Jan P A Baak

Summary

Affiliation: Stavanger University Hospital
Country: Norway

Publications

  1. ncbi request reprint Prognostic value of proliferative activity and nuclear morphometry for progression in TaT1 urothelial cell carcinomas of the urinary bladder
    Marco G W Bol
    Department of Pathology, SIR Hospital, Stavanger, Norway
    Urology 60:1124-30. 2002
  2. ncbi request reprint Prospective multicenter validation of the independent prognostic value of the mitotic activity index in lymph node-negative breast cancer patients younger than 55 years
    Jan P A Baak
    Department of Pathology and Epidemiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 23:5993-6001. 2005
  3. ncbi request reprint Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions
    Jan P A Baak
    Departments of Pathology, Stavanger University Hospital, Stavanger, Norway
    Am J Surg Pathol 29:1062-6. 2005
  4. ncbi request reprint Phosphohistone H3 expression has much stronger prognostic value than classical prognosticators in invasive lymph node-negative breast cancer patients less than 55 years of age
    Ivar Skaland
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Mod Pathol 20:1307-15. 2007
  5. ncbi request reprint Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression
    Jan Pieter Albert Baak
    Department of Pathology, Stavanger University Hospital, Norway
    Hum Pathol 36:555-61. 2005
  6. ncbi request reprint Bacteriological study of pyogenic meningitis with special reference to latex agglutination
    G Viswanath
    Department of Microbiology, J J M Medical College, Davangere
    Indian J Pathol Microbiol 50:97-100. 2007
  7. ncbi request reprint Genomics and proteomics in cancer
    J P A Baak
    Department of Pathology, Central Hospital for Rogaland, Box 8001, 4068 Stavanger, Norway
    Eur J Cancer 39:1199-215. 2003
  8. ncbi request reprint Evaluation of prospective, routine application of Ki-67 immunoquantitation in early CIN for assessment of short-term progression risk
    Amold Jan Kruse
    Department of Pathology, Rogaland Central Hospital, P O Box 8100, 4068 Stavanger, Norway
    Anal Quant Cytol Histol 26:134-40. 2004
  9. ncbi request reprint Multivariate prognostic evaluation of the mitotic activity index and fibrotic focus in node-negative invasive breast cancers
    Jan P A Baak
    Department of Pathology, Stavanger University Hospital, Armauer Hansensveg 20, P O Box 8100, 4068 Stavanger, Norway
    Eur J Cancer 41:2093-101. 2005
  10. pmc Routine morphometrical analysis can improve reproducibility of dysplasia grade in Barrett's oesophagus surveillance biopsies
    J P A Baak
    Department of Pathology, Free University Medical Centre, Amsterdam, 1081HV The Netherlands
    J Clin Pathol 55:910-6. 2002

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Prognostic value of proliferative activity and nuclear morphometry for progression in TaT1 urothelial cell carcinomas of the urinary bladder
    Marco G W Bol
    Department of Pathology, SIR Hospital, Stavanger, Norway
    Urology 60:1124-30. 2002
    ....
  2. ncbi request reprint Prospective multicenter validation of the independent prognostic value of the mitotic activity index in lymph node-negative breast cancer patients younger than 55 years
    Jan P A Baak
    Department of Pathology and Epidemiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 23:5993-6001. 2005
    ..To validate the independent strong prognostic value of mitotic activity index (MAI) in lymph node (LN) -negative invasive breast cancer patients younger than 55 years in a nationwide multicenter prospective study...
  3. ncbi request reprint Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions
    Jan P A Baak
    Departments of Pathology, Stavanger University Hospital, Stavanger, Norway
    Am J Surg Pathol 29:1062-6. 2005
    ....
  4. ncbi request reprint Phosphohistone H3 expression has much stronger prognostic value than classical prognosticators in invasive lymph node-negative breast cancer patients less than 55 years of age
    Ivar Skaland
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Mod Pathol 20:1307-15. 2007
    ..Phosphohistone H3 is by far the strongest prognostic variable in early invasive node-negative breast cancer patients less than 55 years old with long-term follow-up...
