B Davidson

Summary

Affiliation: The Norwegian Radium Hospital
Country: Norway

Publications

  1. ncbi Caveolin-1 expression in advanced-stage ovarian carcinoma--a clinicopathologic study
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo N 0310, Norway
    Gynecol Oncol 81:166-71. 2001
  2. ncbi Expression of cell cycle proteins in ovarian carcinoma cells in serous effusions-biological and prognostic implications
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Gynecol Oncol 83:249-56. 2001
  3. ncbi The role of desmin and N-cadherin in effusion cytology: a comparative study using established markers of mesothelial and epithelial cells
    B Davidson
    Department of Pathology Division of Cytology, Norwegian Radium Hospital, Oslo, Norway
    Am J Surg Pathol 25:1405-12. 2001
  4. ncbi Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, Norway
    Clin Cancer Res 7:3457-64. 2001
  5. ncbi Ets-1 mRNA expression in effusions of serous ovarian carcinoma patients is a marker of poor outcome
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Am J Surg Pathol 25:1493-500. 2001
  6. ncbi Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, Oslo, Norway
    Breast Cancer Res Treat 83:119-28. 2004
  7. ncbi Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo
    Clin Exp Metastasis 19:135-44. 2002
  8. ncbi Expression of the nerve growth factor receptors TrkA and p75 in malignant mesothelioma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, University of Oslo, Oslo, Norway
    Lung Cancer 44:159-65. 2004
  9. ncbi Ovarian carcinoma and serous effusions. Changing views regarding tumor progression and review of current literature
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital University of Oslo, Montebello, N 0310 Oslo, Norway
    Anal Cell Pathol 23:107-28. 2001
  10. ncbi Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello Oslo, Norway
    Clin Exp Metastasis 20:621-31. 2003

Detail Information

Publications103 found, 100 shown here

  1. ncbi Caveolin-1 expression in advanced-stage ovarian carcinoma--a clinicopathologic study
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo N 0310, Norway
    Gynecol Oncol 81:166-71. 2001
    ..The aim of this study was to analyze the correlation among the expression of caveolin-1, the protein constituent of caveolae, and disease outcome in advanced-stage ovarian carcinomas...
  2. ncbi Expression of cell cycle proteins in ovarian carcinoma cells in serous effusions-biological and prognostic implications
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Gynecol Oncol 83:249-56. 2001
    ..The aim of this study was to investigate the expression of cell cycle proteins in ovarian carcinoma cells in serous effusions and respective solid tumors...
  3. ncbi The role of desmin and N-cadherin in effusion cytology: a comparative study using established markers of mesothelial and epithelial cells
    B Davidson
    Department of Pathology Division of Cytology, Norwegian Radium Hospital, Oslo, Norway
    Am J Surg Pathol 25:1405-12. 2001
    ..As has previously been shown, a significant number of diagnoses that are based on morphologic examination alone are modified after the use of a broad antibody panel...
  4. ncbi Expression levels of the nerve growth factor receptors TrkA and p75 in effusions and solid tumors of serous ovarian carcinoma patients
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, Norway
    Clin Cancer Res 7:3457-64. 2001
    ....
  5. ncbi Ets-1 mRNA expression in effusions of serous ovarian carcinoma patients is a marker of poor outcome
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Am J Surg Pathol 25:1493-500. 2001
    ..The identical phenotype of carcinoma cells in pleural and peritoneal effusions provides further evidence for our theory that cells at these sites share similar genotypic and phenotypic profiles...
  6. ncbi Altered expression and activation of the nerve growth factor receptors TrkA and p75 provide the first evidence of tumor progression to effusion in breast carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, Oslo, Norway
    Breast Cancer Res Treat 83:119-28. 2004
    ..Furthermore, the rapid progression to effusion in cases showing NGF expression in tumor cells underscores the aggressive clinical behavior of tumors that are able to utilize this pathway in an autocrine manner...
  7. ncbi Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo
    Clin Exp Metastasis 19:135-44. 2002
    ..Carcinoma cells in pleural and peritoneal effusions show a similar metastatic expression profile, in agreement with our previous findings, supporting the true metastatic nature of ovarian carcinoma cells in ascites...
  8. ncbi Expression of the nerve growth factor receptors TrkA and p75 in malignant mesothelioma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, University of Oslo, Oslo, Norway
    Lung Cancer 44:159-65. 2004
    ....
