-alpha activator
    Ellen Aasum
    Department of Medical Physiology, University of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 283:H949-57. 2002
  2. ncbi request reprint Pyruvate reverses fatty-acid-induced depression of ventricular function and calcium overload after hypothermia in guinea pig hearts
    E Aasum
    Department of Medical Physiology, University of Tromso, Norway
    Cardiovasc Res 33:370-7. 1997
  3. ncbi request reprint Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice
    Ellen Aasum
    Department of Medical Physiology, Faculty of Medicine, University of Tromsoe, Norway
    Diabetes 52:434-41. 2003
  4. ncbi request reprint Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion
    Ellen Aasum
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Mol Cell Biochem 249:97-103. 2003
  5. ncbi request reprint Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice
    Ellen Aasum
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    J Mol Cell Cardiol 44:201-9. 2008
  6. ncbi request reprint Effect of BM 17.0744, a PPARalpha ligand, on the metabolism of perfused hearts from control and diabetic mice
    Ellen Aasum
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    Can J Physiol Pharmacol 83:183-90. 2005
  7. doi request reprint Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss
    Anne D Hafstad
    Department of Medical Physiology, Institute of Medical Biology, University of Tromsø, Tromsø N 9037, Norway
    Cardiovasc Res 83:519-26. 2009
  8. doi request reprint Increased O2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice
    Neoma Boardman
    Dept of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, Univ of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 296:H1373-9. 2009
  9. ncbi request reprint Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice
    Anne D Hafstad
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Am J Physiol Endocrinol Metab 292:E1288-94. 2007
  10. doi request reprint Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice
    Ahmed M Khalid
    Cardiovascular Research Group, Dept of Medical Biology, Univ of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 300:H2116-22. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR-alpha activator
    Ellen Aasum
    Department of Medical Physiology, University of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 283:H949-57. 2002
    ..7-fold) and glucose oxidation (2.3- fold). Correction of the diabetes-induced abnormalities in systemic and cardiac metabolism after BM 17.0744 treatment did not, however, improve left ventricular contractile function...
  2. ncbi request reprint Pyruvate reverses fatty-acid-induced depression of ventricular function and calcium overload after hypothermia in guinea pig hearts
    E Aasum
    Department of Medical Physiology, University of Tromso, Norway
    Cardiovasc Res 33:370-7. 1997
    ....
  3. ncbi request reprint Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice
    Ellen Aasum
    Department of Medical Physiology, Faculty of Medicine, University of Tromsoe, Norway
    Diabetes 52:434-41. 2003
    ..Finally, peroxisome proliferator-activated receptor-alpha treatment (3 weeks) did not affect sensitivity to ischemia-reperfusion, even though carbohydrate oxidation was increased and palmitate oxidation was decreased...
  4. ncbi request reprint Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion
    Ellen Aasum
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Mol Cell Biochem 249:97-103. 2003
    ..We conclude that ischemia-reperfusion in isolated working mouse hearts is associated with a shift in myocardial substrate utilization in favour of fatty acids, in line with previous observations in rat...
  5. ncbi request reprint Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice
    Ellen Aasum
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    J Mol Cell Cardiol 44:201-9. 2008
    ....
  6. ncbi request reprint Effect of BM 17.0744, a PPARalpha ligand, on the metabolism of perfused hearts from control and diabetic mice
    Ellen Aasum
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    Can J Physiol Pharmacol 83:183-90. 2005
    ..Despite normalization of cardiac metabolism, PPARalpha treatment did not improve cardiac function in diabetic hearts...
  7. doi request reprint Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss
    Anne D Hafstad
    Department of Medical Physiology, Institute of Medical Biology, University of Tromsø, Tromsø N 9037, Norway
    Cardiovasc Res 83:519-26. 2009
    ..In this study we have examined the cardiac response to in vivo administration of tetradecylthioacetic acid (TTA, 0.5% w/w added to the diet for 8 days), a PPAR agonist with primarily PPARalpha activity...
  8. doi request reprint Increased O2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice
    Neoma Boardman
    Dept of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, Univ of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 296:H1373-9. 2009
    ..In conclusion, this study provides direct evidence that MVo(2)(BM) and MVo(2)(ECC) are elevated in diabetes and that acute metabolic interventions can have a therapeutic benefit in diabetic hearts due to a MVo(2)-lowering effect...
  9. ncbi request reprint Glucose and insulin improve cardiac efficiency and postischemic functional recovery in perfused hearts from type 2 diabetic (db/db) mice
    Anne D Hafstad
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Am J Physiol Endocrinol Metab 292:E1288-94. 2007
    ..These findings may in part explain the beneficial effect of glucose-insulin-potassium therapy in diabetic patients with cardiac complications...
