K Sandvig

Summary

Affiliation: The Norwegian Radium Hospital
Country: Norway

Publications

  1. doi request reprint Cellular trafficking of quantum dot-ligand bioconjugates and their induction of changes in normal routing of unconjugated ligands
    Christina Tekle
    Centre for Cancer Biomedicine, Faculty Division, Norwegian Radium Hospital, University of Oslo, 0316 Oslo, Norway
    Nano Lett 8:1858-65. 2008
  2. ncbi request reprint Lipid requirements for entry of protein toxins into cells
    Kirsten Sandvig
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Department of Biosciences, University of Oslo, Oslo, Norway Electronic address
    Prog Lipid Res 54:1-13. 2014
  3. pmc Interplay between toxin transport and flotillin localization
    Sascha Pust
    Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    PLoS ONE 5:e8844. 2010
  4. pmc Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin
    Lionel Tcatchoff
    Department of Biochemistry, Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    PLoS ONE 7:e40429. 2012
  5. pmc SNX4 in complex with clathrin and dynein: implications for endosome movement
    Sigrid S Skånland
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    PLoS ONE 4:e5935. 2009
  6. pmc Shiga toxin and its use in targeted cancer therapy and imaging
    Nikolai Engedal
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Microb Biotechnol 4:32-46. 2011
  7. doi request reprint Retrograde transport of protein toxins through the Golgi apparatus
    Kirsten Sandvig
    Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Histochem Cell Biol 140:317-26. 2013
  8. pmc BiP negatively affects ricin transport
    Tone F Gregers
    Department of Biosciences, and Centre for Immune Regulation, University of Oslo, Oslo 0316, Norway
    Toxins (Basel) 5:969-82. 2013
  9. doi request reprint Endocytosis and retrograde transport of Shiga toxin
    Kirsten Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Toxicon 56:1181-5. 2010
  10. ncbi request reprint Pathways followed by ricin and Shiga toxin into cells
    Kirsten Sandvig
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Histochem Cell Biol 117:131-41. 2002

Collaborators

  • Bo van Deurs
  • Tore Skotland
  • K Berg
  • Tore Geir Iversen
  • Tove Irene Klokk
  • Volker Gerke
  • B Risberg
  • Sebastien Walchli
  • S O Kolset
  • A Høgset
  • Grethe Skretting
  • K Prydz
  • P O Falnes
  • J Moan
  • V Kirveliene
  • Gerrit van Meer
  • Kentaro Hanada
  • Sergio Grinstein
  • S Olsnes
  • H L Ploegh
  • Sigrid S Skånland
  • Maria L Torgersen
  • Bjørn Spilsberg
  • Alicia Llorente
  • Stine Grimmer
  • Audrun Utskarpen
  • Silje U Lauvrak
  • Sascha Pust
  • Tone F Gregers
  • P K Selbo
  • S Pust
  • Lionel Tcatchoff
  • Nikolai Engedal
  • Ming Ying
  • Kirstine Roepstorff
  • Anne Berit Dyve
  • Christina Tekle
  • Miguel A Martín-Acebes
  • Alma Kurmanova
  • Vibeke Bertelsen
  • Hege Holte Slagsvold
  • Monika Slominska-Wojewodzka
  • Silje Ugland Lauvrak
  • Anette M Hommelgaard
  • Lina Guerra
  • Kim Are Birkeli
  • Shirley M L Tse
  • Oddmund Bakke
  • L Tcatchoff
  • B Erikstein
  • N Musa
  • H E Danielsen
  • M Jenstad
  • K Liestøl
  • A Llorente
  • Sofia Andersson
  • Ø Garred
  • M L Torgersen
  • G Sivam
  • O Fodstad
  • Andreas Brech
  • Bo van Deurs
  • Mónica González-Magaldi
  • Anna Polesskaya
  • Inger Helene Madshus
  • Espen Stang
  • Francisco Sobrino
  • Rosario Armas-Portela
  • Juri Kozlov
  • Angela Wandinger-Ness
  • Hege H Slagsvold
  • Kamilla Breen
  • Oystein Garred
  • Maria Lyngaas Torgersen
  • Teresa Frisan
  • Bo Stenerlow
  • Randall K Holmes
  • Monica Thelestam
  • Brendan N Lilley
  • Ken Teter
  • Frederik Vilhardt
  • Robert D Inman
  • Wendy Furuya
  • Alan D Schreiber
  • Guy Keryer
  • Elizabeth Gold
  • Kjetil Tasken
  • Peter Thomsen
  • M Sprangers
  • S K Rodal

Detail Information

Publications62

  1. doi request reprint Cellular trafficking of quantum dot-ligand bioconjugates and their induction of changes in normal routing of unconjugated ligands
    Christina Tekle
    Centre for Cancer Biomedicine, Faculty Division, Norwegian Radium Hospital, University of Oslo, 0316 Oslo, Norway
    Nano Lett 8:1858-65. 2008
    ..Thus, the results demonstrate that Qdots may have severe consequences on cell physiology...