  9. ncbi Ovarian carcinoma and serous effusions. Changing views regarding tumor progression and review of current literature
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital University of Oslo, Montebello, N 0310 Oslo, Norway
    Anal Cell Pathol 23:107-28. 2001
    ..Finally, the prognostic role of these molecules was studied in solid tumors from a patient cohort consisting of long- and short-term survivors, followed for up to 20 years. Figure 1 on http://www.esacp.org/acp/2001/23-3,4/davidson.htm...
  10. ncbi Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello Oslo, Norway
    Clin Exp Metastasis 20:621-31. 2003
    ..These data may expand our understanding regarding the mechanisms by which MMP synthesis is regulated in effusions and possibly affect treatment strategies for this form of malignancy...
  11. ncbi Effusion cytology in ovarian cancer: new molecular methods as aids to diagnosis and prognosis
    Ben Davidson
    Department of Pathology, Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Clin Lab Med 23:729-54, viii. 2003
    ....
  12. ncbi PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, University of Oslo, Norway
    Clin Cancer Res 9:1412-9. 2003
    ..The purpose of this study was to analyze the possible correlation between PEA3 mRNA expression and survival in advanced-stage ovarian carcinomas, studying two patient groups with extremely different disease outcome...
  13. ncbi EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Clin Exp Metastasis 20:161-9. 2003
    ..The identical phenotype of carcinoma cells in pleural and peritoneal effusions provides further evidence to our theory that cells at these sites share similar genotypic and phenotypic profiles...
  14. ncbi Coordinated expression of integrin subunits, matrix metalloproteinases (MMP), angiogenic genes and Ets transcription factors in advanced-stage ovarian carcinoma: a possible activation pathway?
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, affiliated with the University of Oslo, Norway
    Cancer Metastasis Rev 22:103-15. 2003
    ..They also suggest the existence of a putative activation sequence of metastatic genes, involving the beta1 (and possibly alpha v) integrin subunits, IL-8, PEA3, Ets-1 and MMP in ovarian carcinoma...
  15. ncbi Malignant effusions: from diagnosis to biology
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Diagn Cytopathol 31:246-54. 2004
    ..The case also is made for potential applications of this rapidly evolving body of knowledge in the diagnosis, classification, and prediction of biological behavior of processes resulting in cryptic effusions at the clinical level...
  16. ncbi Ovarian carcinoma cells in serous effusions show altered MMP-2 and TIMP-2 mRNA levels
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310, Oslo, Norway
    Eur J Cancer 37:2040-9. 2001
    ..MMP-1 and MMP-2 production predominates over that of MMP-9 in effusions. Increased MMP-2 and reduced TIMP-2 levels are seen in ovarian carcinoma cells in effusions, possibly marking the acquisition of a metastatic phenotype...
  17. ncbi HLA-G expression in effusions is a possible marker of tumor susceptibility to chemotherapy in ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Gynecol Oncol 96:42-7. 2005
    ..The objective of this study was to evaluate the expression and clinical role of HLA-G in effusions and corresponding solid tumors from patients diagnosed with advanced-stage ovarian carcinoma...
  18. ncbi MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization
    B Davidson
    Affiliated with Sackler School of Medicine, Sheba Medical Center, Tel Hashomer, Israel
    Gynecol Oncol 73:372-82. 1999
    ..The present study evaluated the role of matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinases-2 (TIMP-2), and membrane-type metalloproteinase (MT1-MMP) in cervical neoplasia...
  19. ncbi Detection of cancer cells in effusions from patients diagnosed with gynaecological malignancies. Evaluation of five epithelial markers
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo
    Virchows Arch 435:43-9. 1999
    ..Analysis of all staining results should be based on a thorough morphological examination...
  20. ncbi Expression of topoisomerase II and Ki-67 in cervical carcinoma--clinicopathological study using immunohistochemistry
    B Davidson
    Department of Pathology, Sheba Medical Center, Tel Hashomer, Israel
    APMIS 108:209-15. 2000
    ..To study the correlation between the expression of topoisomerase II and Ki-67 antigen and disease outcome in cervical squamous cell carcinomas...
  21. ncbi Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, Radiumhospitalet Rikshospitalet Medical Center, Oslo, Norway
    Cancer 110:1264-71. 2007
    ..In the current study, they analyzed the expression of low-molecular weight (LMW) forms of cyclin E in ovarian carcinoma, malignant mesothelioma, and benign reactive effusions...