  5. ncbi request reprint Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progression
    Jan Pieter Albert Baak
    Department of Pathology, Stavanger University Hospital, Norway
    Hum Pathol 36:555-61. 2005
    ..Unless endometrial hyperplasias are stratified by histological morphometric D-Score, PTEN has a low positive predictive value...
  6. ncbi request reprint Bacteriological study of pyogenic meningitis with special reference to latex agglutination
    G Viswanath
    Department of Microbiology, J J M Medical College, Davangere
    Indian J Pathol Microbiol 50:97-100. 2007
    ..5%. Hence, Gram stain and/or latex agglutination tests, if done properly are most rapid and reliable tests for the diagnosis of pyogenic meningitis...
  7. ncbi request reprint Genomics and proteomics in cancer
    J P A Baak
    Department of Pathology, Central Hospital for Rogaland, Box 8001, 4068 Stavanger, Norway
    Eur J Cancer 39:1199-215. 2003
    ..However, it is likely that they will take a central place in the understanding, diagnosis, monitoring and treatment of (pre)cancers of many different sites...
  8. ncbi request reprint Evaluation of prospective, routine application of Ki-67 immunoquantitation in early CIN for assessment of short-term progression risk
    Amold Jan Kruse
    Department of Pathology, Rogaland Central Hospital, P O Box 8100, 4068 Stavanger, Norway
    Anal Quant Cytol Histol 26:134-40. 2004
    ..To prospectively validate, in early cervical intraepithelial neoplasia (CIN), routine assessment of a previously developed prognostic Ki-67 immunoquantitative progression-risk model...
  9. ncbi request reprint Multivariate prognostic evaluation of the mitotic activity index and fibrotic focus in node-negative invasive breast cancers
    Jan P A Baak
    Department of Pathology, Stavanger University Hospital, Armauer Hansensveg 20, P O Box 8100, 4068 Stavanger, Norway
    Eur J Cancer 41:2093-101. 2005
    ..The FF may be important as it has additional prognostic value to the MAI in the small subgroup of invasive ductal or mixed-ductal breast cancer patients with combined MAI < 10 and an FF > 1/3 of the tumour area...
  10. pmc Routine morphometrical analysis can improve reproducibility of dysplasia grade in Barrett's oesophagus surveillance biopsies
    J P A Baak
    Department of Pathology, Free University Medical Centre, Amsterdam, 1081HV The Netherlands
    J Clin Pathol 55:910-6. 2002
    ..The grade of dysplasia found in Barrett's oesophagus surveillance biopsies is a major factor to determine follow up and treatment. However, it has been reported that the reproducibility of the grading system is not optimal...
  11. ncbi request reprint The framework of pathology: good laboratory practice by quantitative and molecular methods
    Jan P A Baak
    Department of Pathology, Central Hospital of Rogaland, Norway
    J Pathol 198:277-83. 2002
    ..Pathologists should focus on carefully reacting to new clinical needs, using GLP criteria. Reproducibility and predictive accuracy should be major themes in any pathology practice...
  12. pmc The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification system
    Jan P Baak
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Cancer 103:2304-12. 2005
    ....
  13. doi request reprint Prognostic relevance of androgen receptor detection in operable breast cancer
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Stavanger, Norway
    J Surg Oncol 98:551-8. 2008
    ..Different determination methods and cut-off levels hamper interpretation and comparisons of studies. Long-term prognostic evaluation of different AR assays in patients comprising operable breast cancers is scarce...
  14. doi request reprint D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients
    Einar Gudlaugsson
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Mod Pathol 24:502-11. 2011
    ..In conclusion, T(1-2)N(0)M(0) invasive breast cancer patients ≥55 years with phosphohistone H3≥13, D2-40+/p63- defined lymph vessel invasion identifies a subgroup with a high risk of distant metastases...