  2. ncbi request reprint Lipid requirements for entry of protein toxins into cells
    Kirsten Sandvig
    Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Department of Biosciences, University of Oslo, Oslo, Norway Electronic address
    Prog Lipid Res 54:1-13. 2014
    ..These toxins can be a threat to human health, but can also be exploited for diagnosis and therapy, and have proven valuable as tools to study intracellular transport. ..
  3. pmc Interplay between toxin transport and flotillin localization
    Sascha Pust
    Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    PLoS ONE 5:e8844. 2010
    ..Thus, flotillin proteins regulate and facilitate the retrograde transport of Stx and ricin...
  4. pmc Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin
    Lionel Tcatchoff
    Department of Biochemistry, Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, Norway
    PLoS ONE 7:e40429. 2012
    ..The most prominent role is played by annexin A1 which normally works as a negative regulator of retrograde transport from the endosomes to the Golgi network, most likely by complex formation and inhibition of cPLA(2)...
  5. pmc SNX4 in complex with clathrin and dynein: implications for endosome movement
    Sigrid S Skånland
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    PLoS ONE 4:e5935. 2009
    ..Some members regulate intracellular trafficking. We have here investigated mechanisms underlying SNX4 mediated endosome to Golgi transport...
  6. pmc Shiga toxin and its use in targeted cancer therapy and imaging
    Nikolai Engedal
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Microb Biotechnol 4:32-46. 2011
    ..Finally, we discuss the possibility of utilizing Stx or StxB coupled to therapeutic compounds or contrast agents in targeted cancer therapy and imaging...
  7. doi request reprint Retrograde transport of protein toxins through the Golgi apparatus
    Kirsten Sandvig
    Centre for Cancer Biomedicine, University of Oslo, Oslo, Norway
    Histochem Cell Biol 140:317-26. 2013
    ..In this review, we will discuss transport of different protein toxins, but we will focus on factors involved in entry and sorting of ricin and Shiga toxin into and through the Golgi apparatus. ..
  8. pmc BiP negatively affects ricin transport
    Tone F Gregers
    Department of Biosciences, and Centre for Immune Regulation, University of Oslo, Oslo 0316, Norway
    Toxins (Basel) 5:969-82. 2013
    ..Our findings suggest that in contrast to what was shown with the Shiga toxin, the presence of BiP does not facilitate, but rather inhibits the entry of ricin into the cytosol...
  9. doi request reprint Endocytosis and retrograde transport of Shiga toxin
    Kirsten Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Toxicon 56:1181-5. 2010
    ..This ribotoxic effect is in some cells followed by apoptosis. In this article we focus on new discoveries concerning endocytosis and retrograde transport of Shiga toxin to the Golgi, the ER and the cytosol...
  10. ncbi request reprint Pathways followed by ricin and Shiga toxin into cells
    Kirsten Sandvig
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Histochem Cell Biol 117:131-41. 2002
    ..Trafficking of protein toxins along these pathways will be discussed in the present article...
