D Aarsland

Summary

Affiliation: Stavanger University Hospital
Country: Norway

Publications

  1. pmc A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry
    Mona K Beyer
    Department of Radiology, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:254-9. 2007
  2. doi request reprint Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease
    Ragnhild Skogseth
    Institute of Clinical Medicine, School of Medicine, University of Bergen, Bergen, Norway
    Dement Geriatr Cogn Disord 25:559-63. 2008
  3. ncbi request reprint Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study
    Martin Wilhelm Kurz
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 21:2170-4. 2006
  4. ncbi request reprint Prevalence and correlates of disruptive behavior in patients in Norwegian nursing homes
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Int J Geriatr Psychiatry 22:916-21. 2007
  5. ncbi request reprint Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial
    Dag Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4068 Stavanger, Norway
    Lancet Neurol 8:613-8. 2009
  6. doi request reprint Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study
    D Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO 8100, N 4068 Stavanger, Norway
    Neurology 72:1121-6. 2009
  7. ncbi request reprint [Neuropsychiatric and cognitive symptoms in Parkinson disease]
    Dag Aarsland
    Nasjonalt kompetansesenter for bevegelsesforstyrrelser, Stavanger universitetssjukehus, 4068 Stavanger
    Tidsskr Nor Laegeforen 128:2072-6. 2008
  8. doi request reprint The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease
    D Aarsland
    Stavanger University Hospital, The Norwegian Centre for Movement Disorders, PO Box 8100, 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:928-30. 2009
  9. ncbi request reprint Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time
    M D Gjerstad
    The Norwegian Centre for Movement Disorders, Stavanger, Norway, PB 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 79:387-91. 2008
  10. doi request reprint Incidence of Parkinson's disease in Norway: the Norwegian ParkWest study
    G Alves
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:851-7. 2009

Detail Information

Publications72

  1. pmc A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry
    Mona K Beyer
    Department of Radiology, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:254-9. 2007
    ..Dementia is common in Parkinson's disease, but the underlying brain pathology is not yet fully understood...
  2. doi request reprint Neuropsychiatric correlates of cerebrospinal fluid biomarkers in Alzheimer's disease
    Ragnhild Skogseth
    Institute of Clinical Medicine, School of Medicine, University of Bergen, Bergen, Norway
    Dement Geriatr Cogn Disord 25:559-63. 2008
    ..Psychosis, agitation, apathy and depression were assessed using standardised measures in 32 patients with mild Alzheimer's disease...
  3. ncbi request reprint Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study
    Martin Wilhelm Kurz
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 21:2170-4. 2006
    ..Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms...
  4. ncbi request reprint Prevalence and correlates of disruptive behavior in patients in Norwegian nursing homes
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Int J Geriatr Psychiatry 22:916-21. 2007
    ....
  5. ncbi request reprint Memantine in patients with Parkinson's disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial
    Dag Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, 4068 Stavanger, Norway
    Lancet Neurol 8:613-8. 2009
    ..We aimed to test the safety and efficacy of the N-methyl D-aspartate (NMDA) receptor antagonist memantine in patients with PDD or DLB...
  6. doi request reprint Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study
    D Aarsland
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO 8100, N 4068 Stavanger, Norway
    Neurology 72:1121-6. 2009
    ..The aim of this study was to explore the proportion with mild cognitive impairment (MCI) and subtypes in an incidence cohort of untreated PD in Southern and Western Norway...
  7. ncbi request reprint [Neuropsychiatric and cognitive symptoms in Parkinson disease]
    Dag Aarsland
    Nasjonalt kompetansesenter for bevegelsesforstyrrelser, Stavanger universitetssjukehus, 4068 Stavanger
    Tidsskr Nor Laegeforen 128:2072-6. 2008
    ..A variety of neuropsychiatric symptoms commonly occur in Parkinson's disease. Extensive research the last 10 years has provided new knowledge in the field...
  8. doi request reprint The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease
    D Aarsland
    Stavanger University Hospital, The Norwegian Centre for Movement Disorders, PO Box 8100, 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:928-30. 2009
    ..Neuropsychiatric symptoms are common in Parkinson's disease (PD) and have important clinical consequences for patients, caregivers and society. Few studies of neuropsychiatric symptoms in early untreated PD exist...