  22. ncbi Expression and clinical role of DJ-1, a negative regulator of PTEN, in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
    Hum Pathol 39:87-95. 2008
    ..In contrast, PTEN expression is infrequent in this disease. These findings may provide one of the molecular mechanisms that mediate cancer cell survival and aggressiveness in this tumor...
  23. ncbi Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, Norway
    Clin Cancer Res 9:2248-59. 2003
    ..In addition, we wished to study the possible link between expression of NGF, a novel angiogenic factor and its receptor TrkA, and the expression of factors involved in angiogenesis in effusions and solid tumors...
  24. ncbi High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Clin Exp Metastasis 17:799-808. 1999
    ..006) and MMP-9 levels in tumor cells (P = 0.011) retained their predictive value. We conclude that MMP-2, MMP-9, MT1-MMP and TIMP-2 are valid markers of poor survival in advanced-stage ovarian carcinoma...
  25. ncbi E-Cadherin complex protein expression and survival in ovarian carcinoma
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, N 0310, Norway
    Gynecol Oncol 79:362-71. 2000
    ..The aim of this study was to analyze the correlation between expression of E-cadherin complex proteins, epidermal growth factor receptor (EGFR), and c-erbB-2 and disease outcome in advanced-stage ovarian carcinomas...
  26. ncbi E-cadherin and alpha-, beta-, and gamma-catenin protein expression is up-regulated in ovarian carcinoma cells in serous effusions
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    J Pathol 192:460-9. 2000
    ..The up-regulation of E-cadherin complex proteins in serous effusions and metastatic lesions may mark an early metastatic phenotype and possibly mediates survival of tumour cells at these sites through the inhibition of apoptosis...
  27. ncbi Primary ovarian angiosarcoma presenting as malignant cells in ascites: case report and review of the literature
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo
    Diagn Cytopathol 32:307-9. 2005
    ..Despite the rarity of metastasis from gynecological sarcomas in effusions, this possibility needs to be included in the differential diagnosis of malignant effusions that are negative for epithelial and germ cell markers...
  28. ncbi Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, Oslo, Norway
    Clin Exp Metastasis 21:469-76. 2004
    ....
  29. ncbi Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo
    Clin Cancer Res 7:551-7. 2001
    ....
  30. ncbi AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello N 0310 Oslo, University of Oslo, Norway
    Gynecol Oncol 90:248-57. 2003
    ....
  31. ncbi Alphav integrin expression is a novel marker of poor prognosis in advanced-stage ovarian carcinoma
    I Goldberg
    Department of Pathology, Sheba Medical Center, Tel-Hashomer 52621, Israel
    Clin Cancer Res 7:4073-9. 2001
    ..CONCLUSIONS: To our best knowledge, this is the first evidence associating integrin expression with poor survival in ovarian carcinoma. Alphav integrin is, thus, a novel prognostic marker in advanced-stage ovarian carcinoma...
  32. ncbi Expression of carbohydrate antigens in advanced-stage ovarian carcinomas and their metastases-A clinicopathologic study
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Gynecol Oncol 77:35-43. 2000
    ....
  33. ncbi Carbohydrate antigen expression in primary tumors, metastatic lesions, and serous effusions from patients diagnosed with epithelial ovarian carcinoma: evidence of up-regulated Tn and Sialyl Tn antigen expression in effusions
    B Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo
    Hum Pathol 31:1081-7. 2000
    ..Ovarian carcinoma cells in effusions show up-regulation of Tn and Sialyl Tn, possibly representing a transient phenotypic alteration facilitating metastasis...
  34. ncbi Expression of membrane-type 1, 2, and 3 matrix metalloproteinases messenger RNA in ovarian carcinoma cells in serous effusions
    B Davidson
    Dept of Pathology, The Norwegian Radium Hospital, Montebello N-0310, Oslo, Norway
    Am J Clin Pathol 115:517-24. 2001
    ..Tumor cell MT1-MMP expression in effusion specimens did not differ from primary or metastatic lesions. MT-MMP expression in tumor cells in effusions showed no association with effusion site or tumor type using ISH and RT-PCR...
  35. ncbi Flow cytometric measurement of cellular FLICE-inhibitory protein (c-FLIP) in ovarian carcinoma effusions
    H P Dong
    Division of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway Department of Gynecologic Oncology, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway The Medical Faculty, University of Oslo, Oslo, Norway Institute for Medical Informatics, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cytopathology 22:373-82. 2011
    ..029). Conclusions:  An assay for measuring c-FLIP in cytology specimens is presented. c-FLIP is frequently expressed in ovarian carcinoma effusions, but its expression appears to be unrelated to disease aggressiveness...
