O Spigset

Summary

Country: Norway

Publications

  1. ncbi request reprint [From ready-made to tailor-made--future possibilities for individualized drug therapy]
    O Spigset
    Avdeling for legemidler Regionsykehuset i Trondheim
    Tidsskr Nor Laegeforen 120:73-6. 2000
  2. ncbi request reprint Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance
    O Spigset
    Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 54:943-6. 1999
  3. ncbi request reprint Adverse reactions of selective serotonin reuptake inhibitors: reports from a spontaneous reporting system
    O Spigset
    Adverse Drug Reactions Monitoring Center, Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Drug Saf 20:277-87. 1999
  4. ncbi request reprint Enhanced platelet serotonin 5-HT2A receptor binding in anorexia nervosa and bulimia nervosa
    O Spigset
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur Neuropsychopharmacol 9:469-73. 1999
  5. ncbi request reprint Citalopram pharmacokinetics in patients with chronic renal failure and the effect of haemodialysis
    O Spigset
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 56:699-703. 2000
  6. ncbi request reprint Analgesics and breast-feeding: safety considerations
    O Spigset
    Department of Clinical Pharmacology, Regional and University Hospital, Trondheim, Norway
    Paediatr Drugs 2:223-38. 2000
  7. ncbi request reprint Binding of [3H]paroxetine to serotonin uptake sites and of [3H]lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment
    M Bixo
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, S 901 85, Umea, Sweden
    Psychoneuroendocrinology 26:551-64. 2001
  8. ncbi request reprint Absence of interaction between erythromycin and a single dose of clozapine
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 55:221-6. 1999
  9. ncbi request reprint The major fluvoxamine metabolite in urine is formed by CYP2D6
    O Spigset
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 57:653-8. 2001
  10. ncbi request reprint Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 57:493-7. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint [From ready-made to tailor-made--future possibilities for individualized drug therapy]
    O Spigset
    Avdeling for legemidler Regionsykehuset i Trondheim
    Tidsskr Nor Laegeforen 120:73-6. 2000
    ..This article presents the current status in these fields and discusses to which extent the present promises can be expected to be realised in the future...
  2. ncbi request reprint Lack of correlation between fluvoxamine clearance and CYP1A2 activity as measured by systemic caffeine clearance
    O Spigset
    Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 54:943-6. 1999
    ..Evidence exists to suggest that fluvoxamine is metabolized by CYP1A2. The present study was undertaken in order to further elucidate the role of CYPIA2 in fluvoxamine disposition...
  3. ncbi request reprint Adverse reactions of selective serotonin reuptake inhibitors: reports from a spontaneous reporting system
    O Spigset
    Adverse Drug Reactions Monitoring Center, Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Drug Saf 20:277-87. 1999
    ..The aim of this study was to investigate the pattern of adverse reactions reported on SSRIs in Sweden and assess possible risk factors associated with the occurrence of adverse reactions to these agents...
  4. ncbi request reprint Enhanced platelet serotonin 5-HT2A receptor binding in anorexia nervosa and bulimia nervosa
    O Spigset
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur Neuropsychopharmacol 9:469-73. 1999
    ..The present study indicates that patients with anorexia nervosa as well as patients with bulimia nervosa have an enhanced 5-HT2A receptor binding and provides further evidence for a serotonergic dysfunction in eating disorders...
  5. ncbi request reprint Citalopram pharmacokinetics in patients with chronic renal failure and the effect of haemodialysis
    O Spigset
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 56:699-703. 2000
    ..To study the effects of severe renal failure and haemodialysis on the pharmacokinetics of citalopram...
  6. ncbi request reprint Analgesics and breast-feeding: safety considerations
    O Spigset
    Department of Clinical Pharmacology, Regional and University Hospital, Trondheim, Norway
    Paediatr Drugs 2:223-38. 2000
    ....
  7. ncbi request reprint Binding of [3H]paroxetine to serotonin uptake sites and of [3H]lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment
    M Bixo
    Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, S 901 85, Umea, Sweden
    Psychoneuroendocrinology 26:551-64. 2001
    ..The results are consistent with the hypothesis that changes in serotonergic transmission could be a trait in the premenstrual dysphoric disorder...
  8. ncbi request reprint Absence of interaction between erythromycin and a single dose of clozapine
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 55:221-6. 1999
    ..To study the suggested pharmacokinetic interaction between erythromycin, a strong inhibitor of CYP3A4, and clozapine...
  9. ncbi request reprint The major fluvoxamine metabolite in urine is formed by CYP2D6
    O Spigset
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 57:653-8. 2001
    ..The present study was designed to investigate this issue...
  10. ncbi request reprint Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Eur J Clin Pharmacol 57:493-7. 2001
    ..Limited data suggest that CYP1A2 and CYP2D6 are involved in the metabolism of olanzapine. The purpose of this study was to further elucidate the role of these enzymes in the disposition of olanzapine in vivo...
  11. ncbi request reprint Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity
    K Hedenmalm
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Ther Drug Monit 19:643-9. 1997
    ....
  12. ncbi request reprint Serotonin 5-HT2A receptor binding in platelets from patients with Alzheimer's disease or vascular dementia
    O Spigset
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Int Psychogeriatr 12:537-45. 2000
    ..There was no correlation between 5-HT2A receptor status before treatment and the therapeutic effect of citalopram. The study indicates that platelet 5-HT2A receptor status is of limited value as a peripheral marker in dementia...
  13. ncbi request reprint Influence of postmenopausal hormone replacement therapy on platelet serotonin uptake site and serotonin 2A receptor binding
    A C Wihlbäck
    Department of Clinical Sciences Obstetrics and Gynecology, University Hospital of Umea, Umea, Sweden
    Obstet Gynecol 98:450-7. 2001
    ..To examine whether binding of [3H]paroxetine to the platelet serotonin transporter or binding of [3H]lysergic acid diethylamide (LSD) to the platelet 5-HT(2A) receptor are influenced by postmenopausal estrogen/progestogen treatment...
  14. pmc Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Br J Clin Pharmacol 51:169-73. 2001
    ..The study was carried out in order to assess the effects of gender and the use of oral contraceptives (OCs) on CYP2D6 and CYP2C19 activities in healthy volunteers...
  15. ncbi request reprint Myocarditis related to clozapine treatment
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    J Clin Psychopharmacol 21:382-8. 2001
    ..Admittance for observation, interruption of the clozapine treatment, and treatment with corticosteroids should be considered for patients in whom this reaction is suspected...
  16. ncbi request reprint Anticonvulsant use during lactation
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Drug Saf 22:425-40. 2000
    ..As breast milk has considerable advantages over formula milk, the benefits of continuing breast feeding should always be taken into consideration in the risk-benefit analysis...
  17. ncbi request reprint Platelet serotonin 5-HT2A receptor binding in patients with carcinoid tumor
    O Spigset
    Division of Clinical Pharmacology, University of Northern Sweden, Umea, Sweden
    Scand J Clin Lab Invest 64:3-8. 2004
    ....
  18. ncbi request reprint Effects of comedication on the serum levels of aripiprazole: evidence from a routine therapeutic drug monitoring service
    I Castberg
    Department of Clinical Pharmacology, St Olav University Hospital, Trondheim, Norway
    Pharmacopsychiatry 40:107-10. 2007
    ..The objective of the study was to compare the serum concentrations of the atypical antipsychotic aripiprazole in monotherapy with the concentrations found during concomitant therapy with other drugs...
  19. ncbi request reprint Gender differences in drug effects: implications for anesthesiologists
    H Pleym
    Departments of Anesthesia and Intensive Care, St Olav s University Hospital, Trondheim, Norway
    Acta Anaesthesiol Scand 47:241-59. 2003
    ..Knowledge of previous work is required to decide if gender-based differences in clinical practice is justified, and to determine the need for research...