  10. doi request reprint Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice
    Ahmed M Khalid
    Cardiovascular Research Group, Dept of Medical Biology, Univ of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 300:H2116-22. 2011
    ..The present study strongly advocates the need for investigation of the cardiac effects of PPAR ligands used in antidiabetic/hypolipidemic therapy, because of their pleiotropic properties...
  11. ncbi request reprint Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin
    Anne Dragøy Hafstad
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, N 9037 Tromsø, Norway
    Am J Physiol Heart Circ Physiol 290:H1763-9. 2006
    ..These results should advocate the use of insulin therapy (glucose-insulin-potassium) in diabetic patients undergoing cardiac surgery or during reperfusion after an ischemic insult...
  12. doi request reprint Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling
    Neoma T Boardman
    Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
    Am J Physiol Heart Circ Physiol 300:H1631-6. 2011
    ....
  13. ncbi request reprint Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    Ole Jakob How
    Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Norway
    Diabetes 55:466-73. 2006
    ..Thus, by means of pressure-volume technology, we have for the first time documented decreased cardiac efficiency in diabetic hearts caused by oxygen waste for noncontractile purposes...
  14. doi request reprint Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice
    Anje C Höper
    Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Sciences, Institute of Medical Biology, University of Tromsø, N 9037 Tromsø, Norway
    Br J Nutr 110:2186-93. 2013
    ..It should be noted that the concentration of n-3 fatty acids in the Calanus oil diet was considerably lower than the concentrations used in similar studies reporting beneficial effects on obesity and obesity-related abnormalities...
  15. doi request reprint Metabolic (in)flexibility of the diabetic heart
    Terje S Larsen
    Department of Medical Physiology, Faculty of Medicine, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Cardiovasc Drugs Ther 22:91-5. 2008
    ....
  16. ncbi request reprint Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts
    Ole Jakob How
    Dept of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, Univ of Tromsø, Tromsø N 9037 Norway
    Am J Physiol Heart Circ Physiol 288:H2979-85. 2005
    ..The methodology can be an important tool for phenotypic assessment of the relationship among metabolism, contractile performance, and cardiac efficiency in various mouse models...
  17. pmc High- and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity
    Anne D Hafstad
    Cardiovascular Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
    Diabetes 62:2287-94. 2013
    ....
  18. ncbi request reprint Myocardial mechanical dysfunction and calcium overload following rewarming from experimental hypothermia in vivo
    Timofei V Kondratiev
    Department of Anaesthesiology, Institute of Clinical Medicine, University of Tromsø, 9037 Tromsø, Norway
    Cryobiology 56:15-21. 2008
    ..These findings indicate that hypothermia-induced alterations in the Ca2+-handling result in Ca2+ overload during hypothermia, which may contribute to myocardial failure during and after rewarming...
  19. ncbi request reprint Endogenous glycogen prevents Ca2+ overload and hypercontracture in harp seal myocardial cells during simulated ischemia
    Thale Henden
    Department of Medical Physiology, Faculty of Medicine, Institute of Medical Biology, University of Tromsø, Tromsø N 9037, Norway
    J Mol Cell Cardiol 37:43-50. 2004
    ..Seal cardiomyocytes thus tolerate low oxygen conditions better than rat cardiomyocytes. This finding is most likely due to a higher glycolysis rate in seals, fueled by larger myocardial glycogen stores...
  20. doi request reprint Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness
    Leif Erik Vinge
    Institute for Surgical Research, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Oslo N 0027, Norway
    J Biol Chem 283:10601-10. 2008
    ..The reduced tolerance to elevation of preload may cause impaired ability to withstand pathophysiological mechanisms of heart failure...
  21. ncbi request reprint Cardiac metabolism in mice: tracer method developments and in vivo application revealing profound metabolic inflexibility in diabetes
    Nicholas D Oakes
    Integrative Pharmacology, AstraZeneca R and D, S 431 83 Molndal, Sweden
    Am J Physiol Endocrinol Metab 290:E870-81. 2006
    ....
  22. ncbi request reprint Treatment of type 2 diabetic db/db mice with a novel PPARgamma agonist improves cardiac metabolism but not contractile function
    Andrew N Carley
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Am J Physiol Endocrinol Metab 286:E449-55. 2004
    ..Metabolic changes in COOH-treated db/db hearts are most likely indirect, secondary to changes in supply of exogenous substrates in vivo and insulin sensitization...
  23. ncbi request reprint Overexpression of angiotensinogen in the myocardium induces downregulation of the fatty acid oxidation pathway
    Corinne Pellieux
    Cardiology Center, University Hospitals of Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    J Mol Cell Cardiol 41:459-66. 2006
    ....