Anne Lise Børresen-Dale

Summary

Affiliation: The Norwegian Radium Hospital
Country: Norway

Publications

  1. pmc Screening breast cancer patients for Norwegian ATM mutations
    K Laake
    Department of Genetics, The Norwegian Radium Hospital, Montebello, Oslo, 0310
    Br J Cancer 83:1650-3. 2000
  2. pmc Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002
    Jonine L Bernstein
    Department of Community Medicine, Mount Sinai School of Medicine, New York, USA
    Breast Cancer Res 4:249-52. 2002
  3. pmc Discovery and validation of breast cancer subtypes
    Amy V Kapp
    Department of Statistics, Stanford University, Stanford, CA, USA
    BMC Genomics 7:231. 2006
  4. pmc ATM variants and cancer risk in breast cancer patients from Southern Finland
    Johanna Tommiska
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Cancer 6:209. 2006
  5. pmc Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models
    Siver A Moestue
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    BMC Cancer 10:433. 2010
  6. ncbi request reprint TP53 and breast cancer
    Anne Lise Børresen-Dale
    Department of Genetics, Institute for Cancer Research, The University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Hum Mutat 21:292-300. 2003
  7. ncbi request reprint Genetic profiling of breast cancer: from molecular portraits to clinical utility
    A L Børresen-Dale
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Int J Biol Markers 18:54-6. 2003
  8. ncbi request reprint TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival
    A L Børresen-Dale
    Department of Genetics, Norwegian Radium Hospital, Oslo, Norway
    Clin Cancer Res 4:203-10. 1998
  9. ncbi request reprint Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
    Yun Wang
    Department of Gynecologic Oncology, The Norwegian Radium Hospital, Oslo, Norway
    Hum Mutat 24:21-34. 2004
  10. ncbi request reprint Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients
    Thomas Fleischer
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway The K G Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway
    Int J Cancer 134:2615-25. 2014

Detail Information

Publications92

  1. pmc Screening breast cancer patients for Norwegian ATM mutations
    K Laake
    Department of Genetics, The Norwegian Radium Hospital, Montebello, Oslo, 0310
    Br J Cancer 83:1650-3. 2000
    ..Only one carrier was found. These results provide no evidence in favour of an excess risk of breast cancer associated with heterozygosity for classical AT mutations, but remain consistent with a maximum 2.4-fold increased risk...
  2. pmc Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002
    Jonine L Bernstein
    Department of Community Medicine, Mount Sinai School of Medicine, New York, USA
    Breast Cancer Res 4:249-52. 2002
    ..In the present meeting report, the aims of each project are described...
  3. pmc Discovery and validation of breast cancer subtypes
    Amy V Kapp
    Department of Statistics, Stanford University, Stanford, CA, USA
    BMC Genomics 7:231. 2006
    ..The most recent study presented evidence for the existence of five different subtypes: normal breast-like, basal, luminal A, luminal B, and ERBB2+...
  4. pmc ATM variants and cancer risk in breast cancer patients from Southern Finland
    Johanna Tommiska
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Cancer 6:209. 2006
    ..We also aimed to investigate whether there are other ATM mutations or variants contributing to breast cancer risk in our population...
  5. pmc Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models
    Siver A Moestue
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    BMC Cancer 10:433. 2010
    ..However, underlying mechanisms for the abnormal choline metabolism are poorly understood...
  6. ncbi request reprint TP53 and breast cancer
    Anne Lise Børresen-Dale
    Department of Genetics, Institute for Cancer Research, The University Hospital, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Hum Mutat 21:292-300. 2003
    ..All data available on TP53 mutation analyses of human breast carcinomas, as well data from transgenic animal studies and experimental cell studies, support an important role for TP53 in mammary carcinogenesis...
  7. ncbi request reprint Genetic profiling of breast cancer: from molecular portraits to clinical utility
    A L Børresen-Dale
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Int J Biol Markers 18:54-6. 2003
  8. ncbi request reprint TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival
    A L Børresen-Dale
    Department of Genetics, Norwegian Radium Hospital, Oslo, Norway
    Clin Cancer Res 4:203-10. 1998
    ....