  9. ncbi request reprint Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson's disease over time
    M D Gjerstad
    The Norwegian Centre for Movement Disorders, Stavanger, Norway, PB 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 79:387-91. 2008
    ..To examine the occurrence and clinical and demographic correlates of REM sleep behaviour disorder (RBD) in patients with Parkinson's disease (PD) in a community-based cohort over 8 years...
  10. doi request reprint Incidence of Parkinson's disease in Norway: the Norwegian ParkWest study
    G Alves
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:851-7. 2009
    ....
  11. pmc Neuropsychiatric symptoms in patients with Parkinson's disease and dementia: frequency, profile and associated care giver stress
    D Aarsland
    Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:36-42. 2007
    ..To explore the profile of neuropsychiatric symptoms in patients with dementia associated with Parkinson's disease (PDD)...
  12. doi request reprint Dementia and survival in Parkinson disease: a 12-year population study
    T C Buter
    Section of Geriatric Psychiatry, Stavanger University Hospital, Arm Hansen v 20, N 4095 Stavanger, Norway
    Neurology 70:1017-22. 2008
    ..However, the absolute risk of dementia and how it affects survival in PD are not known. Such questions are important for patients, their families, and service providers but require long-term studies...
  13. doi request reprint Caregiver distress associated with neuropsychiatric problems in patients with early Parkinson's disease: the Norwegian ParkWest study
    Ingrid Leiknes
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Acta Neurol Scand 122:418-24. 2010
    ..We investigated caregiver distress associated with neuropsychiatric problems in patients with newly diagnosed Parkinson's disease (PD)...
  14. pmc Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis
    D Aarsland
    Stavanger University Hospital, Psychiatric Division, PO Box 8100, 4068 Stavanger, Norway
    Neurology 75:1062-9. 2010
    ..In studies of mild cognitive impairment (MCI) in Parkinson disease (PD), patients without dementia have reported variable prevalences and profiles of MCI, likely to be due to methodologic differences between the studies...
  15. doi request reprint Neuropsychiatric symptoms in mild dementia with lewy bodies and Alzheimer's disease
    J Bjoerke-Bertheussen
    Department of Psychiatry, Centre for Age Related Medicine, Stavanger University Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 34:1-6. 2012
    ..To compare neuropsychiatric symptoms in patients with Alzheimer's disease (AD) and dementia with Lewy bodies(DLB)...
  16. ncbi request reprint Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study
    K F Pedersen
    The Norwegian Centre for Movement Disorders, Stavanger University Hospital, PO Box 8100, N 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 80:1279-82. 2009
    ..Apathy is a common but under-recognised behavioural disorder associated with depression and cognitive impairment in patients with Parkinson disease (PD). However, the longitudinal course of apathy in PD has not been studied...
  17. ncbi request reprint Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis
    N Figved
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mult Scler 14:1084-90. 2008
    ..The association between apathy and intrusions supports the hypothesis that lesions in frontal areas or frontal connections contribute to a specific neuropsychiatric syndrome in patients with MS...
  18. ncbi request reprint Nursing home structure and association with agitation and use of psychotropic drugs in nursing home residents in three countries: Norway, Austria and England
    I Testad
    Psychiatric Clinic, Stavanger University Hospital, Stavanger, Norway
    Int J Geriatr Psychiatry 25:725-31. 2010
    ..International comparative studies offer special advantages in elucidating environmental risk factors by providing a wider diversity of environmental exposures such as nursing home structures, health care systems and genetic diversity...
  19. doi request reprint Multivariate classification of patients with Alzheimer's and dementia with Lewy bodies using high-dimensional cortical thickness measurements: an MRI surface-based morphometric study
    Alexander V Lebedev
    Centre for Age Related Medicine, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway
    J Neurol 260:1104-15. 2013
    ..Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the most common neurodegenerative dementia types. It is important to differentiate between them because of the differences in prognosis and treatment approaches...
  20. pmc Insomnia in Parkinson's disease: frequency and progression over time
    M D Gjerstad
    Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:476-9. 2007
    ..To examine the development of nocturnal sleeping problems in patients with Parkinson's disease (PD) over an 8-year period and to study the clinical and demographic correlates of insomnia...
  21. doi request reprint Health and well-being in care staff and their relations to organizational and psychosocial factors, care staff and resident factors in nursing homes
    I Testad
    Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway
    Int J Geriatr Psychiatry 25:789-97. 2010
    ..The aim of this study is to investigate the association of psychosocial factors and patient factors with stress in care staff in nursing homes...
  22. ncbi request reprint Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease?