  11. pmc Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity
    Kirsten Sandvig
    Centre for Cancer Biomedicine, University of Oslo and Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Histochem Cell Biol 129:267-76. 2008
    ....
  12. ncbi request reprint Membrane traffic exploited by protein toxins
    Kirsten Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Annu Rev Cell Dev Biol 18:1-24. 2002
    ..With increasing information about the internalization and intracellular trafficking of these opportunistic toxins, new avenues have been opened for their application in areas of medicine such as drug delivery and therapy...
  13. ncbi request reprint Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin
    Kirsten Sandvig
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway
    FEBS Lett 529:49-53. 2002
    ..The toxins can also be used as vectors to carry other proteins into the cells. Studies with protein toxins reveal that there are more pathways along the plasma membrane to ER route than originally believed...
  14. ncbi request reprint Shiga toxins
    K Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Toxicon 39:1629-35. 2001
    ..An increasing knowledge about the toxins and their interactions with cells is important both for treatment of disease, and for elucidation of pathways of intracellular transport...
  15. ncbi request reprint Pathways followed by protein toxins into cells
    Kirsten Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Med Microbiol 293:483-90. 2004
    ....
  16. ncbi request reprint Endocytosis and intracellular transport of ricin: recent discoveries
    K Sandvig
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    FEBS Lett 452:67-70. 1999
    ..The different transport steps have been analyzed by studying trafficking of ricin as well as modified ricin molecules...
  17. doi request reprint Clathrin-independent endocytosis: mechanisms and function
    Kirsten Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Curr Opin Cell Biol 23:413-20. 2011
    ....
  18. doi request reprint Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine
    Kirsten Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    FEBS Lett 584:2626-34. 2010
    ..Increased knowledge about toxins is important to prevent and treat these diseases in an optimal way. Interestingly, toxins can be used for diagnosis and treatment of cancer...
  19. ncbi request reprint Ricin transport into cells: studies of endocytosis and intracellular transport
    K Sandvig
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Med Microbiol 290:415-20. 2000
    ..By using ricin we have characterized different types of endocytosis and the transport steps used by this toxin...
  20. ncbi request reprint Apical macropinocytosis in polarized MDCK cells: regulation by N-ethylmaleimide-sensitive proteins
    K Sandvig
    Institute for Cancer Research, The Norwegian Radium Hospital, Department of Biochemistry, Montebello, Oslo
    Eur J Cell Biol 79:447-57. 2000
    ..The results suggest that the fusogenic property of both the apical and the basolateral plasma membrane of MDCK cells differs from that typically observed in cells unable to polarize...
  21. pmc Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases
    T G Iversen
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello 0310 Oslo, Norway
    Mol Biol Cell 12:2099-107. 2001
    ..In conclusion, ricin is transported from endosomes to the Golgi apparatus by a Rab9-, Rab11-, and clathrin-independent pathway...
  22. ncbi request reprint Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
    K Berg
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo
    Cancer Res 59:1180-3. 1999
    ..g., in gene therapy, vaccination, and cancer treatment...
  23. ncbi request reprint Reconstitution of clathrin-independent endocytosis at the apical domain of permeabilized MDCK II cells: requirement for a Rho-family GTPase
    Ø Garred
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Traffic 2:26-36. 2001
    ....
  24. ncbi request reprint Internalization of cholera toxin by different endocytic mechanisms
    M L Torgersen
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Cell Sci 114:3737-47. 2001
    ..In conclusion, a large fraction of CT can be endocytosed by clathrin-dependent as well as by caveolae- and clathrin-independent endocytosis in different cell types...
  25. ncbi request reprint Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
    P K Selbo
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Int J Cancer 87:853-9. 2000
    ..Our results indicate that PCI is a promising tool for increasing the cytotoxicity of immunotoxins, which is important for further improvement of the PCI concept towards possible use in cancer therapy...