  15. ncbi request reprint Ki67 predicts progression in early CIN: validation of a multivariate progression-risk model
    Arnold Jan Kruse
    Department of Pathology, Rogaland Central Hospital, Norway and Free University, 4068 Stavanger, Norway
    Cell Oncol 26:13-20. 2004
    ..Routine application of the quantitative Ki67-model in CIN1 and CIN2 was well reproducible. In conclusion, the results confirm that quantitative Ki67 features have strong prognostic value for progression in early CIN lesions...
  16. ncbi request reprint DNA cytometric features in biopsies of TaT1 urothelial cell cancer predict recurrence and stage progression more accurately than stage, grade, or treatment modality
    Jan P A Baak
    Department of Pathology, SIR Hospital, Stavanger, Norway
    Urology 61:1266-72. 2003
    ....
  17. doi request reprint Metachronous cancer development in patients with sporadic colorectal adenomas-multivariate risk model with independent and combined value of hTERT and survivin
    Kjetil Søreide
    Department of Pathology, Stavanger University Hospital, P O Box 8100, 4068 Stavanger, Norway
    Int J Colorectal Dis 23:389-400. 2008
    ..We sought to validate biomarkers predictive of metachronous colorectal cancer (mCRC) in patients with sporadic colorectal adenomas, using 374 consecutive patients from a large defined population...
  18. ncbi request reprint The prognostic value of the orphan nuclear receptor DAX-1 (NROB1) in node-negative breast cancer
    Hui Zhang
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Anticancer Res 31:443-9. 2011
    ..DAX-1 inhibits oestrogen receptor (ER) activities and aromatase P450 expression. The prognostic effect of DAX-1 expression in breast cancer was investigated...
  19. doi request reprint In patients younger than age 55 years with lymph node-negative breast cancer, proliferation by mitotic activity index is prognostically superior to adjuvant!
    Tone Hoel Lende
    Stavanger University Hospital, Stavanger, Norway
    J Clin Oncol 29:852-8. 2011
    ..We compared the accuracy of the online program Adjuvant!, the Norwegian Breast Cancer Group (NBCG) guidelines, and the proliferation factor mitotic activity index (MAI) in patients with lymph node (LN) -negative disease (pN0)...
  20. ncbi request reprint Comparing the prognostic value of PTEN and Akt expression with the Mitotic Activity Index in adjuvant chemotherapy-treated node-negative breast cancer patients aged <55 years
    Emiel A M Janssen
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Cell Oncol 29:25-35. 2007
    ..Cell proliferation, especially the Mitotic Activity Index (MAI), is strongly prognostic in lymph node-negative (LNneg) invasive breast cancer. However, its prognostic value has not been compared with the value of Akt and PTEN expression...
  21. pmc A protein profile study to discriminate CIN lesions from normal cervical epithelium
    Kai Erik Uleberg
    Pathology Department, Stavanger University Hospital, Armauer Hansen Road 20, PO Box 8100, 4068 Stavanger, Norway
    Cell Oncol (Dordr) 34:443-50. 2011
    ....
  22. doi request reprint Microsatellite instability and DNA ploidy in colorectal cancer: potential implications for patients undergoing systematic surveillance after resection
    Kjetil Søreide
    Department of General and Gastroenterological Surgery, Stavanger University Hospital, Stavanger, Norway
    Cancer 115:271-82. 2009
    ..The objective of the current study was to investigate the effect of microsatellite instability (MSI) and DNA ploidy on surveillance after surgery...
  23. doi request reprint The prognostic value of molecular biomarkers in tissue removed by curettage from FIGO stage 1 and 2 endometrioid type endometrial cancer
    Anita Steinbakk
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Am J Obstet Gynecol 200:78.e1-8. 2009
    ..To analyze the prognostic value of molecular biomarkers in curettages of endometrioid endometrial cancer pathologic FIGO stages 1 and 2...
  24. doi request reprint Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Norway
    Acta Oncol 48:514-21. 2009
    ..Hence, the co-expression of ApoD may therefore identify clinical relevant subgroups of ERalpha positive breast cancer patients...
  25. doi request reprint LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer
    Emiel A M Janssen
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Cell Oncol 31:335-43. 2009
    ..The mitotic activity index (MAI) is a strong prognosticator in node-negative invasive breast cancer patients. Recently, a correlation between the MAI and specific chromosomal aberrations at chromosome 1p was described...