  9. ncbi request reprint Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
    Yun Wang
    Department of Gynecologic Oncology, The Norwegian Radium Hospital, Oslo, Norway
    Hum Mutat 24:21-34. 2004
    ..008) and tended to increase with increasing FIGO stages (P=0.05), but had no significant effect on survival. No association between p63 protein accumulation and TP53 protein accumulation was seen...
  10. ncbi request reprint Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients
    Thomas Fleischer
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway The K G Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway
    Int J Cancer 134:2615-25. 2014
    ..Our study provides evidence for the promise of DNA methylation alterations for clinical applications...
  11. ncbi request reprint ABCB1 and GST polymorphisms associated with TP53 status in breast cancer
    Silje H Nordgard
    Department of Genetics, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Pharmacogenet Genomics 17:127-36. 2007
    ..The goal of this study was to characterize the genetic variation in the ABCB1, GSTM1, GSTT1 and GSTP1 genes, as well as the haplotype structure in the ABCB1 gene...
  12. pmc Repeated observation of breast tumor subtypes in independent gene expression data sets
    Therese Sorlie
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:8418-23. 2003
    ..Our results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities...
  13. ncbi request reprint Principles and methods of integrative genomic analyses in cancer
    Vessela N Kristensen
    1 Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway 2 K G Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway 3 Department of Clinical Molecular Oncology, Division of Medicine, Akershus University Hospital, 1478 Ahus, Norway
    Nat Rev Cancer 14:299-313. 2014
    ..The objectives, methods and computational tools of integrative genomics that are available to date are reviewed here, as is their implementation in cancer research. ..
  14. ncbi request reprint Evaluation of arrayed primer extension for TP53 mutation detection in breast and ovarian carcinomas
    Pedro Kringen
    The Norwegian Radium Hospital, Oslo, Norway
    Biotechniques 39:755-61. 2005
    ..5% for sense and/or antisense strand. We conclude that the APEX TP53 microarray is a robust, rapid, and comprehensive screening tool for sequence alterations in tumors...
  15. ncbi request reprint Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Genes Chromosomes Cancer 45:1033-40. 2006
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat..
  16. ncbi request reprint The TP53 codon 72 polymorphism may affect the function of TP53 mutations in breast carcinomas but not in colorectal carcinomas
    Anita Langerød
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    Cancer Epidemiol Biomarkers Prev 11:1684-8. 2002
    ..2%) versus 7 in 16 Pro72 homozygous cases (43.8%). These results suggest a selective growth advantage for cells carrying a type of TP53 mutation seen in breast carcinomas when the mutation resides on an Arg72 allele...
  17. pmc Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
    Vessela N Kristensen
    Department of Genetics, Institute for Cancer Research, and Cancer Clinic, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 109:2802-7. 2012
    ..In conclusion, by means of a pathway-based modeling methodology (PARADIGM) integrating different layers of molecular data from whole-tumor samples, we demonstrate that we can stratify immune signatures that predict patient survival...
  18. pmc Combining gene signatures improves prediction of breast cancer survival
    Xi Zhao
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e17845. 2011
    ..Gene sets from eleven previously published gene signatures are included in the study...
  19. doi request reprint Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II
    Hege Landmark-Høyvik
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    Genomics 102:278-87. 2013
    ..Further, we investigated the associations that were specific for BC survivors by performing identical analyses for a group of healthy women and comparing the results...
  20. pmc Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    BMC Cancer 11:332. 2011
    ..High serum levels of estradiol are associated with increased risk of postmenopausal breast cancer. Little is known about the gene expression in normal breast tissue in relation to levels of circulating serum estradiol...
  21. doi request reprint Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
    Simen Myhre
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, N 0310 Oslo, Norway
    Mol Oncol 7:704-18. 2013
    ..Further stratification suggested subtype-specific regulation that was not evident across the entire sample set...
  22. pmc Genetic variation in putative regulatory loci controlling gene expression in breast cancer
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 103:7735-40. 2006
    ..It provides the statistical framework for further genotype expression correlation studies in cancer data sets...
  23. pmc Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
    Vilde D Haakensen
    Dept of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Norway
    BMC Med Genomics 4:77. 2011
    ..Increased understanding of the variability in normal breast biology will enable us to identify mechanisms of breast cancer initiation and the origin of different subtypes, and to better predict breast cancer risk...