    M D Gjerstad
    Norwegian Centre for Movement Disorders, Department of Neurology, Stavanger University Hospital, Stavanger, Norway
    Neurology 67:853-8. 2006
    ..To examine associated demographic and clinical correlates and the development of excessive daytime sleepiness (EDS) over 8 years in a community-based cohort of patients with Parkinson disease (PD)...
  23. ncbi request reprint Neuropsychiatric disturbances in Parkinson's disease clusters in five groups with different prevalence of dementia
    K Bronnick
    Section of Geriatric Psychiatry, Stavanger University Hospital, Helse Stavanger, Norway
    Acta Psychiatr Scand 112:201-7. 2005
    ..To investigate the inter-relationship of neuropsychiatric disturbances in Parkinson's disease (PD) by cluster analysis and describe the properties of the clusters...
  24. ncbi request reprint The effect of age of onset of PD on risk of dementia
    D Aarsland
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Arm Hansen v 20, N 4005, Stavanger, Norway
    J Neurol 254:38-45. 2007
    ..However, age at onset (AAO) and age at baseline assessment are often correlated. The aim of this study was to explore whether AAO of PD symptoms is a risk factor for dementia independent of the general effect of age...
  25. ncbi request reprint The influence of cerebrovascular risk factors on incident dementia in patients with Parkinson's disease
    K Haugarvoll
    The Norwegian Centre for Movement Disorders, Rogaland Central Hospital, Stavanger, Norway
    Acta Neurol Scand 112:386-90. 2005
    ..To examine if risk factors for cerebrovascular disease would increase the risk for dementia in patients with Parkinson's disease (PD)...
  26. pmc Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease
    K Bronnick
    Psychiatric Clinic, Stavanger University Hospital, Helse Stavanger, Post Box 8100, 4068 Stavanger, Norway
    J Neurol Neurosurg Psychiatry 77:1136-42. 2006
    ..To investigate the effects of attentional deficits on activities of daily living (ADL) in patients with dementia associated with Parkinson's disease (PDD)...
  27. doi request reprint Grey matter atrophy in early versus late dementia in Parkinson's disease
    M K Beyer
    Department of Radiology, Stavanger University Hospital, Postbox 8100, 4068 Stavanger, Norway
    Parkinsonism Relat Disord 14:620-5. 2008
    ..Our results indicate that the early development of dementia in PD is associated with more severe degeneration of cortical and sub-cortical structures...
  28. pmc White matter hyperintensities in mild lewy body dementia
    K Oppedal
    Centre for Age Related Medicine, Stavanger University Hospital, Stavanger, Norway Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway
    Dement Geriatr Cogn Dis Extra 2:481-95. 2012
    ..The objective of this study was to explore the load of white matter hyperintensities (WMH) in patients with Lewy body dementia (LBD) and compare to Alzheimer's disease (AD) and normal controls (NC)...
  29. ncbi request reprint Neuropsychiatric symptoms in patients with multiple sclerosis
    N Figved
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Acta Psychiatr Scand 112:463-8. 2005
    ..To explore the range of psychiatric symptoms in patients with multiple sclerosis (MS) and their association with neurological disability...
  30. ncbi request reprint Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial
    B S Husebo
    Department of Global Public Health and Primary Care, Center for Elderly and Nursing Home Medicine, University of Bergen, Bergen, Norway Center for Age Related Medicine, Stavanger University Hospital, Stavanger, Norway
    Int J Geriatr Psychiatry 29:828-36. 2014
    ..An association between pain and depressive symptoms has been reported, but the impact of pain management on depression and other mood symptoms has not been investigated...
  31. doi request reprint Scales to assess psychosis in Parkinson's disease: Critique and recommendations
    Hubert H Fernandez
    Department of Neurology, McKnight Brain Institute University of Florida, Gainesville, Florida 32611, USA
    Mov Disord 23:484-500. 2008
    ..The CGIS is suggested as a secondary outcome scale to measure change and response to treatment over time...
  32. ncbi request reprint FMR1 alleles in Parkinson's disease: relation to cognitive decline and hallucinations, a longitudinal study
    Martin Wilhelm Kurz
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    J Geriatr Psychiatry Neurol 20:89-92. 2007
    ..However, the marked cognitive decline in 2 patients carrying intermediate-size alleles points to a possible association. More studies with larger PD samples are warranted...