  26. ncbi request reprint Prognostic comparison of the proliferation markers (mitotic activity index, phosphohistone H3, Ki67), steroid receptors, HER2, high molecular weight cytokeratins and classical prognostic factors in T₁₋₂N₀M₀ breast cancer
    Einar Gudlaugsson
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Pol J Pathol 64:1-8. 2013
    ..5% assessed by digital image analysis in the periphery of the tumor is prognostically strong. The combination of either PPH3/Ki67 or MAI/Ki67 overshadowed the prognostic value of all other features including Ki67 alone...
  27. doi request reprint Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2-3 regression
    Ane Cecilie Munk
    Department of Gynecology and Obstetrics, Stavanger University Hospital, Stavanger, Norway
    Gynecol Oncol 127:489-94. 2012
    ..The aim of this study was to investigate whether punch-biopsy derived immunohistochemical biomarkers, local immune response, CIN lesion size and condom use are independently correlated to regression of CIN2-3...
  28. doi request reprint The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer
    Kristin Jonsdottir
    Department of Pathology, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway
    Breast Cancer Res Treat 135:381-90. 2012
    ..In conclusion, MARCKSL1 has strong prognostic value in lymph node-negative breast cancer patients, especially in those with high proliferation...
  29. ncbi request reprint Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients
    Kjetil Soreide
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Cell Oncol 29:301-13. 2007
    ..We assessed whether differential expression of cell-cycle and apoptosis-regulating proteins and a monotonous population of elongated cells (MPECs) in colorectal adenomas could predict metachronous CRC...
  30. ncbi request reprint Quantitative molecular parameters to identify low-risk and high-risk early CIN lesions: role of markers of proliferative activity and differentiation and Rb availability
    Arnold Jan Kruse
    Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
    Int J Gynecol Pathol 23:100-9. 2004
    ..57). Increased RbDeep can reduce proliferation, including its upward spread. Combined quantitation of Ki67, Rb, CK13, and CK14 gives accurate information about the progression risk of early CIN lesions...
  31. ncbi request reprint Low- and high-risk CIN 1 and 2 lesions: prospective predictive value of grade, HPV, and Ki-67 immuno-quantitative variables
    Arnold Jan Kruse
    Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
    J Pathol 199:462-70. 2003
    ..In conclusion, Ki-67 immuno-quantitation of small biopsies showing CIN 1 or CIN 2 has strong independent prognostic value for progression...
  32. ncbi request reprint The prognostic value of the proliferation marker phosphohistone H3 (PPH3) in luminal, basal-like and triple negative phenotype invasive lymph node-negative breast cancer
    Ivar Skaland
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Cell Oncol 31:261-71. 2009
    ..Prognostic comparison of phosphohistone-H3 (PPH3) with Cytokeratin 5/6 and/or 14 positive (=basal-CK), triple (ER, PR, HER2)-negative (=TNP) and basal-like (=TNP and basal-CK positive) phenotype in invasive breast cancers...
  33. ncbi request reprint Prospective multicenter validation confirms the prognostic superiority of the endometrial carcinoma prognostic index in international Federation of gynecology and obstetrics stage 1 and 2 endometrial carcinoma
    Jan P A Baak
    Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
    J Clin Oncol 21:4214-21. 2003
    ..To validate the prognostic value of the endometrial carcinoma prognostic index (ECPI; combined myometrium invasion, flow cytometric DNA ploidy, and morphometric mean shortest nuclear axis [MSNA]) versus classic prognosticators...
  34. doi request reprint Apolipoprotein D predicts adverse outcome in women >or=70 years with operable breast cancer
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Stavanger, Norway
    Breast Cancer Res Treat 113:519-28. 2009
    ..6; 95% CI = 2.3-40.4). The potential relevance of ApoD in this increasingly frequent group of breast cancer patients should be further explored...