  36. ncbi Expression of CD44 in effusions of patients diagnosed with serous ovarian carcinoma--diagnostic and prognostic implications
    H S Berner
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello
    Clin Exp Metastasis 18:197-202. 2000
    ..The similar expression profile of CD44 in carcinoma cells in peritoneal and pleural effusions supports our previous observations and the hypothesis that carcinoma cells in peritoneal effusions are truly metastatic...
  37. ncbi PINCH-2 expression in cancers involving serosal effusions using quantitative PCR
    Y Yuan
    Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cytopathology 22:22-9. 2011
    ..The objective of the present study was to validate this finding at the mRNA and protein level...
  38. ncbi Detection of monocyte/macrophage cell populations in effusions: a comparative study using flow cytometric immunophenotyping and immunocytochemistry
    B Risberg
    Division of Cytology, Department of Pathology, Norwegian Radium Hospital, Oslo, Norway
    Diagn Cytopathol 25:214-9. 2001
    ..Both FCM and ICC aid in the recognition of these cells, and thus provide an effective tool for the identification of different cell populations in effusions...
  39. ncbi Flow cytometric immunophenotyping of serous effusions and peritoneal washings: comparison with immunocytochemistry and morphological findings
    B Risberg
    Department of Pathology, Norwegian Radium Hospital, University of Oslo, Norway
    J Clin Pathol 53:513-7. 2000
    ..To evaluate immunophenotyping by means of flow cytometry as a complementary method for the detection of malignant cells in serous effusions and peritoneal washings...
  40. ncbi The clinical role of phospholipase A2 isoforms in advanced-stage ovarian carcinoma
    Michal Gorovetz
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel, and Department of Gynecologic Oncology, National Hospital-Norwegian Radium Hospital, Oslo, Norway
    Gynecol Oncol 103:831-40. 2006
    ..PLA2 isoenzyme expression differs in pre- and post-chemotherapy specimens. PLAP and sPLA2-XII may be independent predictors of poor outcome for patients with post-chemotherapy effusions...
  41. ncbi The diagnostic and molecular characteristics of malignant mesothelioma and ovarian/peritoneal serous carcinoma
    B Davidson
    Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Cytopathology 22:5-21. 2011
    ..This review will present current data regarding the diagnostic and biological aspects of malignant mesothelioma and ovarian/peritoneal serous carcinoma...
  42. ncbi Differential expression of CD44s and CD44v3-10 in adenocarcinoma cells and reactive mesothelial cells in effusions
    H S Berner
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello
    Virchows Arch 436:330-5. 2000
    ..We advocate the use of CD44s and CD44v3-10 immunostaining in diagnostic evaluation of difficult serous effusions...
  43. ncbi Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous effusions
    Yuan Yuan
    National Resource Center for Women s Health, Rikshospitalet University Hospital, Oslo, Norway
    Hum Pathol 40:1453-60. 2009
    ..The high expression of folate receptors in ovarian carcinoma supports their validity as molecular therapeutic targets in this disease...
  44. ncbi Caveolin-1 expression in ovarian carcinoma is MDR1 independent
    Ben Davidson
    Department of Pathology, Norwegian Radium Hospital, Oslo
    Am J Clin Pathol 117:225-34. 2002
    ..Expression seems MDR1 independent...
  45. ncbi MUC4 is upregulated in ovarian carcinoma effusions and differentiates carcinoma cells from mesothelial cells
    Ben Davidson
    Department of Pathology, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Montebello N 0310 Oslo, Norway
    Diagn Cytopathol 35:756-60. 2007
    ..The data in the present study, together with our earlier report, show that MUC4 is an excellent marker for differentiating OC/PPC from both benign and malignant mesothelial cells...
  46. ncbi Measurement of apoptosis in cytological specimens by flow cytometry: comparison of Annexin V, caspase cleavage and dUTP incorporation assays
    H P Dong
    Division of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway Institute for Medical Informatics, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway The Medical Faculty, University of Oslo, Oslo, Norway
    Cytopathology 22:365-72. 2011
    ....