  33. ncbi request reprint Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies
    Mona K Beyer
    Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    Neurology 69:747-54. 2007
    ..We conducted a study using voxel-based morphometry (VBM) to explore the pattern of cortical atrophy in DLB and PDD...
  34. ncbi request reprint Validation of the Unified Parkinson's Disease Rating Scale (UPDRS) section I as a screening and diagnostic instrument for apathy in patients with Parkinson's disease
    Kenn Freddy Pedersen
    The Norwegian Centre for Movement Disorders, Stavanger, Norway
    Parkinsonism Relat Disord 14:183-6. 2008
    ..A score of 2 or more on the motivation/initiative item was adequate to screen for apathy, whereas a score of 4 had high diagnostic accuracy at the cost of unacceptable low sensitivity...
  35. ncbi request reprint Visual rating of white matter hyperintensities in Parkinson's disease
    Mona K Beyer
    Department of Radiology, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 21:223-9. 2006
    ..Our findings suggest that WMH in the deep white matter may contribute to dementia in PD...
  36. ncbi request reprint Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force
    Bruno Dubois
    INSERM UPMC UMRS 610, Federation of Neurology, AP HP, Salpêtrière Hospital Université Paris6, Paris, France
    Mov Disord 22:2314-24. 2007
    ..We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies...
  37. pmc Profile of cognitive impairment in dementia associated with Parkinson's disease compared with Alzheimer's disease
    Kolbjorn Bronnick
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Helse Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:1064-8. 2007
    ..To compare the profile of cognitive impairment in Alzheimer's disease (AD) with dementia associated with Parkinson's disease (PDD)...
  38. doi request reprint Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers
    Dag Aarsland
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 25:195-205. 2008
    ..Our aim was to identify biomarkers that may differentiate DLB from Alzheimer's disease (AD)...
  39. ncbi request reprint Management of Parkinson's disease dementia : practical considerations
    Arvid Rongve
    Haugesund County Hospital, Haugesund, Norway University of Bergen, Bergen, Norway
    Drugs Aging 23:807-22. 2006
    ..Non-pharmacological interventions can also be effective but require further study...
  40. ncbi request reprint Cognitive profiles of individual patients with Parkinson's disease and dementia: comparison with dementia with lewy bodies and Alzheimer's disease
    Carmen Cristea Janvin
    Stavanger University Hospital, Section of Geriatric Psychiatry, Stavanger, Norway
    Mov Disord 21:337-42. 2006
    ..These findings suggest that in some patients with PDD, frontosubcortical changes are the main contributing factor to dementia, whereas in other patients, cortical and hippocampal changes are more important...
  41. ncbi request reprint The psychosocial burden on spouses of the elderly with stroke, dementia and Parkinson's disease
    Bente Thommessen
    Department of Geriatric Medicine, Ullevaal Hospital, Oslo, Norway
    Int J Geriatr Psychiatry 17:78-84. 2002
    ..66-0.69). Covariates of this factor were identified using structural equation modeling (SEM) by regression on patient's age, gender, cognitive function (MMSE), activities of daily living (ADL) and depressive symptoms (MADRS)...
  42. ncbi request reprint Psychiatric and behavioral symptoms in Alzheimer's disease and other dementias: etiology and management
    Dag Aarsland
    Centre for Clinical Neuroscience Research, Stavanger University Hospital, PO Box 1163, 4095 Stavanger, Norway
    Curr Neurol Neurosci Rep 5:345-54. 2005
    ..More studies are needed to clarify the role of cholinergic and other psychotropic agents as well as nonpharmacologic interventions for psychiatric and behavioral symptoms in patients with dementia...
  43. ncbi request reprint Cognitive predictors of dementia in Parkinson's disease: a community-based, 4-year longitudinal study
    Carmen Cristea Janvin
    Department for Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    J Geriatr Psychiatry Neurol 18:149-54. 2005
    ..This finding may have important clinical implications as a marker of subsequent development of dementia...
  44. ncbi request reprint A systematic review of prevalence studies of dementia in Parkinson's disease
    Dag Aarsland
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    Mov Disord 20:1255-63. 2005
    ..The estimated prevalence of PDD in the general population aged 65 years and over is 0.2 to 0.5%...
  45. ncbi request reprint Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias
    Dag Aarsland
    Section of Geriatric Psychiatry, Central Hospital, Rogaland, Stavanger, Norway
    J Clin Psychiatry 66:633-7. 2005
    ..Severe sensitivity to neuroleptic agents is a major clinical problem in dementia with Lewy bodies (DLB), but has not been determined in Parkinson's disease (PD) and PD with dementia (PDD)...
  46. ncbi request reprint The rate of cognitive decline in Parkinson disease
    Dag Aarsland
    Section of Geriatric Psychiatry, Central Hospital of Rogaland, Stavanger, N 4095 Hillevåg, Norway
    Arch Neurol 61:1906-11. 2004
    ....
  47. ncbi request reprint Are Parkinson's disease with dementia and dementia with Lewy bodies the same entity?
    Dag Aarsland
    Psychiatric Clinic, Rogaland Central Hospital, PO Box 1163, Hillevaag, 4095 Stavanger, Norway
    J Geriatr Psychiatry Neurol 17:137-45. 2004
    ....
  48. ncbi request reprint Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
    John T O'Brien
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, England
    Arch Neurol 61:919-25. 2004
    ..Dementia with Lewy bodies (DLB) is a common form of late-life dementia that can be difficult to differentiate from other disorders, especially Alzheimer disease (AD), during life. At autopsy the striatal dopaminergic transporter is reduced...
  49. ncbi request reprint Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer's disease, Parkinson's disease and Parkinson's disease with dementia
    Francesca Cormack
    Psychology Department, The Henry Wellcome Building For Neuroecology, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 19:371-7. 2004
    ..There have been suggestions that constructional apraxia is prevalent in DLB, and may provide a sensitive marker of the disease...
  50. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...
  51. ncbi request reprint Neuropsychological profile of patients with Parkinson's disease without dementia
    Carmen Janvin
    Section of Geriatric Psychiatry, Rogaland Psychiatric Hospital, Stavanger, Norway
    Dement Geriatr Cogn Disord 15:126-31. 2003
    ..Identification of mild cognitive impairment is important, since these symptoms are important for patient management and may also facilitate to determine prognosis...
  52. ncbi request reprint Neuropathology of dementia in Parkinson's disease: a prospective, community-based study
    Dag Aarsland
    Stavanger University Hospital, Stavanger, Norway
    Ann Neurol 58:773-6. 2005
    ..This study strongly suggests that Lewy body disease is the main substrate driving the progression of cognitive impairment in Parkinson's disease...
  53. ncbi request reprint Progression of motor impairment and disability in Parkinson disease: a population-based study
    Guido Alves
    Norwegian Centre for Movement Disorders, Stavanger, Norway
    Neurology 65:1436-41. 2005
    ..To investigate risk factors and the rate of progression of motor symptoms and disability in a population-based cohort of patients with Parkinson disease (PD)...
  54. ncbi request reprint Disorders of motivation, sexual conduct, and sleep in Parkinson's disease
    Dag Aarsland
    Stavanger University Hospital, Psychiatric Clinic and School of Medicine, University of Bergen, Norway
    Adv Neurol 96:56-64. 2005
    ..Although some placebo-controlled trials have been published recently, no established treatments are currently available for these symptoms (85) (see Table 5-2), and thus future clinical trials are needed...
  55. ncbi request reprint Familial occurrence of dementia and parkinsonism: a systematic review
    Martin Wilhelm Kurz
    Department of Neurology, Heinrich Heine University Dusseldorf, Germany
    Dement Geriatr Cogn Disord 22:288-95. 2006
    ..There is a convincing genetic overlap between both syndromes, suggesting that they share a common etiological factor...
  56. ncbi request reprint Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Italy
    Neurobiol Dis 23:481-9. 2006
    ..05). This study demonstrates distinct combinations of subunits contributing to heteromeric nicotinic receptor binding in the human brain that are area/pathway specific and differentially affected by neurodegeneration...
  57. ncbi request reprint Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia
    Carmen Cristea Janvin
    Stavanger University Hospital, Section of Geriatric Psychiatry, Stavanger, Norway
    Mov Disord 21:1343-9. 2006
    ..However, these findings should be interpreted with caution due to the relatively small number of subjects included in this study...
  58. ncbi request reprint Changes in motor subtype and risk for incident dementia in Parkinson's disease
    Guido Alves
    The Norwegian Center for Movement Disorders, Stavanger, Norway
    Mov Disord 21:1123-30. 2006
    ..These findings raise the question whether PIGD and dementia share common or parallel neuropathology...