  35. ncbi request reprint Evaluation of MIB-1-positive cell clusters as a diagnostic marker for cervical intraepithelial neoplasia
    Arnold Jan Kruse
    Department of Pathology, Stavanger, Norway
    Am J Surg Pathol 26:1501-7. 2002
    ..When tangentially cut parabasal cells and inflammatory cells are carefully excluded, MIB-C is a strong diagnostic adjunct in distinguishing CIN from normal or benign cervical squamoepithelial lesions...
  36. ncbi request reprint In lymph node-negative invasive breast carcinomas, specific chromosomal aberrations are strongly associated with high mitotic activity and predict outcome more accurately than grade, tumour diameter, and oestrogen receptor
    Emiel A M Janssen
    Department of Pathology, Central Hospital for Rogaland, Stavanger, Norway
    J Pathol 201:555-61. 2003
    ..In conclusion, loss of 1p is associated with a high MAI. A gain of 3q is a stronger predictor of recurrence than grade, MAI, and other features in invasive breast cancers...
  37. doi request reprint Prospective multicenter comparison of proliferation and other prognostic factors in lymph node negative lobular invasive breast cancer
    Einar Gudlaugsson
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Breast Cancer Res Treat 121:35-40. 2010
    ..0001). In multivariate analysis only subtype and MAI but none of the other characteristics had independent prognostic value. Histologic subtype and MAI have independent prognostic value in node negative invasive lobular cancers...
  38. doi request reprint Comparison of different commercial methods for HPV detection in follow-up cytology after ASCUS/LSIL, prediction of CIN2-3 in follow up biopsies and spontaneous regression of CIN2-3
    Irene T Ovestad
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Gynecol Oncol 123:278-83. 2011
    ..Different Human Papilloma Virus (HPV) tests are currently used. An integrated comparison of the Amplicor, Cobas4800, PreTect HPV-Proofer and APTIMA HPV tests has not been done...
  39. doi request reprint Low p53 and retinoblastoma protein expression in cervical intraepithelial neoplasia grade 3 lesions is associated with coexistent adenocarcinoma in situ
    Arnold Jan Kruse
    Department of Pathology, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway
    Hum Pathol 39:573-8. 2008
    ....
  40. doi request reprint Androgen receptor determination in breast cancer: a comparison of the dextran-coated charcoal method and quantitative immunohistochemical analysis
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Stavanger, The Netherlands
    Appl Immunohistochem Mol Morphol 16:362-70. 2008
    ..Thus, AR determination by charc-AR is inaccurate due to evaluation of both normal and cancer cells. IHC is more sensitive and specific than charc-AR in WS samples, but not when applied to single or a few TMA samples...
  41. doi request reprint Prognostic differences of World Health Organization-assessed mitotic activity index and mitotic impression by quick scanning in invasive ductal breast cancer patients younger than 55 years
    Ivar Skaland
    Department of Pathology, Stavanger University Hospital, Box 8100, 4068 Stavanger, Norway
    Hum Pathol 39:584-90. 2008
    ....
  42. pmc Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers
    Kristin Jonsdottir
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    PLoS ONE 7:e48692. 2012
    ..Previously it has been shown that miR-18a/b, miR-25, miR-29c and miR-106b correlate to high proliferation...
  43. pmc Consistent condom use increases the regression rate of cervical intraepithelial neoplasia 2-3
    Ane Cecilie Munk
    Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway
    PLoS ONE 7:e45114. 2012
    ....
  44. ncbi request reprint The relationship between syntactic structure analysis features, histological grade and high-risk HPV DNA in cervical intraepithelial neoplasia
    Arnold Jan Kruse
    Department of Pathology, Rogaland Central Hospital SiR, Stavanger, Norway
    Cell Oncol 26:135-41. 2004
    ..To assess the correlation between syntactic structure analysis (SSA) features, revised dysplasia grade and the presence of high-risk human papillomavirus DNA in cervical intraepithelial neoplasia (CIN)...
  45. doi request reprint Proliferation is the strongest prognosticator in node-negative breast cancer: significance, error sources, alternatives and comparison with molecular prognostic markers
    Jan P A Baak
    Department of Pathology, Stavanger University Hospital, P O Box 8100, Stavanger 4068, Norway
    Breast Cancer Res Treat 115:241-54. 2009
    ....