  24. pmc Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes
    Silje H Nordgard
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Montebello, N 0310 Oslo, Norway
    Breast Cancer Res 9:113. 2007
    ....
  25. ncbi request reprint Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Clin Cancer Res 11:878s-83s. 2005
    ..Using significance analysis of microarrays, we identified 298 genes significantly differently expressed between partial response and progressive disease groups...
  26. ncbi request reprint Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts
    Olaug Kristin Rødningen
    Department of Genetics, Institute of Cancer Research, Faculty Division, The Norwegian Radium Hospital, University of Oslo, Norway
    Radiother Oncol 77:231-40. 2005
    ....
  27. pmc Allele-specific disparity in breast cancer
    Fatemeh Kaveh
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    BMC Med Genomics 4:85. 2011
    ..We focus on the disparity of CNAs in tumour samples, which were compared to those in blood in order to identify the directional loss of heterozygosity...
  28. ncbi request reprint Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas
    Yun Wang
    Department of Gynecologic Oncology, the Norwegian Radium Hospital and the University of Oslo, Oslo, Norway
    Am J Clin Pathol 124:392-401. 2005
    ..The PI3K/AKT and RAS/MEK/ERK pathways seem to be activated in some cases of advanced ovarian carcinomas, although PIK3CA, p-AKT, p-ERK, and PTEN do not seem to be independent prognostic markers in this group of patients...
  29. pmc TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
    Anita Langerød
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway N 0310
    Breast Cancer Res 9:R30. 2007
    ....
  30. pmc High levels of genomic aberrations in serous ovarian cancers are associated with better survival
    Lars O Baumbusch
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway
    PLoS ONE 8:e54356. 2013
    ....
  31. pmc Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling
    Marinela Capanu
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genet Epidemiol 35:389-97. 2011
    ..Hierarchical modeling is a strategy that has promise for interpreting the evidence from future association studies that involve sequencing of known or suspected cancer genes...
  32. doi request reprint Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue
    Eldrid Borgan
    Department of Genetics, Institute of Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway
    Mol Oncol 5:564-76. 2011
    ..The induced miRNAs may play both direct and indirect roles in biological responses. Caution should be taken when the miRNAs and mRNAs reported to be affected by ischemia time are included in a prognostic or predictive signature...
  33. ncbi request reprint Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Hum Mutat 21:542-50. 2003
    ..Finally, we report novel mutations in the ATM gene identified both in patients with ataxia-telangiectasia and in patients with unilateral or bilateral breast cancer...
  34. doi request reprint Blood gene expression profiling of breast cancer survivors experiencing fibrosis
    Hege Landmark-Høyvik
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Institute for Clinical Medicine, University of Oslo, Oslo, Norway
    Int J Radiat Oncol Biol Phys 79:875-83. 2011
    ....
  35. doi request reprint Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
    Aslaug Aamodt Muggerud
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway
    Mol Oncol 4:357-68. 2010
    ....
  36. pmc Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
    Aslaug Aa Muggerud
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, Oslo, N 0310, Norway
    Breast Cancer Res 12:R3. 2010
    ....
  37. ncbi request reprint Experimental validation of data mined single nucleotide polymorphisms from several databases and consecutive dbSNP builds
    Hege Edvardsen
    Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Faculty Division of the University of Oslo, Oslo, Norway
    Pharmacogenet Genomics 16:207-17. 2006
    ..The selected genotypes represent a valuable set of verified candidate SNPs for pharmacogenetic studies in Caucasian populations...
  38. pmc Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms
    Therese Sørlie
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, N 0310 Oslo, Norway
    BMC Genomics 7:127. 2006
    ..To further validate and more thoroughly characterize these two subtypes at the molecular level in tumors at an early stage, we report a gene expression profiling study using three different DNA microarray platforms...
  39. pmc Multilocus analysis of SNP and metabolic data within a given pathway
    Vessela N Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, 0310 Oslo, Norway
    BMC Genomics 7:5. 2006
    ..One of the greatest challenges facing human geneticists is the identification and characterization of susceptibility genes for common multifactorial diseases and their association to different quantitative phenotypic traits...