  59. ncbi request reprint Depressive symptom profile in Parkinson's disease: a comparison with depression in elderly patients without Parkinson's disease
    Uwe Ehrt
    Section of Geriatric Psychiatry, Stavanger University Hospital, Norway
    Int J Geriatr Psychiatry 21:252-8. 2006
    ..It is still unclear whether the disturbances of neurotransmitter activities lead to a specific profile of depressive symptoms, that is characteristic for PD and differs from that in depressed patients without PD...
  60. ncbi request reprint Effects of rivastigmine in patients with and without visual hallucinations in dementia associated with Parkinson's disease
    David Burn
    Regional Neuroscience Center, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Mov Disord 21:1899-907. 2006
    ..Visual hallucinations appear to predict more rapid decline and possibly greater therapeutic benefit from rivastigmine treatment in PDD...
  61. ncbi request reprint Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study
    Dag Aarsland
    Section of Geriatric Psychiatry, Psychiatric Clinic, Central Hospital of Rogaland, PO 1163, Hillevag, N 4095 Stavanger, Norway
    Arch Neurol 60:387-92. 2003
    ..Few longitudinal studies of dementia in Parkinson disease (PD) have been reported, and the proportion of patients with PD who eventually develop dementia is unknown...
  62. ncbi request reprint Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work group
    Bernard Ravina
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
    Mov Disord 22:1061-8. 2007
    ..These criteria require validation and may be refined, but form a starting point for studies of the epidemiology and pathophysiology of PDPsy, and are a potential indication for therapy development...
  63. ncbi request reprint A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease
    Roy W Jones
    Research Institute for the Care of the Elderly, St Martin s Hospital, Bath, UK
    Int J Geriatr Psychiatry 19:58-67. 2004
    ....
  64. pmc Caregiver burden in multiple sclerosis: the impact of neuropsychiatric symptoms
    Nanna Figved
    Section of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway
    J Neurol Neurosurg Psychiatry 78:1097-102. 2007
    ..We studied the level of distress in caregivers of patients with recently diagnosed multiple sclerosis (MS), and their relation to clinical characteristics...
  65. ncbi request reprint Improvement in behavioral symptoms and advance of activity acrophase after short-term bright light treatment in severe dementia
    Arvid Skjerve
    Olaviken Treatment Center, University of Bergen, Bergen, Norway
    Psychiatry Clin Neurosci 58:343-7. 2004
    ..There was an advance of the activity rhythm acrophase during treatment. These results suggest that short-time bright light improves behavioral symptoms and aspects of activity rhythm disturbances even in severely demented subjects...
  66. ncbi request reprint Subthreshold depression in patients with Parkinson's disease and dementia--clinical and demographic correlates
    Uwe Ehrt
    Norwegian Centre for Movement Disorders, Stavanger University Hospital, Norway
    Int J Geriatr Psychiatry 22:980-5. 2007
    ....
  67. ncbi request reprint Rivastigmine for dementia associated with Parkinson's disease
    Murat Emre
    Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    N Engl J Med 351:2509-18. 2004
    ..Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor rivastigmine in such patients...
  68. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  69. ncbi request reprint Lewy body disease: thalamic cholinergic activity related to dementia and parkinsonism
    Iryna Ziabreva
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neurobiol Aging 27:433-8. 2006
    ..These findings show that significant thalamic presynaptic cholinergic deficits occur only in cases of combined cortical and subcortical neurodegeneration in which dementia developed after prolonged parkinsonism...
  70. doi request reprint Who suffers most? Dementia and pain in nursing home patients: a cross-sectional study
    Bettina Sandgathe Husebo
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    J Am Med Dir Assoc 9:427-33. 2008
    ..To explore the relationship between nursing home patients with different stages of dementia and different dementia diagnoses and use of pain medication according to pain intensity...
  71. ncbi request reprint A systematic review of prevalence studies of depression in Parkinson's disease
    Jennifer S A M Reijnders
    Department of Psychiatry, Maastricht University Hospital, Maastricht, The Netherlands
    Mov Disord 23:183-9; quiz 313. 2008
    ..This systematic review suggests that the average prevalence of major depressive disorder in PD is substantial, but lower than generally assumed...
  72. ncbi request reprint Role of cholinesterase inhibitors in Parkinson's disease and dementia with Lewy bodies
    Dag Aarsland
    Rogaland Central Hospital, Psychiatric Clinic, PO Box 1163, Hillevaag, 4095 Stavanger, Norway
    J Geriatr Psychiatry Neurol 17:164-71. 2004
    ....