  26. ncbi request reprint Proteoglycan synthesis is increased in cells with impaired clathrin-dependent endocytosis
    A Llorente
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Norway
    J Cell Sci 114:335-43. 2001
    ..Thus, the activation of protein kinase C observed upon inhibition of clathrin-dependent endocytosis may be responsible for the increased synthesis of proteoglycans...
  27. ncbi request reprint Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis
    K Sandvig
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo
    J Biol Chem 265:6382-8. 1990
    ..The data support the view that there are different endocytic mechanisms, and they indicate that at least in some cell types the non-clathrin-coated endocytosis can be modulated...
  28. ncbi request reprint Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization
    P K Selbo
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Biochim Biophys Acta 1475:307-13. 2000
    ..Thus, although gelonin can enter the cytosol from lysosomes, lysosomal degradation is a limiting factor for the outcome of PCI of gelonin...
  29. ncbi request reprint Toxin-induced cell lysis: protection by 3-methyladenine and cycloheximide
    K Sandvig
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello, Oslo
    Exp Cell Res 200:253-62. 1992
    ..The data suggest that autophagy is important for the toxin-induced cell lysis...
  30. ncbi request reprint Delivery into cells: lessons learned from plant and bacterial toxins
    K Sandvig
    Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Montebello
    Gene Ther 12:865-72. 2005
    ..In conclusion, the protein toxins are useful tools to study transport and cytosolic translocation, and they can be used as vectors for transport to the interior of the cell...
  31. ncbi request reprint Penetration of protein toxins into cells
    P O Falnes
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, 0310, Norway
    Curr Opin Cell Biol 12:407-13. 2000
    ..In addition, the intracellular targets of many of these toxins have been identified recently...
  32. pmc Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA
    T G Iversen
    Institute for Cancer Research at The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 100:5175-80. 2003
    ....
  33. ncbi request reprint In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy
    P K Selbo
    Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Int J Cancer 92:761-6. 2001
    ..These results demonstrate that the synergistic effect of combining photoactivation of photosensitizer located in endocytic vesicles and gelonin is indeed a result of PCI of gelonin...
  34. doi request reprint Flotillins as regulators of ErbB2 levels in breast cancer
    S Pust
    Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    Oncogene 32:3443-51. 2013
    ..As a consequence, ErbB2-triggered downstream signalling is inhibited. Our data demonstrate a novel mechanism for interfering with ErbB2 signalling, which potentially can have clinical impact. ..
  35. ncbi request reprint SNX1 and SNX2 mediate retrograde transport of Shiga toxin
    Audrun Utskarpen
    Institute for Cancer Research, Centre for Cancer Biomedicine, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Biochem Biophys Res Commun 358:566-70. 2007
    ..Inhibition of PI(3)P formation by wortmannin resulted in a similar reduction. Thus, although being partly redundant, both SNX1 and SNX2 are required for efficient Stx trafficking to the Golgi apparatus...
  36. ncbi request reprint Selective regulation of the Rab9-independent transport of ricin to the Golgi apparatus by calcium
    Silje U Lauvrak
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Cell Sci 115:3449-56. 2002
    ..Together, these findings indicate that the different pathways to the Golgi apparatus utilized by ricin and the mannose 6-phosphate receptor are regulated by different mechanisms...
  37. pmc The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking
    Sebastien Walchli
    Department of Biochemistry and Centre for Cancer Biomedicine, Institute for Cancer Research, The Norwegian Radium Hospital, University of Oslo, Montebello, N 0310 Oslo, Norway
    Mol Biol Cell 19:95-104. 2008
    ..Intracellular transport of Stx is Ca(2+) dependent, and we provide evidence that Stx activates a signaling cascade involving cross talk between Ca(2+) and p38, to regulate its trafficking to the Golgi apparatus...
  38. ncbi request reprint Membrane ruffling and macropinocytosis in A431 cells require cholesterol
    Stine Grimmer
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Cell Sci 115:2953-62. 2002
    ..Thus, our results demonstrate that cholesterol is required for the membrane localization of activated Rac1, actin reorganization, membrane ruffling and macropinocytosis...