  40. pmc Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res 6:R199-214. 2004
    ..Three genes (ATM, BRCA1, and BRCA2) encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated...
  41. pmc Gene expression profiling of peripheral blood cells for early detection of breast cancer
    Jørgen Aarøe
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, Oslo, NO 0310, Norway
    Breast Cancer Res 12:R7. 2010
    ..The aim of the present study was to refine these findings using a larger sample size and a commercially available microarray platform...
  42. pmc In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome
    Simen Myhre
    Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 5:e14002. 2010
    ..These findings were confirmed in gene expression data from the representative compartments from microdissected breast tissue. The method described was also found to be robust to different histopathological procedures...
  43. pmc Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters
    Lars O Baumbusch
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, 0310 Oslo, Norway
    Mol Cancer 5:47. 2006
    ..The tumor suppressor gene p53 (TP53) controls numerous signaling pathways and is frequently mutated in human cancers. Novel p53 isoforms suggest alternative splicing as a regulatory feature of p53 activity...
  44. doi request reprint The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells
    Kristine Kleivi Sahlberg
    Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital, Radiumhospitalet, 0310 Oslo, Norway
    Mol Oncol 7:392-401. 2013
    ..The observed additive effects seem to culminate to both apoptosis and cell proliferation pathways indicating that these pathways may be interesting targets for combinatorial treatment of HER2+ breast cancers...
  45. pmc Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypes
    Aslaug Aamodt Muggerud
    Department of Genetics, Faculty Division, The Norwegian Radium Hospital, University of Oslo, N 0310 Oslo, Norway
    BMC Cancer 6:59. 2006
    ..A new MetriGenix 4D array proposed for diagnostic use was evaluated...
  46. pmc Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data
    Miriam Ragle Aure
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 8:e53014. 2013
    ..Validation in an independent data set supports the conclusion that the method identifies genes implicated in cancer...
  47. pmc Allele-specific copy number analysis of tumors
    Peter Van Loo
    Department of Genetics, Institute for Cancer Research, Clinic for Cancer and Surgery, Oslo University Hospital, Montebello, N 0310 Oslo, Norway
    Proc Natl Acad Sci U S A 107:16910-5. 2010
    ..We hypothesize that these alternative alleles have a different influence on breast carcinoma development...
  48. pmc Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer
    Hiroko K Solvang
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Montebello, and Department of Biostatistics, Institute of Basic Medical Science, University of Oslo, 0310 Oslo, Norway
    BMC Bioinformatics 12:197. 2011
    ..Here, we propose a statistical approach to investigate and distinguish between linear and nonlinear dependences between DNA copy number alteration and mRNA expression...
  49. doi request reprint Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients
    Silje H Nordgard
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Genes Chromosomes Cancer 47:680-96. 2008
    ..The genes where these SNPs reside encode proteins involved in the extracellular matrix (CHST3 and SPOCK2), in regulation of the cell cycle (JMY, PTPRN2, and Cwf19L2) and chromosome stability (KPNB1)...
  50. pmc Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status
    Xi Zhao
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello 0310 Oslo, Norway
    BMC Cancer 14:211. 2014
    ....
  51. ncbi request reprint BRCA1 mutation screening using restriction endonuclease fingerprinting-single-strand conformation polymorphism in an automated capillary electrophoresis system
    Pedro Kringen
    Department of Medical Genetics, Ulleval University Hospital, Oslo, Norway
    Electrophoresis 23:4085-91. 2002
    ..The novel strategy allows high-throughput mutation scanning without radioactive labeling and polyacrylamide gel electrophoresis (PAGE)...
  52. ncbi request reprint The genetics and epigenetics of fatigue
    Hege Landmark-Høyvik
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, Norway
    PM R 2:456-65. 2010
    ....
  53. ncbi request reprint Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
    Vessela Nedelcheva Kristensen
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    J Steroid Biochem Mol Biol 95:105-11. 2005
    ..Using significance analysis of microarrays (SAM), we identified 298 genes significantly differently expressed between the partial response and progressive disease groups...