  46. doi request reprint Comparison of the effect of different techniques for measurement of Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer
    Einar Gudlaugsson
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Histopathology 61:1134-44. 2012
    ..We compared the reproducibility and prognostic value of different Ki67 sampling and measurement methods...
  47. doi request reprint Validating the prognostic value of proliferation measured by Phosphohistone H3 (PPH3) in invasive lymph node-negative breast cancer patients less than 71 years of age
    Ivar Skaland
    Department of Pathology, Stavanger University Hospital, Box 8100, 4068, Stavanger, Norway
    Breast Cancer Res Treat 114:39-45. 2009
    ..PPH3 is robust as it showed high inter-observer reproducibility and was prognostic over wide range of thresholds around 13 and is the strongest prognostic variable in invasive node-negative breast cancer patients less than 71 years old...
  48. ncbi request reprint The prognostic value of proliferation in lymph-node-negative breast cancer patients is age dependent
    Jan P A Baak
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands, and Department of Pathology, Stavanger University Hospital, P O Box 8100, 4068 Stavanger, Norway
    Eur J Cancer 43:527-35. 2007
    ..006) for patients aged 55-70 years, while over 70 years, MAI was not significant (P=.11). The prognostic value of proliferation was age-dependent. Prognostic breast cancer studies must clearly indicate the age group being studied...
  49. doi request reprint Local immune response in the microenvironment of CIN2-3 with and without spontaneous regression
    Irene Tveiterås Øvestad
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Mod Pathol 23:1231-40. 2010
    ..In conclusion, in non-HPV-16 CIN2-3 lesions, assessing stromal immune cells can be a useful prognostic indicator of regression or persistence...
  50. doi request reprint Cervical intraepithelial neoplasia grade 3 lesions can regress
    Ane Cecilie Munk
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    APMIS 115:1409-14. 2007
    ..001). These results favour the hypothesis that CIN3 can regress, and do not support the "curative punch biopsy" theory...
  51. doi request reprint Biologic profiling of lymph node negative breast cancers by means of microRNA expression
    Emiel A M Janssen
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Mod Pathol 23:1567-76. 2010
    ..The current study shows that estrogen receptor negativity and cytokeratin 5 and 6 expression are important, and specific biological processes in lymph node negative breast cancer, as microRNA signatures are strongest in these subgroups...
  52. ncbi request reprint Comparison of apolipoprotein D determination methods in breast cancer
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Stavanger, Norway
    Anticancer Res 28:1151-60. 2008
    ..Apolipoprotein D (ApoD) is a promising prognostic and predictive factor in breast cancer, but the analysis methods and results vary...
  53. ncbi request reprint Prognostic comparison of proliferation markers and World Health Organization 1973/2004 grades in urothelial carcinomas of the urinary bladder
    Ok Målfrid Mangrud
    Department of Pathology, Stavanger University Hospital, 4068 Stavanger, Norway Clinical Institute 1, Medical Odontology Faculty, University in Bergen, 5020 Bergen, Norway Electronic address
    Hum Pathol 45:1496-503. 2014
    ..In conclusion, in non-muscle-invasive urinary bladder urothelial carcinomas, proliferation biomarkers have prognostic value, possibly exceeding that of the WHO classifications. ..
  54. doi request reprint Mitotic activity and bone marrow micrometastases have independent prognostic value in node positive breast cancer patients
    Bjørnar Gilje
    Department of Haematology and Oncology, Stavanger University Hospital, Stavanger, Norway
    Breast Cancer Res Treat 128:137-46. 2011
    ..2-50) and LN-positive (HR 6.0, CI 1.4 to 26.4) patients with regard to breast cancer-specific survival. A combination of MAI and BM DTC detection identified both LN-negative and LN-positive breast cancer patients with poor prognosis...
  55. doi request reprint Digital image analysis improves the quality of subjective HER-2 expression scoring in breast cancer
    Ivar Skaland
    Department of Pathology, Stavanger University Hospital, Stavanger, The Netherlands
    Appl Immunohistochem Mol Morphol 16:185-90. 2008
    ..To compare HER-2 scoring reproducibility by subjective and digital image analysis (DIA) scores with each other and with fluorescence in situ hybridization (FISH) assessed HER-2 amplification...
  56. ncbi request reprint Correlation of grade of urothelial cell carcinomas and DNA histogram features assessed by flow cytometry and automated image cytometry
    Marco G W Bol
    Department of Pathology, SIR Hospital, Stavanger, Norway
    Anal Cell Pathol 25:147-53. 2003
    ..To analyse how DNA ploidy and S-phase fraction (SPF) by flow cytometry (FCM) and an optimised fully automatic DNA image cytometer (ICM) correlate with grade in TaT1 urothelial cell carcinomas (UC) of the urinary bladder...
  57. ncbi request reprint Success predictors of adjuvant chemotherapy in node-negative breast cancer patients under 55 years
    Emiel A M Janssen
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Cell Oncol 28:295-303. 2006
    ..The majority of (LN-) patients receive ASCT when the St. Gallen criteria or its modifications are used, as accurate identifiers which patients benefit from ASCT are lacking. This may imply over-treatment in many patients...
  58. doi request reprint Evaluation of 5 different labeled polymer immunohistochemical detection systems
    Ivar Skaland
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Appl Immunohistochem Mol Morphol 18:90-6. 2010
    ..We conclude that there are significant differences in sensitivity, specificity, costs, and total assay time in the immunohistochemical detection systems currently in use...
  59. ncbi request reprint Prognostic value and reproducibility of koilocytosis in cervical intraepithelial neoplasia
    Arnold Jan Kruse
    Department of Pathalogy, Rogaland Central Hospital, Stavanger, Norway
    Int J Gynecol Pathol 22:236-9. 2003
    ..Therefore, other more objective and better reproducible criteria are required to extract the potentially important prognostic information contained in the microscopic image of CIN 1 and 2 lesions...
  60. ncbi request reprint Confocal DNA cytometry: a contour-based segmentation algorithm for automated three-dimensional image segmentation
    Jeroen A M Belien
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Cytometry 49:12-21. 2002
    ..So far, these measurements have been performed manually, which is quite time-consuming...
  61. ncbi request reprint The effect of different DNA isolation methods on the outcome of high-risk HPV testing
    Irene T Oevestad
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Indian J Pathol Microbiol 50:733-9. 2007
    ..In conclusion both the manual and standard MPLC DNA isolation methods give good HPV results. The standard MPLC is the fastest DNA isolation method...
  62. pmc Prognostic value of gene signatures and proliferation in lymph-node-negative breast cancer
    Kristin Jonsdottir
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    PLoS ONE 9:e90642. 2014
    ..The prognostic value of gene sets from commercial gene-expression assays were compared with proliferation markers...
  63. ncbi request reprint Use of biomarkers in the evaluation of CIN grade and progression of early CIN
    Jan P A Baak
    Department of Pathology, Stavanger University Hospital, Norway
    Methods Mol Med 119:85-99. 2005
    ....
  64. ncbi request reprint Further testing of morphometric grading in T(A,1) urothelial carcinomas of the urinary bladder and the additional value of p53 immunoquantitation
    Marco G W Bol
    Department of Pathology, SIR Hospital, Stavanger, Norway
    Anal Quant Cytol Histol 24:114-20. 2002
    ....
  65. ncbi request reprint Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha)
    Reinhard Bos
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Oncogene 22:8948-51. 2003
    ..The cases with amplification in BCL-6 showed an increased (25%) incidence of BCL-6 protein overexpression. Thus, this study is the first to show that BCL-6 oncogene activation plays a role in cancers other than lymphomas...
  66. ncbi request reprint Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer
    Mariël Brinkhuis
    Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands
    Anal Cell Pathol 24:17-23. 2002
    ..Further studies are required to elucidate the biological background of the strong prognostic value of mean nuclear area in advanced ovarian cancer...