  47. ncbi Site-related expression of metastasis-associated and signaling molecules in malignant mesothelioma--a new model for the study of tumor biology and disease progression
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, N-0310 Oslo, Norway
    Lung Cancer 49:S89-93. 2005
  48. ncbi Quantitative analysis of integrin expression in effusions using flow cytometric immunophenotyping
    Eva Sigstad
    Department of Pathology (Section of Cytology, The Norwegian Radium Hospital, Oslo, Norway
    Diagn Cytopathol 33:325-31. 2005
    ..The frequent expression of the alphaV and beta1 subunits support attachment to fibronectin and vitronectin as the major ECM ligands in body cavities...
  49. ncbi Mammalian target of rapamycin is a biomarker of poor survival in metastatic serous ovarian carcinoma
    Mari Bunkholt Elstrand
    Division of Obstetrics and Gynecology, Section for Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Hum Pathol 41:794-804. 2010
    ....
  50. ncbi Expression of HLA-G in malignant mesothelioma and clinically aggressive breast carcinoma
    Lilach Kleinberg
    Department of Pathology, Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway
    Virchows Arch 449:31-9. 2006
    ..However, the up-regulated expression of HLA-G in MM effusions and its possible association with shorter disease-free survival in advanced stage of breast carcinoma suggest a possible role in immune response evasion in some tumors...
  51. ncbi Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients: a novel model for tumor progression
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, University of Oslo, Oslo, Norway
    Clin Cancer Res 10:7335-46. 2004
    ....
  52. ncbi Expression of the chromatin remodeling factor Rsf-1 is upregulated in ovarian carcinoma effusions and predicts poor survival
    Ben Davidson
    Department of Pathology, National Hospital Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Gynecol Oncol 103:814-9. 2006
    ..However, its clinical role in ovarian cancer effusions is not clear. In the present study, we assessed the clinical significance of Rsf-1 overexpression in ovarian carcinoma effusions...
  53. ncbi The diagnostic role of claudins in serous effusions
    Lilach Kleinberg
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Oslo, Norway
    Am J Clin Pathol 127:928-37. 2007
    ..Claudins may, therefore, be of diagnostic value in effusion cytology...
  54. ncbi Anatomic site-related expression of cancer-associated molecules in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, National Hospital Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Curr Cancer Drug Targets 7:109-20. 2007
    ..This review will present the current knowledge in this area...
  55. ncbi Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma
    Ben Davidson
    Department of Pathology, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Oslo, Norway
    Clin Cancer Res 12:5944-50. 2006
    ..It remains unclear whether both tumors are molecularly distinct neoplasms. The current study compared global gene expression patterns in OC/PPC and DMPM...
  56. ncbi Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma
    Hiep Phuc Dong
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Cancer 112:84-93. 2008
    ..Death receptors mediate both apoptosis and survival in cancer cells. The authors analyzed death receptor expression in metastatic ovarian carcinoma...
  57. ncbi The chemokine receptor CXCR4 is more frequently expressed in breast compared to other metastatic adenocarcinomas in effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Medical Center, Montebello, Oslo, Norway
    Breast J 14:476-82. 2008
    ..The prognostic role of CCR7 expression in monocytes and CD8 counts in breast carcinoma effusions merits further research...
  58. ncbi Expression of the peroxisome proliferator-activated receptors-alpha, -beta, and -gamma in ovarian carcinoma effusions is associated with poor chemoresponse and shorter survival
    Ben Davidson
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet Medical Center, Montebello N 0310, Oslo, Norway
    Hum Pathol 40:705-13. 2009
    ..Peroxisome proliferator-activated receptor expression in effusions is associated with poor response to chemotherapy at disease recurrence and poor survival, suggesting a role in tumor biology at this unique microenvironment...
  59. ncbi Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites
    Gunhild M Maelandsmo
    Department of Tumor Biology and Surgery, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Tumour Biol 30:15-25. 2009
    ....
  60. ncbi Survivin, a member of the inhibitors of apoptosis family, is down-regulated in breast carcinoma effusions
    Lilach Kleinberg
    The Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Am J Clin Pathol 128:389-97. 2007
    ..Survivin expression may predict disease-free survival for patients with postchemotherapy effusions...
  61. ncbi The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello, University of Oslo, Oslo, Norway
    Clin Exp Metastasis 21:191-9. 2004
    ..These findings support a biological role for Ets transcription factors in these malignancies and suggests that they may be targets for therapeutic intervention...
  62. ncbi Diagnosis and treatment of borderline ovarian neoplasms "the state of the art"
    C Trope
    Department of Gynaecologic Oncology, The Norwegian Radium Hospital Rikshospitalet Oslo University Hospital, Oslo, Norway
    Eur J Gynaecol Oncol 30:471-82. 2009
    ..been over-treated and how should these patients be treated? How to define the high-risk patients? In which group of patients is fertility-sparing surgery advisable and, do patients with borderline tumours benefit from adjuvant treatment?..
  63. ncbi Rates of Jewish ancestral mutations in BRCA1 and BRCA2 in borderline ovarian tumors
    W H Gotlieb
    Division of Gynecologic Oncology, Sheba Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    J Natl Cancer Inst 90:995-1000. 1998
    ..To gain insight into these issues, we determined the rates of 185delAG-BRCA1 and 6174delT-BRCA2 mutations in patients with borderline ovarian tumors...
  64. ncbi D2-40 is not a specific marker for cells of mesothelial origin in serous effusions
    Assia V Bassarova
    Pathology Clinic, The National Hospital The Norwegian Radium Hospital, University of Oslo, Montebello 0310 Oslo, Norway
    Am J Surg Pathol 30:878-82. 2006
    ....
  65. ncbi Methods for simultaneous measurement of apoptosis and cell surface phenotype of epithelial cells in effusions by flow cytometry
    Hiep Phuc Dong
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet Medical Center, Ullernchaussen 70, Montebello, N 0310 Oslo, Norway
    Nat Protoc 3:955-64. 2008
    ..The culturing of cell lines requires 2-3 days and induction of apoptosis requires 16 h...
  66. ncbi Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma
    Ben Davidson
    Department of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Hum Pathol 39:1630-6. 2008
    ..This suggests altered cellular function for this kinase along disease progression, possibly chemotherapy mediated...
  67. ncbi The fatty acid binding protein 7 (FABP7) is involved in proliferation and invasion of melanoma cells
    Ana Slipicevic
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello N 0310 Oslo, Norway
    BMC Cancer 8:276. 2008
    ..One of the new candidates that emerged from a recent gene expression profiling study is fatty acid-binding protein 7 (FABP7), involved in lipid metabolism, gene regulation, cell growth and differentiation...
  68. ncbi New diagnostic and molecular characteristics of malignant mesothelioma
    Ben Davidson
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Ultrastruct Pathol 32:227-40. 2008
    ..This review presents current data regarding the diagnostic and biological aspects of malignant mesothelioma...
  69. ncbi Flow cytometric immunphenotyping of epithelial cancer cells in effusions--technical considerations and pitfalls
    Hiep P Dong
    Pathology Clinic, Radiumhospitalet Rikshospitalet Medical Center, University of Oslo, Montebello, N 0310 Oslo, Norway
    Cytometry B Clin Cytom 72:332-43. 2007
    ..In the present study, we optimized the conditions for FCM immunphenotyping of effusions using a four-color analysis and investigated aspects related to the advantages and limitations of this method in this setting...
  70. ncbi Diagnostic and prognostic role of the insulin growth factor pathway members insulin-like growth factor-II and insulin-like growth factor binding protein-3 in serous effusions
    Ana Slipicevic
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet Medical Center, N 0310 Oslo, Norway
    Hum Pathol 40:527-37. 2009
    ..Insulin-like growth factor-II and insulin-like growth factor binding protein-3 may be novel prognostic markers in metastatic ovarian carcinoma...
  71. ncbi Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma
    Mari Bunkholt Elstrand
    Section for Gynecologic Oncology, Division of Obstetrics and Gynecology, Norwegian Radium Hospital, Oslo, Norway
    Int J Gynecol Pathol 28:211-21. 2009
    ..HSP70 expression in effusions may be a prognostic marker of poor survival, with a similar role for Bcl-2 in primary carcinomas...
  72. ncbi Heparanase expression correlates with poor survival in metastatic ovarian carcinoma
    Ben Davidson
    Department of Pathology, National Hospital Norwegian Radium Hospital, Montebello N 0310 Oslo, University of Oslo, Norway
    Gynecol Oncol 104:311-9. 2007
    ..To analyze the expression of Heparanase, an enzyme involved in cancer metastasis and angiogenesis, in ovarian and breast carcinoma cells in effusions...
  73. ncbi Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression
    Stine Sivertsen
    Department of Pathology, Radiumhospitalet-Rikshospitalet Medical Center, University of Oslo, Montebello, N-0310 Oslo, Norway
    Lung Cancer 54:309-17. 2006
    ..The increased E-cadherin expression in effusions may be related to lack of negative regulation at the epigenetic level. The relationship between Snail and MMP in MM is uncertain at present...
  74. ncbi Evaluation of cell surface expression of phosphatidylserine in ovarian carcinoma effusions using the annexin-V/7-AAD assay: clinical relevance and comparison with other apoptosis parameters
    Hiep Phuc Dong
    Division of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello N 0310 Oslo, Norway
    Am J Clin Pathol 132:756-62. 2009
    ..The higher annexin-V expression compared with other apoptosis parameters and its association with high-grade disease and poor survival in postchemotherapy patients suggest a role in cell survival rather than apoptosis in effusions...
  75. ncbi Detection of malignant epithelial cells in effusions using flow cytometric immunophenotyping: an analysis of 92 cases
    Ben Davidson
    Department of Pathology, Division of Cytology, Norwegian Radium Hospital, Oslo
    Am J Clin Pathol 118:85-92. 2002
    ..By using established cellular markers coupled with biological markers, FCM also has great promise for experimental purposes...
  76. ncbi Tenascin-X is a novel diagnostic marker of malignant mesothelioma
    Yuan Yuan
    Department of Pathology, Norwegian Radium Hospital, Norway
    Am J Surg Pathol 33:1673-82. 2009
    ....
  77. ncbi Expression of the chromatin remodeling factor Rsf-1 is down-regulated in breast carcinoma effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, N 0310 Oslo, Norway
    Hum Pathol 39:616-22. 2008
    ..In conclusion, in contrast to ovarian carcinoma, Rsf-1 expression is down-regulated in breast carcinoma cells in effusions compared with the solid counterparts and has no prognostic role at this anatomic site...
  78. ncbi The prognostic value of metalloproteinases and angiogenic factors in ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    Mol Cell Endocrinol 187:39-45. 2002
    ..05). We conclude that bFGF is the major angiogenic factor expressed in ovarian carcinoma at the mRNA level. MMP-2, MMP-9, MT1-MMP and TIMP-2 are valid markers of poor survival in advanced-stage ovarian carcinoma...
  79. ncbi Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, Oslo, Norway
    Am J Clin Pathol 123:360-8. 2005
    ..hK4 expression in carcinoma cells of effusions or solid tumors does not predict survival...
  80. ncbi NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma
    Hiep Phuc Dong
    Department of Pathology, Norwegian Radium Hospital, University of Oslo, Norway
    Am J Clin Pathol 125:451-8. 2006
    ..Immune response parameters in ovarian cancer effusions are weak predictors of outcome...
  81. ncbi The biological differences between ovarian serous carcinoma and diffuse peritoneal malignant mesothelioma
    Ben Davidson
    Department of Pathology, Norwegian Radium Hospital National Hospital, University of Oslo, Oslo, Norway
    Semin Diagn Pathol 23:35-43. 2006
    ....
  82. ncbi Cadherin expression in ovarian carcinoma and malignant mesothelioma cell effusions
    Stine Sivertsen
    Department of Pathology, National Hospital-Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Acta Cytol 50:603-7. 2006
    ..05). CONCLUSION: MM and OC/PPC coexpress different cadherin family members. P-cadherin, E-cadherin and N-cadherin are not useful for differentiation between OC/PPC and MM in effusions...
  83. ncbi The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma
    Ben Davidson
    Department of Pathology, The National Hospital Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Gynecol Oncol 102:453-61. 2006
    ..To investigate the activation of mitogen-activated protein kinases (MAPK) in breast carcinoma effusions and to analyze its relationship to anatomic site and clinical parameters...
  84. ncbi The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma
    Elin Ødegaard
    Department of Gynecology, Ulleval University Hospital, University of Oslo, N 0407 Oslo, Norway
    Hum Pathol 38:140-6. 2007
    ..These data provide further evidence regarding the clinical role of p-TrkA in ovarian carcinoma. NGF receptors probably signal via MAPK-independent pathways in ovarian carcinoma...
  85. ncbi Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma
    Lilach Kleinberg
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Hum Pathol 38:986-94. 2007
    ..XIAP is upregulated in mesothelioma effusions and peritoneal mesotheliomas, suggesting a prosurvival role in malignant mesothelioma cells, particularly at these anatomic sites...
  86. ncbi Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, University of Oslo, Montebello Oslo, Norway
    Hum Pathol 38:1030-6. 2007
    ..NAC-1 is up-regulated in tumor cells after chemotherapy, suggesting a role for this protein in tumor progression and in the development of chemotherapy resistance in ovarian cancer...
  87. ncbi Assessment of endoglin and calprotectin as potential biomarkers in ovarian carcinoma and borderline tumors of the ovary
    Elin Ødegaard
    Department of Obstetrics, Ulleval University Hospital, Oslo, Norway
    Am J Obstet Gynecol 199:533.e1-8. 2008
    ..The objective of the study was to analyze circulating endoglin concentration in ovarian carcinoma and evaluate a prognostic role for calprotectin and endoglin in effusions in advanced-stage disease...
  88. ncbi Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma
    Eleonora Karbova
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Int J Surg Pathol 10:175-80. 2002
    ..The mechanism behind the down-regulated expression of APC in serous ovarian carcinoma and its significance has yet to be elucidated...
  89. ncbi Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome
    Ana Slipicevic
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Am J Clin Pathol 124:528-36. 2005
    ..025) for patients with superficial spreading melanoma...
  90. ncbi Kallikrein 4 is expressed in malignant mesothelioma--further evidence for the histogenetic link between mesothelial and epithelial cells
    Ben Davidson
    Pathology Clinic, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
    Diagn Cytopathol 35:80-4. 2007
    ..The presence of hK4 in MM, a non-hormonally regulated tumor, provides further support to the histogenetic link between mesothelial and epithelial cells...
  91. ncbi Differential expression of the 67 kilodalton laminin receptor in epithelioid malignant mesothelioma and carcinomas that spread to serosal cavities
    Reuven Reich
    Department of Pharmacology and Experimental Therapeutics, Faculty of Medicine, Hebrew University, Jerusalem, Israel
    Diagn Cytopathol 33:332-7. 2005
    ....
  92. ncbi Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions
    Vered Givant-Horwitz
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Gynecol Oncol 91:160-72. 2003
    ....
  93. ncbi Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma
    Kjersti Jørgensen
    Department of Pathology, The Norwegian Radium Hospital HF, University of Oslo, Oslo, Norway
    Mod Pathol 19:1446-55. 2006
    ..In contrast, activation of p38 seems to play a less important role in development and progression of malignant melanomas...
  94. ncbi The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma
    Vered Givant-Horwitz
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Gynecol Oncol 93:517-23. 2004
    ....
  95. ncbi Measurement of cyclin E genomic copy number and strand length in cell-free DNA distinguish malignant versus benign effusions
    Ritu Salani
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 13:5805-9. 2007
    ..We hypothesized that analysis of both DNA copy number and strand length of cell-free DNA from an amplified chromosomal region could improve the diagnosis of malignant diseases in body fluids...
  96. ncbi Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma
    Ben Davidson
    Molecular Signaling Section, Laboratory of Pathology, Center for Cancer Research, The National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer 100:2139-47. 2004
    ..The objective of the current study was to evaluate the anatomic site-related and cellular expression of GEP and its association with clinicopathologic parameters and survival in patients with advanced-stage ovarian carcinoma...
  97. ncbi Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
    Sivan Elloul
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel
    Cancer 103:1631-43. 2005
    ..For the current study, the authors analyzed the relation between the expression of Snail, Slug, and Sip1; the expression of MMP-2 and E-cadherin; and clinical parameters in patients with metastatic ovarian and breast carcinoma...
  98. ncbi Variation in gene expression patterns in effusions and primary tumors from serous ovarian cancer patients
    Marci E Schaner
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    Mol Cancer 4:26. 2005
    ....
  99. ncbi Expression of xeroderma pigmentosum A protein predicts improved outcome in metastatic ovarian carcinoma
    Ellen V Stevens
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cancer 103:2313-9. 2005
    ..The authors hypothesized that expression of the NER protein xeroderma pigmentosum A (XPA) would be reduced in a clinically significant fashion in metastatic ovarian carcinoma...
  100. ncbi Proteomic analysis of malignant ovarian cancer effusions as a tool for biologic and prognostic profiling
    Ben Davidson
    Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, Bethesda Maryland 20892, USA
    Clin Cancer Res 12:791-9. 2006
    ..Biochemical characterization of clinical effusions may provide either predictive and/or correlative information on patient outcome from which to further understand the mechanisms of effusion development and target clinical intervention...
  101. ncbi Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma
    Yu Chi Chen
    Department of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Biochim Biophys Acta 1730:96-102. 2005
    ..001). In conclusion, these findings represent the first characterization of human membralin and suggest that membralin is a novel tumor-associated marker in ovarian serous carcinomas...