  54. doi request reprint Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
    Ivan O Potapenko
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Mol Oncol 4:98-118. 2010
    ....
  55. pmc Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
    Gro Nilsen
    Biomedical Informatics, Dept of Informatics, University of Oslo, Oslo, Norway
    BMC Genomics 13:591. 2012
    ..In addition, there is a demand for highly computationally efficient segmentation algorithms, due to the emergence of very high density scans of copy number...
  56. pmc miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors
    Espen Enerly
    Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e16915. 2011
    ..In this study we present and analyze data derived from expression profiling of 799 miRNAs in 101 primary human breast tumors, along with genome-wide mRNA profiles and extensive clinical information...
  57. pmc Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
    Vilde D Haakensen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Montebello, NO 0310, Norway
    Breast Cancer Res 12:R65. 2010
    ..However, the biologic correlates of density are little known...
  58. pmc Early detection of breast cancer based on gene-expression patterns in peripheral blood cells
    Praveen Sharma
    DiaGenic ASA, Oslo, Norway
    Breast Cancer Res 7:R634-44. 2005
    ..In this study, we investigated whether early detection of breast cancer is possible by analyzing gene-expression patterns in peripheral blood cells...
  59. ncbi request reprint Radiation-induced effects on gene expression: an in vivo study on breast cancer
    Aslaug Helland
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Radiother Oncol 80:230-5. 2006
    ..The purpose of this study was to investigate the molecular basis underlying response to radiotherapy in breast cancer tissue...
  60. pmc Improving breast cancer survival analysis through competition-based multidimensional modeling
    Erhan Bilal
    IBM TJ Watson Research, Yorktown Heights, New York, USA
    PLoS Comput Biol 9:e1003047. 2013
    ....
  61. pmc Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
    Hege G Russnes
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway
    Sci Transl Med 2:38ra47. 2010
    ..This study emphasizes the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that objective score of genomic complexity (CAAI) is an independent prognostic marker in breast cancer...
  62. ncbi request reprint Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis
    Therese Sørlie
    Department of Genetics, The Norwegian Radium Hospital, Oslo, Norway
    Methods Mol Biol 291:207-16. 2005
    ..The result is a rapid and sensitive screening technique that is robust and easily set up in smaller laboratory environments...
  63. doi request reprint Mutation screening of the TP53 gene by temporal temperature gel electrophoresis (TTGE)
    Therese Sørlie
    Department of Genetics, Oslo University Hospital The Norwegian Radium Hospital, Institute for Cancer Research, 4953, Nydalen, 0424, Oslo, Norway
    Methods Mol Biol 1105:315-24. 2014
    ..The result is a rapid and sensitive screening technique which is robust and easily set up in smaller laboratory environments. ..
  64. ncbi request reprint Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy
    Hege Edvardsen
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Int J Radiat Oncol Biol Phys 67:1163-71. 2007
    ..To explore whether certain glutathione S-transferase (GST) polymorphisms are associated with an increased risk of breast cancer or the level of radiation-induced adverse effects after two fractionation patterns of adjuvant radiotherapy...
  65. ncbi request reprint BUB1 infrequently mutated in human breast carcinomas
    Anita Langerød
    Dep of Genetics, Inst for Cancer Research, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Hum Mutat 22:420. 2003
    ..No somatic mutations were detected. These results indicate that genomic instability scored as copy number alterations by CGH in TP53 wild type breast carcinomas is not caused by somatic mutations in the BUB1 gene...
  66. ncbi request reprint PIK3CA mutations in advanced ovarian carcinomas
    Yun Wang
    Department of Gynecologic Oncology, The Norwegian Radium Hospital, N 0310, Oslo, Norway
    Hum Mutat 25:322. 2005
    ..Two of the cases with mutations were mucinous and clear cell tumors, suggesting that PIK3CA mutations are more common in these rare histological types...
  67. doi request reprint Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts
    Eldrid Borgan
    Department of Genetics, Institute for Cancer Research, Division for Cancer Medicine, Surgery and Transplantation, Oslo University Hospital, Norwegian Radium Hospital, P O Box 4953 Nydalen, 0424 Oslo, Norway
    Mol Oncol 7:130-42. 2013
    ..This study underlines the importance of characterizing biological differences between subtypes of breast cancer to identify personalized biomarkers for improved patient stratification and evaluation of response to therapy...
  68. doi request reprint High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
    Randi R Mathiesen
    Department of Genetics, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    Int J Cancer 131:E405-15. 2012
    ..Similar aberration patterns were visible in DTCs collected at diagnosis and at 3 years relapse-free follow-up. SCaCGH may be a powerful tool for the molecular characterization of DTCs...
  69. doi request reprint Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer
    Jo Anders Rønneberg
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    Mol Oncol 5:61-76. 2011
    ..Some of the transcription factors identified, with key roles in differentiation and development might play a role in inducing and maintaining the different phenotypes...
  70. pmc Merging transcriptomics and metabolomics--advances in breast cancer profiling
    Eldrid Borgan
    Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    BMC Cancer 10:628. 2010
    ..The aim of this study was to explore the potential of combining these two different types of information...
  71. doi request reprint High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
    Suvi Katri Leivonen
    Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radiumhospital, N 0310 Oslo, Norway The K G Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, N 0424 Oslo, Norway Medical Biotechnology, VTT Technical Research Centre of Finland, FI 20520 Turku, Finland Electronic address
    Mol Oncol 8:93-104. 2014
    ..These results give mechanistic insights in HER2 regulation which may open potential new strategies towards prevention and therapeutic inhibition of HER2-positive breast cancer. ..
  72. doi request reprint Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival
    Silje H Nordgard
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Montebello, Oslo, Norway
    Int J Cancer 123:577-85. 2008
    ..These data suggest that 3 copies of the TYMS 5'UTR repeat may give a treatment specific reduced survival in breast cancer patients, and that TP53 may have a direct, allele specific, role in 5-FU mediated response...
  73. ncbi request reprint The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer
    R A Lothe
    Department of Genetics, The Norwegian Radium Hospital, Oslo
    Cancer Res 58:2923-4. 1998
    ..Our data show that the I1307K variant is rare in the Norwegian population and should not be viewed as a candidate for susceptibility testing for colorectal cancer...
  74. ncbi request reprint Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B-cell Non-Hodgkin's lymphoma
    T Stokke
    Department of Biophysics, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Int J Cancer 89:313-24. 2000
    ..003). Apoptotic fractions were similar in all these groups (p=0.09). Multivariate analysis showed that the presence of TP53/p53 aberrations is a strong and independent prognostic parameter in B-cell Non-Hodgkin's lymphoma...
  75. pmc Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
    William A Freed-Pastor
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Cell 148:244-58. 2012
    ..Finally, p53 mutation correlates with highly expressed sterol biosynthesis genes in human breast tumors. These findings implicate the mevalonate pathway as a therapeutic target for tumors bearing mutations in p53...
  76. ncbi request reprint X chromosome inactivation in cervical cancer patients
    Marianne Kristiansen
    Department of Medical Genetics, Rikshospitalet, Oslo, Norway
    Cancer Genet Cytogenet 146:73-6. 2003
    ..03). Our results indicate that if X-inactivation analysis is to be used in clonality studies of cervical cancers, it is essential to consider both the age and the X-inactivation pattern in blood cells...
  77. doi request reprint Triple-negative breast cancer and the need for new therapeutic targets
    Olav Engebraaten
    Division of Cancer Medicine, Surgery and Transplantation, Department of Oncology, Oslo University Hospital, Oslo, Norway K G Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway Electronic address
    Am J Pathol 183:1064-74. 2013
    ..Currently used conventional therapeutic strategies and targeted therapy studies are discussed, with references to recently published results on the molecular characterization of TNBCs. ..
  78. pmc Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers
    Aslaug Helland
    Division of Surgery and Cancer, Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway
    PLoS ONE 6:e18064. 2011
    ..By defining the drivers of a molecular subtype of serous ovarian cancers we provide a novel strategy for targeted therapeutic intervention...
  79. ncbi request reprint Single tube multiplex polymerase chain reaction genotype analysis of GSTM1, GSTT1 and GSTP1: relation of genotypes to TP53 tumor status and clinicopathological variables in breast cancer patients
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, Norwegian Radium Hospital, Montebello
    Pharmacogenetics 8:441-7. 1998
    ..05). Patients who were homozygous for the deleted GSTM1 allele were found to have a significantly shorter overall survival (P = 0.036)...
  80. ncbi request reprint Screening for ESR mutations in breast and ovarian cancer patients
    T I Anderson
    Department of Genetics, Norwegian Radnon Hospital, Oslo, Norway
    Hum Mutat 9:531-6. 1997
    ....
  81. ncbi request reprint Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis
    Olaug Kristin Rødningen
    Department of Genetics, Institute of Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Oslo, Norway
    Radiother Oncol 86:314-20. 2008
    ..Our aim was to identify basal and radiation-induced transcriptional profiles in fibroblasts from breast cancer patients that might be related to the individual risk of RIF in these patients...
  82. pmc CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Mol Oncol 2:327-39. 2008
    ..Our findings identify CAMK1D as a novel amplified oncogene linked to EMT in breast cancer, and as a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors...
  83. doi request reprint GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas
    Jo Anders Rønneberg
    Department of Genetics, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway
    Cancer Res 68:5562-71. 2008
    ..GSTP1 expression was moderately but significantly (P = 0.01) reduced after siRNA-mediated knockdown of c-Myb. Our results indicate that haplotype structure of a promoter is important for the extent of DNA methylation...
  84. doi request reprint Found in transcription: gene expression and other novel blood biomarkers for the early detection of breast cancer
    Anders Lönneborg
    DiaGenic ASA, Oslo, Norway
    Expert Rev Anticancer Ther 9:1115-23. 2009
    ..These novel biomarkers and their potential use will be presented and discussed in this review, with special emphasis on gene expression-based markers...
  85. ncbi request reprint CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
    Cancer Res 59:2825-8. 1999
    ..Age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype...
  86. ncbi request reprint Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors
    J Breivik
    Department of Immunology, Institute of Cancer Research, The Norwegian Radium Hospital, Oslo
    Int J Cancer 74:664-9. 1997
    ..0001). Our data confirm that different genetic pathways to colorectal cancer dominate in the proximal and distal segments of the bowel and suggest that the K-ras- and MIN-dependent pathways are influenced by different sex-related factors...
  87. ncbi request reprint Constant denaturant gel electrophoresis (CDGE) in BRCA1 mutation screening
    T I Andersen
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Oslo
    Hum Mutat 11:166-74. 1998
    ..CDGE may become an efficient tool in diagnostic and population based screening for BRCA1 mutations...
  88. ncbi request reprint Automated constant denaturant capillary electrophoresis applied for detection of KRAS exon 1 mutations
    J Bjørheim
    Department of Immunology, Section for Immunotherapy, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
    Biotechniques 30:972-5. 2001
    ..6% in this automated CDCE technique. The automation of CDCE allowed rapid analysis of a large number of test samples over as short period of time and with a commercially available apparatus...
  89. ncbi request reprint Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
    A Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Centre, Montebello, Oslo, Norway
    J Pathol 214:357-67. 2008
    ....
  90. pmc Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
    L O Baumbusch
    Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, 0310 Oslo, Norway
    BMC Genomics 9:379. 2008
    ..Various platforms, brands and underlying technologies are available, facing the user with many choices regarding platform sensitivity and number, localization, and density distribution of probes...
  91. ncbi request reprint Identical mutation in 55% of the ATM alleles in 11 Norwegian AT families: evidence for a founder effect
    K Laake
    Department of Genetics, Norwegian Radium Hospital, Montebello, Oslo, Norway
    Eur J Hum Genet 6:235-44. 1998
    ..The prevalence of this mutation in Norwegian patients now allows a major subset of AT heterozygotes to be identified, both in the general population and in breast cancer patients, so that their cancer risk can be evaluated...
  92. ncbi request reprint High-throughput methods for detection of genetic variation
    V N Kristensen
    Institute for Cancer Research, Norwegian Radium Hospital, Montebello 0310, Oslo, Norway
    Biotechniques 30:318-22, 324, 326 passim. 2001
    ..The most frequently used techniques and instrumental settings applied in different combinations are described, and other methods that are less broadly used but have interesting potentials are discussed...