  67. ncbi request reprint Emerging concepts of apolipoprotein D with possible implications for breast cancer
    Håvard Søiland
    Department of Surgery, Stavanger University Hospital, Stavanger, University of Bergen, Norway
    Cell Oncol 29:195-209. 2007
    ..The triangular relationship between oestrogen receptor, tamoxifen and ApoD should be further explored...
  68. ncbi request reprint Genomics and proteomics in neoplasia
    Jan P A Baak
    Department of Pathology, Stavanger University Hospital, Norway
    Indian J Pathol Microbiol 50:1-5. 2007
    ..Pathologists should quickly familiarize themselves with both -omic techniques and applications, thereby going beyond the usual pathology boundaries...
  69. ncbi request reprint A monotonous population of elongated cells (MPECs) in colorectal adenoma indicates a high risk of metachronous cancer
    Kjetil Soreide
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Am J Surg Pathol 30:1120-9. 2006
    ..Dysplasia grade and histologic growth pattern had no additional value. Thus, colorectal adenomas with subsequent metachronous cancer development can be identified more accurately with MPECs than with classical prognostic factors...
  70. ncbi request reprint The role of quantitative pathology in clinical decision making for Barrett's oesophagus
    Wojciech Polkowski
    Department of Surgery, Academic Medical Center, University of Amsterdam, The Netherlands
    Anal Cell Pathol 25:123-7. 2003
  71. pmc Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis
    Jonathan L Hecht
    Department of Pathology, Beth Israel Hospital, Boston, MA 02115, USA
    Mod Pathol 18:324-30. 2005
    ....
  72. pmc Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: a Gynecologic Oncology Group study
    George L Mutter
    Department of Pathology, BDivision of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 39:866-74. 2008
    ....
  73. ncbi request reprint Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia
    George L Mutter
    Department of Pathology at Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 26:103-14. 2007
    ..The resolution of hormonal and premalignant subsets of traditional "endometrial hyperplasias" is possible using redefined diagnostic criteria, enabling patient therapy to be appropriately matched with the underlying disease mechanisms...
  74. ncbi request reprint Predictive testing of early CIN behaviour by molecular biomarkers
    Jan P A Baak
    Cell Oncol 27:277-80. 2005
    ....
  75. ncbi request reprint Barrett's adenocarcinomas resemble adenocarcinomas of the gastric cardia in terms of chromosomal copy number changes, but relate to squamous cell carcinomas of the distal oesophagus with respect to the presence of high-level amplifications
    Marjan M Weiss
    Department of Gastroenterology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Pathol 199:157-65. 2003
    ..With respect to Barrett's cancer, the chromosomal aberrations more closely reflect the adenocarcinoma phenotype than the squamous origin of the epithelium...
  76. ncbi request reprint Re: "the expressions of the Rb pathway in cervical intraepithelial neoplasia: predictive and prognostic significance" by Nam et al
    Arnold Jan Kruse
    Gynecol Oncol 105:556-7; author reply 557-8. 2007
  77. ncbi request reprint Quantitative histopathological analysis of CIN sections
    Jan P A Baak
    Cell Oncol 28:63-5; author reply 61-2. 2006
  78. ncbi request reprint Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization
    Erna M C Michiels
    Department of Pediatric Oncology, Emma Kinderziekenhuis Academic Medical Center, Amsterdam, The Netherlands
    J Pediatr Hematol Oncol 24:205-10. 2002
    ..Previous reports on the relation between 17q gain and survival could not be confirmed, whereas amplification of N-myc or L-myc seems to indicate poor clinical outcome...
  79. ncbi request reprint Quantitative assessment of gastric antrum atrophy shows restitution to normal histology after Helicobacter pylori eradication
    Nicole C T van Grieken
    Department of Gastroenterology, Free University Medical Center, Amsterdam, The Netherlands
    Digestion 69:27-33. 2004
    ..The aims of the present study were to evaluate the applicability of this method for the grading of antral atrophy and to study the effect of Helicobacter pylori eradication on the antral mucosa...