  39. ncbi request reprint Caveolae: anchored, multifunctional platforms in the lipid ocean
    Bo van Deurs
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Denmark
    Trends Cell Biol 13:92-100. 2003
    ..Rather than having a specific function, caveolae might be considered to be multifunctional organelles with a physiological role that varies depending on cell type and cellular needs...
  40. ncbi request reprint Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'
    Audrun Utskarpen
    Department of Biochemistry, Institute for Cancer Research, Faculty Division The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Traffic 7:663-72. 2006
    ..In conclusion, both Rab6A and Rab6A' seem to be involved in the transport of ricin from endosomes to the Golgi apparatus...
  41. ncbi request reprint Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
    Maria L Torgersen
    Institute for Cancer Research, Faculty Division, The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    J Biol Chem 282:16317-28. 2007
    ..These results are in agreement with our previous data, which show that Stx is able to stimulate its own transport...
  42. ncbi request reprint Polyunsaturated fatty acids regulate Shiga toxin transport
    Bjørn Spilsberg
    Department of Biochemistry, Centre for Cancer Biomedicine, Institute for Cancer Research, Faculty Division The Norwegian Radium Hospital, University of Oslo, Montebello, N 0310 Oslo, Norway
    Biochem Biophys Res Commun 364:283-8. 2007
    ..In conclusion, these results clearly demonstrate the importance of PUFA for Stx and cholera toxin trafficking...
  43. ncbi request reprint Endosome-to-Golgi transport is regulated by protein kinase A type II alpha
    Kim Are Birkeli
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Biol Chem 278:1991-7. 2003
    ..In conclusion, our results demonstrate that transport of ricin from endosomes to the Golgi apparatus and further to the ER is regulated by PKA type II alpha isozyme...
  44. ncbi request reprint Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis
    Shirley M L Tse
    Department of Pediatrics, Division of Rheumatology, Hospital for Sick Children, Institute of Medical Science, and University Health Network, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 278:3331-8. 2003
    ..These results imply that, contrary to prevailing notions, normal dynamin and clathrin function is not required for phagocytosis and reveal the existence of a component of phagocytosis that is independent of actin and Rab5...
  45. pmc Shiga toxin regulates its entry in a Syk-dependent manner
    Silje Ugland Lauvrak
    Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Mol Biol Cell 17:1096-109. 2006
    ..Also, Golgi transport of Stx was inhibited under all these conditions. In conclusion, our data suggest that Stx regulates its entry into target cells...
  46. pmc EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol
    Monika Slominska-Wojewodzka
    Department of Biochemistry, Institute for Cancer Research, Faculty Division The Norwegian Radium Hospital, University of Oslo, Montebello, N 0310 Oslo, Norway
    Mol Biol Cell 17:1664-75. 2006
    ..In conclusion, our results indicate that EDEM is involved in retrotranslocation of ricin from the ER to the cytosol...
  47. ncbi request reprint Efficient endosome-to-Golgi transport of Shiga toxin is dependent on dynamin and clathrin
    Silje U Lauvrak
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Cell Sci 117:2321-31. 2004
    ....
  48. ncbi request reprint Induction of direct endosome to endoplasmic reticulum transport in Chinese hamster ovary (CHO) cells (LdlF) with a temperature-sensitive defect in epsilon-coatomer protein (epsilon-COP)
    Alicia Llorente
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    J Biol Chem 278:35850-5. 2003
    ..In conclusion, our results suggest that in ldlF cells depleted of epsilon-COP ricin might be transported to the ER by an induced brefeldin A-resistant pathway that circumvents the Golgi apparatus...
  49. ncbi request reprint Depletion of sphingolipids facilitates endosome to Golgi transport of ricin
    Stine Grimmer
    Institute for Cancer Research, Department of Biochemistry, The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Traffic 7:1243-53. 2006
    ..Our results indicate that the presence of sphingolipids actually limits and may function to control endosome to Golgi transport of ricin...
  50. ncbi request reprint Role of lipids in the retrograde pathway of ricin intoxication
    Bjørn Spilsberg
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Traffic 4:544-52. 2003
    ..Binding of ricin to glycoproteins is sufficient for all transport steps required for ricin intoxication...
  51. ncbi request reprint Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins
    Sigrid S Skånland
    Department of Biochemistry, Institute for Cancer Research, University of Oslo, Faculty Department The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Traffic 8:297-309. 2007
    ..Interestingly, knocking down both SNX2 and SNX4 results in a better inhibition than knocking down only one of them, suggesting that they may act on separate pathways...
  52. ncbi request reprint Cellular internalization of cytolethal distending toxin: a new end to a known pathway
    Lina Guerra
    Microbiology and Tumorbiology Center, Karolinska Institutet, Stockholm, Sweden
    Cell Microbiol 7:921-34. 2005
    ....
  53. ncbi request reprint Cholesterol loading induces a block in the exit of VSVG from the TGN
    Ming Ying
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Traffic 4:772-84. 2003
    ..Furthermore, the data illustrate the importance of actin filaments for Golgi structure...
  54. ncbi request reprint Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism
    Stine Grimmer
    Institute for Cancer Research, Department of Biochemistry, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Traffic 6:144-56. 2005
    ..Thus, our results demonstrate that the cholesterol-induced vesiculation of the Golgi apparatus is mediated by a cPLA2- and dynamin-dependent mechanism...
  55. ncbi request reprint The A-subunit of surface-bound Shiga toxin stimulates clathrin-dependent uptake of the toxin
    Maria L Torgersen
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    FEBS J 272:4103-13. 2005
    ..In conclusion, the data indicate that the Shiga toxin A-subunit of cell surface-bound toxin stimulates clathrin-dependent uptake of the toxin. Possible explanations for this phenomenon are discussed...
  56. ncbi request reprint Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding
    Kirstine Roepstorff
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    J Biol Chem 277:18954-60. 2002
    ..We propose that non-caveolar lipid rafts function as negative regulators of EGF receptor signaling by sequestering a fraction of the EGF receptors in a state inaccessible for ligand binding...
  57. ncbi request reprint Caveolae: stable membrane domains with a potential for internalization
    Anette M Hommelgaard
    Structural Cell Biology Unit, Department of Medical Anatomy, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Traffic 6:720-4. 2005
    ..Finally, we propose that future studies dealing with internalization of caveolae should actually document such internalization and include kinetic data...
  58. ncbi request reprint Diphtheria toxin translocation across cellular membranes is regulated by sphingolipids
    Bjørn Spilsberg
    Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Biochem Biophys Res Commun 329:465-73. 2005
    ..In conclusion, diphtheria toxin translocation is facilitated by depletion of membrane sphingolipids...
  59. ncbi request reprint Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol
    Miguel A Martín-Acebes
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Cantoblanco 28049, Madrid, Spain
    Virology 369:105-18. 2007
    ....
  60. ncbi request reprint Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells
    Alicia Llorente
    Centre for Cancer Biomedicine, Faculty Division The Norwegian Radium Hospital, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, N 0310 Oslo, Norway
    Eur J Cell Biol 86:405-15. 2007
    ....
  61. ncbi request reprint Structural requirements for furin-induced cleavage and activation of Shiga toxin
    Alma Kurmanova
    W A Engelhardt Institute for Molecular Biology, The Russian Academy of Sciences, Moscow, Russia
    Biochem Biophys Res Commun 357:144-9. 2007
    ..In contrast, LoVo/neo cells lacking functional furin were unable to activate both wild type Shiga toxin and Shiga-2D toxin. In conclusion, an extended loop structure is required for furin-induced cleavage of Shiga toxin...
  62. ncbi request reprint The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis
    Vibeke Bertelsen
    Institute of Pathology, Faculty Division Rikshospitalet, University of Oslo, Rikshospitalet Radiumhospitalet Medical Centre, 0027 Oslo, Norway
    Exp Cell Res 313:1696-709. 2007
    ..We conclude that TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin...